Computational analysis of affinity dynamics between the variants of SARS-CoV-2 spike protein (RBD) and human ACE-2 receptor
The novel coronavirus SARS-CoV-2 resulted in a significant worldwide health emergency known as the COVID-19 pandemic. This crisis has been marked by the widespread of various variants, with certain ones causin... (Source: Virology Journal)
Source: Virology Journal - April 19, 2024 Category: Virology Authors: Nishad Sultana, S. N. Nagesha, C. N. Lakshminarayana Reddy, B. N. Ramesh, S. Shyamalamma, K. S. Shashidhara, K. M. Satish, C. Pradeep and G. D Vidyadhar Tags: Research Source Type: research
MST1/2 exerts a pivotal role in inducing neuroinflammation and Coxsackievirus-A10 replication by interacting with innate immunity
Coxsackievirus-A10 (CV-A10), responsible for the hand, foot and mouth disease (HFMD) pandemic, could cause serious central nervous system (CNS) complications. The underlying molecular basis of CV-A10 and host ... (Source: Virology Journal)
Source: Virology Journal - April 19, 2024 Category: Virology Authors: Yajie Hu, Minigmei Zhong, Yaming Lv, Wei Zhao, Baojiang Qian, Jie Song and Yunhui Zhang Tags: Research Source Type: research
Melatonin: a ferroptosis inhibitor with potential therapeutic efficacy for the post-COVID-19 trajectory of accelerated brain aging and neurodegeneration
The unprecedented pandemic of COVID-19 swept millions of lives in a short period, yet its menace continues among its survivors in the form of post-COVID syndrome. An exponentially growing number of COVID-19 su... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - April 19, 2024 Category: Neurology Authors: Asmaa Yehia and Osama A. Abulseoud Tags: Review Source Type: research
Comparison of the Measurement Properties of EQ-5D-5L and SF-6Dv2 in COVID-19 Patients in China
ConclusionsThe utility indices generated by EQ-5D-5L and SF-6Dv2 in COVID-19 patients demonstrate strong correlation and responsiveness. However, the agreement between these two instruments does not reach a satisfactory level. Consequently, these two measures cannot be used interchangeably. In situations where apprehensions about ceiling effects affecting outcome measurement arise, it is advisable to consider SF-6Dv2 as a preferable outcome measure for studies on patients with COVID-19. (Source: Applied Health Economics and Health Policy)
Source: Applied Health Economics and Health Policy - April 19, 2024 Category: Health Management Source Type: research
Mindfulness and Well-being: A Longitudinal Serial Mediation Model of Psychological Adjustment and COVID-19 Fear
AbstractNumerous studies have been carried out globally related to COVID-19 since the onset of the pandemic, most of which were cross-sectional. Therefore, there is a need for longitudinal studies to fully understand the impact of COVID-19 on mental health. In the present longitudinal study, our aim was to examine whether psychological adjustment and fear of COVID-19 would serially mediate the relationship between mindfulness and well-being in a Turkish sample (N = 300,Mage=22.21 years, SD = 3.01, 60.3% female). The results of a two-wave longitudinal study were analyzed via bootstrapping. The findings of the seria...
Source: Journal of Rational-Emotive and Cognitive-Behavior Therapy - April 19, 2024 Category: Psychiatry & Psychology Source Type: research
A longitudinal cohort study on the use of health and care services by older adults living at home with/without dementia before and during the COVID-19 pandemic: the HUNT study
Older adults and people with dementia were anticipated to be particularly unable to use health and care services during the lockdown period following the COVID-19 pandemic. To better prepare for future pandemi... (Source: BMC Health Services Research)
Source: BMC Health Services Research - April 19, 2024 Category: General Medicine Authors: Tanja Louise Ibsen, Bj ørn Heine Strand, Sverre Bergh, Gill Livingston, Hilde Lurås, Svenn-Erik Mamelund, Richard Oude Voshaar, Anne Marie Mork Rokstad, Pernille Thingstad, Debby Gerritsen and Geir Selbæk Tags: Research Source Type: research
The impact of the COVID-19 pandemic on symptomatic breast cancer presentations in an Irish breast cancer unit: a retrospective cohort study
ConclusionSymptomatic breast cancers diagnosed since the onset of COVID-19 demonstrated an increase in new metastatic presentations and more aggressive histopathological characteristics when compared to a pre-pandemic control group. Rates of adjuvant radiotherapy and axillary surgery increased during the pandemic. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - April 19, 2024 Category: General Medicine Source Type: research
Experiences of physical and emotional intimate partner violence during the COVID-19 pandemic: a comparison of prepandemic and pandemic data in a longitudinal study of Australian mothers
Conclusions
Findings suggest that the spike in IPV-related crime statistics following the onset of the pandemic (typically incidents of physical violence) is the tip of the iceberg for women’s IPV experiences. There is a need to increase the capacity of health practitioners to recognise emotional as well as physical IPV, and IPV ought to be considered where women present with mental health problems. (Source: BMJ Open)
Source: BMJ Open - April 19, 2024 Category: General Medicine Authors: FitzPatrick, K. M., Brown, S. J., Hegarty, K., Mensah, F. K., Gartland, D. Tags: Open access, Mental health Source Type: research
Community antibiotic prescribing in patients with COVID-19 across three pandemic waves: a population-based study in Scotland, UK
Conclusion
Community antibiotic prescriptions in COVID-19 episodes were uncommon in this population and likelihood was associated with patient factors. The reduction over pandemic waves may represent increased knowledge regarding COVID-19 treatment and/or evolving symptomatology. (Source: BMJ Open)
Source: BMJ Open - April 19, 2024 Category: General Medicine Authors: Ciaccio, L., Donnan, P. T., Parcell, B. J., Marwick, C. A. Tags: Open access, Infectious diseases, COVID-19 Source Type: research
An insight into the use of telemedicine technology for cancer patients during the Covid-19 pandemic: a scoping review
This study aimed to investigate the use of telemedicine technology for cancer patients... (Source: BMC Medical Informatics and Decision Making)
Source: BMC Medical Informatics and Decision Making - April 19, 2024 Category: Information Technology Authors: Esmaeel Toni and Haleh Ayatollahi Tags: Research Source Type: research
Leadership's perceptions of palliative care during the COVID-19 pandemic: a qualitative study
Palliative care played a leading role in the COVID-19 pandemic. However, little is known regarding health system leadership's perceptions. (Source: Journal of Pain and Symptom Management)
Source: Journal of Pain and Symptom Management - April 19, 2024 Category: Palliative Care Authors: Tamara Vesel, Audrey Covaleski, Veronica Burkarth, Emma Ernst, Linda Vesel Tags: Original Article Source Type: research
Next Level Nurse Partnership
Nursing is the backbone of the health care industry. No other sector of health care has as broad of a reach or direct impact on patient care and in the post-pandemic environment, the importance of nursing has been amplified as new technologies and workflows disrupt the status quo, and nurse teams and leaders continue to face new pressures and obstacles in their efforts to care for patients. Despite the significant role nursing plays in maintaining and improving access to care, there is a growing challenge involving the state of the nursing workforce, and nurses are leaving the profession at an alarming rate, with retiremen...
Source: Nurse Leader - April 19, 2024 Category: Nursing Authors: Aundrea Mills Source Type: research
Changes in parenting behavior in the time of COVID —19: A mixed method approach
This study was designed to explore mothers’ perceptions about changes in parenting behavior in the middle of the pandemic COVID 19 period. Based on the convergent mixed-method design and Parental Stress model, we illustrated these changes by taking into account the impact of the pandemic perceiv ed by mothers and the resources they had available. Research on parenting changes was important in the Romanian context because, in that challenging period, there were no regulations to safeguard parents, especially single parents as mothers. Mothers experienced increased levels of stress, some of t hem having to leave their jobs...
Source: PLoS One - April 19, 2024 Category: Biomedical Science Authors: Luiza Mesesan-Schmitz Source Type: research
IJERPH, Vol. 21, Pages 508: Cognitive and Relational Processes Associated to Mental Health in Italian High School Students during COVID-19 and Russian & ndash;Ukrainian War Outbreaks
This study explored the mental health of 215 Italian adolescents during the COVID-19 pandemic and the subsequent outbreak of the Russian–Ukrainian war. By administering a set of questionnaires, several cognitive and emotional variables were investigated, including core belief violation, meaning attribution to the pandemic and war, attachment, and emotion regulation, social media addiction, and relationships with significant others and teachers. We conducted some descriptive, mean difference, correlational, and predictive analyses that revealed a significant association between core belief violation caused by ...
Source: International Journal of Environmental Research and Public Health - April 19, 2024 Category: Environmental Health Authors: Att à Negri Arianna Barazzetti Alice Rinzivillo Rachele Mariani Cinzia Di Monte Tags: Article Source Type: research
Surgical recovery from the COVID-19 pandemic in English adult neurosurgical centres
. (Source: British Journal of Neurosurgery)
Source: British Journal of Neurosurgery - April 19, 2024 Category: Neurosurgery Authors: Daniel ThompsonAdam WilliamsPeter C. WhitfieldPeter HutchinsonNicholas PhillipsDavid CromwellAdel Helmya Department of Neurosurgery, North Bristol NHS Trust, Bristol, UKb Department of Clinical Neurosciences, University of Cambridge, Cambridge, UKc Depart Source Type: research
