Risk factors for progressing to critical illness in patients with hospital-acquired COVID-19
CONCLUSIONS: Among patients with hospital-acquired COVID-19, preexisting respiratory disease, preexisting cardiovascular disease, immunocompromised status, and higher clinical frailty scale and SOFA scores at baseline were risk factors for progression to critical illness. Patients with these risk factors must be prioritized and appropriately isolated or treated in a timely manner, especially in pandemic settings.PMID:38632896 | DOI:10.3904/kjim.2023.347 (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - April 18, 2024 Category: Internal Medicine Authors: Kyung-Eui Lee Jinwoo Lee Sang-Min Lee Hong Yeul Lee Source Type: research
PACRAT: Pathogen detection with aptamer-detected cascaded recombinase polymerase amplification-in vitro transcription
RNA. 2024 Apr 18:rna.079891.123. doi: 10.1261/rna.079891.123. Online ahead of print.ABSTRACTThe SARS-CoV-2 pandemic underscored the need for early, rapid, and widespread pathogen detection tests that are readily accessible. Many existing rapid isothermal detection methods employ the recombinase polymerase amplification (RPA), which exhibits PCR-like sensitivity, specificity, and even higher speed. However, coupling RPA to other enzymatic reactions has proven difficult. For the first time, we demonstrate that with tuning of buffer conditions and optimization of reagent concentrations, RPA can be cascaded into an in vitro tr...
Source: RNA - April 18, 2024 Category: Genetics & Stem Cells Authors: Pavana Khan Lauren Aufdembrink Katarzyna P Adamala Aaron Engelhart Source Type: research
Characteristics of primary care practices associated with patient education during COVID-19: results of the cross-sectional PRICOV-19 study in 38 countries
CONCLUSION: The model presented in this article is still incomplete and requires further investigation to identify other configuration elements favorable to educational activities. However, the results already highlight certain levers that will enable the development of this educational approach appropriate to primary care.PMID:38637765 | PMC:PMC11027213 | DOI:10.1186/s12875-024-02348-x (Source: Primary Care)
Source: Primary Care - April 18, 2024 Category: Primary Care Authors: Delphine Kirkove Sara Willems Esther Van Poel Nadia Dardenne Anne-Fran çoise Donneau Elodie Perrin C écile Ponsar Christian Mallen Neophytos Stylianou Claire Collins R émi Gagnayre Benoit P étré Source Type: research
Factors associated with plans for early retirement among Ontario family physicians during the COVID-19 pandemic: a cross-sectional study
CONCLUSIONS: Over 20% of Ontario FP respondents were considering retiring earlier by the third-wave of the COVID-19 pandemic. Supporting FPs in their clinical and non-clinical roles, such that they feel able to provide good care and that their work is valued, reducing non-clinical (e.g., administrative) responsibilities, dealing with pandemic-related fears, and supporting infection control practices and personal protective equipment acquisition in clinic, particularly in those aged 50 years or older may help increase family physician retention during future pandemics.PMID:38637731 | PMC:PMC11025226 | DOI:10.1186/s12875-024...
Source: Primary Care - April 18, 2024 Category: Primary Care Authors: Rachel Walsh Deanna Telner Debra A Butt Paul Krueger Karen Fleming Sarah MacDonald Aakriti Pyakurel Michelle Greiver Liisa Jaakkimainen Source Type: research
Evaluation of the impact of COVID-19 on stress and burnout among Ajman university (AU) medical students
This study was conducted at AU to estimate the prevalence of stress and burnout among medical students during the COVID-19 pandemic. This study aimed to provide insights into the levels of stress and burnout experienced by medical students at AU and identify potential risk factors. The research methodology involved a cross-sectional survey using a self-administered questionnaire among 215 College of Medicine AU students. The findings indicated that many participants experienced moderate stress levels, as revealed by data collected on a Likert scale. No significant differences in stress scores were found based on sex, but v...
Source: Acta Psychologica - April 18, 2024 Category: Psychiatry & Psychology Authors: Ibrahim Bani Yehia Mohamed Gabriel Andrade Source Type: research
Listening to School Nurses' Voices: A Mixed Methods Study on the Continued Impact of COVID-19 on School Nursing Practice
J Sch Nurs. 2024 Apr 18:10598405241237726. doi: 10.1177/10598405241237726. Online ahead of print.ABSTRACTSchool closures in March 2020 due to the COVID-19 pandemic precipitated losses of critical student resources as physical, mental, emotional, and social needs escalated. Identifying the challenges, strategies, and changes in school nurse (SN) practice in Massachusetts during this pandemic is fundamental to understanding how to manage future anticipated pandemics while protecting children, communities, and SNs. The purpose of this mixed-methods descriptive study in the second year of the global pandemic was to (a) listen ...
Source: The Journal of School Nursing - April 18, 2024 Category: Nursing Authors: M Laurette Hughes Laura White Mary Jane O'Brien Judy Aubin Carol Bradford Source Type: research
Exploring COVID-19 vaccine uptake and hesitancy among vulnerable populations in inner city Vancouver, Canada: Insights into characteristics and clinical outcomes
In this study, we investigated vaccination rates and variables as facilitators or barriers to COVID-19 vaccination among vulnerable populations living in Vancouver's inner-city residents. On a weekly basis, a team (including health care providers [HCPs] and support staff) conducts a Community Pop-up Clinic (CPC) event at single room occupancy dwellings in Vancouver's inner city to provide COVID-19 vaccine and/or related information. Participants also completed a survey about their COVID-19 vaccination status and COVID knowledge, including knowledge about COVID vaccination. We collected data from 892 CPC participants betwee...
Source: Vaccine - April 18, 2024 Category: Allergy & Immunology Authors: Saina Beitari Shana Yi Shawn Sharma Rossitta Yung Brian Conway Source Type: research
Age, Gender, and Liver Enzyme Impact Hospital Stay in COVID-19 Minority Patient with Cancer in the USA: Does Race Matters in the Pandemic?
Ann Clin Med Case Rep. 2024;13:7. Epub 2024 Mar 21.ABSTRACTPatients with cancer are known to have a poor prognosis when infected with SARS-CoV-2 infection. We aimed in this study to assess health outcomes in COVID-19 patients with different cancers in comparison to non-cancer COVID-19 patients from different centers in the United States (US). We evaluated medical records of 1,943 COVID-19 Cancer patients from 3 hospitals admitted between December 2019 to October 2021 and compared them with non-cancer COVID-19 patients. Among 1,943 hospitalized COVID-19 patients, 18.7% (n=364) have an active or previous history of cancer. A...
Source: Clinical Lung Cancer - April 18, 2024 Category: Cancer & Oncology Authors: H Ashktorab G Oskrochi S R Challa L G Chirumamilla S Saroya S Dusmatova N Shayegh V Nair K Senthilvelan D Byer N Morrison B Grossi A Barclay T Smith K Watson M Rashid R Rashid M Deverapalli G Latella J M Carethers A Youssef H Brim Source Type: research
Potential application of mesenchymal stromal cells as a new therapeutic approach in acute respiratory distress syndrome and pulmonary fibrosis
Respir Res. 2024 Apr 18;25(1):170. doi: 10.1186/s12931-024-02795-1.ABSTRACTWhile the COVID-19 outbreak and its complications are still under investigation, post-inflammatory pulmonary fibrosis (PF) has already been described as a long-term sequela of acute respiratory distress syndrome (ARDS) secondary to SARS-CoV2 infection. However, therapeutical strategies for patients with ARDS and PF are still limited and do not significantly extend lifespan. So far, lung transplantation remains the only definitive treatment for end-stage PF. Over the last years, numerous preclinical and clinical studies have shown that allogeneic mes...
Source: Cell Research - April 18, 2024 Category: Cytology Authors: Giulia Gazzaniga Marta Voltini Alessandro Carletti Elisa Lenta Federica Meloni Domenica Federica Briganti Maria Antonietta Avanzini Patrizia Comoli Mirko Belliato Source Type: research
Extracorporeal membrane oxygenation (ECMO) during aplasia: A bridge towards myopericarditis recovery after autologous hematopoietic stem cell transplant for systemic sclerosis and recent Coronarovirus disease (COVID-19) vaccination
This report illustrates, for the first time to our knowledge, that ECMO can be indicated despite aplasia during aHSCT and successfully used as a bridge towards heart function recovery in highly selected and fragile AD patients. We review the factors that may contribute to endothelial and myocardial stunning and acute reversible cardiac failure in SSc and aggravate intrinsic endothelial injury during the aHSCT procedure. These classically include: cyclophosphamide drug toxicity, viral infections and autoimmune activation with disease flair per se. In the COVID-19 pandemic times, acute myocarditis due to recent viral infecti...
Source: Cell Research - April 18, 2024 Category: Cytology Authors: Carlotta Cacciatore Mathilde Baudet Estelle Jean Simona Presente Marylou Para Romain Sonneville Dimitri Arangalage Nassim Ait Abdallah Flore Sicre de Fontbrune Pedro Henrique Prata Benjamin Crichi Baptiste Hervier Nathalie Parquet Gilles Soulat Elie Mouss Source Type: research
Post-Pandemic Changes to Employment and Employment Satisfaction in Early Career and Career Advancing Athletic Trainers
CONCLUSIONS: The pandemic brought changes to employers and employment settings for many YPATs. To reduce turnover and attrition, administrators must begin to prioritize employee well-being and satisfaction. In addition to increasing salary and reducing workload, employers should recognize the importance of administrative support in promoting well-being together with satisfaction and professional optimism in early professional and career-advancing athletic trainers.PMID:38632841 | DOI:10.4085/1062-6050-0508.23 (Source: Journal of Athletic Training)
Source: Journal of Athletic Training - April 18, 2024 Category: Sports Medicine Authors: Nicolette A Harris Emily K Mulkey Sanam Rezazadeh Matthew C Smitley Alicia M Montalvo Source Type: research
Construction of AlGaN/GaN high-electron-mobility transistor-based biosensor for ultrasensitive detection of SARS-CoV-2 spike proteins and virions
Biosens Bioelectron. 2024 Mar 15;257:116171. doi: 10.1016/j.bios.2024.116171. Online ahead of print.ABSTRACTThe COVID-19 pandemic has highlighted the need for rapid and sensitive detection of SARS-CoV-2. Here, we report an ultrasensitive SARS-CoV-2 immunosensor by integration of an AlGaN/GaN high-electron-mobility transistor (HEMT) and anti-SARS-CoV-2 spike protein antibody. The AlGaN/GaN HEMT immunosensor has demonstrated the capability to detect SARS-CoV-2 spike proteins at an impressively low concentration of 10-22 M. The sensor was also applied to pseudoviruses and SARS-CoV-2 ΔN virions that display the Spike proteins...
Source: Biosensors and Bioelectronics - April 18, 2024 Category: Biotechnology Authors: Chenyang Yang Jianwen Sun Yulong Zhang Jingya Tang Zizheng Liu Teng Zhan Dian-Bing Wang Guoqi Zhang Zewen Liu Xian-En Zhang Source Type: research
Assessment of the neutralizing antibody response in Omicron breakthrough cases in healthcare workers who received the homologous booster of Moderna mRNA-1273
Virology. 2024 Apr 8;595:110082. doi: 10.1016/j.virol.2024.110082. Online ahead of print.ABSTRACTVaccines against SARS-CoV-2 were developed during the pandemic including the BNT162b2 and the mRNA-1273. We evaluated the levels of binding antibodies against the receptor binding domain and the levels of NAbs in individuals who developed a breakthrough infection after having received three doses of mRNA-1273. A total of 51 participants were included. The breakthrough group was compared to a 1:1 matched-control group. Among the 51 individuals, 18 (35%) developed a breakthrough infection. The GMT of NAbs against the BA.1 in the ...
Source: Virology - April 18, 2024 Category: Virology Authors: Constant Gillot Marie Tr é-Hadry Roberto Cupaiolo Laurent Blairon Alain Wilmet Ingrid Beukinga Jean-Michel Dogn é Jonathan Douxfils Julien Favresse Source Type: research
Non-peptidic inhibitors targeting SARS-CoV-2 main protease: A review
Bioorg Chem. 2024 Apr 16;147:107380. doi: 10.1016/j.bioorg.2024.107380. Online ahead of print.ABSTRACTThe COVID-19 pandemic continues to pose a threat to global health, and sounds the alarm for research & development of effective anti-coronavirus drugs, which are crucial for the patients and urgently needed for the current epidemic and future crisis. The main protease (Mpro) stands as an essential enzyme in the maturation process of SARS-CoV-2, playing an irreplaceable role in regulating viral RNA replication and transcription. It has emerged as an ideal target for developing antiviral agents against SARS-CoV-2 due to ...
Source: Bioorganic Chemistry - April 18, 2024 Category: Chemistry Authors: Ya-Qi Xiao Jiao Long Shuang-Shuang Zhang Yuan-Yuan Zhu Shuang-Xi Gu Source Type: research
Risk factors for progressing to critical illness in patients with hospital-acquired COVID-19
CONCLUSIONS: Among patients with hospital-acquired COVID-19, preexisting respiratory disease, preexisting cardiovascular disease, immunocompromised status, and higher clinical frailty scale and SOFA scores at baseline were risk factors for progression to critical illness. Patients with these risk factors must be prioritized and appropriately isolated or treated in a timely manner, especially in pandemic settings.PMID:38632896 | DOI:10.3904/kjim.2023.347 (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - April 18, 2024 Category: Internal Medicine Authors: Kyung-Eui Lee Jinwoo Lee Sang-Min Lee Hong Yeul Lee Source Type: research
