Regulation of Microtubule Stability in Pulmonary Microvascular Endothelial Cells in Rats with Severe Acute Pancreatitis: Qingyi Decoction is a Potential CDK5 Inhibitor
(Source: Journal of Inflammation Research)
Source: Journal of Inflammation Research - April 24, 2024 Category: Allergy & Immunology Tags: Journal of Inflammation Research Source Type: research
Buprenorphine Affects the Initiation and Severity of Interleukin Induced Acute Pancreatitis in Mice
Am J Physiol Gastrointest Liver Physiol. 2024 Apr 23. doi: 10.1152/ajpgi.00083.2024. Online ahead of print.ABSTRACTAcute pancreatitis (AP) is a common disease with no targeted therapy and has varied outcomes ranging from spontaneous resolution to being lethal. While typically painful, AP can also be painless. Various agents, including opioids are used for pain control in AP; the risks, and benefits of which are often debated. Since experimental AP in mice is used to study the efficacy of potential therapies, we studied the effect of a commonly used opioid buprenorphine on the initiation and progression of AP. For this we a...
Source: Am J Physiol Gastroi... - April 23, 2024 Category: Gastroenterology Authors: Sarah Jahangir Biswajit Khatua Nabil Smichi Prasad Rajalingamgari Anoop Narayana Pillai Megan J Summers Bryce McFayden Sergiy Kostenko Naomi M Gades Vijay P Singh Source Type: research
Pancreatitis after Percutaneous Transhepatic Biliary Intervention
A 50-year-old man who had undergone distal gastrectomy and adjuvant chemotherapy for gastric adenocarcinoma presented with new hyperbilirubinemia and biliary ductal dilation (Fig 1a, black arrow) secondary to a common bile duct (CBD) mass (Fig 1a, white arrow). Owing to his gastrojejunostomy (Fig 1a, open arrow), he was not a candidate for endoscopic retrograde cholangiopancreatography. A percutaneous transhepatic cholangiogram confirmed abrupt truncation of the CBD (Fig 1b, white arrow), and a brush biopsy (Cellebrity Cytology Brush; Boston Scientific, Marlborough, Massachsetts) was performed (Fig 1b, black arrow) bef...
Source: Journal of Vascular and Interventional Radiology : JVIR - April 23, 2024 Category: Radiology Authors: Jacob DePolo, Alexander Miller, Joseph Buchholz, James Ronald Tags: Lessons in IR: M & Source Type: research
Novel anthropometric indicators of visceral obesity predict the severity of hyperlipidemic acute pancreatitis
Obesity substantially contributes to the onset of acute pancreatitis (AP) and influences its progression to severe AP. Although body mass index (BMI) is a widely used anthropometric parameter, it fails to deli... (Source: Lipids in Health and Disease)
Source: Lipids in Health and Disease - April 23, 2024 Category: Lipidology Authors: Yi Zhu, Yingbao Huang, Houzhang Sun, Lifang Chen, Huajun Yu, Liuzhi Shi, Weizhi Xia, Xuecheng Sun, Yunjun Yang and Hang Huang Tags: Research Source Type: research
Identifying novel acute pancreatitis sub-phenotypes using total serum calcium trajectories
Acute pancreatitis (AP) has heterogeneous clinical features, and identifying clinically relevant sub-phenotypes is useful. We aimed to identify novel sub-phenotypes in hospitalized AP patients using longitudin... (Source: BMC Gastroenterology)
Source: BMC Gastroenterology - April 23, 2024 Category: Gastroenterology Authors: Chang-li Li, Xing-chen Lin and Meng Jiang Tags: Research Source Type: research
Clinical predictive value of Control attenuation parameters in combination with miR-192-5p in patients with acute pancreatitis in nonalcoholic fatty liver disease
CONCLUSIONS: NAFLD exacerbated the progression of AP, and CAP combined with miR-192-5p could predict the severity of AP. Our study may provide more reference for AP disease progression and treatment.PMID:38646989 | DOI:10.5603/ep.98765 (Source: Endokrynologia Polska)
Source: Endokrynologia Polska - April 22, 2024 Category: Endocrinology Authors: Yang Hu Liang Zhu Ronglai Cao Source Type: research
Investigating potential biomarkers of acute pancreatitis in patients with a BMI > 30 using Mendelian randomization and transcriptomic analysis
Acute pancreatitis (AP) has become a significant global health concern, and a high body mass index (BMI) has been identified as a key risk factor exacerbating this condition. Within this context, lipid metabol... (Source: Lipids in Health and Disease)
Source: Lipids in Health and Disease - April 22, 2024 Category: Lipidology Authors: Hua Ji, Zheng Tang, Kexin Jiang, Shuang Lyu, Yiwen Zhao, Jiajie Feng, Ruiwu Dai and Hongyin Liang Tags: Research Source Type: research
Impact of Geospatial Food Access on Acute Pancreatitis Outcomes
ConclusionLow food access had a significant association with 30-day AP-related readmissions and AP severity. However, mortality and LOS lacked significant association with food access. The association between nutrition, lifestyle, and AP outcomes warrants further prospective investigation. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - April 22, 2024 Category: Gastroenterology Source Type: research
A Case Report of Therapeutic Plasma Exchange in Hypertriglyceridemia-Induced Pancreatitis
AbstractTo support the evidence of plasma exchange ’s ability to rapidly lower serum TG levels and provide upcoming research opportunities for evaluating the long-term effects of this treatment, we present the case of a 35-year-old female who was admitted for Hypertriglyceridemia-induced Pancreatitis (HTGP). She underwent Therapeutic Plasma Excha nge (TPE) using Spectra Optia Apheresis System on an emergency basis. The patient had a remarkable reduction of serum Triglycerides (TG) from 3953 to 291 mg/dl, which was life saving. On subsequent follow-up the serum TG levels remained constant post-TPE with conservative trea...
Source: Indian Journal of Hematology and Blood Transfusion - April 20, 2024 Category: Hematology Source Type: research
Quantitative MR imaging biomarkers for distinguishing inflammatory pancreatic mass and pancreatic cancer —a systematic review and meta-analysis
ConclusionsQuantitative MR imaging biomarkers are useful in distinguishing between IPM and PC. ADC values differ between MFP and AIP, and they should be separated for consideration in future studies.Clinical relevance statementQuantitative MR parameters could serve as non-invasive imaging biomarkers for differentiating malignant pancreatic neoplasms from inflammatory masses of the pancreas, and hence help to avoid unnecessary surgery.Key Points•Several quantitative MR imaging biomarkers performed well in differential diagnosis between inflammatory pancreatic mass and pancreatic cancer.•The ADC value could discern pancr...
Source: European Radiology - April 19, 2024 Category: Radiology Source Type: research
Revealing Prdx4 as a potential diagnostic and therapeutic target for acute pancreatitis based on machine learning analysis
Acute pancreatitis (AP) is a common systemic inflammatory disease resulting from the activation of trypsinogen by various incentives in ICU. The annual incidence rate is approximately 30 out of 100,000. Some p... (Source: BMC Medical Genomics)
Source: BMC Medical Genomics - April 19, 2024 Category: Genetics & Stem Cells Authors: Zhonghua Lu, Yan Tang, Ruxue Qin, Ziyu Han, Hu Chen, Lijun Cao, Pinjie Zhang, Xiang Yang, Weili Yu, Na Cheng and Yun Sun Tags: Research Source Type: research
Synergistic effect of independent risk factors for post-endoscopic retrograde cholangiopancreatography pancreatitis: a multicenter retrospective study in Japan
CONCLUSIONS: As the number of risk factors for PEP increases, the risk of PEP may not be additive; however, it may multiply. Thus, aggressive prophylaxis for PEP is strongly recommended in patients with multiple risk factors.PMID:38632965 | DOI:10.5946/ce.2023.203 (Source: Clinical Endoscopy)
Source: Clinical Endoscopy - April 18, 2024 Category: Gastroenterology Authors: Hirokazu Saito Yoshihiro Kadono Takashi Shono Kentaro Kamikawa Atsushi Urata Jiro Nasu Masayoshi Uehara Ikuo Matsushita Tatsuyuki Kakuma Shunpei Hashigo Shuji Tada Source Type: research
Acute pancreatitis secondary to severe hypertriglyceridemia induced by antiretroviral therapy (ART)
Rev Esp Enferm Dig. 2024 Apr 18. doi: 10.17235/reed.2024.10423/2024. Online ahead of print.ABSTRACTHypertriglyceridemia is the third cause of acute pancreatitis after lithiasis and alcohol. When triglycerides are >2000 mg/dL the risk increases to 20%. Acute pancreatitis is an important cause of morbidity in patients infected with human immunodeficiency virus (HIV), especially in those treated with lamivudine, due to hypertriglyceridemia.PMID:38634897 | DOI:10.17235/reed.2024.10423/2024 (Source: Revista Espanola de Enfermedades Digestivas)
Source: Revista Espanola de Enfermedades Digestivas - April 18, 2024 Category: Gastroenterology Authors: Miryam Moreta Rodr íguez Irene Pe ñas Herrero Pablo Cubero Morais Cristina Crespo Soto Gloria S ánchez-Antolín Source Type: research
Changes in cytokines and chemokines in an acute pancreatitis model
CONCLUSION: CXCL-1, MCP-1, and IL-6 exhibit predictive characteristics for the occurrence and clinical course of pancreatitis. Our results highlight the production and working pathways of these cytokines as potential targets for therapeutic intervention.PMID:38634842 | DOI:10.14744/tjtes.2024.18049 (Source: Turkish Journal of Trauma and Emergency Surgery : TJTES)
Source: Turkish Journal of Trauma and Emergency Surgery : TJTES - April 18, 2024 Category: Emergency Medicine Authors: Erdem K ınacı Mert Mahsuni Sevinc Anil Demir Emre Erdogan Fatih Alper Ahlatci Ufuk Oguz Idiz Source Type: research
Laparoscopic Cholecystectomy vs Endoscopic Retrograde Cholangiopancreatography With Sphincterotomy in Elderly Patients With Acute Gallstone Pancreatitis
CONCLUSION: Laparoscopic cholecystectomy represents the gold standard for elderly patients with GSP.PMID:38636538 | DOI:10.1177/00031348241248564 (Source: The American Surgeon)
Source: The American Surgeon - April 18, 2024 Category: Surgery Authors: Irena Stefanova Ewan Kyle Iain Wilson Mohammed Tobbal Darmarajah Veeramootoo Henry D De'Ath Source Type: research
