Sugars that coat proteins are a possible drug target for pancreatitis
(Cold Spring Harbor Laboratory) CA19-9 is a complex sugar structure that coats proteins. Elevated levels of CA19-9 was found to cause inflammation in the pancreas in mice and promote rapid progression to pancreatic cancer. By neutralizing the functions of CA19-9 with antibodies, researchers were able to reduce and even prevent pancreatic damage in animal models. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - June 20, 2019 Category: Cancer & Oncology Source Type: news

The glycan CA19-9 promotes pancreatitis and pancreatic cancer in mice
Glycosylation alterations are indicative of tissue inflammation and neoplasia, but whether these alterations contribute to disease pathogenesis is largely unknown. To study the role of glycan changes in pancreatic disease, we inducibly expressed human fucosyltransferase 3 and β1,3-galactosyltransferase 5 in mice, reconstituting the glycan sialyl-Lewisa, also known as carbohydrate antigen 19-9 (CA19-9). Notably, CA19-9 expression in mice resulted in rapid and severe pancreatitis with hyperactivation of epidermal growth factor receptor (EGFR) signaling. Mechanistically, CA19-9 modification of the matricellular protein f...
Source: ScienceNOW - June 19, 2019 Category: Science Authors: Engle, D. D., Tiriac, H., Rivera, K. D., Pommier, A., Whalen, S., Oni, T. E., Alagesan, B., Lee, E. J., Yao, M. A., Lucito, M. S., Spielman, B., Da Silva, B., Schoepfer, C., Wright, K., Creighton, B., Afinowicz, L., Yu, K. H., Grützmann, R., Aust, Tags: Medicine, Diseases r-articles Source Type: news

Steffanie Strathdee: ‘Phages have evolved to become perfect predators of bacteria’
In 2015, the scientist ’s husband was almost killed by an antibiotic-resistant superbug, until she found a cure that is now saving othersInfectious disease epidemiologist Steffanie Strathdee ’s husband survived a deadly antibiotic-resistant bacterial infection thanks to her suggestion of using an unconventional cure popular in the former Soviet Union: fighting the bug with a virus. Now the global health expert at the University of California, San Diego, she has, along with her husband , Tom Patterson, who is also a scientist at the institution, written an account of their nine month ordeal –The Perfect Predator: A Sc...
Source: Guardian Unlimited Science - June 16, 2019 Category: Science Authors: Zo ë Corbyn Tags: Medical research Antibiotics Biology Science Books Society Source Type: news

Pancreatic cancer symptoms: Signs to look out for and when you MUST see a doctor
PANCREATIC cancer does not have any major symptoms to look out for at the start. Many of the symptoms described could be caused by other conditions. The symptoms could also be a sing of other illnesses such as pancreatitis, gastritis or gallstones. It is important to distinguish the difference and know when to speak with your doctor. (Source: Daily Express - Health)
Source: Daily Express - Health - May 24, 2019 Category: Consumer Health News Source Type: news

Pentazocine Cuts Acute Pancreatitis Pain Better Than Diclofenac Pentazocine Cuts Acute Pancreatitis Pain Better Than Diclofenac
In acute pancreatitis, the opioid pentazocine relieves pain better than the nonsteroidal anti-inflammatory drug (NSAID) diclofenac, a randomized controlled trial from India shows.Reuters Health Information (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - May 17, 2019 Category: Consumer Health News Tags: Gastroenterology News Source Type: news

Medical News Today: Why does my stool smell foul?
This article looks at eight reasons why a person's stool might smell particularly bad, as well as diagnosis, treatment, and when to see a doctor. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - April 11, 2019 Category: Consumer Health News Tags: GastroIntestinal / Gastroenterology Source Type: news

Case report: Necrotizing pancreatitis after SAE
Splenic artery embolization (SAE) is a relatively safe, effective, and commonly...Read more on AuntMinnie.comRelated Reading: Case report: TAE for life-threatening hemobilia Case report: Interventional retrieval of portacath fragment (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - March 12, 2019 Category: Radiology Source Type: news

A Patient with Chronic Pancreatitis, Requesting Demerol
A 47 y/o woman with cirrhosis, HCV, and chronic pancreatitis requests Demerol for the worst abdominal pain she has ever had. What ' s your diagnosis?   (Source: ConsultantLive)
Source: ConsultantLive - March 10, 2019 Category: Internal Medicine Authors: Brady Pregerson, MD Tags: Gastrointestinal Disorders Source Type: news

Medical News Today: What is an amylase blood test?
Doctors typically use amylase blood tests to diagnose and monitor people with acute or chronic pancreatitis. However, abnormally high or low levels of amylase in the blood can be a sign of several other conditions. Learn about what to expect from an amylase blood test here. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - February 22, 2019 Category: Consumer Health News Tags: Blood / Hematology Source Type: news

Risk of acute pancreatitis with carbimazole use (MHRA Drug Safety Update)
The MHRA has released a Drug Safety Update about the risk of acute pancreatitis with the use of products containing carbimazole and thiamazole. If acute pancreatitis occurs during treatment with ca (Source: Royal Pharmaceutical Society News)
Source: Royal Pharmaceutical Society News - February 18, 2019 Category: Drugs & Pharmacology Source Type: news

Risk of acute pancreatitis with carbimazole use (MHRA Drug Safety Update)
The MHRA has released a Drug Safety Update about the risk of acute pancreatitis with the use of products containing carbimazole. If acute pancreatitis occurs during treatment with carbimazole, imme (Source: Royal Pharmaceutical Society News)
Source: Royal Pharmaceutical Society News - February 18, 2019 Category: Drugs & Pharmacology Source Type: news