Acute High-Output Heart Failure with Pulmonary Hypertension and Severe Liver Injury Caused by Amlodipine Poisoning: A Case Report
We report a 52-year-old woman who suffered from severe shock after an overdose of amlodipine. Hemodynamic monitoring showed that while her left ventricular systolic function and cardiac output were elevated, her systemic vascular resistance decreased significantly. At the same time, the size of her right heart, her central venous pressure, and the oxygen saturation of her central venous circulation all increased abnormally. The patient's circulatory function and right ventricular dysfunction gradually improved after large doses of vasopressors and detoxification measures. However, her bilirubin and transaminase levels incr...
Source: Cardiovascular Toxicology - March 26, 2024 Category: Cardiology Authors: Chenlong Wang Qingcheng Zhu Dingyu Tan Joseph Walline Yachao Wang Source Type: research
Efficacy and safety of mesenchymal stem cell-derived microvesicles in mouse inflammatory arthritis
CONCLUSIONS: Appropriate dosages of MVs and MSCs are effective treatments for inflammatory arthritis while MVs and MSCs overdose is unsafe by causing cardiopulmonary complications.PMID:38531171 | DOI:10.1016/j.intimp.2024.111845 (Source: International Immunopharmacology)
Source: International Immunopharmacology - March 26, 2024 Category: Allergy & Immunology Authors: Shixiong Wei Chenyang Lu Sujia Li Qiuping Zhang Ruijuan Cheng ShuYue Pan QiuHong Wu Xueting Zhao Xinping Tian Xiaofeng Zeng Yi Liu Source Type: research
Use of dietary supplements by children and adolescents
CONCLUSION: Despite having specific indications, most of the time they are not prescribed by a healthcare professional. The reasons for use are varied. In children, the main reasons are protection against infections, stimulating growth, and poor food intake, with multivitamins and minerals being the most commonly used supplements. In adolescents, they are used to improve athletic performance and attain the "ideal body", with proteins and amino acids being the most often used nutrients. As they are not regulated by health agencies and are sold without a prescription, their unsupervised use can lead to inadequate doses, with...
Source: Jornal de Pediatria - March 26, 2024 Category: Pediatrics Authors: Junaura Rocha Barretto Mara Alves da Cruz Gouveia Cr ésio Alves Source Type: research
Efficacy and safety of mesenchymal stem cell-derived microvesicles in mouse inflammatory arthritis
CONCLUSIONS: Appropriate dosages of MVs and MSCs are effective treatments for inflammatory arthritis while MVs and MSCs overdose is unsafe by causing cardiopulmonary complications.PMID:38531171 | DOI:10.1016/j.intimp.2024.111845 (Source: International Immunopharmacology)
Source: International Immunopharmacology - March 26, 2024 Category: Allergy & Immunology Authors: Shixiong Wei Chenyang Lu Sujia Li Qiuping Zhang Ruijuan Cheng ShuYue Pan QiuHong Wu Xueting Zhao Xinping Tian Xiaofeng Zeng Yi Liu Source Type: research
Use of dietary supplements by children and adolescents
CONCLUSION: Despite having specific indications, most of the time they are not prescribed by a healthcare professional. The reasons for use are varied. In children, the main reasons are protection against infections, stimulating growth, and poor food intake, with multivitamins and minerals being the most commonly used supplements. In adolescents, they are used to improve athletic performance and attain the "ideal body", with proteins and amino acids being the most often used nutrients. As they are not regulated by health agencies and are sold without a prescription, their unsupervised use can lead to inadequate doses, with...
Source: Jornal de Pediatria - March 26, 2024 Category: Pediatrics Authors: Junaura Rocha Barretto Mara Alves da Cruz Gouveia Cr ésio Alves Source Type: research
Nurse Practitioners Are Doing Their Part in Substance Use Disorder Care
The focus on opioid overdose death rates has national attention and they continue to increase despite better management of prescription opioid use.1 Nurse Practitioners in many settings, but especially in primary care, have expanded their practices to include both acute and chronic pain management, and more recently have expanded their skill set to include comprehensive substance use disorder care (SUD). To achieve this, NPs have modified their clinical practices and have engaged with continuing education (CE) programs that are focused on nationally vetted practice guidelines published by the Center for Disease Control (CD...
Source: The Journal for Nurse Practitioners - March 26, 2024 Category: Nursing Authors: Randall S. Hudspeth Tags: Guest Editorial Source Type: research
Extra-corporeal non-liver transplant therapies for acute liver failure: Focus on plasma exchange and continuous renal replacement therapy
AbstractThe acute inflammatory milieu in patients with acute liver failure (ALF) results in ‘toxic’ blood in these patients. In vitro experiments have shown that the plasma obtained from ALF patients is toxic to rabbit hepatocytes and inhibits regeneration of rat hepatocytes. Treatments such as plasma exchange and continuous renal replacement therapy to cleanse the blood have improved survival in ALF patients. In the liver microcirculation, the exchange of fluid across fenestrae in liver sinusoidal endothelial cells (LSECs) is vital for proper functioning of hepatocytes. Clogging of the liver filter bed by inflammatory...
Source: Indian Journal of Gastroenterology - March 26, 2024 Category: Gastroenterology Source Type: research
Providing medication for opioid use disorder and HIV pre-exposure prophylaxis at syringe services programs via telemedicine: a pilot study
People who inject drugs (PWID) are at high risk for opioid overdose and infectious diseases including HIV. We piloted PARTNER UP, a telemedicine-based program to provide PWID with medication for opioid use dis... (Source: Harm Reduction Journal)
Source: Harm Reduction Journal - March 26, 2024 Category: Drugs & Pharmacology Authors: Mehri S. McKellar, Andrea C. Des Marais, Hillary Chen, Yujung Choi, Rebecca Lilly, Denae Ayers, Jesse Bennett, Lauren Kestner, Brian Perry, Stephanie Poley, Amy Corneli, Christina S. Meade and Nidhi Sachdeva Tags: Research Source Type: research
Drug-related physician continuing medical education requirements, 2010 –2020
The crisis of drug-related harm in the United States continues to worsen. While prescription-related overdoses have fallen dramatically, they are still far above pre-2010 levels. Physicians can reduce the risk of overdose and other drug-related harms by improving opioid prescribing practices and ensuring that patients are able to easily access medications for substance use disorder treatment. Most physicians received little or no training in those subjects in medical school. It is possible that continuing medical education can improve physician knowledge of appropriate prescribing and substance use disorder treatment and p...
Source: Journal of Substance Abuse Treatment - March 26, 2024 Category: Addiction Authors: Corey S. Davis, Derek H. Carr, Bradley D. Stein Source Type: research
Extra-corporeal non-liver transplant therapies for acute liver failure: Focus on plasma exchange and continuous renal replacement therapy
AbstractThe acute inflammatory milieu in patients with acute liver failure (ALF) results in ‘toxic’ blood in these patients. In vitro experiments have shown that the plasma obtained from ALF patients is toxic to rabbit hepatocytes and inhibits regeneration of rat hepatocytes. Treatments such as plasma exchange and continuous renal replacement therapy to cleanse the blood have improved survival in ALF patients. In the liver microcirculation, the exchange of fluid across fenestrae in liver sinusoidal endothelial cells (LSECs) is vital for proper functioning of hepatocytes. Clogging of the liver filter bed by inflammatory...
Source: Indian Journal of Gastroenterology - March 26, 2024 Category: Gastroenterology Source Type: research
Effect of intravenous lipid therapy in critically ill pediatric patients with calcium channel blocker toxicity
CONCLUSIONS: ILE therapy should be kept in mind as a salvage therapy in hemodynamically unstable CCB poisoning cases that do not respond to initial and advanced options.PMID:38523381 | DOI:10.24953/turkjped.2023.543 (Source: The Turkish Journal of Pediatrics)
Source: The Turkish Journal of Pediatrics - March 25, 2024 Category: Pediatrics Authors: Sinan Yavuz Ali Avc ı Rabia G ündoğan Serin Mustafa Mesut Kaya Dilfuza A ğalıoğlu Source Type: research
Effect of intravenous lipid therapy in critically ill pediatric patients with calcium channel blocker toxicity
CONCLUSIONS: ILE therapy should be kept in mind as a salvage therapy in hemodynamically unstable CCB poisoning cases that do not respond to initial and advanced options.PMID:38523381 | DOI:10.24953/turkjped.2023.543 (Source: The Turkish Journal of Pediatrics)
Source: The Turkish Journal of Pediatrics - March 25, 2024 Category: Pediatrics Authors: Sinan Yavuz Ali Avc ı Rabia G ündoğan Serin Mustafa Mesut Kaya Dilfuza A ğalıoğlu Source Type: research
Effect of intravenous lipid therapy in critically ill pediatric patients with calcium channel blocker toxicity
CONCLUSIONS: ILE therapy should be kept in mind as a salvage therapy in hemodynamically unstable CCB poisoning cases that do not respond to initial and advanced options.PMID:38523381 | DOI:10.24953/turkjped.2023.543 (Source: The Turkish Journal of Pediatrics)
Source: The Turkish Journal of Pediatrics - March 25, 2024 Category: Pediatrics Authors: Sinan Yavuz Ali Avc ı Rabia G ündoğan Serin Mustafa Mesut Kaya Dilfuza A ğalıoğlu Source Type: research
Effect of intravenous lipid therapy in critically ill pediatric patients with calcium channel blocker toxicity
CONCLUSIONS: ILE therapy should be kept in mind as a salvage therapy in hemodynamically unstable CCB poisoning cases that do not respond to initial and advanced options.PMID:38523381 | DOI:10.24953/turkjped.2023.543 (Source: The Turkish Journal of Pediatrics)
Source: The Turkish Journal of Pediatrics - March 25, 2024 Category: Pediatrics Authors: Sinan Yavuz Ali Avc ı Rabia G ündoğan Serin Mustafa Mesut Kaya Dilfuza A ğalıoğlu Source Type: research
Effect of intravenous lipid therapy in critically ill pediatric patients with calcium channel blocker toxicity
CONCLUSIONS: ILE therapy should be kept in mind as a salvage therapy in hemodynamically unstable CCB poisoning cases that do not respond to initial and advanced options.PMID:38523381 | DOI:10.24953/turkjped.2023.543 (Source: The Turkish Journal of Pediatrics)
Source: The Turkish Journal of Pediatrics - March 25, 2024 Category: Pediatrics Authors: Sinan Yavuz Ali Avc ı Rabia G ündoğan Serin Mustafa Mesut Kaya Dilfuza A ğalıoğlu Source Type: research
