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The fentanyl-specific antibody FenAb024 can shield against carfentanil effects
Toxicol Lett. 2024 Apr 6;396:1-10. doi: 10.1016/j.toxlet.2024.03.008. Online ahead of print.ABSTRACTThe surge in opioid-related deaths, driven predominantly by fentanyl and its synthetic derivatives, has become a critical public health concern, which is particularly evident in the United States. While the situation is less severe in Europe, the European Monitoring Centre for Drugs and Drug Addiction reports a rise in drug overdose deaths, with emerging concerns about the impact of fentanyl-related molecules. Synthetic opioids, initially designed for medical use, have infiltrated illicit markets due to their low production ...
Source: Toxicology Letters - April 8, 2024 Category: Toxicology Authors: Katharina Urban Anastasia Gkeka Monica Chandra Dennis Greiner Selina Pollich Sandra Ruf Yosip Kelemen Tom Sundermann Marco Pravetoni Carly Baehr C Erec Stebbins F Nina Papavasiliou Joseph P Verdi Source Type: research

Plasma drug screening using paper spray mass spectrometry with integrated solid phase extraction
AbstractDrug overdoses have risen dramatically in recent years. We developed a simple nontargeted method using a disposable paper spray cartridge with an integrated solid phase extraction column. This method was used to screen for ~160 fentanyl analogs, synthetic cannabinoids, other synthetic drugs, and traditional drugs of abuse in over 300 authentic overdose samples collected at emergency departments in Indianapolis. A solid phase extraction step was implemented on the paper spray cartridge to enable subnanograms per milliliter synthetic drugs screening in plasma. Analysis was performed on a quadrupole orbitrap mass spec...
Source: Drug Testing and Analysis - April 8, 2024 Category: Drugs & Pharmacology Authors: Hannah Zimmerman ‐Federle, Greta Ren, Sarah Dowling, Cassandra Warren, Daniel Rusyniak, Robert Avera, Nicholas E. Manicke Tags: SPECIAL ISSUE ‐ RESEARCH ARTICLE Source Type: research

Outcomes of Out-of-Hospital Cardiac Arrest Patients Who Received Naloxone in an EMS System with a High Prevalence of Opioid Overdose
Opioid-associated out-of-hospital cardiac arrest (OA-OHCA) is a subset of cardiac arrests that could benefit from measures outside of standard Advanced Cardiac Life Support (ACLS), such as naloxone. (Source: The Journal of Emergency Medicine)
Source: The Journal of Emergency Medicine - April 8, 2024 Category: Emergency Medicine Authors: Eric Quinn, Emily Murphy, Daniel Du Pont, Paul Comber, Marley Blood, Aman Shah, Alexander Kuc, Krystal Hunter, Gerard Carroll Tags: Selected Topics: Prehospital Care Source Type: research

Indole-3-carboxaldehyde alleviates acetaminophen-induced liver injury via inhibition of oxidative stress and apoptosis
In conclusion, our study demonstrates that I3A modulates hepatotoxicity and can be used as a potential therapeutic agent for DILI.PMID:38581952 | DOI:10.1016/j.bbrc.2024.149880 (Source: Biochemical and Biophysical Research communications)
Source: Biochemical and Biophysical Research communications - April 6, 2024 Category: Biochemistry Authors: Xinlei Liu Rui Liu Yancheng Wang Source Type: research

Indole-3-carboxaldehyde alleviates acetaminophen-induced liver injury via inhibition of oxidative stress and apoptosis
In conclusion, our study demonstrates that I3A modulates hepatotoxicity and can be used as a potential therapeutic agent for DILI.PMID:38581952 | DOI:10.1016/j.bbrc.2024.149880 (Source: Cell Research)
Source: Cell Research - April 6, 2024 Category: Cytology Authors: Xinlei Liu Rui Liu Yancheng Wang Source Type: research

Indole-3-carboxaldehyde alleviates acetaminophen-induced liver injury via inhibition of oxidative stress and apoptosis
In conclusion, our study demonstrates that I3A modulates hepatotoxicity and can be used as a potential therapeutic agent for DILI.PMID:38581952 | DOI:10.1016/j.bbrc.2024.149880 (Source: Atherosclerosis)
Source: Atherosclerosis - April 6, 2024 Category: Cardiology Authors: Xinlei Liu Rui Liu Yancheng Wang Source Type: research

The relationship between felt stigma and non-fatal overdose among rural people who use drugs
Drug overdose deaths in the United States exceeded 100,000 in 2021 and 2022. Substance use stigma is a major barrier to treatment and harm reduction utilization and is a priority target in ending the overdose ... (Source: Harm Reduction Journal)
Source: Harm Reduction Journal - April 6, 2024 Category: Drugs & Pharmacology Authors: Adams L. Sibley, Emma Klein, Hannah L.F. Cooper, Melvin D. Livingston III, Robin Baker, Suzan M. Walters, Rachel E. Gicquelais, Stephanie A. Ruderman, Peter D. Friedmann, Wiley D. Jenkins, Vivian F. Go, William C. Miller, Ryan P. Westergaard and Heidi M C Tags: Research Source Type: research

“It’s Like A Partnership”: Exploring the Primary Care Experiences and Patient-Defined Goals of People Who Use Drugs
ConclusionsTo best meet the primary care goals of PWUD, these findings underscore the importance of primary care providers and programs facilitating such partnerships through organizational-level support anchored in harm reduction. Future research should explore how these experiences in primary care affect patient health outcomes, ultimately shaping best practices in the provision of high-quality primary care for PWUD. (Source: Journal of General Internal Medicine)
Source: Journal of General Internal Medicine - April 5, 2024 Category: Internal Medicine Source Type: research

County-level factors associated with a mismatch between opioid overdose mortality and availability of opioid treatment facilities
ConclusionAssessing mismatch between treatment availability and need provides useful information to characterize counties that require greater public health investment. Interventions to reduce overdose mortality are unlikely to be effective if they do not take into account diverse upstream factors, including sociodemographics, disease burden, and geographic context of communities. (Source: PLoS One)
Source: PLoS One - April 5, 2024 Category: Biomedical Science Authors: John G. Rizk Source Type: research

Substance use patterns, sociodemographics, and health profiles of harm reduction service recipients in Burlington, Vermont
Understanding current substance use practices is critical to reduce and prevent overdose deaths among individuals at increased risk including persons who use and inject drugs. Because individuals participating... (Source: Harm Reduction Journal)
Source: Harm Reduction Journal - April 5, 2024 Category: Drugs & Pharmacology Authors: Tyler G. Erath, Rosalie LaCroix, Erin O ’Keefe, Stephen T. Higgins and Richard A. Rawson Tags: Research Source Type: research

Disparities in Overdose Deaths: Looking Back at Larochelle and Colleagues' 2021 Paper
Am J Public Health. 2024 Apr 4:e1-e3. doi: 10.2105/AJPH.2024.307659. Online ahead of print.NO ABSTRACTPMID:38574319 | DOI:10.2105/AJPH.2024.307659 (Source: Am J Public Health)
Source: Am J Public Health - April 4, 2024 Category: International Medicine & Public Health Authors: Nora D Volkow Beth Han Redonna K Chandler Source Type: research

Disparities in Overdose Deaths: Looking Back at Larochelle and Colleagues' 2021 Paper
Am J Public Health. 2024 Apr 4:e1-e3. doi: 10.2105/AJPH.2024.307659. Online ahead of print.NO ABSTRACTPMID:38574319 | DOI:10.2105/AJPH.2024.307659 (Source: American Journal of Public Health)
Source: American Journal of Public Health - April 4, 2024 Category: International Medicine & Public Health Authors: Nora D Volkow Beth Han Redonna K Chandler Source Type: research