Neutrophil-dependent hepatic platelet accumulation and liver injury revealed by acetaminophen dose-response studies
CONCLUSION: The results indicate a role of neutrophils in APAP-induced liver injury that is dependent on the APAP dose and suggest involvement of neutrophil-platelet interactions in promoting hepatic injury in experimental APAP-induced ALF.PMID:38404941 | PMC:PMC10883821 | DOI:10.1016/j.rpth.2024.102323 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - February 26, 2024 Category: Hematology Authors: Anthony Schulte Dafna J Groeneveld Zimu Wei Bianca Hazel Matthew P Bernard Lauren G Poole James P Luyendyk Source Type: research

Performance of the Medical Priority Dispatch System ® in identifying patients requiring chest compressions at overdose prevention services: a retrospective cohort study
CONCLUSIONS: The ability of MPDS ® to correctly identify patients needing telecommunicator cardiopulmonary resuscitation instructions differed between OPS settings and other locations, frequently recommending T-CPR for patients not suffering OHCA at an OPS. Different strategies developed in collaboration with people who use substances are required to better tailor dispatch instructions prior to EMS arrival to avoid delays in life-saving interventions.PMID:38407219 | DOI:10.1080/10903127.2024.2319150 (Source: Prehospital Emergency Care)
Source: Prehospital Emergency Care - February 26, 2024 Category: Endocrinology Authors: Richard Armour Brian Grunau Sammy Iammarino Jane Buxton Brooke Kinniburgh Heather Burgess Kali-Olt Sedgemore Paul Choisil Suzanne Nielsen Linda Ross Source Type: research

Neutrophil-dependent hepatic platelet accumulation and liver injury revealed by acetaminophen dose-response studies
CONCLUSION: The results indicate a role of neutrophils in APAP-induced liver injury that is dependent on the APAP dose and suggest involvement of neutrophil-platelet interactions in promoting hepatic injury in experimental APAP-induced ALF.PMID:38404941 | PMC:PMC10883821 | DOI:10.1016/j.rpth.2024.102323 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - February 26, 2024 Category: Hematology Authors: Anthony Schulte Dafna J Groeneveld Zimu Wei Bianca Hazel Matthew P Bernard Lauren G Poole James P Luyendyk Source Type: research

Community Support for Harm Reduction and Treatment of Opioid Use Disorder
This study sought to understand beliefs and attitudes associated with support for three community-based strategies to address opioid misuse and addiction: naloxone, needle exchange, and medication-assisted treatment. We conducted a cross-sectional online survey with 545 adults. Results of the survey showed that participants supported all three strategies, with the strongest support for medication-assisted treatment. Multiple regression showed that stigma and perceived stigma were significant predictors for all three strategies, with inverse relationships. Stigmatizing beliefs predicted less support while perceiving stigma ...
Source: Journal of Community Health - February 26, 2024 Category: International Medicine & Public Health Source Type: research

Predicting Risk of Heroin Overdose, Remission, Use, and Mortality Using Ensemble Learning Methods in a Cohort of People with Heroin Dependence
This study provides clinically relevant information on key risk factors associated with heroin use, remission, non-fatal overdose, and mortality among people with heroin dependence, to help guide clinical decision-making in the selection and tailor ing of interventions to ensure that the ‘right treatment’ is delivered to the ‘right person’ at the ‘right time’. (Source: International Journal of Mental Health and Addiction)
Source: International Journal of Mental Health and Addiction - February 26, 2024 Category: Addiction Source Type: research

Community Support for Harm Reduction and Treatment of Opioid Use Disorder
This study sought to understand beliefs and attitudes associated with support for three community-based strategies to address opioid misuse and addiction: naloxone, needle exchange, and medication-assisted treatment. We conducted a cross-sectional online survey with 545 adults. Results of the survey showed that participants supported all three strategies, with the strongest support for medication-assisted treatment. Multiple regression showed that stigma and perceived stigma were significant predictors for all three strategies, with inverse relationships. Stigmatizing beliefs predicted less support while perceiving stigma ...
Source: Journal of Community Health - February 26, 2024 Category: International Medicine & Public Health Source Type: research

Predicting Risk of Heroin Overdose, Remission, Use, and Mortality Using Ensemble Learning Methods in a Cohort of People with Heroin Dependence
This study provides clinically relevant information on key risk factors associated with heroin use, remission, non-fatal overdose, and mortality among people with heroin dependence, to help guide clinical decision-making in the selection and tailor ing of interventions to ensure that the ‘right treatment’ is delivered to the ‘right person’ at the ‘right time’. (Source: International Journal of Mental Health and Addiction)
Source: International Journal of Mental Health and Addiction - February 26, 2024 Category: Addiction Source Type: research

A young man with amnesia after drug overdose
Eur J Intern Med. 2024 Feb 24:S0953-6205(24)00067-0. doi: 10.1016/j.ejim.2024.02.013. Online ahead of print.NO ABSTRACTPMID:38403538 | DOI:10.1016/j.ejim.2024.02.013 (Source: European Journal of Internal Medicine)
Source: European Journal of Internal Medicine - February 25, 2024 Category: Internal Medicine Authors: Dhairya A Lakhani Francis Deng Source Type: research

A young man with amnesia after drug overdose
Eur J Intern Med. 2024 Feb 24:S0953-6205(24)00067-0. doi: 10.1016/j.ejim.2024.02.013. Online ahead of print.NO ABSTRACTPMID:38403538 | DOI:10.1016/j.ejim.2024.02.013 (Source: European Journal of Internal Medicine)
Source: European Journal of Internal Medicine - February 25, 2024 Category: Internal Medicine Authors: Dhairya A Lakhani Francis Deng Source Type: research

In vitro test methods for evaluating high molecular weight polyethylene oxide polymer induced hemolytic and thrombotic potential
Toxicol In Vitro. 2024 Feb 22:105793. doi: 10.1016/j.tiv.2024.105793. Online ahead of print.ABSTRACTTo combat opioid abuse, the U.S. Food and Drug Administration (FDA) released a comprehensive action plan to address opioid addiction, abuse, and overdose that included increasing the prevalence of abuse-deterrent formulations (ADFs) in opioid tablets. Polyethylene oxide (PEO) has been widely used as an excipient to deter abuse via nasal insufflation. However, changes in abuse patterns have led to unexpected shifts in abuse from the nasal route to intravenous injection. Case reports identify adverse effects similar to thrombo...
Source: Toxicology in Vitro - February 24, 2024 Category: Toxicology Authors: Dongjune Kim Rucha Natu Richard Malinauskas Jin Hyen Baek Paul Buehler Xin Feng Haiou Qu Julia Pinto Xiaoming Xu Luke Herbertson Source Type: research

In vitro test methods for evaluating high molecular weight polyethylene oxide polymer induced hemolytic and thrombotic potential
Toxicol In Vitro. 2024 Feb 22:105793. doi: 10.1016/j.tiv.2024.105793. Online ahead of print.ABSTRACTTo combat opioid abuse, the U.S. Food and Drug Administration (FDA) released a comprehensive action plan to address opioid addiction, abuse, and overdose that included increasing the prevalence of abuse-deterrent formulations (ADFs) in opioid tablets. Polyethylene oxide (PEO) has been widely used as an excipient to deter abuse via nasal insufflation. However, changes in abuse patterns have led to unexpected shifts in abuse from the nasal route to intravenous injection. Case reports identify adverse effects similar to thrombo...
Source: Toxicology in Vitro - February 24, 2024 Category: Toxicology Authors: Dongjune Kim Rucha Natu Richard Malinauskas Jin Hyen Baek Paul Buehler Xin Feng Haiou Qu Julia Pinto Xiaoming Xu Luke Herbertson Source Type: research

In vitro test methods for evaluating high molecular weight polyethylene oxide polymer induced hemolytic and thrombotic potential
Toxicol In Vitro. 2024 Feb 22:105793. doi: 10.1016/j.tiv.2024.105793. Online ahead of print.ABSTRACTTo combat opioid abuse, the U.S. Food and Drug Administration (FDA) released a comprehensive action plan to address opioid addiction, abuse, and overdose that included increasing the prevalence of abuse-deterrent formulations (ADFs) in opioid tablets. Polyethylene oxide (PEO) has been widely used as an excipient to deter abuse via nasal insufflation. However, changes in abuse patterns have led to unexpected shifts in abuse from the nasal route to intravenous injection. Case reports identify adverse effects similar to thrombo...
Source: Toxicology in Vitro - February 24, 2024 Category: Toxicology Authors: Dongjune Kim Rucha Natu Richard Malinauskas Jin Hyen Baek Paul Buehler Xin Feng Haiou Qu Julia Pinto Xiaoming Xu Luke Herbertson Source Type: research

In vitro test methods for evaluating high molecular weight polyethylene oxide polymer induced hemolytic and thrombotic potential
Toxicol In Vitro. 2024 Feb 22:105793. doi: 10.1016/j.tiv.2024.105793. Online ahead of print.ABSTRACTTo combat opioid abuse, the U.S. Food and Drug Administration (FDA) released a comprehensive action plan to address opioid addiction, abuse, and overdose that included increasing the prevalence of abuse-deterrent formulations (ADFs) in opioid tablets. Polyethylene oxide (PEO) has been widely used as an excipient to deter abuse via nasal insufflation. However, changes in abuse patterns have led to unexpected shifts in abuse from the nasal route to intravenous injection. Case reports identify adverse effects similar to thrombo...
Source: Toxicology in Vitro - February 24, 2024 Category: Toxicology Authors: Dongjune Kim Rucha Natu Richard Malinauskas Jin Hyen Baek Paul Buehler Xin Feng Haiou Qu Julia Pinto Xiaoming Xu Luke Herbertson Source Type: research

In vitro test methods for evaluating high molecular weight polyethylene oxide polymer induced hemolytic and thrombotic potential
Toxicol In Vitro. 2024 Feb 22:105793. doi: 10.1016/j.tiv.2024.105793. Online ahead of print.ABSTRACTTo combat opioid abuse, the U.S. Food and Drug Administration (FDA) released a comprehensive action plan to address opioid addiction, abuse, and overdose that included increasing the prevalence of abuse-deterrent formulations (ADFs) in opioid tablets. Polyethylene oxide (PEO) has been widely used as an excipient to deter abuse via nasal insufflation. However, changes in abuse patterns have led to unexpected shifts in abuse from the nasal route to intravenous injection. Case reports identify adverse effects similar to thrombo...
Source: Toxicology in Vitro - February 24, 2024 Category: Toxicology Authors: Dongjune Kim Rucha Natu Richard Malinauskas Jin Hyen Baek Paul Buehler Xin Feng Haiou Qu Julia Pinto Xiaoming Xu Luke Herbertson Source Type: research

In vitro test methods for evaluating high molecular weight polyethylene oxide polymer induced hemolytic and thrombotic potential
Toxicol In Vitro. 2024 Feb 22;97:105793. doi: 10.1016/j.tiv.2024.105793. Online ahead of print.ABSTRACTTo combat opioid abuse, the U.S. Food and Drug Administration (FDA) released a comprehensive action plan to address opioid addiction, abuse, and overdose that included increasing the prevalence of abuse-deterrent formulations (ADFs) in opioid tablets. Polyethylene oxide (PEO) has been widely used as an excipient to deter abuse via nasal insufflation. However, changes in abuse patterns have led to unexpected shifts in abuse from the nasal route to intravenous injection. Case reports identify adverse effects similar to thro...
Source: Toxicology in Vitro - February 24, 2024 Category: Toxicology Authors: Dongjune Kim Rucha Natu Richard Malinauskas Jin Hyen Baek Paul Buehler Xin Feng Haiou Qu Julia Pinto Xiaoming Xu Luke Herbertson Source Type: research