A Study to Assess the Dosimetric Impact of the Anatomical Changes Occurring in the Parotid Glands and Tumour Volume during Intensity Modulated Radiotherapy using Simultaneous Integrated Boost (IMRT ‐SIB) in Head and Neck Squamous Cell Cancers
Functional impairment and toxicities associated with radiation underscore the need to develop novel treatment strategies in the management of patients with advanced head and neck cancer to improve survival at the cost of minimal toxicity. Conformal radiotherapy techniques such as intensity-modulated radiotherapy (IMRT) in head neck cancer aids to deliver curative high accuracy radiation doses to the tumor and restricts dose to organs at risk consequently reduce treatment-related morbidity. However dosimetric variations are evident in IMRT due to variation in patient, tumor volume and organ at risk positions during the cour...
Source: Cancer Medicine - June 23, 2021 Category: Cancer & Oncology Authors: Arunima Ghosh, Seema Gupta, Danial Johny, Vivek Vidyadhar Bhosale, Mahendra Pal Singh Negi Tags: ORIGINAL RESEARCH Source Type: research

Medically treated opioid overdoses among New Jersey Medicaid beneficiaries: Rapid growth and complex comorbidity amid growing fentanyl penetration
This study reports on medically treated opioid overdose trends in a state with rapid fentanyl spread. (Source: Journal of Substance Abuse Treatment)
Source: Journal of Substance Abuse Treatment - June 23, 2021 Category: Addiction Authors: Stephen Crystal, Molly Nowels, Mark Olfson, Hillary Samples, Arthur Robinson Williams, Peter Treitler Source Type: research

Radiation dose estimation for pencil beam X-ray luminescence computed tomography imaging
CONCLUSION: Our results indicate that an X-ray benchtop source (like the X-ray source from Sigray Inc.) with high brilliance and quasi-monochromatic properties can reduce dose concerns with the pencil beam geometry. Findings of this work can be applicable to other imaging modalities like X-ray fluorescence computed tomography if the imaging protocol consists of the pencil beam geometry.PMID:34151883 | DOI:10.3233/XST-210904 (Source: Journal of X-Ray Science and Technology)
Source: Journal of X-Ray Science and Technology - June 21, 2021 Category: Radiology Authors: Ignacio O Romero Changqing Li Source Type: research

A Promising Chemical Series of Positive Allosteric Modulators of the μ-Opioid Receptor that Enhance the Antinociceptive Efficacy of Opioids but not their Adverse Effects
Neuropharmacology. 2021 Jun 18:108673. doi: 10.1016/j.neuropharm.2021.108673. Online ahead of print.ABSTRACTPositive allosteric modulators (PAMs) of the μ-opioid receptor (MOR) have been proposed to exhibit therapeutic potential by maximizing the analgesic properties of clinically used opioid drugs while limiting their adverse effects or risk of overdose as a result of using lower drug doses. We herein report in vitro and in vivo characterization of two small molecules from a chemical series of MOR PAMs that exhibit: (i) MOR PAM activity and receptor subtype selectivity in vitro, (ii) a differential potentiation of the ...
Source: Neuropharmacology - June 21, 2021 Category: Drugs & Pharmacology Authors: Kerri D Pryce Hye Jin Kang Farhana Sakloth Yongfeng Liu Susan Khan Katalin Toth Abhijeet Kapoor Andrew Nicolais Tao Che Lihuai Qin Feodora Bertherat H Ümit Kaniskan Jian Jin Michael D Cameron Bryan L Roth Venetia Zachariou Marta Filizola Source Type: research

Radiation dose estimation for pencil beam X-ray luminescence computed tomography imaging
CONCLUSION: Our results indicate that an X-ray benchtop source (like the X-ray source from Sigray Inc.) with high brilliance and quasi-monochromatic properties can reduce dose concerns with the pencil beam geometry. Findings of this work can be applicable to other imaging modalities like X-ray fluorescence computed tomography if the imaging protocol consists of the pencil beam geometry.PMID:34151883 | DOI:10.3233/XST-210904 (Source: Journal of X-Ray Science and Technology)
Source: Journal of X-Ray Science and Technology - June 21, 2021 Category: Radiology Authors: Ignacio O Romero Changqing Li Source Type: research

A Promising Chemical Series of Positive Allosteric Modulators of the μ-Opioid Receptor that Enhance the Antinociceptive Efficacy of Opioids but not their Adverse Effects
Neuropharmacology. 2021 Jun 18:108673. doi: 10.1016/j.neuropharm.2021.108673. Online ahead of print.ABSTRACTPositive allosteric modulators (PAMs) of the μ-opioid receptor (MOR) have been proposed to exhibit therapeutic potential by maximizing the analgesic properties of clinically used opioid drugs while limiting their adverse effects or risk of overdose as a result of using lower drug doses. We herein report in vitro and in vivo characterization of two small molecules from a chemical series of MOR PAMs that exhibit: (i) MOR PAM activity and receptor subtype selectivity in vitro, (ii) a differential potentiation of the ...
Source: Neuropharmacology - June 21, 2021 Category: Drugs & Pharmacology Authors: Kerri D Pryce Hye Jin Kang Farhana Sakloth Yongfeng Liu Susan Khan Katalin Toth Abhijeet Kapoor Andrew Nicolais Tao Che Lihuai Qin Feodora Bertherat H Ümit Kaniskan Jian Jin Michael D Cameron Bryan L Roth Venetia Zachariou Marta Filizola Source Type: research

Interstitial multi-catheter breast brachytherapy: Technical aspects and experience feedback in a comprehensive cancer center
CONCLUSION: The first dosimetric results and early clinical tolerance and efficacy achieved by the implementation of breast interstitial multicatheter brachytherapy in routine clinical practice are very encouraging, and confirm the interest of extending this practice.PMID:34147341 | DOI:10.1016/j.canrad.2021.06.001 (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - June 20, 2021 Category: Cancer & Oncology Authors: M Bruand S Renard J Salleron E Meknaci C Charra-Brunaud D Peiffert Source Type: research

Interstitial multi-catheter breast brachytherapy: Technical aspects and experience feedback in a comprehensive cancer center
CONCLUSION: The first dosimetric results and early clinical tolerance and efficacy achieved by the implementation of breast interstitial multicatheter brachytherapy in routine clinical practice are very encouraging, and confirm the interest of extending this practice.PMID:34147341 | DOI:10.1016/j.canrad.2021.06.001 (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - June 20, 2021 Category: Cancer & Oncology Authors: M Bruand S Renard J Salleron E Meknaci C Charra-Brunaud D Peiffert Source Type: research

Police Officers' addiction frameworks and policy attitudes
Addict Behav. 2021 Jun 7;122:107007. doi: 10.1016/j.addbeh.2021.107007. Online ahead of print.ABSTRACTPolice officers have frequent encounters with people who use drugs, either by making an arrest for a drug-related offense or responding to a drug overdose call. Yet, little is known about how police officers view drug addiction - as a disease, a moral failure, or something else - and how their frameworks for conceptualizing addiction impact their attitudes toward drug policies, including the use of naloxone. This research examined police officers' adherence to a moralistic addiction framework in relation to their support f...
Source: Addictive Behaviors - June 19, 2021 Category: Addiction Authors: Jennifer Murphy Brenda Russell Source Type: research

Police Officers' addiction frameworks and policy attitudes
Addict Behav. 2021 Jun 7;122:107007. doi: 10.1016/j.addbeh.2021.107007. Online ahead of print.ABSTRACTPolice officers have frequent encounters with people who use drugs, either by making an arrest for a drug-related offense or responding to a drug overdose call. Yet, little is known about how police officers view drug addiction - as a disease, a moral failure, or something else - and how their frameworks for conceptualizing addiction impact their attitudes toward drug policies, including the use of naloxone. This research examined police officers' adherence to a moralistic addiction framework in relation to their support f...
Source: Addictive Behaviors - June 19, 2021 Category: Addiction Authors: Jennifer Murphy Brenda Russell Source Type: research

A Case of Massive Diphenhydramine and Naproxen Overdose
Diphenhydramine, a first generation H1 histamine receptor antagonist, is a commonly used nonprescription medication that is used for the treatment of allergy, as a sleep aid, or combined with cough and cold remedies. Naproxen, a nonsteroidal anti-inflammatory drug (NSAID), is used commonly for analgesia. Although most cases of diphenhydramine or naproxen overdose require excellent supportive care only, meticulous attention should be given to cardiovascular and neurologic status. (Source: The Journal of Emergency Medicine)
Source: The Journal of Emergency Medicine - June 17, 2021 Category: Emergency Medicine Authors: Sanjay Mohan, Timothy Backus, Emma Furlano, Mary Ann Howland, Silas W. Smith, Mark K. Su Tags: Selected Topics: Toxicology Source Type: research

A pilot study of the functionality and clinician acceptance of a clinical decision support tool to improve primary care of opioid use disorder
CONCLUSION: The OUD-CDS tool was functional and accurate, but PCP use rates were low. Despite low use, the OUD-CDS improved confidence in OUD screening, diagnosis and use of buprenorphine. NIH Trial registration NCT03559179. Date of registration: 06/18/2018. URL: https://clinicaltrials.gov/ct2/show/NCT03559179.PMID:34130758 | DOI:10.1186/s13722-021-00245-7 (Source: Addiction Science and Clinical Practice)
Source: Addiction Science and Clinical Practice - June 16, 2021 Category: Addiction Authors: Rebecca C Rossom JoAnn M Sperl-Hillen Patrick J O'Connor A Lauren Crain Laurel Nightingale Anne Pylkas Kristen V Huntley Gavin Bart Source Type: research

A Global Pandemic and Substance Use Disorder: Healthcare Professionals' Viewpoints on the Merging of Two Crises
Conclusion: During the COVID-19 pandemic, overdose deaths have dramatically increased. As the short-term and long-term effects of the pandemic become more apparent, swift and comprehensive responses and policies must be enacted. This study provides insight from healthcare providers on the effects of the pandemic for persons with SUD. Many preexisting issues remain unresolved (e.g. stigma and healthcare disparities), and now the pandemic has presented new obstacles as noted by the providers. The findings from this study provide implications for important discussion regarding the development of strategies for substance use t...
Source: Substance Use and Misuse - June 16, 2021 Category: Addiction Authors: Jacob Shreffler Megan Shreffler Jessica R Murfree Martin Huecker Source Type: research

A pilot study of the functionality and clinician acceptance of a clinical decision support tool to improve primary care of opioid use disorder
CONCLUSION: The OUD-CDS tool was functional and accurate, but PCP use rates were low. Despite low use, the OUD-CDS improved confidence in OUD screening, diagnosis and use of buprenorphine. NIH Trial registration NCT03559179. Date of registration: 06/18/2018. URL: https://clinicaltrials.gov/ct2/show/NCT03559179.PMID:34130758 | DOI:10.1186/s13722-021-00245-7 (Source: Addiction Science and Clinical Practice)
Source: Addiction Science and Clinical Practice - June 16, 2021 Category: Addiction Authors: Rebecca C Rossom JoAnn M Sperl-Hillen Patrick J O'Connor A Lauren Crain Laurel Nightingale Anne Pylkas Kristen V Huntley Gavin Bart Source Type: research

A Global Pandemic and Substance Use Disorder: Healthcare Professionals' Viewpoints on the Merging of Two Crises
Conclusion: During the COVID-19 pandemic, overdose deaths have dramatically increased. As the short-term and long-term effects of the pandemic become more apparent, swift and comprehensive responses and policies must be enacted. This study provides insight from healthcare providers on the effects of the pandemic for persons with SUD. Many preexisting issues remain unresolved (e.g. stigma and healthcare disparities), and now the pandemic has presented new obstacles as noted by the providers. The findings from this study provide implications for important discussion regarding the development of strategies for substance use t...
Source: Substance Use and Misuse - June 16, 2021 Category: Addiction Authors: Jacob Shreffler Megan Shreffler Jessica R Murfree Martin Huecker Source Type: research

A pilot study of the functionality and clinician acceptance of a clinical decision support tool to improve primary care of opioid use disorder
CONCLUSION: The OUD-CDS tool was functional and accurate, but PCP use rates were low. Despite low use, the OUD-CDS improved confidence in OUD screening, diagnosis and use of buprenorphine. NIH Trial registration NCT03559179. Date of registration: 06/18/2018. URL: https://clinicaltrials.gov/ct2/show/NCT03559179.PMID:34130758 | DOI:10.1186/s13722-021-00245-7 (Source: Addiction Science and Clinical Practice)
Source: Addiction Science and Clinical Practice - June 16, 2021 Category: Addiction Authors: Rebecca C Rossom JoAnn M Sperl-Hillen Patrick J O'Connor A Lauren Crain Laurel Nightingale Anne Pylkas Kristen V Huntley Gavin Bart Source Type: research

A pilot study of the functionality and clinician acceptance of a clinical decision support tool to improve primary care of opioid use disorder
CONCLUSION: The OUD-CDS tool was functional and accurate, but PCP use rates were low. Despite low use, the OUD-CDS improved confidence in OUD screening, diagnosis and use of buprenorphine. NIH Trial registration NCT03559179. Date of registration: 06/18/2018. URL: https://clinicaltrials.gov/ct2/show/NCT03559179.PMID:34130758 | DOI:10.1186/s13722-021-00245-7 (Source: Addiction Science and Clinical Practice)
Source: Addiction Science and Clinical Practice - June 16, 2021 Category: Addiction Authors: Rebecca C Rossom JoAnn M Sperl-Hillen Patrick J O'Connor A Lauren Crain Laurel Nightingale Anne Pylkas Kristen V Huntley Gavin Bart Source Type: research

A pilot study of the functionality and clinician acceptance of a clinical decision support tool to improve primary care of opioid use disorder
CONCLUSION: The OUD-CDS tool was functional and accurate, but PCP use rates were low. Despite low use, the OUD-CDS improved confidence in OUD screening, diagnosis and use of buprenorphine. NIH Trial registration NCT03559179. Date of registration: 06/18/2018. URL: https://clinicaltrials.gov/ct2/show/NCT03559179.PMID:34130758 | DOI:10.1186/s13722-021-00245-7 (Source: Addiction Science and Clinical Practice)
Source: Addiction Science and Clinical Practice - June 16, 2021 Category: Addiction Authors: Rebecca C Rossom JoAnn M Sperl-Hillen Patrick J O'Connor A Lauren Crain Laurel Nightingale Anne Pylkas Kristen V Huntley Gavin Bart Source Type: research

A pilot study of the functionality and clinician acceptance of a clinical decision support tool to improve primary care of opioid use disorder
CONCLUSION: The OUD-CDS tool was functional and accurate, but PCP use rates were low. Despite low use, the OUD-CDS improved confidence in OUD screening, diagnosis and use of buprenorphine. NIH Trial registration NCT03559179. Date of registration: 06/18/2018. URL: https://clinicaltrials.gov/ct2/show/NCT03559179.PMID:34130758 | PMC:PMC8207778 | DOI:10.1186/s13722-021-00245-7 (Source: Addiction Science and Clinical Practice)
Source: Addiction Science and Clinical Practice - June 16, 2021 Category: Addiction Authors: Rebecca C Rossom JoAnn M Sperl-Hillen Patrick J O'Connor A Lauren Crain Laurel Nightingale Anne Pylkas Kristen V Huntley Gavin Bart Source Type: research

Discovering Non-Invasive Biomarkers Predictive of Opioid Use Disorder Treatment Response
DISCUSSION: Naltrexone, which is used in treatment of OUD and other substance use disorders as well as disorders of impulse control, was found to have multiple potential corresponding molecular signatures that can be identified after long-term treatment. It remains to be seen if these markers can also be a good predictor for treatment response. In addition, significant gender differences in EV content are found between men and women with OUD, which supports the importance of examining changes in response to treatment in a gender informed way.PMID:34127132 | DOI:10.1017/S1092852920002825 (Source: CNS Spectrums)
Source: CNS Spectrums - June 15, 2021 Category: Neurology Authors: Amir Levine Kelly Clemenza Shira Weiss Adam Bisaga Erez Eitan Maria Carla Gerra Claudia Donnini Gilberto Gerra Benjamin Garcia Source Type: research

Discovering Non-Invasive Biomarkers Predictive of Opioid Use Disorder Treatment Response
DISCUSSION: Naltrexone, which is used in treatment of OUD and other substance use disorders as well as disorders of impulse control, was found to have multiple potential corresponding molecular signatures that can be identified after long-term treatment. It remains to be seen if these markers can also be a good predictor for treatment response. In addition, significant gender differences in EV content are found between men and women with OUD, which supports the importance of examining changes in response to treatment in a gender informed way.PMID:34127132 | DOI:10.1017/S1092852920002825 (Source: CNS Spectrums)
Source: CNS Spectrums - June 15, 2021 Category: Neurology Authors: Amir Levine Kelly Clemenza Shira Weiss Adam Bisaga Erez Eitan Maria Carla Gerra Claudia Donnini Gilberto Gerra Benjamin Garcia Source Type: research

Discovering Non-Invasive Biomarkers Predictive of Opioid Use Disorder Treatment Response
DISCUSSION: Naltrexone, which is used in treatment of OUD and other substance use disorders as well as disorders of impulse control, was found to have multiple potential corresponding molecular signatures that can be identified after long-term treatment. It remains to be seen if these markers can also be a good predictor for treatment response. In addition, significant gender differences in EV content are found between men and women with OUD, which supports the importance of examining changes in response to treatment in a gender informed way.PMID:34127132 | DOI:10.1017/S1092852920002825 (Source: CNS Spectrums)
Source: CNS Spectrums - June 15, 2021 Category: Neurology Authors: Amir Levine Kelly Clemenza Shira Weiss Adam Bisaga Erez Eitan Maria Carla Gerra Claudia Donnini Gilberto Gerra Benjamin Garcia Source Type: research

Discovering Non-Invasive Biomarkers Predictive of Opioid Use Disorder Treatment Response
DISCUSSION: Naltrexone, which is used in treatment of OUD and other substance use disorders as well as disorders of impulse control, was found to have multiple potential corresponding molecular signatures that can be identified after long-term treatment. It remains to be seen if these markers can also be a good predictor for treatment response. In addition, significant gender differences in EV content are found between men and women with OUD, which supports the importance of examining changes in response to treatment in a gender informed way.PMID:34127132 | DOI:10.1017/S1092852920002825 (Source: CNS Spectrums)
Source: CNS Spectrums - June 15, 2021 Category: Neurology Authors: Amir Levine Kelly Clemenza Shira Weiss Adam Bisaga Erez Eitan Maria Carla Gerra Claudia Donnini Gilberto Gerra Benjamin Garcia Source Type: research

Discovering Non-Invasive Biomarkers Predictive of Opioid Use Disorder Treatment Response
DISCUSSION: Naltrexone, which is used in treatment of OUD and other substance use disorders as well as disorders of impulse control, was found to have multiple potential corresponding molecular signatures that can be identified after long-term treatment. It remains to be seen if these markers can also be a good predictor for treatment response. In addition, significant gender differences in EV content are found between men and women with OUD, which supports the importance of examining changes in response to treatment in a gender informed way.PMID:34127132 | DOI:10.1017/S1092852920002825 (Source: CNS Spectrums)
Source: CNS Spectrums - June 15, 2021 Category: Neurology Authors: Amir Levine Kelly Clemenza Shira Weiss Adam Bisaga Erez Eitan Maria Carla Gerra Claudia Donnini Gilberto Gerra Benjamin Garcia Source Type: research

The association between opioids, environmental, demographic, and socioeconomic indicators and COVID-19 mortality rates in the United States: an ecological study at the county level
ConclusionsThis study indicates need for public health efforts in hard hit COVID-19 regions to also focus prevention efforts on overdose risk among people who use opioids. Future studies using individual-level data are needed to allow for detailed inferences. (Source: Archives of Public Health)
Source: Archives of Public Health - June 15, 2021 Category: International Medicine & Public Health Source Type: research

Advocating for Multimodal Pain Management and Reducing the Need for Opioids in the Acute and Chronic Pain Setting
The opioid epidemic skyrocketed around 2017 when many pharmaceutical companies guaranteed effective pain relief with nonaddictive properties of prescription opioids. However, this has proven to be inadequate because opioid misuse has increased in the United States. These catastrophic consequences led many providers to take on a different approach to pain management in the acute and chronic setting. In the last few years, a great deal of research has focused more on a multimodal pain management approach, in hopes to decrease the rate of opioid misuse and related overdoses and help assist in putting an end to this public hea...
Source: Nursing Clinics of North America - June 15, 2021 Category: Nursing Authors: Janelle M. Delle, Cheryl Gazley Source Type: research

Pharmacological mechanisms underlying the efficacy of antibodies generated by a vaccine to treat oxycodone use disorder
Neuropharmacology. 2021 Jun 11:108653. doi: 10.1016/j.neuropharm.2021.108653. Online ahead of print.ABSTRACTTherapeutic vaccines offer a viable strategy to treat opioid use disorders (OUD) complementary to current pharmacotherapies. The candidate Oxy(Gly)4-sKLH vaccine targeting oxycodone displayed pre-clinical proof of efficacy, selectivity and safety, and it is now undergoing clinical evaluation. To further support its implementation in the clinic, this study tested critical in vivo neuropsychopharmacological properties of the Oxy(Gly)4-sKLH vaccine in rats. While repeated immunizations with Oxy(Gly)4-sKLH were necessary...
Source: Neuropharmacology - June 14, 2021 Category: Drugs & Pharmacology Authors: M D Raleigh S J King F Baruffaldi A Saykao F A Hamid S Winston M G LeSage P R Pentel M Pravetoni Source Type: research

Pharmacological mechanisms underlying the efficacy of antibodies generated by a vaccine to treat oxycodone use disorder
Neuropharmacology. 2021 Jun 11:108653. doi: 10.1016/j.neuropharm.2021.108653. Online ahead of print.ABSTRACTTherapeutic vaccines offer a viable strategy to treat opioid use disorders (OUD) complementary to current pharmacotherapies. The candidate Oxy(Gly)4-sKLH vaccine targeting oxycodone displayed pre-clinical proof of efficacy, selectivity and safety, and it is now undergoing clinical evaluation. To further support its implementation in the clinic, this study tested critical in vivo neuropsychopharmacological properties of the Oxy(Gly)4-sKLH vaccine in rats. While repeated immunizations with Oxy(Gly)4-sKLH were necessary...
Source: Neuropharmacology - June 14, 2021 Category: Drugs & Pharmacology Authors: M D Raleigh S J King F Baruffaldi A Saykao F A Hamid S Winston M G LeSage P R Pentel M Pravetoni Source Type: research

Pharmacological mechanisms underlying the efficacy of antibodies generated by a vaccine to treat oxycodone use disorder
Neuropharmacology. 2021 Jun 11:108653. doi: 10.1016/j.neuropharm.2021.108653. Online ahead of print.ABSTRACTTherapeutic vaccines offer a viable strategy to treat opioid use disorders (OUD) complementary to current pharmacotherapies. The candidate Oxy(Gly)4-sKLH vaccine targeting oxycodone displayed pre-clinical proof of efficacy, selectivity and safety, and it is now undergoing clinical evaluation. To further support its implementation in the clinic, this study tested critical in vivo neuropsychopharmacological properties of the Oxy(Gly)4-sKLH vaccine in rats. While repeated immunizations with Oxy(Gly)4-sKLH were necessary...
Source: Neuropharmacology - June 14, 2021 Category: Drugs & Pharmacology Authors: M D Raleigh S J King F Baruffaldi A Saykao F A Hamid S Winston M G LeSage P R Pentel M Pravetoni Source Type: research

Pharmacological mechanisms underlying the efficacy of antibodies generated by a vaccine to treat oxycodone use disorder
Neuropharmacology. 2021 Jun 11:108653. doi: 10.1016/j.neuropharm.2021.108653. Online ahead of print.ABSTRACTTherapeutic vaccines offer a viable strategy to treat opioid use disorders (OUD) complementary to current pharmacotherapies. The candidate Oxy(Gly)4-sKLH vaccine targeting oxycodone displayed pre-clinical proof of efficacy, selectivity and safety, and it is now undergoing clinical evaluation. To further support its implementation in the clinic, this study tested critical in vivo neuropsychopharmacological properties of the Oxy(Gly)4-sKLH vaccine in rats. While repeated immunizations with Oxy(Gly)4-sKLH were necessary...
Source: Neuropharmacology - June 14, 2021 Category: Drugs & Pharmacology Authors: M D Raleigh S J King F Baruffaldi A Saykao F A Hamid S Winston M G LeSage P R Pentel M Pravetoni Source Type: research

Pharmacological mechanisms underlying the efficacy of antibodies generated by a vaccine to treat oxycodone use disorder
Neuropharmacology. 2021 Jun 11:108653. doi: 10.1016/j.neuropharm.2021.108653. Online ahead of print.ABSTRACTTherapeutic vaccines offer a viable strategy to treat opioid use disorders (OUD) complementary to current pharmacotherapies. The candidate Oxy(Gly)4-sKLH vaccine targeting oxycodone displayed pre-clinical proof of efficacy, selectivity and safety, and it is now undergoing clinical evaluation. To further support its implementation in the clinic, this study tested critical in vivo neuropsychopharmacological properties of the Oxy(Gly)4-sKLH vaccine in rats. While repeated immunizations with Oxy(Gly)4-sKLH were necessary...
Source: Neuropharmacology - June 14, 2021 Category: Drugs & Pharmacology Authors: M D Raleigh S J King F Baruffaldi A Saykao F A Hamid S Winston M G LeSage P R Pentel M Pravetoni Source Type: research

Pharmacological mechanisms underlying the efficacy of antibodies generated by a vaccine to treat oxycodone use disorder
Neuropharmacology. 2021 Jun 11:108653. doi: 10.1016/j.neuropharm.2021.108653. Online ahead of print.ABSTRACTTherapeutic vaccines offer a viable strategy to treat opioid use disorders (OUD) complementary to current pharmacotherapies. The candidate Oxy(Gly)4-sKLH vaccine targeting oxycodone displayed pre-clinical proof of efficacy, selectivity and safety, and it is now undergoing clinical evaluation. To further support its implementation in the clinic, this study tested critical in vivo neuropsychopharmacological properties of the Oxy(Gly)4-sKLH vaccine in rats. While repeated immunizations with Oxy(Gly)4-sKLH were necessary...
Source: Neuropharmacology - June 14, 2021 Category: Drugs & Pharmacology Authors: M D Raleigh S J King F Baruffaldi A Saykao F A Hamid S Winston M G LeSage P R Pentel M Pravetoni Source Type: research

Changes in overdose knowledge and attitudes in an incarcerated sample of people living with HIV
Int J Prison Health. 2021 Jun 15;ahead-of-print(ahead-of-print). doi: 10.1108/IJPH-01-2021-0004.ABSTRACTPURPOSE: The purpose of this paper is to present evaluation results. People exiting incarceration who use opioids are at an elevated risk for overdose following release. People living with HIV (PLWH) who use drugs are also at increased overdose risk. Overdose education and naloxone distribution (OEND) is an effective community-based intervention, but few OEND programs have been evaluated in a correctional setting and none have specifically targeted PLWH.DESIGN/METHODOLOGY/APPROACH: An OEND pilot program was implemented i...
Source: International Journal of Prisoner Health - June 13, 2021 Category: Criminology Authors: Megan Reed Anne Siegler Loni P Tabb Florence Momplaisir Dorsche Krevitz Stephen Lankenau Source Type: research

When a house is never a home: Housing instability among youth affected by parental drug abuse
CONCLUSION: The residual impacts of parental substance use have caused youth to experience the toxic stress and trauma associated with housing instability. It is important that young people have safe, stable and reliable housing to promote child health and normative development.PMID:34118586 | DOI:10.1016/j.chiabu.2021.105131 (Source: Child Abuse and Neglect)
Source: Child Abuse and Neglect - June 12, 2021 Category: Child Development Authors: Quiana J Lewis Bianca D Smith Asari Offiong Morgan Prioleau Terrinieka W Powell Source Type: research

An Ultrasensitive Electrochemical Sensor for the Detection of Acetaminophen via a Three-Dimensional Hierarchical Nanoporous Gold Wire Electrode
Analyst, 2021, Accepted Manuscript DOI: 10.1039/D1AN00755F, PaperLanting Qian, Reem Elmahdy, Antony Raj Thiruppathi, Aicheng Chen Acetaminophen is one of the most commonly used non-steroidal anti-inflammatory drugs worldwide. However, due to the increasing popularity of this drug, overdosing and the contamination of ambient waterways have emerged... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Analyst latest articles)
Source: RSC - Analyst latest articles - June 11, 2021 Category: Chemistry Authors: Lanting Qian Source Type: research

Transcriptional alterations in dorsolateral prefrontal cortex and nucleus accumbens implicate neuroinflammation and synaptic remodeling in opioid use disorder
Prevalence rates of opioid use disorder (OUD) have increased dramatically, accompanied by a surge of overdose deaths. While opioid dependence has been extensively studied in preclinical models, an understanding of the biological alterations that occur in the brains of people who chronically use opioids and who are diagnosed with OUD remains limited. To address this limitation, RNA-sequencing (RNA-seq) was conducted on the dorsolateral prefrontal cortex (DLPFC) and nucleus accumbens (NAc), regions heavily implicated in OUD, from postmortem brains in subjects with OUD. (Source: Biological Psychiatry)
Source: Biological Psychiatry - June 11, 2021 Category: Psychiatry Authors: Marianne L. Seney, Sam-Moon Kim, Jill R. Glausier, Mariah A. Hildebrand, Xiangning Xue, Wei Zong, Jiebiao Wang, Micah A. Shelton, BaDoi N. Phan, Chaitanya Srinivasan, Andreas R. Pfenning, George C. Tseng, David A. Lewis, Zachary Freyberg, Ryan W. Logan Tags: Archival Report Source Type: research

A spatio-temporal Bayesian model to estimate risk and evaluate factors related to drug-involved emergency department visits in the greater Baltimore metropolitan area
This study uses an ongoing sample of ED visits from four hospitals in the University of Maryland Medical System (UMMS) from January 2016 to December 2019 to provide locally sensitive information on ED visit rates and disease risk for drug-related health outcomes. (Source: Journal of Substance Abuse Treatment)
Source: Journal of Substance Abuse Treatment - June 11, 2021 Category: Addiction Authors: Jeffery Sauer, Kathleen Stewart, Zachary D.W. Dezman Source Type: research

Monitoring nociception and awareness during palliative sedation: A systematic review
Palliat Med. 2021 Jun 10:2692163211022943. doi: 10.1177/02692163211022943. Online ahead of print.ABSTRACTBACKGROUND: Providing unawareness and pain relief are core elements of palliative sedation. In addition to clinical scales, nociception and electroencephalogram-based depth of sedation monitoring are used to assess the level of consciousness and analgesia during sedation in intensive care units and during procedures.AIM: To determine whether reported devices impact the outcomes of palliative sedation.DESIGN: Systematic review and narrative synthesis of research published between January 2000 and December 2020.DATA SOURC...
Source: Palliative Medicine - June 10, 2021 Category: Palliative Care Authors: Nathalie Dieudonn é Rahm Ghizlaine Morawska Sophie Pautex Nadia Elia Source Type: research

Monitoring nociception and awareness during palliative sedation: A systematic review
Palliat Med. 2021 Jun 10:2692163211022943. doi: 10.1177/02692163211022943. Online ahead of print.ABSTRACTBACKGROUND: Providing unawareness and pain relief are core elements of palliative sedation. In addition to clinical scales, nociception and electroencephalogram-based depth of sedation monitoring are used to assess the level of consciousness and analgesia during sedation in intensive care units and during procedures.AIM: To determine whether reported devices impact the outcomes of palliative sedation.DESIGN: Systematic review and narrative synthesis of research published between January 2000 and December 2020.DATA SOURC...
Source: Palliative Medicine - June 10, 2021 Category: Palliative Care Authors: Nathalie Dieudonn é Rahm Ghizlaine Morawska Sophie Pautex Nadia Elia Source Type: research

Monitoring nociception and awareness during palliative sedation: A systematic review
Palliat Med. 2021 Jun 10:2692163211022943. doi: 10.1177/02692163211022943. Online ahead of print.ABSTRACTBACKGROUND: Providing unawareness and pain relief are core elements of palliative sedation. In addition to clinical scales, nociception and electroencephalogram-based depth of sedation monitoring are used to assess the level of consciousness and analgesia during sedation in intensive care units and during procedures.AIM: To determine whether reported devices impact the outcomes of palliative sedation.DESIGN: Systematic review and narrative synthesis of research published between January 2000 and December 2020.DATA SOURC...
Source: Palliative Medicine - June 10, 2021 Category: Palliative Care Authors: Nathalie Dieudonn é Rahm Ghizlaine Morawska Sophie Pautex Nadia Elia Source Type: research

Monitoring nociception and awareness during palliative sedation: A systematic review
Palliat Med. 2021 Jun 10:2692163211022943. doi: 10.1177/02692163211022943. Online ahead of print.ABSTRACTBACKGROUND: Providing unawareness and pain relief are core elements of palliative sedation. In addition to clinical scales, nociception and electroencephalogram-based depth of sedation monitoring are used to assess the level of consciousness and analgesia during sedation in intensive care units and during procedures.AIM: To determine whether reported devices impact the outcomes of palliative sedation.DESIGN: Systematic review and narrative synthesis of research published between January 2000 and December 2020.DATA SOURC...
Source: Palliative Medicine - June 10, 2021 Category: Palliative Care Authors: Nathalie Dieudonn é Rahm Ghizlaine Morawska Sophie Pautex Nadia Elia Source Type: research

Black clients in expansion states who used opioids were more likely to access medication for opioid use disorder after ACA implementation
Black people in the United States who use opioids receive less treatment and die from overdoses at higher rates than White people. Medication for opioid use disorder (MOUD) decreases overdose risk. Implementation of the Affordable Care Act (ACA) in the United States was associated with an increase in MOUD. To what extent racial disparity exists in MOUD following ACA implementation remains unclear. Using a national sample of people seeking treatment for opioids (clients), we compared changes in MOUD after the ACA to determine whether implementation was associated with increased MOUD for Black clients relative to White clien...
Source: Journal of Substance Abuse Treatment - June 10, 2021 Category: Addiction Authors: Natrina L. Johnson, Sugy Choi, Carolina-Nicole Herrera Source Type: research

Engineering Quick- and Long-acting Naloxone Delivery Systems for Treating Opioid Overdose
ConclusionsNaloxone released from the three selected formulations could inhibit DAMGO-induced β-arrestin 2 recruitment. This indicates that the proposed naloxone delivery system is adequate for opioid reversal during the naloxone release duration. (Source: Pharmaceutical Research)
Source: Pharmaceutical Research - June 10, 2021 Category: Drugs & Pharmacology Source Type: research

The Cedar Project: Relationship between child apprehension and attempted suicide among young Indigenous mothers impacted by substance use in two Canadian cities
This study examined relationships between child apprehension and suicide attempt within a cohort of young Indigenous women impacted by substance use. We utilized data collected every 6 months (2008–2016) by the Cedar Project, an Indigenous-governed cohort study involving young Indigenous people who use drugs in British Columbia, Canada. Recent child apprehension was defined as having a child apprehended by the Ministry of Child and Family Development since last visit. Recurrent event Cox proportional hazards models estimated the independent effect of child apprehension on maternal suicide attempt. Amon g 293 particip...
Source: PLoS One - June 10, 2021 Category: Biomedical Science Authors: Lisa Ritland Source Type: research

Timing of Oversedation Events Following Opiate Administration in Hospitalized Patients
CONCLUSION: Opiate-induced oversedation routinely occurs after predicted based upon duration of action. The study findings have profound implications upon nursing practice regarding duration of time required to monitor for opiate-induced oversedation.PMID:34104282 | PMC:PMC8166287 | DOI:10.14740/jocmr4498 (Source: Clin Med Res)
Source: Clin Med Res - June 9, 2021 Category: Research Authors: John S Garrett Annelise Vanston Hoa L Nguyen Cindy Cassity Angela Straza Source Type: research

Differences and similarities between emergency department syndromic surveillance and hospital discharge data for nonfatal drug overdose
CONCLUSIONS: Results demonstrate that discharge data may be better for reporting counts, yet syndromic data are preferable to detect changes quickly and to alert practitioners and public health officials to local overdose clusters. These data sources do serve complementary purposes when examining overdose trends.PMID:34107342 | DOI:10.1016/j.annepidem.2021.05.008 (Source: Annals of Epidemiology)
Source: Annals of Epidemiology - June 9, 2021 Category: Epidemiology Authors: Alana M Vivolo-Kantor Herschel Smith Iv Lawrence Scholl Source Type: research

Fatal opioid overdoses in the U.S. declined more than reported between 2017 and 2018
Conclusions: Our models suggest that opioid overdose-related mortality declined from 2017 to 2018 at a higher rate than reported (7.0% versus than the reported 2.0%), potentially indicating that clinical efforts and federal, state, and local government policies designed to control the epidemic have been effective in most states. Our local area estimates can be used by researchers, policy-makers and public health officials to assess effectiveness of state policies and interventions in smaller jurisdictions implemented in response to the crisis.PMID:34107224 | DOI:10.1080/00952990.2021.1929273 (Source: The American Journal o...
Source: The American Journal of Drug and Alcohol Abuse - June 9, 2021 Category: Addiction Authors: Andrew Boslett Alina Denham Elaine Hill Source Type: research

Hypofractionation and Stereotactic Body Radiation Therapy in Inoperable Locally Advanced Non-small Cell Lung Cancer
The objective of this article is to introduce professionals to the role that hypoRT and SBRT can play in the treatment of LA-NSCLC to offer the best treatment to their patients.PMID:34104822 | PMC:PMC8177839 (Source: Clinical Lung Cancer)
Source: Clinical Lung Cancer - June 9, 2021 Category: Cancer & Oncology Authors: Mikel Rico Maribel Mart ínez Maitane Rodr íguez Lombardo Rosas Andrea Barco Enrique Mart ínez Source Type: research

Hypofractionation and Stereotactic Body Radiation Therapy in Inoperable Locally Advanced Non-small Cell Lung Cancer
The objective of this article is to introduce professionals to the role that hypoRT and SBRT can play in the treatment of LA-NSCLC to offer the best treatment to their patients.PMID:34104822 | PMC:PMC8177839 (Source: Biomed Res)
Source: Biomed Res - June 9, 2021 Category: Research Authors: Mikel Rico Maribel Mart ínez Maitane Rodr íguez Lombardo Rosas Andrea Barco Enrique Mart ínez Source Type: research

Timing of Oversedation Events Following Opiate Administration in Hospitalized Patients
CONCLUSION: Opiate-induced oversedation routinely occurs after predicted based upon duration of action. The study findings have profound implications upon nursing practice regarding duration of time required to monitor for opiate-induced oversedation.PMID:34104282 | PMC:PMC8166287 | DOI:10.14740/jocmr4498 (Source: Clin Med Res)
Source: Clin Med Res - June 9, 2021 Category: Research Authors: John S Garrett Annelise Vanston Hoa L Nguyen Cindy Cassity Angela Straza Source Type: research