Opioid withdrawal increases health risks for people who inject drugs
(Keck School of Medicine of USC) Experiencing the symptoms of opioid withdrawal increases the odds that a person who injects drugs will share needles or have a non-fatal overdose, according to new USC study published in the journal Drug and Alcohol Dependence. The study, which has implications for others with opioid use disorder, says medication-assisted treatment for opioid withdrawal is urgently needed and recommends that the drug buprenorphine be made available to those at risk. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - March 18, 2020 Category: Infectious Diseases Source Type: news

Opioid-involved overdose deaths with fentanyl or fentanyl analogs detected - 28 states and the District of Columbia, July 2016-December 2018 - O'Donnell J, Gladden RM, Goldberger BA, Mattson CL, Kariisa M.
Approximately two thirds of the 70,237 U.S. drug overdose deaths reported in 2017 involved opioids (1). Since 2013, opioid-involved overdose deaths involving illicitly manufactured fentanyl has sharply increased (1,2). Fentanyl analogs are structurally... (Source: SafetyLit)
Source: SafetyLit - March 17, 2020 Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news

Characterization of intentional lurasidone ingestions using the United States National Poison Data System - Weiss SJ, Cueto-Vilorio VA, Dharmaraj R, Barolia D, Nashat A, Walsh SJ, Simpson SE.
Introduction: The ziprasidone analogue lurasidone is approved for the treatment of schizophrenia and bipolar disorder for adults and children older than 10  years. Small studies and case reports suggest lurasidone overdose is not generally associate... (Source: SafetyLit)
Source: SafetyLit - March 16, 2020 Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news

CVS Melds Opioid Support Into Social Determinants Network
CVS Health is melding a program designed to help those who ’ve suffered an opioid overdose into its widening effort to address social determinants of health. (Source: Forbes.com Healthcare News)
Source: Forbes.com Healthcare News - March 16, 2020 Category: Pharmaceuticals Authors: Bruce Japsen, Contributor Source Type: news

Drivers of opioid use in Appalachian Pennsylvania: cross-cutting social and community-level factors - Thompson JR, Creasy SL, Mair CF, Burke JG.
BACKGROUND: Four Appalachian states including Pennsylvania (PA) have the highest drug overdose rates in the country, calling for better understanding of the social and economic drivers of opioid use in the region. Using key informant interviews, we explore... (Source: SafetyLit)
Source: SafetyLit - March 13, 2020 Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news

Notes from the Field: Opioid-Involved Overdose Deaths with Fentanyl or Fentanyl Analogs Detected - 28 States and the District of Columbia, July 2016-December 2018
The declines in overdose deaths with fentanyl analogs (carfentanil, furanylfentanyl, acrylfentanyl, and cyclopropylfentanyl) detected contributed to declines in opioid-involved overdose deaths during 2018 among a subset of states, even as deaths with fentanyl detected increased over time, which highlights the continued need to test for fentanyl analogs. (Source: CDC Morbidity and Mortality Weekly Report)
Source: CDC Morbidity and Mortality Weekly Report - March 12, 2020 Category: American Health Tags: Alcohol Binge Drinking Cancer Colorectal Cancer Colorectal Cancer Control Program (CRCCP) Drinking and Driving HIV/AIDS HIV/AIDS and STDs MMWR Morbidity & Mortality Weekly Report Overdose Pain management Synthetic Opioids Tra Source Type: news

Blue light phones as potential locations for deploying public access naloxone kits on a college campus - Dworkis DA, Tang W, Ritcheson NC, Raviv O, Fowler A, Ellig K, Goley S, Arora S.
Objective: Opioid use and the risk of opioid overdose are growing public health concerns for college-aged adults. Naloxone can temporarily reverse opioid overdoses, but only if easily accessible. On most college campuses, "blue light" phones (BLPs)-... (Source: SafetyLit)
Source: SafetyLit - March 11, 2020 Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news

The spatio-temporal distribution of naloxone administration events in rural Ohio 2010-16 - Thurston H, Freisthler B.
INTRODUCTION: In 2017, Ohio had the second highest rate of drug overdose deaths in the United States. Current opioid related epidemiologic literature has begun to uncover the environmental level influences on the opioid epidemic and how the end results may... (Source: SafetyLit)
Source: SafetyLit - March 11, 2020 Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news

The protective effect of trusted dealers against opioid overdose in the U.S - Carroll JJ, Rich JD, Green TC.
BACKGROUND: Opioid overdose has become the leading cause of death among adults between 25 and 54 years old in the U.S. The purpose of this study is to explore the social and relational factors that shape the current opioid overdose epidemic. METHOD... (Source: SafetyLit)
Source: SafetyLit - March 10, 2020 Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news

6 Italian inmates die during protest over virus measures
They died after breaking into the infirmary and overdosing on methadone. (Source: ABC News: Health)
Source: ABC News: Health - March 9, 2020 Category: Consumer Health News Tags: Health Source Type: news

Italy: 6 inmates protesting virus restrictions die after breaking into prison infirmary, overdosing on methadone
(Source: ABC News: Health)
Source: ABC News: Health - March 9, 2020 Category: Consumer Health News Tags: Health Source Type: news

Associations between stopping prescriptions for opioids, length of opioid treatment, and overdose or suicide deaths in US veterans: observational evaluation - Oliva EM, Bowe T, Manhapra A, Kertesz S, Hah JM, Henderson P, Robinson A, Paik M, Sandbrink F, Gordon AJ, Trafton JA.
OBJECTIVE: To examine the associations between stopping treatment with opioids, length of treatment, and death from overdose or suicide in the Veterans Health Administration. DESIGN: Observational evaluation. SETTING: Veterans Health Administration... (Source: SafetyLit)
Source: SafetyLit - March 9, 2020 Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news

Suicide via intentional insulin overdose through first commercial hybrid closed-loop - Shah VN, Forlenza GP.
[Abstract unavailable] Language: en... (Source: SafetyLit)
Source: SafetyLit - March 9, 2020 Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news

The role of substance use disorders in experiencing a repeat opioid overdose, and substance use treatment patterns among patients with a non-fatal opioid overdose - Karmali RN, Ray GT, Rubinstein AL, Sterling SA, Weisner CM, Campbell CI.
BACKGROUND: A non-fatal opioid overdose (NFOO) increases the risk of another overdose and identifies high-risk patients. We estimated the risk of repeat opioid overdose for patients with and without substance use disorder (SUD) diagnoses and the change in ... (Source: SafetyLit)
Source: SafetyLit - March 6, 2020 Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news

Taro Pharmaceuticals U.S.A. Issues Voluntary Nationwide Recall of Phenytoin Oral Suspension Usp, 125 Mg/5 Ml due to Possible Underdosing or Overdosing
Taro Pharmaceuticals U.S.A., Inc. ( “Taro” or the “Company”) is voluntarily recalling two (2) lots of Phenytoin Oral Suspension USP, 125 mg/5 mL both in 237 mL bottles, to the consumer level. Phenytoin Oral Suspension USP, 125 mg/5 mL is indicated for the treatment of tonic-clonic (grand mal) and psy (Source: FDA Center for Drug Evaluation and Research - What's New)
Source: FDA Center for Drug Evaluation and Research - What's New - March 5, 2020 Category: Drugs & Pharmacology Authors: FDA Source Type: news

Can'World's First' Opioid Vending Machine Cut Overdose Deaths? Can'World's First' Opioid Vending Machine Cut Overdose Deaths?
A Canadian pilot project is testing an opioid vending machine for dispensing safe doses of hydromorphone to opioid addicts in an attempt to reduce overdose deaths.Medscape Medical News (Source: Medscape Psychiatry Headlines)
Source: Medscape Psychiatry Headlines - March 4, 2020 Category: Psychiatry Tags: Psychiatry News Source Type: news

Syndromic surveillance used to monitor emergency department visits during a synthetic cannabinoid overdose outbreak - Connecticut, August 2018 - Jones SA, Soto K, Grogan E, Senetcky A, Logan S, Cartter M.
On the morning of August 15, 2018, the Connecticut Department of Public Health (CTDPH) learned from media reports about multiple persons found unresponsive in a city park in New Haven County after using synthetic cannabinoids (SCs), manmade psychoactiv... (Source: SafetyLit)
Source: SafetyLit - March 2, 2020 Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news

Science historian examines how an anti-overdose medication helped revolutionize America’s view of drug addiction
Nancy D. Campbell’s book looks at the influence of naloxone over the nation’s attitude about the prevention of ODs and drug users. (Source: Washington Post: To Your Health)
Source: Washington Post: To Your Health - February 29, 2020 Category: Consumer Health News Authors: Erin Blakemore Source Type: news

New Data Strongly Support Opioid Agonists for Addiction New Data Strongly Support Opioid Agonists for Addiction
New research provides strong support that opioid agonists, methadone, or buprenorphine cut the risk of overdose death by 80%, yet many addiction programs don't offer them.Medscape Medical News (Source: Medscape Emergency Medicine Headlines)
Source: Medscape Emergency Medicine Headlines - February 28, 2020 Category: Emergency Medicine Tags: Psychiatry News Source Type: news

Death toll from opioids may be 28% higher due to death certificates omitting the exact drug
After analyzing overdoses from 1999 through 2016, a researcher discovered there were 99,160 additional opioid-related deaths that went unclassified - increasing the death toll by 28%. (Source: the Mail online | Health)
Source: the Mail online | Health - February 28, 2020 Category: Consumer Health News Source Type: news

The death toll of the opioid epidemic is higher than originally thought, researchers say
Opioid-related overdoses could be 28 percent higher than reported, researchers found. (Source: Washington Post: To Your Health)
Source: Washington Post: To Your Health - February 28, 2020 Category: Consumer Health News Authors: Meryl Kornfield Source Type: news

Study: The Opioid Crisis May Be Far Worse than We Thought
New research appearing in the journal Addiction shows that the number of deaths attributed to opioid-related overdoses could be 28 percent higher than reported due to incomplete death records. This discrepancy is more pronounced in several states, including Alabama, Mississippi, Pennsylvania, Louisiana, and Indiana, where the estimated number of deaths more than doubles – obscuring the scope of the opioid crisis and potentially affecting programs and funding intended to confront the epidemic. (Source: University of Rochester Medical Center Press Releases)
Source: University of Rochester Medical Center Press Releases - February 28, 2020 Category: Universities & Medical Training Authors: University of Rochester Medical Center Source Type: news

A woman took 550 times the usual dose of LSD, with surprisingly positive consequences
Drug overdoses can be life threatening, but for two women who accidentally took massive hits of LSD the experience was life changing -- and in a good way. (Source: CNN.com - Health)
Source: CNN.com - Health - February 28, 2020 Category: Consumer Health News Source Type: news

Study highlights effectiveness of methadone and buprenorphine
In a comparative effectiveness study of 6 approaches to treatment for opioid use disorders, only treatment with buprenorphine or methadone was associated with reduced risk of overdose and serious opioid-related acute care use. (Source: NIDA News)
Source: NIDA News - February 28, 2020 Category: Addiction Tags: Science Highlight, Opioids, Treatment Source Type: news

Notes from the Field: Syndromic Surveillance Used To Monitor Emergency Department Visits During a Synthetic Cannabinoid Overdose Outbreak - Connecticut, August 2018
In 2018, the Connecticut Department of Public Health was able to use syndromic surveillance to rapidly understand the magnitude of an outbreak of synthetic cannabinoid overdoses and provide timely information to state and local health departments. (Source: CDC Morbidity and Mortality Weekly Report)
Source: CDC Morbidity and Mortality Weekly Report - February 27, 2020 Category: American Health Tags: Emergency Department Visits MMWR Morbidity & Mortality Weekly Report Outbreaks Overdose Source Type: news

Public perceptions of risks associated with mixing opioid pain-relievers with alcohol and benzodiazepines - Ellis JD, Resko SM, Kollin R, Lister JJ, Agius E.
Objectives: Use of alcohol or benzodiazepines with opioid pain-relievers increases risk of overdose and overdose death. A substantial proportion of adults receives an opioid prescription each year, and a number of these adults also use benzodiazepin... (Source: SafetyLit)
Source: SafetyLit - February 27, 2020 Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news

Acetaminophen (Tylenol) Poisoning
Acetaminophen Poisoning (Tylenol Overdose) (Source: eMedicineHealth.com)
Source: eMedicineHealth.com - February 27, 2020 Category: General Medicine Source Type: news

Legality of Dispensing Naloxone to Minors in Pennsylvania
Source: Network for Public Health Law. Published: 2/27/2020. In 2017, 272 Pennsylvanians under the age of 24 died of opioid overdose, and overdose among this age group has sharply increased since 2015. This three-page Harm Reduction and Overdose Prevention Fact Sheet discusses whether it is permissible to prescribe the medication naloxone to minors in Pennsylvania. It discusses how opioid overdose is reversible through the timely administration of naloxone and, where needed, the provision of other emergency care. (PDF) (Source: Disaster Lit: Resource Guide for Disaster Medicine and Public Health)
Source: Disaster Lit: Resource Guide for Disaster Medicine and Public Health - February 27, 2020 Category: International Medicine & Public Health Source Type: news

Supervised drug injection site in US is almost ready to open
A nonprofit group in Philadelphia is detailing plans to open the nation's first medically supervised injection site next week to combat overdose deaths, despite outrage from some neighbors (Source: ABC News: Health)
Source: ABC News: Health - February 26, 2020 Category: Consumer Health News Tags: Health Source Type: news

Philadelphia plans to open 1st supervised injection site in U.S. next week
A Philadelphia nonprofit group has detailed plans to open the country's first medically supervised injection site next week to combat overdose deaths despite outrage from neighbours and opposition from the local U.S. Attorney. (Source: CBC | Health)
Source: CBC | Health - February 26, 2020 Category: Consumer Health News Tags: News/World Source Type: news

She thought her daughter was in good hands. Then she died of an overdose
Karma Leroux’s 19-year-old daughter died of an overdose in a B.C. treatment centre (Source: CBC | Health)
Source: CBC | Health - February 26, 2020 Category: Consumer Health News Tags: News/Canada/British Columbia Source Type: news

Circumstances of overdose among street-involved, opioid-injecting women: drug, set, and setting - Ataiants J, Roth AM, Mazzella S, Lankenau SE.
INTRODUCTION: Current discourses about the causes of the overdose crisis largely focus on the harmful effects of drugs. Prior research, however, indicates that drug use experience is shaped by complex interactions of drugs with physiological and mental "se... (Source: SafetyLit)
Source: SafetyLit - February 25, 2020 Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news

The microRNA-based liquid biopsy improves early assessment of lethal acetaminophen poisoning: a case report - Krauskopf J, Gosink MM, Schomaker S, Caiment F, Warner R, Johnson K, Kleinjans J, Aubrecht J.
BACKGROUND Acetaminophen overdose is the most common cause of acute liver failure. Nevertheless, new biomarker approaches enabling early prediction of the outcome of the acetaminophen overdose are needed. Recently, using next-generation sequencing analysis... (Source: SafetyLit)
Source: SafetyLit - February 25, 2020 Category: International Medicine & Public Health Tags: Poisoning Source Type: news

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Every 8 minutes someone dies from an accidental drug overdose. Most of the time, it's from fentanyl. (Source: CNN.com - Health)
Source: CNN.com - Health - February 25, 2020 Category: Consumer Health News Source Type: news

Medication Treatment May Lower Risk for Opioid Overdose Death
But protective effect during care does not last after discontinuation of treatment for opioid use disorder (Source: The Doctors Lounge - Psychiatry)
Source: The Doctors Lounge - Psychiatry - February 25, 2020 Category: Psychiatry Tags: Family Medicine, Internal Medicine, Pharmacy, Psychiatry, Anesthesiology & amp; Pain, Journal, Source Type: news

Medication Treatment May Lower Risk for Opioid Overdose Death
TUESDAY, Feb. 25, 2020 -- Medication treatment with methadone and buprenorphine is associated with a significantly lower risk for overdose death for people with opioid use disorder (OUD) compared with nonmedication treatment, but this lower risk... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - February 25, 2020 Category: Pharmaceuticals Source Type: news

Medication treatments led to 80% lower risk of fatal overdose for patients with opioid use disorder
(NYU Langone Health / NYU School of Medicine) Patients with opioid use disorder (OUD) receiving treatment with opioid agonists (medications such as methadone or buprenorphine) had an 80 percent lower risk of dying from an opioid overdose compared to patients in treatment without the use of medications. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 25, 2020 Category: International Medicine & Public Health Source Type: news

Overdose deaths decrease in B.C. but officials say safer drug supply needed
More than 5,000 people have died in B.C. since a public health emergency was declared in 2016. (Source: CBC | Health)
Source: CBC | Health - February 24, 2020 Category: Consumer Health News Tags: News/Canada/British Columbia Source Type: news

Hepatotoxicity in a child following an accidental overdose of liquid paracetamol - Chiew AL, Domingo G, Buckley NA, Stathakis P, Ress K, Roberts DM.
Introduction: Accidental pediatric liquid paracetamol exposure is common. Most children do not require treatment with acetylcysteine and acute liver injury is rare.Case report: An otherwise well 3-year-old (15.4  kg) girl with recent vomitin... (Source: SafetyLit)
Source: SafetyLit - February 24, 2020 Category: International Medicine & Public Health Tags: Age: Infants and Children Source Type: news

Degree of bystander-patient relationship and prehospital care for opioid overdose - McCann MK, Jusko TA, Jones CMC, Seplaki CL, Cushman JT.
BackgroundAcross the spectrum of patient care for opioid overdose, an important, yet frequently overlooked feature is the bystander, or witness to the overdose event. For other acute medical events such as cardiac arrest and stroke, research supports that ... (Source: SafetyLit)
Source: SafetyLit - February 24, 2020 Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news

Florida's opioid crackdown and drug, motor vehicle crash, and suicide mortality: a Bayesian interrupted time-series analysis - Feder KA, Mojtabai R, Stuart EA, Musci R, Letourneau EJ.
In 2011, Florida established a Prescription Drug Monitoring Program and adopted new regulations for independent pain-management clinics. This paper examines the association of those reforms with drug overdose deaths and other injury fatalities. Florida's p... (Source: SafetyLit)
Source: SafetyLit - February 24, 2020 Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news

The association between Florida's opioid crackdown and opioid-related mortality: the role of economic factors and mortality misclassification - Vandoros S.
Opioid overdose mortality has been increasing in the US, and other types of mortality, such as car crash deaths may also be linked to opioid use. In this issue of the Journal, Feder et al. (Am J Epidemiol. XXXX(XX):XXXX-XXXX)) examine the association betwe... (Source: SafetyLit)
Source: SafetyLit - February 24, 2020 Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news

PA school nurses on the frontlines of the opioid epidemic
(University of Pennsylvania School of Nursing) As opioid overdoses continue to grab headlines, more states are providing their communities with easier access to naloxone, which can prevent death by reversing opioid overdoses. But while naloxone may be available at township buildings, libraries, or other community locations, little is known about how schools maintain a supply and use naloxone to prepare for treating overdose. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 24, 2020 Category: International Medicine & Public Health Source Type: news

Teaching Children How to Reverse an Overdose
Health officials in rural Tennessee are teaching children as young as 6 how to administer Narcan to reverse an opioid overdose. Describes how the trainings aim to destigmatize drug use and educate children on the dangers and reality of opioids. (May require a subscription to view full article). (Source: News stories via the Rural Assistance Center)
Source: News stories via the Rural Assistance Center - February 23, 2020 Category: Rural Health Source Type: news

Taro Pharmaceuticals U.S.A. Issues Voluntary Nationwide Recall of Phenytoin Oral Suspension USP, 125 mg/5ml Due to Possible Underdosing or Overdosing
Taro Pharmaceuticals U.S.A., Inc. ( “Taro” or the “Company”) is voluntarily recalling two (2) lots of Phenytoin Oral Suspension USP, 125 mg/5 mL both in 237 mL bottles, to the consumer level. Phenytoin Oral Suspension USP, 125 mg/5 mL is indicated for the treatment of tonic-clonic (grand mal) and psy (Source: FDA Center for Drug Evaluation and Research - What's New)
Source: FDA Center for Drug Evaluation and Research - What's New - February 21, 2020 Category: Drugs & Pharmacology Authors: FDA Source Type: news

Drug overdose deaths rise in the West while they drop in the East
Progress in cutting fatalities has stalled as opioids and stimulants reach new markets. (Source: Washington Post: To Your Health)
Source: Washington Post: To Your Health - February 21, 2020 Category: Consumer Health News Authors: Joel Achenbach Source Type: news

Understanding the increase in opioid overdoses in New Hampshire: a rapid epidemiologic assessment - Meier A, Moore SK, Saunders EC, McLeman B, Metcalf SA, Auty S, Walsh O, Marsch LA.
BACKGROUND: New Hampshire (NH) has had among the highest rates of fentanyl-related overdose deaths per capita in the United States for several years in a row-more than three times the national average in 2016. This mixed-methods study investigated drug-usi... (Source: SafetyLit)
Source: SafetyLit - February 20, 2020 Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news

Potential under-recognised risk of harm from the use of propranolol
The Healthcare safety investigation branch (HSIB) hasconducted a patient safety investigation that explores the under recognised toxicity of propranolol in overdose... (Source: Royal Pharmaceutical Society News)
Source: Royal Pharmaceutical Society News - February 20, 2020 Category: Drugs & Pharmacology Source Type: news