US Senator Joe Manchin calls for a new FDA Commissioner to replace current (acting) one who “has repeatedly ignored public health concerns and shown a dereliction of duty” over opioids and aducanumab
Key Democrat Manchin Bashes FDA Leader on Alzheimer’s Approval (Bloomberg): Senator Joe Manchin, a moderate Democrat considered a crucial vote within the party’s slim Senate majority, said Janet Woodcock, the temporary head of the Food and Drug Administration, should be quickly replaced with a permanent leader. Manchin blasted an FDA decision to approve the controversial Alzheimer’s therapy Aduhelm despite conflicting evidence that the Biogen Inc. drug works and an overwhelmingly negative vote against the therapy by agency advisers. The FDA ruling led three members of that panel to quit in protest…...
Source: SharpBrains - June 18, 2021 Category: Neuroscience Authors: SharpBrains Tags: Brain/ Mental Health aducanumab Aduhelm Alzheimer's treatments Alzheimer’s therapy Alzheimers-disease Biogen FDA Food and Drug Administration Joe Manchin opioids OxyContin public-health Source Type: blogs

On The Eve of The 50th Anniversary of President Nixon Declaring War on Drugs, Two Members of Congress Propose an Armistice
Jeffrey A. SingerYesterday Representatives Cori Bush (D-MO) and Bonnie Watson Coleman (D-NJ) introduced theDrug Policy Reform Act, which would federally decriminalize drug possession and redirect federal funds to harm reduction, substance abuse disorder treatment, and education programs. Furthermore, the bill would expunge and seal the records of people with federal drug violation records within one year of enactment.Among some of the bill ’s other praiseworthy provisions are a ban on civil asset forfeitures related to personal drug possession cases, and preventing individuals in the U.S. from being denied legal...
Source: Cato-at-liberty - June 17, 2021 Category: American Health Authors: Jeffrey A. Singer Source Type: blogs

The Real Reason Fentanyl is So Dangerous
Fentanyl plays a role in more and more opioid overdose deaths. Most fentanyl used ‘on the streets’ starts in China, with precursors shipped to California or Mexico before distribution throughout the US. Fentanyl acts very potently at the same receptors as heroin, morphine, and oxycodone. Reports of overdose deaths caused by fentanyl usually blame potency, but the real reason for fentanyl’s outsized role in overdose is rarely mentioned – at least outside operating rooms. Fentanyl is as ubiquitous in the medical industry as it is on the street, in 50 microgram per cc, sterile vials rather than the ...
Source: Suboxone Talk Zone - June 16, 2021 Category: Addiction Authors: admin Tags: Uncategorized Source Type: blogs

The Iraq war
I found some old files in my basement from the days when I wrote the Today in Iraq blog. They reminded me of how much I used to follow, research and write about the U.S. invasion of Iraq. It was a big part of my political and intellectual life for many years. It makes one despair to see how it's gone down the memory hole.Here are facts which are now generally understood and acknowledged even by many people who were enthusiastic supporters of the war, including some who were in substantial part responsible for it, such as Colin Powell. I'd have to spend the afternoon going through that 3 foot stack of papers to document eve...
Source: Stayin' Alive - June 8, 2021 Category: American Health Source Type: blogs

If Lawmakers Really Want to “Follow the Science” They Will Repeal Codified Opioid Guidelines
This study documents a relationship between opioid prescribing and opioid overdose in a large, national, prospective cohort of individuals receiving opioid therapy for a variety of medical conditions. The risk of opioid overdose should continue to be evaluated relative to the need to reduce pain and suffering and be considered along with other risk factors.University of Alabama Professor of Medicine Stefan Kerteszpointed out thatfollow up research led by Bohnert found the median overdose dosage was 60 MMEs and 86 percent occurred under 90 MMEs. Yet he cautioned policymakers:Reliance on a simple binary dose metric is an ext...
Source: Cato-at-liberty - May 24, 2021 Category: American Health Authors: Jeffrey A. Singer Source Type: blogs

In Massachusetts, as Elsewhere, It ’s The Prohibition, Not The Prescriptions
Jeffrey A. SingerEarlier this month, the Massachusetts Department of Public Health releasedData Brief: Opioid ‐​Related Overdose Deaths Among Massachusetts Residents. The report found that opioid ‐​related overdose deaths remained essentially unchanged at roughly 2,000 per year since 2016. From 2001 thru 2010 the annual overdose rate was relatively stable and then began to accelerate in 2011. (Figure 1 and Figure 2 of the Data Brief).While the overdose rate was 1 percent less in 2019 than in 2016, and 1 percent greater in 2020 than in 2019, neither change was statistically significant.As with ot...
Source: Cato-at-liberty - May 16, 2021 Category: American Health Authors: Jeffrey A. Singer Source Type: blogs

This Sounds All Very Strange To Me! I Suspect There Are Some Key Facts To Come Out.
This report appeared last week: SA hospital staff put on alert after computer glitch adds digit to medication dosages Posted 6 May, 2021at 9:51pm SA Health is investigating whether patients have been overdosed with medication as a result of a glitch in the computer system used at some of the state's major hospitals.  Key points: Staff at some SA hospitals received a memo about a computer system error The glitch was duplicating the last digit of medication doses SA Health says it's not aware of any "adverse clinical outcomes"  On Wednesday night, staff at the Queen Elizabeth Hospital, R...
Source: Australian Health Information Technology - May 12, 2021 Category: Information Technology Authors: Dr David G More MB PhD Source Type: blogs

A daughter ’s addiction. A mother’s love.
An excerpt from About Natalie: A Daughter’s Addiction. A Mother’s Love. Finding Their Way Back to Each Other. I look around at the pale walls of the emergency room. Yes, we are back here. Not for an overdose, but this time for an abscess so severe from injecting needles into her arms that it will […]Find jobs at  Careers by KevinMD.com.  Search thousands of physician, PA, NP, and CRNA jobs now.  Learn more. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - May 11, 2021 Category: General Medicine Authors: < span itemprop="author" > < a href="https://www.kevinmd.com/blog/post-author/christine-naman" rel="tag" > Christine Naman < /a > < /span > Tags: Patient Psychiatry Source Type: blogs

PROP ’s Disproportionate Influence on U.S. Opioid Policy: The Harms of Intended Consequences
ConclusionDespite being turned back from an effort to bluntly reduce opioid prescribing by the FDA in 2013 based on a lack of scientific evidence for its position (17,18), PROP has had a disproportionate effect on opioid policy in the Untied States for almost a decade. PROP found a willing federal regulatory partner in the CDC, and while PROP may not have “secretly written” the 2016 CDC Pain Guidelines (75), they certainly enjoyed disproportionate representation on CDC’s review panels and Core Expert Group (23-25) in a process that lacked transparency (22, 23, 26, 27). When the CDC admitted that its Pain ...
Source: Pallimed: A Hospice and Palliative Medicine Blog - May 3, 2021 Category: Palliative Care Tags: CDC health policy kollas opioids pain prop Source Type: blogs

I Have To Say I Thought We Were Moving Faster Than This! What Is Really Happening?
This appeared a week or so go. South Australia implements real-time prescription monitoring system It is the second state in Australia to introduce an initiative that enables monitoring of high-risk medicines. By Thiru Gunasegaran April 18, 2021 10:00 PM ScriptCheckSA, a real-time prescription monitoring system, was introduced earlier this month in South Australia. The system provides doctors and pharmacists with information about a patient ’s history and use of controlled medicines, aiding them in decision-making when it comes to prescribing or dispensing such medicines. WHY IT MATTERS ScriptCheckSA can help mitigat...
Source: Australian Health Information Technology - April 30, 2021 Category: Information Technology Authors: Dr David G More MB PhD Source Type: blogs

Misguided Opioid Narrative Takes On More Water
Jeffrey A. SingerThe seemingly unsinkable prevailing narrative that the opioid overdose crisis was caused by health care practitioners ‘hooking” their pain patients on opioids just took on more water.Researchers in the surgery departments at Case Western Reserve University, University of Alabama at Birmingham, and American University of Antigua College of Medicine expected that opioids used to manage pain in trauma patients would lead to a  higher rate of injury‐​related deaths—including the subcategories of suicide, homicide, and “unintentional deaths” (a leading cause of which is dr...
Source: Cato-at-liberty - April 6, 2021 Category: American Health Authors: Jeffrey A. Singer Source Type: blogs

The pandemic ’s epidemic: opioid use disorder and subpar suboxone access   
The COVID-19 pandemic has devastated America ’s health, taking more than 500 thousand American lives, upending the economy, and perpetuating racial health disparities. It also has worsened the country’s ongoing opioid use disorder (OUD) epidemic. In fact, in the twelve-month period ending June 2020, 83 thousand Americans died of a drug overdose, the highest ever recorded in a one-year period and 21 percent higher than the previous year. This dramatic increase in overdose deaths is mostly attributable to...
Source: Kevin, M.D. - Medical Weblog - March 26, 2021 Category: General Medicine Authors: < span itemprop="author" > < a href="https://www.kevinmd.com/blog/post-author/jonathan-staloff-and-claire-simon" rel="tag" > Jonathan Staloff, MD and Claire Simon, MD < /a > < /span > Tags: Meds Psychiatry Source Type: blogs

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Since COVID-19 first started upending life for Americans in March 2020, public health officials have been sounding the alarm about a potential surge in drug overdoses.        (Source: The Commonwealth Fund: Blog)
Source: The Commonwealth Fund: Blog - March 25, 2021 Category: International Medicine & Public Health Authors: Jesse C. Baumgartner, David C. Radley Source Type: blogs

Marijuana Federalism Can Work in South Dakota Too
Trevor Burrus andStacy HansonIn November 2020, 54 percent of South Dakotans approved Amendment A, legalizing the adult use of marijuana. Opposing the outcome of the amendment, state officials initiated a lawsuit arguing that Amendment A violates the South Dakota Constitution ’s single‐​subject rule, which restricts amendments to being about only a single subject. A South Dakota circuit judge agreed, striking down the amendment. Now before the South Dakota Supreme Court, supporters of the amendment are seeking to protect the will of the voters.Over the past half century, states have increasingl...
Source: Cato-at-liberty - March 16, 2021 Category: American Health Authors: Trevor Burrus, Stacy Hanson Source Type: blogs

Pain Patients: Collateral Victims of the War on Drugs
Nita Ghei (George Mason University), Pain Patients: Collateral Victims of the War on Drugs, SSRN: The more than 30 million chronic pain patients use opioid pain medication safely when prescribed. The vast majority of overdose deaths are caused by street... (Source: HealthLawProf Blog)
Source: HealthLawProf Blog - March 8, 2021 Category: Medical Law Authors: Katharine Van Tassel Source Type: blogs

Correlative Adventures with COVID
By ANISH KOKA “The patient in room 1 should be a quick one, its an addon, they just need a prescription for ivermectin” I’m a bit puzzled by this sentence from my assistant doing his best to help me through a very busy day in the clinic that I’m already behind in. I walk into the room, a script pad stuffed into my hand as I enter the room, to meet a very nice couple.  The wife sits patiently with hands crossed on the exam table.  “So, you’re here for Ivermectin?”, I ask. Why yes, a trip to Texas is planned.. COVID is in the air, the internet, and some importan...
Source: The Health Care Blog - March 5, 2021 Category: Consumer Health News Authors: Christina Liu Tags: COVID-19 Health Policy Anish Koka COVID vaccine COVID-19 vaccine Ivermectin Source Type: blogs

Senators Portman, Whitehouse, and Klobuchar Think They Know Better Than The CDC About How To Treat Acute Pain
This study came one year after a largerstudy of more than 568,000 “opioid‐​naïve” patients treated for acute postsurgical pain from 2008–2016 found a total “misuse” rate of 0.6 percent.The press report onCARA 2.0 issued by Senator Portman ’s office states the three‐​day limit is recommended by the CDC in its 2016Guideline for Prescribing Opioids for Chronic Pain (recommendation number 6). But these guidelines were aimed at treatingchronic pain, and were based on what the CDC stipulated was very limited evidence. The CDC also emphasized the guidelines were meant to ...
Source: Cato-at-liberty - February 16, 2021 Category: American Health Authors: Jeffrey A. Singer Source Type: blogs

More Evidence That Prescription Drug Monitoring Programs Might Increase Overdose Deaths
Jeffrey A. SingerAt a Cato Institutepolicy forum in October 2019, Columbia University public health researcher David Fink presented data showing that Prescription Drug Monitoring Programs (PDMPs), designed to surveil opioid prescribing by health care practitioners to their patients in pain, have no appreciable effect on the fatal or non ‐​fatal opioid overdose rate, but may have the unintended consequence of increasing overdoses from heroin. I havecited his work, along with the work of others, that draw similar conclusions.Now researchers at Indiana University are providing even more evidence that PDMPs, alon...
Source: Cato-at-liberty - February 14, 2021 Category: American Health Authors: Jeffrey A. Singer Source Type: blogs

A child ’s cry through haunting eyes
The emergency department. A haven for cardiac arrests and gunshot wounds and respiratory distress and overdoses and auto accidents and children ’s sniffles and fever and coughs that won’t go away. The ED was easy access to many. And at times, it was an easy fix not to pay the bill upfront or to be anonymous […]Find jobs at  Careers by KevinMD.com.  Search thousands of physician, PA, NP, and CRNA jobs now.  Learn more. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - February 2, 2021 Category: General Medicine Authors: < span itemprop="author" > < a href="https://www.kevinmd.com/blog/post-author/debbie-moore-black" rel="tag" > Debbie Moore-Black, RN < /a > < /span > Tags: Conditions Emergency Medicine Source Type: blogs

After Moving Slightly Forward on Buprenorphine, Will We Shift Into Reverse?
Jeffrey A. SingerThe Department of Health and Human Services issuedrelaxed guidelines for physicians wishing to treat Opioid Use Disorder (OUD) with buprenorphine in the closing days of the Trump administration. While I arguedhere that the guidelines don ’t go far enough, it was nevertheless a step in the right direction.Even though outright repeal of the Drug Enforcement Administration ’s so‐​called “X‐​waiver,” required of health care practitioners wishing to treat OUD with buprenorphine receivedbipartisansupport in the last Congress, the Biden administration is consideringrescin...
Source: Cato-at-liberty - February 1, 2021 Category: American Health Authors: Jeffrey A. Singer Source Type: blogs

Confronting Stigma From Opioid Use Diorder in Cancer Care
by Fitzgerald Jones, Ho, Sager, Rosielle and MerlinHave you ever been so distressed by a perspective piece that it kept you up at night? The type of rumination that fills you with so much angst that you have no choice but to act. This is exactly how we felt when we read theAAHPM Quarterly Winter 2020 Let ’s Think About It Again.1 (member paywall)The column, which is structured as a sort of written debate in which two authors argue a clinical question, describes a case of a 45-year-old man with severe substance use disorder (SUD) recently diagnosed with extensive-stage small-cell lung cancer. He was offered ...
Source: Pallimed: A Hospice and Palliative Medicine Blog - January 30, 2021 Category: Palliative Care Tags: ftigerald jones ho merlin rosielle sager Source Type: blogs

Confronting Stigma From Opioid Use Disorder in Cancer Care
by Fitzgerald Jones, Ho, Sager, Rosielle and MerlinHave you ever been so distressed by a perspective piece that it kept you up at night? The type of rumination that fills you with so much angst that you have no choice but to act. This is exactly how we felt when we read theAAHPM Quarterly Winter 2020 Let ’s Think About It Again.1 (member paywall)The column, which is structured as a sort of written debate in which two authors argue a clinical question, describes a case of a 45-year-old man with severe substance use disorder (SUD) recently diagnosed with extensive-stage small-cell lung cancer. He was offered ...
Source: Pallimed: A Hospice and Palliative Medicine Blog - January 30, 2021 Category: Palliative Care Tags: ftigerald jones ho merlin rosielle sager Source Type: blogs

A Small But Certain Step Toward Removing the “X” Waiver
Jeffrey A. SingerOn January 14,  the U.S. Department of Health and Human Services issued new,relaxed guidelines for physicians wishing to prescribe buprenorphine to their patients with opioid use disorder. While the so ‐​called “X” waiver required of prescribers remains, thenew guidelines permit physicians (not nurse practitioners or physician assistants) to prescribe buprenorphine without the waiver. They may only prescribe to patients located within their own state and they may have no more than 30 opioid use disorder patients on buprenorphine at any time.Buprenorphine is a  synthetic ...
Source: Cato-at-liberty - January 16, 2021 Category: American Health Authors: Jeffrey A. Singer Source Type: blogs

Medgadget ’s Best Medical Technologies of 2020
In conclusion, 2020 will certainly be remembered for a world stopped by an pandemic. It will also stand out as a time when people came together to innovate, adapt, and improve the world around them. We wish you all a happy New Year and look forward to better times ahead, together. Flashbacks: Medgadget’s Best Medical Technologies of 2019; 2018; 2017; 2016; 2015 (Source: Medgadget)
Source: Medgadget - December 30, 2020 Category: Medical Devices Authors: Medgadget Editors Tags: Exclusive Source Type: blogs

No, Young Adults Should Not Live in Fear from Coronavirus
What follows is an OpEd that I co-authored with Andrew Foy, MD, from Penn State University. Andrew is an academic cardiologist who studies the quality of scientific evidence. Two outlets have declined to publish our piece. This is not surprising given that we critique a research letter written by prominent academic leaders. As you read our take, please keep in mind that we oppose only the ideas expressed in the interpretation of data. *** The Journal of the American Medical Association recently published a research letter that reported an excess of nearly 12,000 deaths among younger adults th...
Source: Dr John M - December 29, 2020 Category: Cardiology Authors: Dr John Source Type: blogs

Fight Aging! Newsletter, December 28th 2020
In conclusion, our study demonstrated that the molecular processes of aging are relatively subtle in their progress, and the aging process of every tissue depends on the tissue's specialized function and environment. Hence, individual gene or process alone cannot be described as the key of aging in the whole organism. Mouse Age Matters: How Age Affects the Murine Plasma Metabolome A large part of metabolomics research relies on experiments involving mouse models, which are usually 6 to 20 weeks of age. However, in this age range mice undergo dramatic developmental changes. Even small age differences may l...
Source: Fight Aging! - December 27, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Data for COVID-19 Mortality in Older People in the US
The general consensus on mortality due to COVID-19 is that it falls most heavily on people who are more impacted by aging: poor immune function when it comes to defense against pathogens; high levels of chronic inflammation that create a greater susceptibility to the way in which SARS-CoV-2 kills people; existing chronic disease; and a mortality rate that is already high even setting aside the pandemic. When younger people die due to the virus, in much smaller numbers, it is where they share these characteristics of inflammation, deficient immune systems, and chronic disease. This level of morbidity is unusual in younger i...
Source: Fight Aging! - December 23, 2020 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Going After Scapegoats Is Easier Than Confronting The Truth
Jeffrey A. SingerYesterday the Department of Justicefiled suit against the giant retailer Walmart, accusing it of fueling the opioid crisis by encouraging its pharmacists to fill prescriptions –legally written by health care practitioners licensed by the Drug Enforcement Administration–they should have suspected of being inappropriately prescribed.The Justice Department seems uninterested in the fact that there isno correlation between the number of opioid prescriptions and the non ‐​medical use of prescription pain reliever or the development of opioid use disorder. And while the number...
Source: Cato-at-liberty - December 23, 2020 Category: American Health Authors: Jeffrey A. Singer Source Type: blogs

The Effect of Opioid Supply-Side Interventions on Opioid-Related Business Establishments
Justine Mallatt, The Effect of Opioid Supply-Side Interventions on Opioid-Related Business Establishments, SSRN: In response to climbing opioid misuse and overdoses, states passed several types of programs that target the supply side of the prescription opioid market, including Prescription Drug... (Source: HealthLawProf Blog)
Source: HealthLawProf Blog - December 7, 2020 Category: Medical Law Authors: Katharine Van Tassel Source Type: blogs

Drug Makers and Distributors Commandeered by Cops
Jeffrey A. SingerIn the latest episode of “Cops Practicing Medicine,” a floor vote is scheduled in the House of Representatives for H.R. 3878, sponsored by Rep. David McKinney, (R-WV). Under current law, drug makers and distributors are required to report to the Drug Enforcement Administration any suspicious orders for controlled substances. H.R. 3878 would also require them to perform “due diligence” on their suspicions, document and report their due diligence to the DEA, and refuse to fill the order if their suspicions are not resolved by the due diligence.This amounts to the DEA commandeerin...
Source: Cato-at-liberty - November 16, 2020 Category: American Health Authors: Jeffrey A. Singer Source Type: blogs

Defusing the “Benadryl challenge”: Discussing danger with teens
Let’s start with the bottom line: Parents of teens need to help them understand that just because they have been “challenged” to do something doesn’t mean it’s a good idea. But as simple as that sounds to us, it’s tough for many teens to grasp. The latest challenge in the news is the “Benadryl challenge” that appeared on TikTok, a popular social media video platform. The idea was to take a whole lot of Benadryl (diphenhydramine, a common antihistamine) in order to cause a high, with hallucinations. While it’s true that diphenhydramine can make you high and make you hall...
Source: Harvard Health Blog - November 2, 2020 Category: Consumer Health News Authors: Claire McCarthy, MD Tags: Adolescent health Behavioral Health Children's Health Parenting Source Type: blogs

Opioid Policymakers Keep Tilting at Windmills, Striking Patients in the Process
Jeffrey A. SingerThe American Psychological Association Dictionary of Psychologydefines“denial” as “adefense mechanism in which unpleasant thoughts, feelings, wishes, or events are ignored or excluded from conscious awareness. It may take such forms as refusal to acknowledge the reality of a terminal illness, a financial problem, an addiction, or a partner ’s infidelity…”Many policymakers, including many in Congress, remain in a state of denial about the true cause of the overdose crisis:drug prohibition.The Centers for Disease Control and Prevention ’s October...
Source: Cato-at-liberty - October 15, 2020 Category: American Health Authors: Jeffrey A. Singer Source Type: blogs

A Tale of Two Scourges
Jeffrey A. SingerSome observers of our policy toward the coronavirus pandemiccriticize the tendency to focus on case numbers alone, when hospitalization rates and fatality rates are what really matter. And as we learn more about the COVID virus, mitigation and treatment is improving and fatalities are diminishing.Similarly, the U.S. Department of Justice ’s policy toward the overdose epidemic seems to be focused on arrests and drug interdictions, apparent in a DOJpress release today, itemizing the arrests of drug traffickers and seizures of illegal drugs that have resulted since “Operation SOS&rd...
Source: Cato-at-liberty - September 24, 2020 Category: American Health Authors: Jeffrey A. Singer Source Type: blogs

Why the DEA, not the FDA? Revisiting the Regulation of Potentially-Addictive Substances
Taleed El-Sabawi (Elon University), Why the DEA, not the FDA? Revisiting the Regulation of Potentially-Addictive Substances, 16 NYU J. L.& Bus. 2 (2020): In addressing the opioid overdose crisis, Congress has explicitly questioned its historic reliance on a criminal... (Source: HealthLawProf Blog)
Source: HealthLawProf Blog - September 22, 2020 Category: Medical Law Authors: Katharine Van Tassel Source Type: blogs

The Abuse ‐​Deterrent Folly
Jeffrey A. SingerOn September 11 a  Food and Drug Administration Advisory Committeerecommended rejecting Purdue Pharma ’s request to add to the label of the abuse‐​deterrent formulation (ADF) of its drug OxyContin the claim that it reduces the incidence of non‐​medical use and overdose from opioids.In the early part of this century law enforcement officialsreported that many non ‐​medical users of the diverted prescription drug OxyContin, a concentrated, slow‐​release formulation of oxycodone, would crush the pills and snort them, or dissolve them in liquid and inject them. In 2010...
Source: Cato-at-liberty - September 12, 2020 Category: American Health Authors: Jeffrey A. Singer Source Type: blogs

Federal Aid Creates Central ‐​Planning Power
This study argues that Congress should repeal all federal aid-to-state programs for many reasons, including that aid comes with costly strings attached that destroy local democracy.Richard Epstein and Mario Loyolanoted about aid programs: “When Americans vote in state and local elections, they think they are voting on state and local policies. But often they are just deciding which local officials get to implement the dictates of distant and insulated federal bureaucrats, whom even Congress can’t control.”I came across a table (p. 82) in New Jersey ’s budget that lists the $15 billion the state rece...
Source: Cato-at-liberty - September 4, 2020 Category: American Health Authors: Chris Edwards Source Type: blogs

We Can ’t Forget the Nation’s Other Epidemic
Covid isn’t merely overshadowing the drug overdose crisis—it’s directly worsening it. The post We Can’t Forget the Nation’s Other Epidemic appeared first on The Hastings Center. (Source: blog.bioethics.net)
Source: blog.bioethics.net - August 31, 2020 Category: Medical Ethics Authors: Susan Gilbert Tags: Health Care bioethics COVID-19 Hastings Bioethics Forum Health and Health Care Opioid Epidemic overdose Psychiatry and Mental Health syndicated Source Type: blogs

The AMA Opioid Task Force 2020 Report Should Come as No Surprise to Those Who Follow the Data
Jeffrey A. SingerThe American Medical Association recently released itOpioid Task Force 2020 Report. The Task Force found there was a 37.1 percent decrease in opioid prescriptions between 2014 and 2019; a 64.4 percent increase in the use of state prescription drug monitoring programs (PDMPs) in the last year (739 million queries in 2019); and hundreds of thousands of physicians accessing continuing medical education courses on opioid prescribing (now mandatory in some states). However, the report states:Despite these efforts, illicitly manufactured fentanyl, fentanyl analogues and stimulants (e.g. methamphetamine...
Source: Cato-at-liberty - August 31, 2020 Category: American Health Authors: Jeffrey A. Singer Source Type: blogs

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How will the COVID-19 pandemic affect opioid overdose deaths and states’ ability to respond? The Commonwealth Fund’s Jesse Baumgartner, Gabriella Aboulafia, and Sara Collins look at unemployment trends and opioid deaths to determine which states may be battling both an economic downturn and an opioid epidemic.         (Source: The Commonwealth Fund: Blog)
Source: The Commonwealth Fund: Blog - August 28, 2020 Category: International Medicine & Public Health Authors: Jesse C. Baumgartner, Gabriella N. Aboulafia, Sara R. Collins Source Type: blogs

How the Pandemic Is Taking Its Toll on Our Mental Health
The year 2020 will go down in history as one of the most devastating in history. Hundreds of thousands have died and millions have been hospitalized due to the novel coronavirus pandemic. COVID-19 has changed the lives of so many. No matter where you live, dealing with the effects of economic and physical lockdowns in a community leads to multiple mental health challenges. After months of living with the coronavirus, many people are getting tired, burned out, and more and more frustrated. In America, we face a particular challenge. Our federal government has chosen to take a backseat during the pandemic. Instead of leadin...
Source: World of Psychology - August 17, 2020 Category: Psychiatry & Psychology Authors: John M. Grohol, Psy.D. Tags: General Mental Health and Wellness Psychology Research coronavirus COVID-19 pandemic Source Type: blogs

The DEA ’s Opioid Production Quotas Threaten Hospitalized Patients, Yet Supply of Street Fentanyl is Plentiful
Jeffrey A. SingerThe COVID-19 pandemic has placed another stumbling block in the way of the Drug Enforcement Administration ’sfutile effort to reduce the country ’s drug overdose rate through quotas on the manufacture of all forms of prescription opioids.The DEA ’s annual quotas have brought production levels more than 50 percent below 2016 levels. But, in response to the COVID-19 pandemic, the agency increased this year’s quota by 15 percent, to allow drug makers to respond to pandemic‐​induced shortages. Intravenous opioids such as fentanyl are va luable tools used to manage patients on ventil...
Source: Cato-at-liberty - July 24, 2020 Category: American Health Authors: Jeffrey A. Singer Source Type: blogs

A Complication of the COVID Era
Submitted and written by Gia Coleman MD and Roshan Givergis DO, edits by Meyers and SmithA woman in her 30s was found crawling in the streets, altered on arrival to the ED. Here is her presenting ECG:How would you interpret this EKG and what is on your differential?At first glance, it appears to be a sinus rhythm with PR prolongation at a rate of about 75 bpm. The QRS may appear narrow but is in fact slightly wide (see figure below). The computer measured it to be 136 ms.Perhaps the most striking finding in this EKG is the almost complete loss/flattening of the T waves. The computer calculated the QTC to be 427. Looking cl...
Source: Dr. Smith's ECG Blog - July 23, 2020 Category: Cardiology Authors: Pendell Source Type: blogs

Why Is NPR Still Obsessing Over Prescription Numbers When They Are Not Associated With Non ‐​medical Use or Addiction?
Jeffrey A. SingerNational Public Radio released aninvestigative report today showing that doctors and dentists are still prescribing opioids for pain management at “rates widely considered unsafe.”This persistent focus on the number of pills doctors prescribe defies justification in light of the fact that data from the Centers for Disease Control and Prevention and the National Survey on Drug Use and Health consistently revealno association between prescription volume and the non ‐​medical use of prescription opioids or addiction.And despite the overall prescription volume coming down dramatically...
Source: Cato-at-liberty - July 17, 2020 Category: American Health Authors: Jeffrey A. Singer Source Type: blogs

As the War on Drugs Relentlessly Grinds On, Overdose Deaths Relentlessly Mount
Jeffrey A. SingerWhen the Centers for Disease Control and Preventionannounced last January that drug overdoses in 2018 declined by 4.1 percent –from 70,237 in 2017 to 67,367 in 2018 –many in thepress took that as a sign of possible progress in America ’s longest war, the war on drugs. However, a deeper look at the data painted a very different picture.The CDC report stated:The age ‐​adjusted rate of drug overdose deaths involving synthetic opioids other than methadone, which include drugs such as fentanyl, fentanyl analogs, and tramadol, increased from 0.3 per 100,000 sta...
Source: Cato-at-liberty - July 16, 2020 Category: American Health Authors: Jeffrey A. Singer Source Type: blogs

What Is Lean?
Misusing prescription cough medicine can lead to  nausea and dizziness, and in some cases, seizures and overdose. Read  More » (Source: NIDA Drugs and Health Blog)
Source: NIDA Drugs and Health Blog - July 13, 2020 Category: Addiction Source Type: blogs

What Is Lean?
Misusing prescription cough medicine can lead to nausea and dizziness, and in some cases, seizures and overdose.  Read More » (Source: NIDA Drugs and Health Blog)
Source: NIDA Drugs and Health Blog - July 13, 2020 Category: Addiction Source Type: blogs

Fight Aging! Newsletter, July 13th 2020
In conclusion, sitting for prolonged periods of time without interruption is unfavorably associated with DBP and HDL cholesterol. Exercise Slows Inappropriate Growth of Blood Vessels in a Mouse Model of Macular Degeneration https://www.fightaging.org/archives/2020/07/exercise-slows-inappropriate-growth-of-blood-vessels-in-a-mouse-model-of-macular-degeneration/ Excessive growth of blood vessels beneath the retina is a proximate cause of blindness in conditions such as macular degeneration. Researchers here provide evidence for physical activity to be influential in the pace at which this process of tissue...
Source: Fight Aging! - July 12, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Will Isotonitazene Replace Fentanyl on the Black Market?
Jeffrey A. SingerWaging a war on drugs is like playing a game ofWhac ‐​A‐​Mole.In 2005 Congress addressed the “meth crisis” by passing theCombat Methamphetamine Epidemic Act that, among other things, made the popular decongestantSudafed,used by homegrown labs to make meth, a behind ‐​the‐​counter drug and restricted its sale to patients. It didn’t take long for Mexican drug cartels to fill the void created by the crackdown on domestic meth labs, and to findother and better ways to manufacture meth. Now the Centers for Disease Control and Prevention report methamphetamine ‐...
Source: Cato-at-liberty - July 10, 2020 Category: American Health Authors: Jeffrey A. Singer Source Type: blogs

MicroRNA-34a Promotes Vascular Cellular Senescence and Consequent Calcification
With the growing interest in the accumulation of senescent cells as an important cause of aging, and more funding flowing into this part of the field, researchers are uncovering numerous direct links between cellular senescence and age-related conditions. Senescent cells cause harm to tissues via their inflammatory secretions, the senescence-associated secretory phenotype (SASP). The SASP is damaging, but there are usually too few senescent cells, even in later life, to have a significant effect on tissue dysfunction through their localized actions. There may be exceptions to that rule, but the evidence to date strongly su...
Source: Fight Aging! - July 9, 2020 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs