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Sleep and Overactive Bladder in Parkinson's Disease
Urol Clin North Am. 2024 May;51(2):197-207. doi: 10.1016/j.ucl.2024.02.005. Epub 2024 Mar 10.ABSTRACTPatients with Parkinson's disease (PD) have disturbances in their bladder and sleep physiology that lead to nocturia and overactive bladder (OAB). These symptoms can be extremely bothersome and impact not only their quality of life (QoL) but also the QoL of their caretakers. We aim to highlight the changes in bladder and sleep physiology in PD and explore OAB/nocturia treatment strategies in this population.PMID:38609192 | DOI:10.1016/j.ucl.2024.02.005 (Source: The Medical Clinics of North America)
Source: The Medical Clinics of North America - April 12, 2024 Category: General Medicine Authors: Yu Zheng Anne P Cameron Source Type: research

Sleep and Overactive Bladder in Parkinson's Disease
Urol Clin North Am. 2024 May;51(2):197-207. doi: 10.1016/j.ucl.2024.02.005. Epub 2024 Mar 10.ABSTRACTPatients with Parkinson's disease (PD) have disturbances in their bladder and sleep physiology that lead to nocturia and overactive bladder (OAB). These symptoms can be extremely bothersome and impact not only their quality of life (QoL) but also the QoL of their caretakers. We aim to highlight the changes in bladder and sleep physiology in PD and explore OAB/nocturia treatment strategies in this population.PMID:38609192 | DOI:10.1016/j.ucl.2024.02.005 (Source: The Urologic Clinics of North America)
Source: The Urologic Clinics of North America - April 12, 2024 Category: Urology & Nephrology Authors: Yu Zheng Anne P Cameron Source Type: research

The Association Between Wet Overactive Bladder and Consumption of Tea, Coffee, and Caffeine: Results from 2005-2018 National Health and Nutrition Examination Survey
Previous studies have reported an inconsistent relationship between overactive bladder (OAB) and the consumption of tea, coffee, and caffeine. Our study aims to determine these associations in a large and nationally representative adult sample. (Source: Clinical Nutrition)
Source: Clinical Nutrition - April 12, 2024 Category: Nutrition Authors: Fucai Tang, Jiahao Zhang, Ruiying Huang, Haobin Zhou, Ting Yan, Zhicheng Tang, Zhibiao Li, Zechao Lu, Shuqiang Huang, Zhaohui He Source Type: research

Managing External Urinary Catheters
This narrative review explores the use of external urinary catheters. These devices are available in various types and materials for male and female patients. The indications for the use of external urinary catheters include managing incontinence linked to overactive bladder and neurogenic lower urinary tract dysfunction. Contraindications to the use of external urinary catheters include urinary obstruction. Proper skin care and proactive infection control measures are necessary to prevent complications. The collection of a urine specimen for culture requires a standardized technique to prevent contamination. Clinician-led...
Source: Infectious Diseases Clinics of North America - April 10, 2024 Category: Infectious Diseases Authors: Corina Lopez, Barbara W. Trautner, Prathit A. Kulkarni Source Type: research

Predicting muscarinic receptor occupancy in human bladder mucosa from urinary concentrations of antimuscarinic agents for overactive bladder
Drug Metab Pharmacokinet. 2024 Jan 15;56:100998. doi: 10.1016/j.dmpk.2024.100998. Online ahead of print.ABSTRACTTo assess the pharmacologically relevant and selective muscarinic receptor occupancy in the bladder mucosa, we considered not only plasma drug concentrations but also urinary drug concentrations. The purpose of this study was to predict muscarinic receptor occupancy in the human bladder mucosa based on urinary concentrations in response to clinical dosages of antimuscarinic agents used to treat overactive bladder. The calculated mean plasma or serum unbound steady state concentrations were 0.06-11 nM in clinical ...
Source: Drug Metabolism and Pharmacokinetics - April 7, 2024 Category: Drugs & Pharmacology Authors: Mizuki Shiho Gaku Akashita Eriko Nakatani Shimako Tanaka Shizuo Yamada Takashi Okura Source Type: research

Efficacy and Safety of Low-Dose Intravesical OnabotulinumtoxinA Injections in Female Patients With Detrusor Overactivity With Detrusor Underactivity
CONCLUSION: Low-dose intravesical onabotA for DODU demonstrated a relatively shorter duration of efficacy than OAB. Nonetheless, the treatment improved both storage and voiding symptoms in patients with DODU without significant adverse effects.PMID:38569620 | PMC:PMC10990756 | DOI:10.5213/inj.2346228.114 (Source: International Neurourology Journal)
Source: International Neurourology Journal - April 3, 2024 Category: Urology & Nephrology Authors: Hyun Seok Na Chung Lyul Lee Jae Sung Lim Ki Hak Song Ju Hyun Shin Jong Mok Park Ji Yong Lee Source Type: research