The treatment outcomes of rituximab for intractable otitis media with ANCA-associated vasculitis
To investigate treatment outcomes, hearing outcomes, and adverse effects of rituximab (RTX) for intractable otitis media with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (OMAAV). (Source: Auris, Nasus, Larynx)
Source: Auris, Nasus, Larynx - June 6, 2018 Category: ENT & OMF Authors: Masahiro Okada, Koichiro Suemori, Daiki Takagi, Masato Teraoka, Hiroyuki Yamada, Jun Ishizaki, Takuya Matsumoto, Hitoshi Hasegawa, Naohito Hato Source Type: research

Japanese translation, cross-cultural adaption and multicentre validation of the Zurich chronic middle ear inventory (ZCMEI-21-Jap)
In the assessment of chronic otitis media (COM) and its treatment, patient-reported outcomes are becoming increasingly important. The aim of the present study was to translate and validate the Zurich chronic middle ear inventory (ZCMEI-21) in Japanese in order to provide the first Japanese-language instrument for measuring health-related quality of life (HRQoL) in COM. (Source: Auris, Nasus, Larynx)
Source: Auris, Nasus, Larynx - June 2, 2018 Category: ENT & OMF Authors: David B ächinger, Daiki Takagi, Hiroyuki Yamada, Masato Teraoka, Masahiro Okada, Jun Hyodo, Christof Röösli, Alexander M. Huber, Naohito Hato Source Type: research

Study of steroid effects on graft and inner ear outcomes in tympanoplasty: Randomized controlled trial.
In conclusion, administration of steroids after tympanoplasty failed to improve outcome and may put the patient at risk of side effects. PMID: 30036412 [PubMed - in process] (Source: Ear, Nose and Throat Journal)
Source: Ear, Nose and Throat Journal - June 1, 2018 Category: ENT & OMF Authors: Kouhi A, Dabiri S, Amali A, Yazdani N, Baroodabi M, Kouchakinejad T, Mohseni A Tags: Ear Nose Throat J Source Type: research

Revisiting Correlation Between Pre Operative High Resolution Computed Tomography and Operative Findings in Attico Antral Disease
Abstract(1) To correlate the findings of high resolution computed tomography (HRCT) scans with operative findings in chronic otitis media (attico antral disease). (2) To assess the role of HRCT in chronic otitis media (attico antral disease). This prospective observational study undertaken at a tertiary level teaching hospital included 50 patients of chronic otitis media (attico antral disease) who underwent pre-operative HRCT scanning and the findings were compared with the operative findings and correlation between the two was assessed with appropriate statistical methods. HRCT findings correlated well for the status of ...
Source: Indian Journal of Otolaryngology and Head and Neck Surgery - May 31, 2018 Category: ENT & OMF Source Type: research

Increased anti- EBV VCA IgG antibody levels are associated with need for surgery in patients developing upper respiratory tract complications
In this study, we aimed to investigate the relationship between these antibodies and the need for surgery due to complications such as severe AH and COME. (Source: International Journal of Pediatric Otorhinolaryngology)
Source: International Journal of Pediatric Otorhinolaryngology - May 30, 2018 Category: ENT & OMF Authors: Hande Arslan, Tuba Çandar, Özge Vural Source Type: research

Cochlear implantation in patients with bilateral deafness caused by otitis media with ANCA-associated  vasculitis (OMAAV): A report of four cases
Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) without systemic symptoms but with initial symptoms related to the ear, such as hearing loss, otalgia, and dizziness, has recently been reported. We have categorized this condition as otitis media with AAV (OMAAV), and have recently proposed its diagnostic criteria. (Source: Auris, Nasus, Larynx)
Source: Auris, Nasus, Larynx - May 25, 2018 Category: ENT & OMF Authors: Takeshi Watanabe, Haruo Yoshida, Kan Kishibe, Yuka Morita, Naohiro Yoshida, Haruo Takahashi, Yasuaki Harabuchi Source Type: research

Effect of Formaldehyde on Human Middle Ear Epithelial Cells.
This study investigated whether FA causes cytotoxicity, inflammation, or induction of apoptosis in human middle ear epithelial cells (HMEECs). Cell viability was investigated using the trypan blue assay and a cell counting kit (CCK-8) in HMEECs treated with FA for 4 or 24 h. The expression of genes encoding the inflammatory cytokine tumor necrosis factor alpha (TNF-α) and mucin (MUC5AC) was analyzed using RT-PCR. Activation of the apoptosis pathway was determined by measuring mitochondrial membrane potential (MMP), cytochrome oxidase, caspase-9/Mch6/Apaf 3, and Caspase-Glo® 3/7 activities. The CCK-8 assay ...
Source: Biomed Res - May 24, 2018 Category: Research Authors: Kim SH, Choi JW, Suh MW, Lee JH, Oh SH, Song JJ, Park MK Tags: Biomed Res Int Source Type: research

Antimicrobial resistance profile of Staphylococcus aureus isolated from patients with infection at Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia.
Authors: Tadesse S, Alemayehu H, Tenna A, Tadesse G, Tessema TS, Shibeshi W, Eguale T Abstract BACKGROUND: Staphylococcus aureus is one of the major pathogens of public health importance responsible for various forms of infection. Development of resistance to commonly used antimicrobials limited treatment options against infections due to this pathogen. Antimicrobial resistance profile of Staphylococcus aureus isolated from patients with surgical site infection and ear infection and corresponding nasal swab was investigated in Tikur Anbessa Specialized Hospital (TASH), Addis Ababa, Ethiopia. METHODS: Wound and ...
Source: BMC Pharmacology and Toxicology - May 24, 2018 Category: Drugs & Pharmacology Tags: BMC Pharmacol Toxicol Source Type: research

Group A streptococcus acute otitis media progressing to neuroinvasive disease in adults
We describe two such cases from a single institution in Rhode Island in 2017. The clinical presentation, neuroimaging and management are reviewed. The mechanism of intracranial spread may have involved dehiscence of the bony tegmen of the roof of the middle ear cavity. (Source: IDCases)
Source: IDCases - May 24, 2018 Category: Infectious Diseases Source Type: research

Isolation and antimicrobial drug susceptibility pattern of bacterial pathogens from pediatric patients with otitis media in selected health institutions, Addis Ababa, Ethiopia: a prospective cross-sectional study
Otitis media is inflammation of the middle ear and tympanic membrane, which often occurs after an acute upper respiratory tract infection. It is the most common episode of infection in children and the second ... (Source: BMC Ear, Nose and Throat Disorders)
Source: BMC Ear, Nose and Throat Disorders - May 24, 2018 Category: ENT & OMF Authors: Tewodros Tesfa Hailegiyorgis, Wondemagegn Demsiss Sarhie and Hailemariam Mekonnen Workie Tags: Research article Source Type: research

Propylthiouracil-induced Otitis Media with Antineutrophil Cytoplasmic Antibody-associated Vasculitis.
Authors: Tanaka R, Shimojima Y, Moteki H, Kishida D, Ueno KI, Sekijima Y Abstract We herein report a case of otitis media with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (OMAAV) induced by propylthiouracil (PTU). A 30-year-old Japanese woman with Graves' disease, who was treated with PTU, reported with otitis media with sensorineural hearing loss bilaterally and trigeminal neuralgia on the left side, as well as elevated serum levels of myeloperoxidase-ANCA. Prior treatment with antibiotics was ineffective even after tympanostomy. However, clinical remission was immediately achieved after initi...
Source: Internal Medicine - May 23, 2018 Category: Internal Medicine Tags: Intern Med Source Type: research

Post-operative Sensorineural Hearing Loss After Middle Ear Surgery
AbstractChronic suppurative otitis media is managed by tympanomastoid surgery often requires mastoid drilling. Sometimes patients develop sensorineural hearing loss after middle ear surgery. Objective of the study was to compare pre and post operative bone conduction thresholds after middle ear surgeries. The study was conducted on 90 patients who had undergone middle ear surgeries, 30 patients of tympanoplasty (group I), modified intact canal wall mastoidectomy and tympanoplasty type-I (group II) and modified radical mastoidectomy (group III) each ware included. Demographic and clinical data were reviewed. Duration of sur...
Source: Indian Journal of Otolaryngology and Head and Neck Surgery - May 23, 2018 Category: ENT & OMF Source Type: research

Bilateral tympanokeratomas (cholesteatomas) with bilateral otitis media, unilateral otitis interna and acoustic neuritis in a dog
An aural cholesteatoma, more appropriately named tympanokeratoma, is an epidermoid cyst of the middle ear described in several species, including dogs, humans and Mongolian gerbils. The cyst lining consists of... (Source: Acta Veterinaria Scandinavica)
Source: Acta Veterinaria Scandinavica - May 22, 2018 Category: Veterinary Research Authors: Liv Østevik, Kathrine Rudlang, Tuva Holt Jahr, Mette Valheim and Bradley Lyndon Njaa Tags: Case report Source Type: research

Deconstructing Pneumococcal Progression from Colonization to Disease [Commentary]
Despite advances in treatment and prevention, the pneumococcus continues to be a dominant cause of severe pneumonia and sepsis and of otitis media, sinusitis, and nonbacteremic pneumonia. Lewnard and colleagues (Infect Immun 86:e00727-17, 2018, https://doi.org/10.1128/IAI.00727-17) used a unique data set of nasopharyngeal and middle ear fluid samples to provide further insight into the progression of nasopharyngeal pneumococcal colonization to disease. They report the comparative rate of progression from colonization to otitis media by serotype, providing insight into how conjugate vaccines that do not reduce the overall p...
Source: Infection and Immunity - May 22, 2018 Category: Infectious Diseases Authors: Pelton, S. I. Tags: Commentary Source Type: research

Pneumococcal Phenotype and Interaction with Nontypeable Haemophilus influenzae as Determinants of Otitis Media Progression [Bacterial Infections]
All-cause otitis media (OM) incidence has declined in numerous settings following introduction of pneumococcal conjugate vaccines (PCVs) despite increases in carriage of nonvaccine pneumococcal serotypes escaping immune pressure. To understand the basis for the declining incidence, we assessed the intrinsic capacity of pneumococcal serotypes to cause OM independently and in polymicrobial infections involving nontypeable Haemophilus influenzae (NTHi) using samples obtained from middle ear fluid and nasopharyngeal cultures before PCV7/13 rollout. Data included samples from OM episodes (11,811) submitted for cultures during a...
Source: Infection and Immunity - May 22, 2018 Category: Infectious Diseases Authors: Lewnard, J. A., Givon-Lavi, N., Tähtinen, P. A., Dagan, R. Tags: Bacterial Infections Source Type: research

Nontypeable Haemophilus influenzae (NTHi).
Abstract In this infographic the diseases caused by nontypeable Haemophilus influenzae (NTHi), including otitis media, are discussed. Encapsulated type b Haemophilus influenzae (Hib) was responsible for most of the invasive disease (meningitis) prior to the use of Hib vaccines. As Hib vaccines have no effect on infections due to nontypeable H. influenzae (NTHi), in areas where Hib vaccines are used, nontypeable strains are now the most common cause of invasive disease. Moreover, NTHi contributes to the ∼21000 otitis media (OM)-associated deaths per year. Due to this collective global morbidity and mortality, c...
Source: Trends in Microbiology - May 21, 2018 Category: Microbiology Authors: Bakaletz LO, Novotny LA Tags: Trends Microbiol Source Type: research

Development of an otitis media strategy in the Pacific: key informant perspectives.
CONCLUSION: Despite significant challenges, there is potential to develop sustainable otitis media identification, treatment and prevention strategies in Fiji. The sustainability of such a strategy is contingent on a number of key factors, which includes a long-term commitment by stakeholders, be culturally appropriate and responsive to local need, develop close linkages across health, social and educational sectors, and ensure it is embedded within a broader public health framework. PMID: 29771904 [PubMed - in process] (Source: New Zealand Medical Journal)
Source: New Zealand Medical Journal - May 19, 2018 Category: General Medicine Tags: N Z Med J Source Type: research

Prevalence of otitis media and risk-factors for sensorineural hearing loss among infants attending Child Welfare Clinics in the Solomon Islands
The present study aimed to assess the prevalence of otitis media and risk-factors for sensorineural hearing loss among infants in the Solomon Islands, in order to recommend an Infant Ear and Hearing Program that would be suitable to the Pacific Island context. (Source: International Journal of Pediatric Otorhinolaryngology)
Source: International Journal of Pediatric Otorhinolaryngology - May 18, 2018 Category: ENT & OMF Authors: Annette Kaspar, Obiga Newton, Joseph Kei, Carlie Driscoll, De Wet Swanepoel, Helen Goulios Source Type: research

Internationally adopted children with cleft lip and/or cleft palate: Middle ear findings and hearing during childhood
Adopted children with cleft lip and/or palate form a diverse group of patients. Due to increased age at palatal repair, adopted children have a higher risk of velopharyngeal insuffiency and poor speech outcome. Delayed palate repair may also lead to longer lasting Eustachian tube dysfunction. Decreased function of the Eustachian tube causes otitis media with effusion and recurrent acute otitis media, which can lead to other middle ear problems and hearing loss. (Source: International Journal of Pediatric Otorhinolaryngology)
Source: International Journal of Pediatric Otorhinolaryngology - May 18, 2018 Category: ENT & OMF Authors: C.L. Werker, M.T.A. van den Aardweg, S. Coenraad, A.B. Mink van der Molen, C.C. Breugem Source Type: research

Treatment of Acute Otitis Media in the Pediatric Emergency Department
Conclusions: Adherence rate to the local guidelines treatment recommendations for uncomplicated AOM was high, as measured by whether appropriate treatment was given and type and duration of antibiotics. (Source: The Pediatric Infectious Disease Journal)
Source: The Pediatric Infectious Disease Journal - May 17, 2018 Category: Infectious Diseases Tags: Original Studies Source Type: research

Early Vaccine-type Pneumococcal Acute Otitis Media Does not Predispose to Subsequent Otitis When Compared With Early Acute Otitis Media Due to Other Bacterial Etiology
Conclusions: Early vaccine-type AOM was not associated with a higher risk of subsequent AOM compared with AOM due to other confirmed bacterial etiology. These data do not support any specific role of vaccine-type pneumococcus in the hypothesis. (Source: The Pediatric Infectious Disease Journal)
Source: The Pediatric Infectious Disease Journal - May 17, 2018 Category: Infectious Diseases Tags: Vaccine Reports Source Type: research

Etiology of Acute Otitis Media and Characterization of Pneumococcal Isolates After Introduction of 13-Valent Pneumococcal Conjugate Vaccine in Japanese Children
We examined etiologic changes in acute otitis media after introduction of 13-valent pneumococcal conjugate vaccine as routine immunization for Japanese children in 2014. Serotypes, resistance genotypes, antibiotic susceptibilities and multilocus sequence typing of pneumococcal isolates were also characterized. Methods: Otolaryngologists prospectively collected middle ear fluid from 582 children by tympanocentesis or sampling through a spontaneously ruptured tympanic membrane between June 2016 and January 2017. Causative pathogens were identified by bacterial culture and real-time polymerase chain reaction for bacteria. ...
Source: The Pediatric Infectious Disease Journal - May 17, 2018 Category: Infectious Diseases Tags: Vaccine Reports Source Type: research

Otolaryngology and the Global Burden of Disease
The Global Burden of Disease (GBD) project provides longitudinal analysis of the global burden of otolaryngologic diseases by measuring the all-cause mortality, years of life lost, the years of life lived with disability, and disability-adjusted life years. Hearing loss burden is assessed overall and as sequelae of other diseases, such as otitis media or meningitis. Using these measures, we can appreciate the high prevalence and disability related to hearing loss globally. Other otolaryngologic diseases that contribute to the GBD include otitis media, cleft lip and palate, head and neck cancer, facial trauma, and oral diso...
Source: Otolaryngologic clinics of North America - May 15, 2018 Category: ENT & OMF Authors: James E. Saunders, Zane Rankin, Kathryn Y. Noonan Source Type: research

A Comparative Study of Type-I Underlay Tympanoplasty with Temporalis Fascia Graft Alone and with Conchal Cartilage
AbstractTympanoplasty which is the repair of the tympanic membrane using temporalis fascia, has been done worldwide and has stood the test of time. However in cases of reperforation or large/subtotal perforations, we are often left in need of some sturdy material for grafting. To compare the graft uptake and hearing improvement in patients undergoing type I tympanoplasty using temporalis fascia alone and temporalis fascia along with conchal cartilage. The current research is a prospective study of 60 patients with chronic suppurative otitis media (Tubo tympanic type), undergoing type I tympanoplasty, using temporalis fasci...
Source: Indian Journal of Otolaryngology and Head and Neck Surgery - May 11, 2018 Category: ENT & OMF Source Type: research

The Swedish grommet register – Hearing results and adherence to guidelines
The insertion of grommets is one of the most commonly performed surgical procedures in children. The underlying reason might be otitis media with effusion (OME) with concomitant hearing loss, recurrent acute otitis media (rAOM) or a combination of the two. Sweden has a national quality register for children receiving grommets with the purpose of evaluating how treatment guidelines are followed, and if surgery confers good quality health care. The purpose of this study was to investigate the circumstances during which Swedish children receive grommets and to examine how doctors follow the guidelines for grommet surgery. (So...
Source: International Journal of Pediatric Otorhinolaryngology - May 10, 2018 Category: ENT & OMF Authors: Marie Gisselsson-Solen, the Reference group for the National Quality Register for Tympanic Membrane Ventilation Tubes Source Type: research

Safety and Efficacy of Autologous Platelet-rich Fibrin on Graft Uptake in Myringoplasty: A Randomized Controlled Trial
Conclusion Being autologous in nature, and by comparing the groups, platelet-rich fibrin is safe for patients. The postoperative graft uptake rate is better in cases in which platelet-rich fibrin was used. The postoperative infection rate was also lower in the same group. [...] Thieme Revinter Publicações Ltda Rio de Janeiro, BrazilArticle in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text (Source: International Archives of Otorhinolaryngology)
Source: International Archives of Otorhinolaryngology - May 9, 2018 Category: ENT & OMF Authors: Nair, Nithin Prakasan Alexander, Arun Abhishekh, B. Hegde, Jyotirmay S. Ganesan, Sivaraman Saxena, Sunil Kumar Tags: Original Research Source Type: research

Grommets (ventilation tubes) for recurrent acute otitis media in children.
CONCLUSIONS: Current evidence on the effectiveness of grommets in children with rAOM is limited to five RCTs with unclear or high risk of bias, which were conducted prior to the introduction of pneumococcal vaccination. Low to very low-quality evidence suggests that children receiving grommets are less likely to have AOM recurrences compared to those managed by active monitoring and placebo medication, but the magnitude of the effect is modest with around one fewer episode at six months and a less noticeable effect by 12 months. The low to very low quality of the evidence means that these numbers need to be interpreted wit...
Source: Cochrane Database of Systematic Reviews - May 9, 2018 Category: General Medicine Authors: Venekamp RP, Mick P, Schilder AG, Nunez DA Tags: Cochrane Database Syst Rev Source Type: research

Inadequate harms reporting in randomized control trials of antibiotics for pediatric acute otitis media: a systematic review
ConclusionsHarms reporting in pediatric randomized trials, especially the reporting of methods used to collect harms data, remains inadequate. (Source: Drug Safety)
Source: Drug Safety - May 8, 2018 Category: Drugs & Pharmacology Source Type: research

Combined multichannel intraluminal impedance ‐pH monitoring should be used to diagnose reflux‐related otitis media with effusion in children
Acta Paediatrica, EarlyView. (Source: Acta Paediatrica)
Source: Acta Paediatrica - May 7, 2018 Category: Pediatrics Authors: Ivan Pavi ć , Irena Babić , Nuša Matijašić , Iva Hojsak Source Type: research

Stenting the Eustachian tube to treat chronic otitis media - a feasibility study in sheep
Untreated chronic otitis media severely impairs quality of life in affected individuals. Local destruction of the middle ear and subsequent loss of hearing are common sequelae, and currently available treatmen... (Source: Head and Face Medicine)
Source: Head and Face Medicine - May 4, 2018 Category: ENT & OMF Authors: Friederike Pohl, Robert A. Schuon, Felicitas Miller, Andreas Kampmann, Eva B ültmann, Christian Hartmann, Thomas Lenarz and Gerrit Paasche Tags: Research Source Type: research

Aerobic bacteria associated with chronic suppurative otitis media in Angola
ConclusionsThe infection of the middle ear in CSOM is highly polymicrobial, and isolates found in nasopharynx do not correspond well with those found in ear discharge. Pathogens associated with CSOM in Angola are dominated by gram-negatives includingEnterobacteriaceae andP. aeruginosa, while gram-positive enterococci also are common. Based on the results of antimicrobial susceptibility testing topical quinolones would be the preferred antibiotic therapy of CSOM in Angola. Topical antiseptics such as aluminium acetate, acetic acid or boric acid, however, may be more feasible options due to a possibly emerging antimicrobial ...
Source: Infectious Diseases of Poverty - May 3, 2018 Category: Infectious Diseases Source Type: research

Middle ear disease in Danish toddlers attending nursery day-care – Applicability of OM-6, disease specific quality of life and predictors for middle ear symptoms
Otitis media (OM) is a very common childhood disease and impacts child quality of life (QoL) to different extends. The aim of this study was to investigate the difference in quality of life between three groups of children; Children with symptoms of ear disease within the last 4 weeks, children without any ear disease and children scheduled for ventilating tube treatment. Furthermore, we investigated predictors for experiencing middle ear symptoms. Lastly, we assessed psychometric properties of OM-6 used to assess QoL. (Source: International Journal of Pediatric Otorhinolaryngology)
Source: International Journal of Pediatric Otorhinolaryngology - May 3, 2018 Category: ENT & OMF Authors: J.H. Indius, S.K. Alqaderi, A.D. Kjeldsen, C.H. Heidemann Source Type: research

The prevalence and impact of otitis media with effusion in children admitted for adeno-tonsillectomy at Dr George Mukhari Academic Hospital, Pretoria, South Africa
The objective of this study was to determine the prevalence of OME in children admitted for adeno-tonsillectomy at our institution in Pretoria, South Africa. (Source: International Journal of Pediatric Otorhinolaryngology)
Source: International Journal of Pediatric Otorhinolaryngology - May 3, 2018 Category: ENT & OMF Authors: Timothy Els, Ian Paul Olwoch Source Type: research

Current Evidence of Peripheral Vestibular Symptoms Secondary to Otitis Media.
CONCLUSION: most studies evaluating the association between otitis media and vestibular symptoms have potential methodological flaws. Clinical evidence suggests that patients with otitis media have increased chances for having vestibular symptoms, delayed acquisition of developmental milestones, and abnormalities in several vestibular function tests as compared with controls. Future studies with rigorous methodology aiming to assess the clinical significance (and prognostic factors) of the association between otitis media and vestibular impairment are warranted. PMID: 29699430 [PubMed - as supplied by publisher] (Sourc...
Source: Annals of Medicine - April 28, 2018 Category: Internal Medicine Tags: Ann Med Source Type: research

Effect of Lead on Human Middle Ear Epithelial Cells.
Abstract Lead is a ubiquitous metal in the environment, but no studies have examined lead toxicity on the middle ear. Here, we investigated lead toxicity and its mechanism in human middle ear epithelial cells (HMEECs). Moreover, we investigated the protective effects of amniotic membrane extract (AME) and chorionic membrane extract (CME) against lead toxicity in HMEECs. Cell viability was analyzed using the cell counting kit, and reactive oxygen species (ROS) activity was measured using a cellular ROS detection kit. After lead(II) acetate trihydrate treatment, mRNA levels of various genes were assessed by semiquan...
Source: Biomed Res - April 27, 2018 Category: Research Authors: Kim SH, Shin SH, Go YY, Chae SW, Song JJ Tags: Biomed Res Int Source Type: research

Complex Febrile Seizures, Lumbar Puncture, and Central Nervous System Infections: a National Perspective.
Abstract OBJECTIVES: To determine the national lumbar puncture (LP) practice patterns relative to the incidence of central nervous system (CNS) infections among children presenting to the emergency department (ED) with complex febrile seizures (CFS). METHODS: Retrospective study of ED visits for CFS from 2007 to 2014 in patients aged 0 to 5 years using a national sample. Primary outcomes include the frequency of LP, incidence of CNS infections, and ED disposition. RESULTS: Of 28,810 ED visits for CFS (44.4% female; mean age, 1.39 years), LP was performed in 7,445 (25.8%, 95% confidence interval [CI] 23.5...
Source: Accident and Emergency Nursing - April 27, 2018 Category: Emergency Medicine Authors: Lee J, DeLaroche AM, Janke AT, Kannikeswaran N, Levy PD Tags: Acad Emerg Med Source Type: research

Vibrant Soundbridge Implantation: Floating Mass Transducer Coupled with the Stapes Head and Embedded in Fat
This study showed that the FMT works well in an obliterated cavity, and the experience acquired through this successful exploration is worth disseminating.ORL 2018;80:159 –164 (Source: ORL)
Source: ORL - April 26, 2018 Category: ENT & OMF Source Type: research

Otitis media with effusion after radiotherapy of the head and neck: a systematic review.
CONCLUSIONS: The incidence of OM is high after radiotherapy of cancer of the upper head and neck area and the Eustachian tube (ET) irradiation dosage seems associated with development of OM, but the literature is poor. Research is needed to designate patients at risk of developing OM after radiotherapy. Preferably through analysis of dosage relationships between the ET and middle ear, and development of OM. Reporting of OM should be per ear and follow standardized protocols of middle ear assessment before and after radiotherapy. Furthermore, there is a need to find new ways to prevent and treat radiation-induced OME, prefe...
Source: Acta Oncologica - April 26, 2018 Category: Cancer & Oncology Authors: Christensen JG, Wessel I, Gothelf AB, Homøe P Tags: Acta Oncol Source Type: research

[Turicella otitidis, contributions to its role in the etiology of ear infections].
CONCLUSIONS: Since the inclusion of new vaccines that protect against microorganisms typically causing otitis media, is possible there are a change in the etiology of this disease and that microorganisms anecdotally isolated until now have become protagonists. The improvement in the microbiological identification provided by tools such as mass spectrometry will help to clarify if there are or not a change in the etiology of these diseases. PMID: 29696957 [PubMed - as supplied by publisher] (Source: Revista Espanola de Quimioterapia)
Source: Revista Espanola de Quimioterapia - April 26, 2018 Category: Drugs & Pharmacology Authors: De Frutos M, López-Urrutia L, Aragón R, Vegas AM, Vázquez M, Eiros Bouza JM Tags: Rev Esp Quimioter Source Type: research

Shewanella algae in a chronic suppurative otitis media patient with cholesteatoma.
We present Shewanella algea infection in a chronic suppurative otitis media (CSOM) patient with cholesteatoma in terms of clinical course and treatment. This is the first time S. algea is found as solely pathogen in a CSOM patient without history of contact with seawater in Turkey. The patient admitted to the hospital several times with complaints of otorrhoea, was diagnosed as otitis media and treated. He was hospitalized to the otorhinolaryngology department for further evaluation of recurrent infections. The patient was diagnosed as cholesteatoma according to computed tomography scan findings and was operated for choles...
Source: Drug Discoveries and Therapeutics - April 25, 2018 Category: Drugs & Pharmacology Tags: Drug Discov Ther Source Type: research

Whole-Genome Sequence Analysis of Streptococcus pneumoniae Strains That Cause Hospital-Acquired Pneumonia Infections [Bacteriology]
In this study, we analyzed S. pneumoniae strains that caused 19 pneumonia episodes in long-term inpatients with severe underlying disease in a hospital during a period of 14 months (from January 2014 to February 2015). Serotyping and whole-genome sequencing analyses revealed that 18 of the 19 pneumonia cases were caused by S. pneumoniae strains belonging to 3 genetically distinct groups: clonal complex 9999 (CC9999), sequence type 282 (ST282), and ST166. The CC9999 and ST282 strains appeared to have emerged separately by a capsule switch from the pandemic PMEN 1 strain (Spain23F-ST81). After all the long-term inpatients we...
Source: Journal of Clinical Microbiology - April 25, 2018 Category: Microbiology Authors: Chang, B., Morita, M., Lee, K.-i., Ohnishi, M. Tags: Bacteriology Source Type: research

Changes in biofilm in chronic cholesteatomatous otitis media in children following the application of sodium 2-mercaptoethanesulfonate (MESNA)
Pediatric cholesteatoma is a clinically challenging disease entity. Its biological behavior in the pediatric population differs from its behavior in adult population in terms of aggressiveness and recurrence. Several studies have shown the presence of biofilms associated with cholesteatoma that hinder the management and eradication of the infection. This led is to study the use of non-antimicrobial treatments impacting on the structure or composition of biofilms. (Source: International Journal of Pediatric Otorhinolaryngology)
Source: International Journal of Pediatric Otorhinolaryngology - April 23, 2018 Category: ENT & OMF Authors: Carlos de la Torre Gonz ález, Marisol Huante-Guido, Norma Velázquez Guadarrama, Diego Preciado, Genaro Patiño López Source Type: research

Comparison of Ossiculoplasty Using Autograft Ossicle Versus Allograft (Teflon)
AbstractChronic suppurative otitis media in almost any form can disrupt the integrity of ossicular chain. Various materials have been used for ossicular substitution or reconstruction, including both biologic and alloplastic materials. Teflon piston is now the most widely used prosthesis for reconstruction of the ossicular chain in cases of otosclerosis. The oto-surgeons are still confronted with problems of ossicular reconstruction regarding the surgical procedure to be done, type of graft to be selected especially in low and poor socioeconomic population. Thus, there is a need felt to comprehensively and holistically eva...
Source: Indian Journal of Otolaryngology and Head and Neck Surgery - April 19, 2018 Category: ENT & OMF Source Type: research

Fungal Suppurative Otitis Media (Histopathology) Among Patients in North India
AbstractChronic suppurative otitis media (CSOM) has a substantial worldwide prevalence and is a major cause of hearing impairment. In cases of CSOM unresponsive to local antibiotics, superimposed fungal infection should be suspected. The aim of the present study was to study the spectrum of cases with fungal otitis media. The study was conducted over a period of 12  years (2006–2017). Fifteen cases of CSOM clinically not suspected to be of fungal etiology that underwent surgery with identification of fungal organisms on histopathology were included in the study. Age of the patients ranged from 12 to 75 year...
Source: Head and Neck Pathology - April 18, 2018 Category: Pathology Source Type: research

Association between facial nerve second genu angle and facial canal dehiscence in patients with cholesteatoma: evaluation with temporal multidetector computed tomography and surgical findings
Conclusion In patients with dehiscence of the facial canal, the angle at the second genu was found to be wider than those without dehiscence. (Source: Brazilian Journal of Otorhinolaryngology)
Source: Brazilian Journal of Otorhinolaryngology - April 14, 2018 Category: ENT & OMF Source Type: research

Animal models of acute otitis media – A review with practical implications for laboratory research
Publication date: Available online 12 April 2018 Source:European Annals of Otorhinolaryngology, Head and Neck Diseases Author(s): N.H. Davidoss, Y.K. Varsak, P.L. Santa Maria Considerable animal research has focused on developing new strategies for the prevention and treatment of acute otitis media (AOM). Several experimental models of AOM have thus been developed. A PubMed search of the English literature was conducted from 1975 to July 2016 using the search terms “animal model” and “otitis media” from which 91 published studies were included for analysis, yielding 123 animal models. The rat, mous...
Source: European Annals of Otorhinolaryngology, Head and Neck Diseases - April 13, 2018 Category: ENT & OMF Source Type: research

Congenital Cholesteatoma in Adults-Interesting Presentations and Management
AbstractTo report a series of adult patients diagnosed with congenital cholesteatoma (CC) with respect to symptoms, different varieties of presentation, surgical findings and approach used, complications and the postoperative results. A retrospective chart review of adult cases of CC who were treated in the period from January 2014 –2017 was carried out in a tertiary care center. Levenson’s criteria were used for diagnosis. Diagnosis was confirmed by imaging and intraoperatively. Postoperative results and complications were also analyzed. Six adult cases of CC were studied with a mean follow up of 10 month...
Source: Indian Journal of Otolaryngology and Head and Neck Surgery - April 13, 2018 Category: ENT & OMF Source Type: research

Genetically Diversity of Pseudomonas aeruginosa Isolated from Chronic Suppurative Otitis Media with Respect to Their Antibiotic Sensitivity Pattern
AbstractPseudomonas aeruginosa is an important chronic suppurative otitis media (CSOM) pathogen that exhibits multiple resistances to antibiotics with increasing frequency, making patient treatment more difficult. The aim of the study is to ascertain the genetically diversity of this clinically isolatedP. aeruginosa with inter simple sequence repeat (ISSR) markers. All 25P. aeruginosa were isolated from CSOM patients by taking their ear swabs and culturing on blood agar and MacConkey agar. All strains were identified with morphological characters and biochemical testing. The antimicrobial susceptibility testing was carri...
Source: Indian Journal of Otolaryngology and Head and Neck Surgery - April 13, 2018 Category: ENT & OMF Source Type: research

An evidence based protocol for managing neonatal middle ear effusions in babies who fail newborn hearing screening
Conclusions An effective initial management plan for children with suspected middle ear pathology and failed NBHS is diagnostic operative microscopy with placement of a ventilation tube in the presence of a MEE along with either intra-operative ABR or close follow-up ABR. This allows for the identification and treatment of babies with a conductive component due to OME, accurate diagnosing of an underlying SNHL component and for prompt aural rehabilitation. (Source: American Journal of Otolaryngology)
Source: American Journal of Otolaryngology - April 12, 2018 Category: Endocrinology Source Type: research