Immunization with a whole cell vaccine reduces pneumococcal nasopharyngeal density and shedding, and middle ear infection in mice
Vaccine. 2024 Feb 12:S0264-410X(24)00131-2. doi: 10.1016/j.vaccine.2024.01.104. Online ahead of print.ABSTRACTPneumococcal Conjugate Vaccines (PCVs) have substantially reduced the burden of disease caused by Streptococcus pneumoniae (the pneumococcus). However, protection is limited to vaccine serotypes, and when administered to children who are colonized with pneumococci at the time of vaccination, immune responses to the vaccine are blunted. Here, we investigate the potential of a killed whole cell pneumococcal vaccine (WCV) to reduce existing pneumococcal carriage and mucosal disease when given therapeutically to infant...
Source: Vaccine - February 13, 2024 Category: Allergy & Immunology Authors: Jayne Manning Sam Manna Eileen M Dunne Viktoria Bongcaron Casey L Pell Natalie L Patterson Sacha D Kuil Poshmaal Dhar David Goldblatt E Kim Mulholland Paul V Licciardi Roy M Robins-Browne Richard Malley Odilia Wijburg Catherine Satzke Source Type: research
Squamous Cell Carcinoma of the Middle Ear —A Common Tumor at an Uncommon Site
We present a rare case of squamous cell carcinoma of the middle ear which clinically presented as chronic suppurative otitis media.Therefore, clinicians should have a high index of suspicion for clinically refractive cases of otorrhea, otalgia, excess bleeding, and non-responsiveness to treatment. All polyps and granulation tissue in EAC and middle ear should be submitted for histopathological examination especially in cases refractory to treatment. (Source: Indian Journal of Surgical Oncology)
Source: Indian Journal of Surgical Oncology - February 8, 2024 Category: Cancer & Oncology Source Type: research
Speech, Language, Hearing, and Otopathology Results From the International Smith-Magenis Syndrome Patient Registry
CONCLUSIONS: Significant delays and impairment in speech-language were common, but the majority of those with SMS communicated using speech by age 6 years. Age was a significant factor for some aspects of hearing loss and communication. Neither hearing loss nor otitis media exacerbated language impairment. These results confirm and extend previous findings about the nature of speech, language, hearing, and otopathology in those with SMS.PMID:38324273 | DOI:10.1044/2023_JSLHR-23-00179 (Source: Journal of speech, language, and hearing research : JSLHR)
Source: Journal of speech, language, and hearing research : JSLHR - February 7, 2024 Category: Speech-Language Pathology Authors: Christine Brennan Mara Louise Smith Rachael R Baiduc Liam O'Connor Source Type: research
Hearing Improvement in Tympanoplasty, with and Without Canalplasty
This study included 60 patients with chronic mucosal otitis media with narrow external auditory canal, with moderate to large central perforation, presenting to our institution from September 2019 to August 2021. Group A consisted of 30 patients, who underwent tympanoplasty with canalplasty and Group B consisted of 30 patients, who underwent tympanoplasty without canalplasty. Both the groups were followed up for 3 months, compared and analysed for hearing improvement and graft uptake. The results of our study indicated that Group A achieved 93.3% graft uptake rates compared to group B which achieved 80%. In Group A gain ...
Source: Indian Journal of Otolaryngology and Head and Neck Surgery - February 6, 2024 Category: ENT & OMF Source Type: research
Association of iron deficiency with chronic suppurative otitis media in adults
CONCLUSIONS: In adult patients, the incidence of iron deficiency was higher in CSOM patients than in controls. Iron deficiency may be considered a potential risk factor for chronic suppurative otitis media, and serum iron parameters should be evaluated in these CSOM patients and further studies should be conducted to better understand the potential link between iron deficiency and CSOM.PMID:38315117 | DOI:10.1080/00016489.2024.2310013 (Source: Acta Oto-Laryngologica)
Source: Acta Oto-Laryngologica - February 5, 2024 Category: ENT & OMF Authors: Jingwen Cao Zixuan Yang Wei Liu Sijing Chen Gaoya Qu Cuiping Zhong Source Type: research
Improved Hearing Impairment of Granulomatosis with Polyangiitis Treated with Rituximab and Avacopan without Glucocorticoids
Intern Med. 2024 Feb 5. doi: 10.2169/internalmedicine.3072-23. Online ahead of print.ABSTRACTA 78-year-old woman with a history of intractable otitis media presented with a fever, hearing impairment, thigh pain, and a skin rash. She had renal dysfunction, positive myeloperoxidase-antineutrophil cytoplasmic autoantibody, otitis media, and multiple nodules in both lungs. She was diagnosed with granulomatosis with polyangiitis, crescentic glomerulonephritis, and interstitial nephritis, which was confirmed in a kidney biopsy specimen. Induction therapy with rituximab and avacopan without glucocorticoids promptly resolved her f...
Source: Internal Medicine - February 4, 2024 Category: Internal Medicine Authors: Aya Okubo Shoichi Fukui Mai Tanigawa Kanako Kojima Remi Sumiyoshi Tomohiro Koga Satomi Shojinaga Ryosuke Sakamoto Maho Nakashima Atsushi Kawakami Source Type: research
Antibiotics or watchful waiting for acute otitis media in urban Aboriginal and Torres Strait Islander children?
Med J Aust. 2024 Jan 29. doi: 10.5694/mja2.52221. Online ahead of print.NO ABSTRACTPMID:38286032 | DOI:10.5694/mja2.52221 (Source: Med J Aust)
Source: Med J Aust - January 29, 2024 Category: General Medicine Authors: Valerie M Swift Christopher G Brennan-Jones Source Type: research
Antibiotics or watchful waiting for acute otitis media in urban Aboriginal and Torres Strait Islander children?
Med J Aust. 2024 Jan 29. doi: 10.5694/mja2.52221. Online ahead of print.NO ABSTRACTPMID:38286032 | DOI:10.5694/mja2.52221 (Source: Medical Journal of Australia)
Source: Medical Journal of Australia - January 29, 2024 Category: General Medicine Authors: Valerie M Swift Christopher G Brennan-Jones Source Type: research
Cartilage-Perichondrium Myringoplasty for Managing Intratympanic Membrane Cholesteatomas With Chronic Otitis Media in Adults
Conclusions: Endoscopic complete excision of an ITMC and cartilage-perichondrium graft without raising a tympanomeatal flap can lead to successful graft intake and improve the symptoms for the patients with ITMC combined with perforation or atrophic TM.PMID:38279828 | DOI:10.1177/01455613241227714 (Source: Ear, Nose and Throat Journal)
Source: Ear, Nose and Throat Journal - January 27, 2024 Category: ENT & OMF Authors: Zhengcai Lou Zihan Lou Zhengnong Chen Source Type: research
Acute otitis media diagnosis in childhood: still a problem in 2023?
ConclusionsAOM diagnosis still represents a relevant issue among paediatricians in our country, and the presence of tympanic membrane hyperaemia without concomitant bulging can be confusing. (Source: Italian Journal of Pediatrics)
Source: Italian Journal of Pediatrics - January 25, 2024 Category: Pediatrics Source Type: research
Acute otitis media diagnosis in childhood: still a problem in 2023?
Diagnosis of acute otitis media (AOM) in children can be challenging, given that symptoms are often non-specific or absent, and that the direct observation of the tympanic membrane in its entirety through otos... (Source: Italian Journal of Pediatrics)
Source: Italian Journal of Pediatrics - January 25, 2024 Category: Pediatrics Authors: Francesco Folino, Marco Caruso, Pietro Bosi, Mirko Ald è, Sara Torretta and Paola Marchisio Tags: Research Source Type: research
The views of parents and carers on managing acute otitis media in urban Aboriginal and Torres Strait Islander children: a qualitative study
CONCLUSIONS: Parents and carers are key partners in managing acute otitis media in urban Aboriginal and Torres Strait Islander children. Our findings support shared decision making informed by the experience of parents and carers, which could also lead to reduced antibiotic use for managing acute otitis media.PMID:38266503 | DOI:10.5694/mja2.52217 (Source: Med J Aust)
Source: Med J Aust - January 24, 2024 Category: General Medicine Authors: Jennifer S Reath Sarah O'Brien Letitia Campbell Hasantha Gunasekera Claudette A Tyson Deborah A Askew Wendy Hu Tim Usherwood Kelvin Kong Peter Morris Amanda J Leach Robyn Walsh Penelope A Abbott Source Type: research
The views of parents and carers on managing acute otitis media in urban Aboriginal and Torres Strait Islander children: a qualitative study
CONCLUSIONS: Parents and carers are key partners in managing acute otitis media in urban Aboriginal and Torres Strait Islander children. Our findings support shared decision making informed by the experience of parents and carers, which could also lead to reduced antibiotic use for managing acute otitis media.PMID:38266503 | DOI:10.5694/mja2.52217 (Source: Medical Journal of Australia)
Source: Medical Journal of Australia - January 24, 2024 Category: General Medicine Authors: Jennifer S Reath Sarah O'Brien Letitia Campbell Hasantha Gunasekera Claudette A Tyson Deborah A Askew Wendy Hu Tim Usherwood Kelvin Kong Peter Morris Amanda J Leach Robyn Walsh Penelope A Abbott Source Type: research
Otitis media: recent advances in otitis media vaccine development and model systems
Otitis media is an inflammatory disorder of the middle ear caused by airways-associated bacterial or viral infections. It is one of the most common childhood infections as globally more than 80% of children are diagnosed with acute otitis media by 3 years of age and it is a common reason for doctor’s visits, antibiotics prescriptions, and surgery among children. Otitis media is a multifactorial disease with various genetic, immunologic, infectious, and environmental factors predisposing children to develop ear infections. Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis are the most common cu...
Source: Frontiers in Microbiology - January 24, 2024 Category: Microbiology Source Type: research
Lenz-Majewski syndrome and recurrent otitis media: Are they related or not?
Eur J Med Genet. 2024 Jan 21;68:104910. doi: 10.1016/j.ejmg.2024.104910. Online ahead of print.ABSTRACTLenz-Majewski hyperostotic dwarfism (LMHD) is a rare condition characterized by intellectual disability, sclerosing bone dysplasia, dysmorphic facial features, brachydactyly, symphalangism and cutis laxa. Nineteen cases have been reported in the literature so far, eleven of them with PTDSS1 mutations. Although studies have had clinically similar findings, in some cases the authors have reported even rarer features such as hydrocephalus, facial paralysis, and cleft palate. We, hereby, report the case of the first patient w...
Source: European Journal of Medical Genetics - January 23, 2024 Category: Genetics & Stem Cells Authors: Fayize Maden Bedel Özgür Balasar Selma Erol Aytekin Sevgi Kele ş H üseyin Çaksen Source Type: research
