INdigenous Systems and Policies Improved and Reimagined for Ear and hearing care (INSPIRE): a multi-method study protocol
This study has approval from the Australian Institute of Aboriginal and Torres Strait Islander Studies Ethics Committee. Study findings will be disseminated to community through Brains Trust members and study participants, as well as through publications in peer-reviewed journals and research forum presentations. (Source: BMJ Open)
Source: BMJ Open - January 10, 2024 Category: General Medicine Authors: Nash, K., Gwynne, K., Dimitropoulos, Y., Fitzpatrick, M., Gunasekera, H., Halvorsen, L., Kong, K., Lumby, N., Macniven, R., Parter, C., Wingett, A., McMahon, C. Tags: Open access, Public health Source Type: research

Registration of preoperative temporal bone CT-scan to otoendoscopic video for augmented-reality based on convolutional neural networks
ConclusionsA fully automatic 2D registration method based on a convolutional neural network and applied to ear surgery was developed. The method did not rely on any external fiducial markers nor human intervention for landmark recognition. The method was fast and its precision was compatible with ear surgery. (Source: European Archives of Oto-Rhino-Laryngology)
Source: European Archives of Oto-Rhino-Laryngology - January 10, 2024 Category: ENT & OMF Source Type: research

Cost-effectiveness of 20-valent pneumococcal conjugate vaccine in US infants
CONCLUSIONS: Infant vaccination with PCV20 is estimated to further reduce pneumococcal disease and associated healthcare system and societal costs compared to both PCV13 and PCV15.PMID:38191278 | DOI:10.1016/j.vaccine.2023.12.057 (Source: Vaccine)
Source: Vaccine - January 8, 2024 Category: Allergy & Immunology Authors: Mark H Rozenbaum Liping Huang Johnna Perdrizet Alejandro Cane Adriano Arguedas Kyla Hayford Maria J Tort Ruth Chapman Desmond Dillon-Murphy Vincenza Snow Erica Chilson Raymond A Farkouh Source Type: research

Case report: A novel mutation in the EYA1 gene in a child with branchiootic syndrome with secretory otitis media and bilateral vestibular hypofunction
Branchiootic syndrome (BOS) is a rare, autosomal dominant syndrome characterized by malformations of the ear associated with hearing loss, second branchial arch anomalies, and the absence of renal anomalies. Herein, we report the case of an 8-year-old male patient with BOS. The proband also experiences mixed conductive and sensorineural hearing loss in the right ear, and severe-to-profound sensorineural hearing loss in the left ear. Preauricular pits, branchial fistulae, and cochlear hypoplasia were present bilaterally. Type III cup-shaped ear, and external auditory canal stenosis were detected in the right ear. Lateral se...
Source: Frontiers in Genetics - January 8, 2024 Category: Genetics & Stem Cells Source Type: research

Characterization of chicken-derived antibody against Alpha-Enolase of Streptococcus pneumoniae
Int Immunopharmacol. 2024 Jan 5;128:111476. doi: 10.1016/j.intimp.2023.111476. Online ahead of print.ABSTRACTStreptococcus pneumoniae is a clinically relevant pathogen notorious for causing pneumonia, meningitis, and otitis media in immunocompromised patients. Currently, antibiotic therapy is the most efficient treatment for fighting pneumococcal infections. However, an arise in antimicrobial resistance in S. pneumoniae has become a serious health issue globally. To resolve the problem, alternative and cost-effective strategies, such as monoclonal antibody-based targeted therapy, are needed for combating bacterial infectio...
Source: International Immunopharmacology - January 7, 2024 Category: Allergy & Immunology Authors: Chi-Hsin Lee Chao-Jung Wu Yi-Yuan Yang Wei-Chu Wang Sy-Jye Leu Cheng-Tsang Wu Pei-Shih Kao Ko-Jiunn Liu Bor-Yu Tsai Yu-Wei Chiang Yan-Chiao Mao Nhlanhla Benedict Dlamini Jungshan Chang Source Type: research

Group A Streptococcus strains causing meningitis without distinct invasive phenotype
Group A streptococcal (GAS) meningitis causes high morbidity and mortality. To elucidate the invasiveness of GAS in meningitis, we compared five GAS meningitis isolates to otitis and colonizing isolates. Genetic and virulence traits were comparable for all strains suggesting that meningitis likely resulted from a continuous spread of the infection. AbstractGroup A streptococcal (GAS; akaStreptococcus pyogenes) meningitis is a fulminant disease associated with high morbidity and mortality. To elucidate the mechanisms underlying the invasiveness of GAS in meningitis, we compared GAS isolates derived from five cases of mening...
Source: MicrobiologyOpen - January 5, 2024 Category: Microbiology Authors: Laura Marquardt, Federica Andreoni, Mathilde Boumasmoud, Tiziano A. Schweizer, Dorothea M. Heuberger, Elena Parietti, Sanne Hertegonne, Jana Epprecht, Dario Mattle, Anna K. Raez, Ewerton Marques ‐Maggio, Reto A. Schuepbach, Barbara Hasse, S Tags: COMMENTARY Source Type: research

Otitis Media in Atypical Symptoms of Kawasaki Disease
(Source: Indian Journal of Pediatrics)
Source: Indian Journal of Pediatrics - January 1, 2024 Category: Pediatrics Source Type: research

Metapneumovirus: A Rare Agent Causing Myocarditis
Viral causes of myocarditis and cardiomyopathy are well established with known agents such as parvoviruses, enteroviruses, and adenoviruses. Human metapneumovirus (hMPV), belonging to the Pneumovirdiae family, was first discovered in 2001 primarily resulting in upper and lower respiratory tract infections - most common in children, older individuals, and those with a weakened or compromised immune system. Once infected, it has been reported to cause pneumonia, croup, otitis media, and conjunctivitis. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - January 1, 2024 Category: Cardiology Authors: Radha Gopalan, Andres Vargas Rodriguez, McEwan Hopkins, Ambar Andrade, Ryan Ung, Anantharam Kayla, Marc Silver Tags: 398 Source Type: research

Detection of FOX-AmpC- β-lactamase gene and antibiogram of AmpC-beta-lactamase-producing pathogens isolated from chronic suppurative otitis media patients in Nigeria
CONCLUSION: The detection of AmpC β-lactamase-producing multidrug-resistant GNB pathogens harbouring FOX-AmpC-β-lactamase gene among patients with CSOM infections in our study is a serious public health problem which needs urgent intervention.PMID:38156308 | PMC:PMC10751608 | DOI:10.18502/ijm.v15i6.14139 (Source: Iranian Journal of Microbiology)
Source: Iranian Journal of Microbiology - December 29, 2023 Category: Microbiology Authors: Ibiam Francis Amadi Obasikene Catherine Nchedo Ariom Thaddaeus Obaji Monday Agbonifo Egwu Eze Iroha Chidinma Stacy Moses Ikechukwu Benjamin Iroha Ifeanyichukwu Romanus Source Type: research