A clinical epidemiological study on congenital ear malformation (CEM)
Conclusion and Significance: Approximately 69.9% of CEM cases were confined to the ear itself, with the highest proportion being inner ear malformation alone. Multiple malformations were predominantly associated with CMMOE. Syndromes related to CEM were relatively rare. Among cases of microtia, 96.3% were classified as CMMOE. These cases were predominantly observed in males, right ear and exhibited characteristics such as grade III microtia, atresia of the outer ear canal, ossicles malformation, and multiple malformations. The multiple malformations frequently included hemifacial microsomia, accessory ear, preauricular fis...
Source: Acta Oto-Laryngologica - December 10, 2023 Category: ENT & OMF Authors: Ming Zhang JiaHua Lin JingDa Zhang ZeLi Han Chang Liu YiHui Zou Source Type: research
Exploring the OTITIS Research Landscape Through a Scientometric Approach
This study found that research on otitis media has increased significantly in recent years, with an annual growth rate of 4.58%. The average age of the documents analyzed was 18 years, with an average of 21.88 citations and an average of 4.58 authors. The United States, the United Kingdom, and Japan ranked first to third in terms of number of publications. Still, the United States, China, and Sweden were in a better position in terms of impact on the research network. Co- occurrence word analysis showed that significant attention was given to topics such as chronic inflammation in autism, acute inflammation in otitis med...
Source: Indian Journal of Otolaryngology and Head and Neck Surgery - December 9, 2023 Category: ENT & OMF Source Type: research
Solving polymicrobial puzzles: evolutionary dynamics and future directions
Polymicrobial infections include various microorganisms, often necessitating different treatment methods than a monomicrobial infection. Scientists have been puzzled by the complex interactions within these communities for generations. The presence of specific microorganisms warrants a chronic infection and impacts crucial factors such as virulence and antibiotic susceptibility. Game theory is valuable for scenarios involving multiple decision-makers, but its relevance to polymicrobial infections is limited. Eco-evolutionary dynamics introduce causation for multiple proteomic interactions like metabolic syntropy and niche ...
Source: Frontiers in cellular and infection microbiology - December 8, 2023 Category: Microbiology Source Type: research
Efficacy, safety, and tissue penetration of solithromycin in Japanese patients with otorhinolaryngological infections
To assess the efficacy, safety, and tissue penetration of solithromycin for the treatment of otorhinolaryngological infections, we conducted three studies: a tissue penetration study with patients scheduled to undergo otorhinolaryngological tissue removal, an open-label study comprising patients with otitis media, pharyngitis, laryngitis, and tonsillitis, and a non-inferiority study compared with high-dose cefcapene-pivoxil (CFPN-PI). (Source: Auris, Nasus, Larynx)
Source: Auris, Nasus, Larynx - December 7, 2023 Category: ENT & OMF Authors: Yuichi Kurono, Fumiyo Kudo, Akira Watanabe, Takahiro Yamatake, Satoshi Shimada, Kenji Suzuki Source Type: research
Adaptive immune protection of the middle ears differs from that of the respiratory tract
The efficacy of the adaptive immune system in the middle ear (ME) is well established, but the mechanisms are not as well defined as those of gastrointestinal or respiratory tracts. While cellular elements of the adaptive response have been detected in the MEs following infections (or intranasal immunizations), their specific contributions to protecting the organ against reinfections are unknown. How immune protection mechanisms of the MEs compares with those in the adjacent and attached upper and lower respiratory airways remains unclear. To address these knowledge gaps, we used an established mouse respiratory infection ...
Source: Frontiers in cellular and infection microbiology - December 6, 2023 Category: Microbiology Source Type: research
Knowledge and Attitudes of Parents and Caregivers in New Delhi to Childhood Hearing Loss and Hearing Services
In conclusion, this study contributes valuable insights into the preparedness of parents and caregivers for audiology services and the need for contextually appropriate strategies to enhance childhood hearing health services in India. (Source: Indian Journal of Otolaryngology and Head and Neck Surgery)
Source: Indian Journal of Otolaryngology and Head and Neck Surgery - December 6, 2023 Category: ENT & OMF Source Type: research
Middle Ear Meningioma With Recurrence Secretory Otitis Media
Ear Nose Throat J. 2023 Dec 3:1455613231211314. doi: 10.1177/01455613231211314. Online ahead of print.ABSTRACTMiddle ear meningiomas (MEMs) are rare tumors that can present with nonspecific symptoms, posing challenges in diagnosis and management. This case report focuses on a middle-aged female patient who was misdiagnosed with secretory otitis media for 5 years. However, further evaluation through computed tomography imaging and subsequent pathologic biopsy revealed the presence of a MEM. The patient underwent surgical and gamma knife resection of the tumor and follow-up examination after 1 year showed no signs of recurre...
Source: Ear, Nose and Throat Journal - December 4, 2023 Category: ENT & OMF Authors: Haiying Sun Qilin Huang WeiBin Chen Yujuan Hu Source Type: research
Serotype-Dependent Inhibition of < em > Streptococcus pneumoniae < /em > Growth by Short-Chain Fatty Acids
In this study, we investigated the antimicrobial activity of SCFAs (acetate, propionate, and butyrate) against various serotypes pneumococci. Propionate generally inhibited the growth of S. pneumoniae serotypes included in the pneumococcal conjugate vaccine (PCV) 13, except for serotype 3 and 7F, though butyrate and acetate showed no or low inhibition, depending on the serotypes. Of note, butyrate showed strong inhibition against serotype 3, the most prevalent invasive strain since the introduction of the PCV vaccine. No SCFAs showed inhibitory effects against serotype 7F. Remarkably, the nonencapsulated pneumococcal strai...
Source: Journal of Microbiology and Biotechnology - December 4, 2023 Category: Biotechnology Authors: Suwon Lim Dongwook Lee Sungho Jeong Jeong Woo Park Jintaek Im Bokeum Choi Donghyun Gwak Cheol-Heui Yun Ho Seong Seo Seung Hyun Han Source Type: research
Middle Ear Meningioma With Recurrence Secretory Otitis Media
Ear Nose Throat J. 2023 Dec 3:1455613231211314. doi: 10.1177/01455613231211314. Online ahead of print.ABSTRACTMiddle ear meningiomas (MEMs) are rare tumors that can present with nonspecific symptoms, posing challenges in diagnosis and management. This case report focuses on a middle-aged female patient who was misdiagnosed with secretory otitis media for 5 years. However, further evaluation through computed tomography imaging and subsequent pathologic biopsy revealed the presence of a MEM. The patient underwent surgical and gamma knife resection of the tumor and follow-up examination after 1 year showed no signs of recurre...
Source: Ear, Nose and Throat Journal - December 4, 2023 Category: ENT & OMF Authors: Haiying Sun Qilin Huang WeiBin Chen Yujuan Hu Source Type: research
Serotype-Dependent Inhibition of < em > Streptococcus pneumoniae < /em > Growth by Short-Chain Fatty Acids
In this study, we investigated the antimicrobial activity of SCFAs (acetate, propionate, and butyrate) against various serotypes pneumococci. Propionate generally inhibited the growth of S. pneumoniae serotypes included in the pneumococcal conjugate vaccine (PCV) 13, except for serotype 3 and 7F, though butyrate and acetate showed no or low inhibition, depending on the serotypes. Of note, butyrate showed strong inhibition against serotype 3, the most prevalent invasive strain since the introduction of the PCV vaccine. No SCFAs showed inhibitory effects against serotype 7F. Remarkably, the nonencapsulated pneumococcal strai...
Source: Journal of Microbiology and Biotechnology - December 4, 2023 Category: Biotechnology Authors: Suwon Lim Dongwook Lee Sungho Jeong Jeong Woo Park Jintaek Im Bokeum Choi Donghyun Gwak Cheol-Heui Yun Ho Seong Seo Seung Hyun Han Source Type: research
Serotype-Dependent Inhibition of < em > Streptococcus pneumoniae < /em > Growth by Short-Chain Fatty Acids
In this study, we investigated the antimicrobial activity of SCFAs (acetate, propionate, and butyrate) against various serotypes pneumococci. Propionate generally inhibited the growth of S. pneumoniae serotypes included in the pneumococcal conjugate vaccine (PCV) 13, except for serotype 3 and 7F, though butyrate and acetate showed no or low inhibition, depending on the serotypes. Of note, butyrate showed strong inhibition against serotype 3, the most prevalent invasive strain since the introduction of the PCV vaccine. No SCFAs showed inhibitory effects against serotype 7F. Remarkably, the nonencapsulated pneumococcal strai...
Source: Journal of Microbiology and Biotechnology - December 4, 2023 Category: Biotechnology Authors: Suwon Lim Dongwook Lee Sungho Jeong Jeong Woo Park Jintaek Im Bokeum Choi Donghyun Gwak Cheol-Heui Yun Ho Seong Seo Seung Hyun Han Source Type: research
Serotype-Dependent Inhibition of < em > Streptococcus pneumoniae < /em > Growth by Short-Chain Fatty Acids
In this study, we investigated the antimicrobial activity of SCFAs (acetate, propionate, and butyrate) against various serotypes pneumococci. Propionate generally inhibited the growth of S. pneumoniae serotypes included in the pneumococcal conjugate vaccine (PCV) 13, except for serotype 3 and 7F, though butyrate and acetate showed no or low inhibition, depending on the serotypes. Of note, butyrate showed strong inhibition against serotype 3, the most prevalent invasive strain since the introduction of the PCV vaccine. No SCFAs showed inhibitory effects against serotype 7F. Remarkably, the nonencapsulated pneumococcal strai...
Source: Journal of Microbiology and Biotechnology - December 4, 2023 Category: Biotechnology Authors: Suwon Lim Dongwook Lee Sungho Jeong Jeong Woo Park Jintaek Im Bokeum Choi Donghyun Gwak Cheol-Heui Yun Ho Seong Seo Seung Hyun Han Source Type: research
Serotype-Dependent Inhibition of < em > Streptococcus pneumoniae < /em > Growth by Short-Chain Fatty Acids
In this study, we investigated the antimicrobial activity of SCFAs (acetate, propionate, and butyrate) against various serotypes pneumococci. Propionate generally inhibited the growth of S. pneumoniae serotypes included in the pneumococcal conjugate vaccine (PCV) 13, except for serotype 3 and 7F, though butyrate and acetate showed no or low inhibition, depending on the serotypes. Of note, butyrate showed strong inhibition against serotype 3, the most prevalent invasive strain since the introduction of the PCV vaccine. No SCFAs showed inhibitory effects against serotype 7F. Remarkably, the nonencapsulated pneumococcal strai...
Source: Journal of Microbiology and Biotechnology - December 4, 2023 Category: Biotechnology Authors: Suwon Lim Dongwook Lee Sungho Jeong Jeong Woo Park Jintaek Im Bokeum Choi Donghyun Gwak Cheol-Heui Yun Ho Seong Seo Seung Hyun Han Source Type: research
Serotype-Dependent Inhibition of < em > Streptococcus pneumoniae < /em > Growth by Short-Chain Fatty Acids
In this study, we investigated the antimicrobial activity of SCFAs (acetate, propionate, and butyrate) against various serotypes pneumococci. Propionate generally inhibited the growth of S. pneumoniae serotypes included in the pneumococcal conjugate vaccine (PCV) 13, except for serotype 3 and 7F, though butyrate and acetate showed no or low inhibition, depending on the serotypes. Of note, butyrate showed strong inhibition against serotype 3, the most prevalent invasive strain since the introduction of the PCV vaccine. No SCFAs showed inhibitory effects against serotype 7F. Remarkably, the nonencapsulated pneumococcal strai...
Source: Journal of Microbiology and Biotechnology - December 4, 2023 Category: Biotechnology Authors: Suwon Lim Dongwook Lee Sungho Jeong Jeong Woo Park Jintaek Im Bokeum Choi Donghyun Gwak Cheol-Heui Yun Ho Seong Seo Seung Hyun Han Source Type: research
PCR157 Assessment of Health State Utilities for Invasive Pneumococcal Disease, Pneumonia, and Acute Otitis Media in Young Children
New vaccines have been developed for pneumococcal disease in children. Cost-utility analyses (CUAs) are often used to examine the value of new vaccines and require health state utilities as inputs. However, existing utilities for pneumococcal infections in children are limited. The purpose of this study was to estimate health state utilities associated with Streptococcus pneumoniae infections in children. (Source: Value in Health)
Source: Value in Health - December 1, 2023 Category: International Medicine & Public Health Authors: L.S. Matza, T.A. Howell, B. Chun, L. Hetherington, M. White, T. Weiss, M. Huang, D. Rowen, T. Tan, K. Feemster, B. Nozad, M. Kelly, S. Mohanty Source Type: research
