Lack of the hyaluronan receptor CD44 affects the course of bacterial otitis media and reduces leukocyte recruitment to the middle ear
CD44 is a multifunctional molecule that plays major roles in both leukocyte recruitment and tissue proliferation. Since mucosal hyperplasia and leukocyte infiltration of the middle ear cavity are major feature... (Source: BMC Immunology)
Source: BMC Immunology - June 21, 2019 Category: Allergy & Immunology Authors: Hyun Woo Lim, Kwang Pak, Arwa Kurabi and Allen F. Ryan Tags: Research article Source Type: research

Otitis externa in eight horses - clinical signs, treatment and prognosis.
CONCLUSION AND CLINICAL IMPORTANCE: Otitis externa in horses is a rare and treatable condition. The condition may be present for prolonged periods before owners become aware, compromising the welfare of affected horses. Untreated otitis externa is a suggested cause of otitis media and temporohyoid osteoarthropathy, emphasizing the importance of identifying and treating this condition at an early stage. For this reason, clinicians should include a brief inspection of the pinnae and external ear canal in the clinical examination of horses. PMID: 31218772 [PubMed - as supplied by publisher] (Source: Veterinary Dermatology)
Source: Veterinary Dermatology - June 20, 2019 Category: Veterinary Research Authors: Odelros E, Kendall A, Wulcan S, Bergvall K Tags: Vet Dermatol Source Type: research

Effect of vascular endothelial growth factor and its receptors in adult otitis media with effusion
ConclusionsVEGF and its receptors function to induce the production of middle-ear effusions (MEEs) at acute stage of OME rather than chronic or recurrent stage, which is mainly mediated by HIF-1 α pathway. The formation of mucoid effusions is associated with MUC5B and VEGFR2, but not with duration and recurrence of OME. (Source: European Archives of Oto-Rhino-Laryngology)
Source: European Archives of Oto-Rhino-Laryngology - June 19, 2019 Category: ENT & OMF Source Type: research

Age-Dependent Dissimilarity of the Nasopharyngeal and Middle Ear Microbiota in Children With Acute Otitis Media
Acute bacterial otitis media is usually caused by otopathogens ascending to the middle ear from the nasopharynx (NP). However, it is unknown if the nasopharyngeal microbiota of children with acute otitis media (AOM) can serve as an age-dependent or independent proxy for the microbial communities of the middle ear fluid (MEF) as there is a lack of 16S rRNA amplicon sequencing studies simultaneously analyzing the microbial communities of the two sites. Within this study, we performed 16S rRNA next generation sequencing on a total of 286 nasopharyngeal swabs (NPS) collected between 2004 and 2013 within a Swiss national AOM ...
Source: Frontiers in Genetics - June 19, 2019 Category: Genetics & Stem Cells Source Type: research

What's the Connection between Fever and Atraumatic Leg Pain?
​BY ADRIANA PORTO, MD; KELLY LEVASSEUR, DO; & SHANNA JONES, MDA 7-year-old girl presented to the emergency department with intermittent low-grade fever over the previous six days. She also had a sore throat, cough, and nasal congestion. Her mother reported a fever of 105°F with vomiting, cough, and congestion on the day of her presentation. She also noted that the patient complained of right leg pain and refused to walk or bear weight on her right leg, which was new the day of presentation. The patient pointed to the back of her right calf when asked where the pain was located. Her mother said the patient did not...
Source: The Case Files - June 18, 2019 Category: Emergency Medicine Tags: Blog Posts Source Type: research

Clinimetric evaluation and clinical outcomes of the Dutch version of the Chronic Ear Survey
To validate and evaluate the reliability of the Dutch version of the Chronic Ear Survey (CES) in patients suffering from Chronic Suppurative Otitis Media (CSOM) and to evaluate clinical outcomes of surgery usi... (Source: Health and Quality of Life Outcomes)
Source: Health and Quality of Life Outcomes - June 18, 2019 Category: International Medicine & Public Health Authors: S. Geerse, R. J. de Haan, M. J. F. de Wolf, F. A. Ebbens and E. van Spronsen Tags: Research Source Type: research

A Clinical Study on Audiological Evaluation in Patients with Active Squamous Variety of Chronic Otitis Media Following Canal Wall Down Mastoidectomy with Ossicular Reconstruction
AbstractTo evaluate hearing results following canal wall down mastoidectomy with ossicular reconstruction for Chronic Suppurative Otitis Media of Active Squamosal variety& evaluate various factors related to surgery impacting hearing results. This prospective study involves 40 patients of active squamosal variety of chronic otitis media who attended ENT OPD and underwent canal wall down mastoidectomy with ossiculoplasty during the period from November 2014 to October 2015. All the patients were subjected to pre and 3  months post-op hearing assessment. Based on the hearing outcome, we expressed our study results i...
Source: Indian Journal of Otolaryngology and Head and Neck Surgery - June 18, 2019 Category: ENT & OMF Source Type: research

Probiotics for preventing acute otitis media in children.
CONCLUSIONS: Probiotics may prevent AOM in children not prone to AOM, but the inconsistency of the subgroup analyses suggests caution in interpreting these results. Probiotics decreased the proportion of children taking antibiotics for any infection. The proportion of children experiencing adverse events did not differ between the probiotic and comparator groups. The optimal strain, duration, frequency, and timing of probiotic administration still needs to be established. PMID: 31210358 [PubMed - as supplied by publisher] (Source: Cochrane Database of Systematic Reviews)
Source: Cochrane Database of Systematic Reviews - June 18, 2019 Category: General Medicine Authors: Scott AM, Clark J, Julien B, Islam F, Roos K, Grimwood K, Little P, Del Mar CB Tags: Cochrane Database Syst Rev Source Type: research

Hearing impairment and osteogenesis imperfecta: Literature review
Publication date: Available online 13 June 2019Source: European Annals of Otorhinolaryngology, Head and Neck DiseasesAuthor(s): F. Carré, S. Achard, I. Rouillon, M. Parodi, N. LoundonAbstractThe goal is to clarify the epidemiology of hearing loss in patients with osteogenesis imperfecta (OI), so as to improve management. A literature review analyzed data from 15 patient series. Hearing loss prevalence in OI varied widely, from 2% to 94.1%. Typically, hearing loss was conductive in young patients and sensorineural in older patients. Prevalence increased with age, but after 50 years the increase was slight, and seldom...
Source: European Annals of Otorhinolaryngology, Head and Neck Diseases - June 13, 2019 Category: ENT & OMF Source Type: research

Intratympanic Triamcinolone Acetonide as Treatment Option for Idiopathic Sudden Sensorineural Hearing Loss
Conclusion: While the exact role of intratympanic injections requires additional trials, triamcinolone resulted in similar outcomes compared to studies using dexamethasone or methylprednisolone. Due to favorable pharmacological properties, triamcinolone represents a safe and efficacious alternative for intratympanic treatment in idiopathic sensorineural hearing loss. (Source: Otology and Neurotology)
Source: Otology and Neurotology - June 13, 2019 Category: ENT & OMF Tags: SENSORINEURAL HEARING LOSS AND TINNITUS Source Type: research

The Impact of Canalplasty on Outcomes of Medial Graft Tympanoplasty
Conclusions: Data from the current study suggest that canalplasty offers benefit regarding closure rate in medial graft tympanoplasty. Use of cartilage also portended a higher rate of perforation closure. Canalplasty should be considered when using medial graft techniques if exposure is limited due to bony canal anatomy. (Source: Otology and Neurotology)
Source: Otology and Neurotology - June 13, 2019 Category: ENT & OMF Tags: MIDDLE EAR AND MASTOID DISEASE Source Type: research

Mastoid Cavity Myiasis: A Case Report and Review of the Literature
Conclusion: Neglected mastoid cavity care, low socioeconomic status, poor personal hygiene, homelessness, and chronic suppurative otitis media are likely contributing factors to this uncommon presentation occurring in an urban setting. (Source: Otology and Neurotology)
Source: Otology and Neurotology - June 13, 2019 Category: ENT & OMF Tags: MIDDLE EAR AND MASTOID DISEASE Source Type: research

Bezold abscess: a rare complication of acute otitis media
No abstract available (Source: Otology and Neurotology)
Source: Otology and Neurotology - June 13, 2019 Category: ENT & OMF Tags: LETTERS TO THE EDITOR Source Type: research

Acute otitis media and associated complications in united states emergency departments
No abstract available (Source: Otology and Neurotology)
Source: Otology and Neurotology - June 13, 2019 Category: ENT & OMF Tags: LETTERS TO THE EDITOR Source Type: research

Effect of balloon dilation eustachian tuboplasty combined with tympanic tube insertion in the treatment of chronic recurrent secretory otitis media
ConclusionBET combined with TTI surgery is an effective therapy for patients with CRSOM. (Source: European Archives of Oto-Rhino-Laryngology)
Source: European Archives of Oto-Rhino-Laryngology - June 13, 2019 Category: ENT & OMF Source Type: research

Clinical and immunological features in a cohort of patients with partial DiGeorge syndrome followed at a single center
DiGeorge syndrome (DGS) is a primary immunodeficiency characterized by various degrees of T-cell deficiency. In partial DGS (pDGS), other risk factors could predispose to recurrent infections, autoimmunity, and allergy. The aim of this study was to assess the effect of different factors in the development of infections, autoimmunity, and/or allergy in patients with pDGS. We studied 467 pDGS patients in follow-up at Great Ormond Street Hospital. Using a multivariate approach, we observed that palatal anomalies represent a risk factor for the development of recurrent otitis media with effusion. Gastroesophageal reflux/dyspha...
Source: Blood - June 13, 2019 Category: Hematology Authors: Giardino, G., Radwan, N., Koletsi, P., Morrogh, D. M., Adams, S., Ip, W., Worth, A., Jones, A., Meyer-Parsonson, I., Gaspar, H. B., Gilmour, K., Davies, E. G., Ladomenou, F. Tags: Pediatric Hematology, Immunobiology and Immunotherapy Source Type: research

Four methods for identifying ambiguous Streptococcus pneumoniae isolates: the experience from a Swedish university hospital.
Authors: Kazdaglis G, Lucin J, Kertat K, Persis S Abstract Streptococcus pneumoniae is a Gram-positive, alpha-hemolytic, facultative anaerobic coccus. It is the most common cause of community acquired pneumonia in adults and infants, and a major cause of morbidity and mortality. It is also a frequent cause of otitis media and sinus infections. It spreads through close person-to-person contact via respiratory droplets. It presents as pneumonia, bacteremia, or meningitis. PMID: 31184099 [PubMed - as supplied by publisher] (Source: Journal of Biological Regulators and Homeostatic Agents)
Source: Journal of Biological Regulators and Homeostatic Agents - June 12, 2019 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

A Rare Case of Idiopathic Temporal Muscle Abscess in a Nine-month-old Infant.
We report a rare case of a nine-month-old infant who showed right temporal mass with no evidence of infection. Computed tomography showed an osteolytic round mass, and magnetic resonance imaging revealed heterogenous enhancement with a high apparent diffusion coefficient. Malignant tumor was first suspected, but an open biopsy revealed the swelling to be temporal muscle abscess. It should be noted that temporal abscess may mimic the features of a malignant tumor, and multiple examinations should be performed for an accurate diagnosis. PMID: 31178474 [PubMed - as supplied by publisher] (Source: Internal Medicine)
Source: Internal Medicine - June 12, 2019 Category: Internal Medicine Tags: Intern Med Source Type: research

Readout-Segmented Echo-Planar DWI for the Detection of Cholesteatomas: Correlation with Surgical Validation [HEAD & NECK]
CONCLUSIONS: Readout-segmented echo-planar DWI is a promising and reliable MR imaging sequence for the detection and exclusion of cholesteatoma. (Source: American Journal of Neuroradiology)
Source: American Journal of Neuroradiology - June 12, 2019 Category: Radiology Authors: Fischer, N., Schartinger, V. H., Dejaco, D., Schmutzhard, J., Riechelmann, H., Plaikner, M., Henninger, B. Tags: HEAD & amp; NECK Source Type: research

Transcription factors T-bet/GATA-3/Foxp3 in peripheral blood of patients with chronic otitis media with effusion.
PMID: 31205074 [PubMed - as supplied by publisher] (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - June 12, 2019 Category: General Medicine Authors: Yang L, Zhao SQ, Li Y, Ren R, Wei CY, Yang JS, Yang BB Tags: Chin Med J (Engl) Source Type: research

Respiratory Complications in Patients with Hyper IgM Syndrome
ConclusionsRespiratory complications are common in patients with HIgM syndrome. A proper awareness of respiratory manifestations in patients with HIgM may result in improved management, reduced morbidity and mortality, and an improvement in the quality of life of the patients. (Source: Journal of Clinical Immunology)
Source: Journal of Clinical Immunology - June 11, 2019 Category: Allergy & Immunology Source Type: research

Fibro-muscular-periosteal flap and bilobed flap for post-auricular cutaneous mastoid fistula closure.
CONCLUSION: The fibro-muscular-periosteal flap combined with a bilobed flap from the mastoid and lateral neck regions, in our view, can be considered a valid option for post-auricular cutaneous mastoid fistula closure. PMID: 31169088 [PubMed - as supplied by publisher] (Source: Journal of Laryngology and Otology)
Source: Journal of Laryngology and Otology - June 7, 2019 Category: ENT & OMF Tags: J Laryngol Otol Source Type: research

Associations between Otitis media, taste sensitivity and adiposity: Two studies across childhood
ConclusionsOM history was associated with higher BMI among 5–9 year old children and this may be linked to taste impairments. This association was not observed in 2–3 year old children. Potential sex differences in these associations require further investigation. (Source: Physiology and Behavior)
Source: Physiology and Behavior - June 6, 2019 Category: Physiology Source Type: research

ELOM-080 as Add-On Treatment for Respiratory Tract Diseases – A Review of Clinical Studies Conducted in China
Planta Med DOI: 10.1055/a-0942-1993ELOM-080, also known as Myrtol, represents a distillate of a mixture of 4 rectified essential oils: eucalyptus oil, sweet orange oil, myrtle oil, and lemon oil. ELOM-080 is an approved herbal medicinal product for the secretolytic therapy and facilitation of expectoration in acute and chronic bronchitis and for the secretolytic therapy of sinusitis. Its clinical efficacy has been reported by several randomized control trials. Interestingly, in the recent past, a considerable number of clinical studies on the use of ELOM-080 as add-on treatment of different respiratory tract diseases has b...
Source: Planta Medica - June 5, 2019 Category: Drugs & Pharmacology Authors: F ürst, Robert Luong, Betty Thomsen, J örn Wittig, Thomas Tags: Reviews Source Type: research

Vitamin D and Otitis Media
AbstractPurpose of ReviewTo examine the relationship between vitamin D and otitis media.Recent FindingsVitamin D deficiency has been associated with several respiratory diseases, including otitis media. Vitamin D supplementation may reduce the risk of otitis media. This relationship may be explained by vitamin D supporting the immune system by upregulating antimicrobial peptides which are effective against otopathogens and biofilm formation, supporting a less inflammatory immune response, or promoting beneficial commensal bacteria.SummaryThis review will explore risk factors of both otitis media and vitamin D deficiency, t...
Source: Current Allergy and Asthma Reports - June 3, 2019 Category: Allergy & Immunology Source Type: research

Role of Obesity in Otorhinolaryngologic Diseases
AbstractPurpose of ReviewObesity is a major public health problem associated with various diseases. Improving obesity control and achieving greater patient satisfaction are critical unmet needs. Various otorhinolaryngologic diseases can have negative effects on quality of life or actual health status depending on their type. Over the past decade, the relationship between obesity and otorhinolaryngologic conditions has been investigated. The purpose of this review was to discuss the relationship between obesity and otorhinolaryngological diseases.Recent FindingsThis is a narrative review on the current state of incidence, e...
Source: Current Allergy and Asthma Reports - June 3, 2019 Category: Allergy & Immunology Source Type: research

A Retrospective Study to Identify the Relationship Between the Dimension of Osseous External Auditory Canal and Chronic Otitis Media.
In this study, we intended to investigate the relationship between the diameter or shape of OEAC and COM. We retrospectively reviewed the high-resolution computed tomography (HRCT) images of the temporal bones of 62 patients with unilateral COM who underwent tympanoplasty from January 1, 2011, to December 31, 2013. For comparison, the HRCT images of another 62 patients with normal ears were collected to be the control group. The shape of OEAC was categorized into 5 groups according to Mahboubi's classification, and the dimension of each patient's OEAC was measured at 2 defined sections (annular section and isthmus/midcanal...
Source: Ear, Nose and Throat Journal - June 2, 2019 Category: ENT & OMF Authors: Lee YF, Wei PY, Chu CH, Liao WH, Shiao AS, Wang MC Tags: Ear Nose Throat J Source Type: research

Abnormalities of the muscles of the soft palate and their impact on auditory function in patients operated on for cleft palate: a case-control study
We examined the anatomy of the eustachian tube and the paratubal muscles of the soft palate with magnetic resonance imaging (MRI), assessed auditory function, and correlated the results to evaluate the impact of the pathological anatomy on the function of the middle ear. A total of 64 ears in 32 patients were evaluated (Group A, n = 16) (Group B, controls = 16). MRI showed a short eustachian tube with a shortened tensor attachment in Group A when compared with Group B. The pterygoid hamulus was found to be intact in both groups, but extensive perihamular fibrosis was seen in Group A. A total of 15 ears in Group A h...
Source: British Journal of Oral and Maxillofacial Surgery - June 1, 2019 Category: ENT & OMF Source Type: research

Contribution of the Use of a Pen-Type Endoscope to Evaluate and Treat Ears Simultaneously During Cleft Palate Surgery in Late Presented Cases
Conclusion: The pen-type camera instead of an operating microscope was a tremendous contribution, as it was easy to handle and contributed to the good outcomes. The use of this technique is strongly recommended in surgical camps. Level of Evidence: III (Source: Journal of Craniofacial Surgery)
Source: Journal of Craniofacial Surgery - June 1, 2019 Category: Surgery Tags: Clinical Studies Source Type: research

Abnormalities of the muscles of the soft palate and their impact on auditory function in patients operated on for cleft palate: a case-control study
We examined the anatomy of the eustachian tube and the paratubal muscles of the soft palate with magnetic resonance imaging (MRI), assessed auditory function, and correlated the results to evaluate the impact of the pathological anatomy on the function of the middle ear. (Source: The British Journal of Oral and Maxillofacial Surgery)
Source: The British Journal of Oral and Maxillofacial Surgery - May 31, 2019 Category: ENT & OMF Authors: D. Arunachalam, S. Pendem, P. Ravi, K.K. Raja V.B. Source Type: research

Total Endoscopic Transcanal Cartilage Myringoplasty: A Prospective Study
The objective of the present study was to evaluate the graft uptake rate and to evaluate the hearing results. Methods This is a prospective study. We have analyzed 139 patients who underwent surgery for chronic otitis media (COM) of the mucosal type. All of the surgeries were performed exclusively under total endoscopic transcanal approach using tragal cartilage as graft, underlay technique. We have evaluated the postoperative graft uptake and performed a hearing evaluation at 6 weeks, at 12 weeks, and at 6 months. Results During the study period, 139 patients were included, out of which 13 were lost to fol...
Source: International Archives of Otorhinolaryngology - May 31, 2019 Category: ENT & OMF Authors: Shakya, Dipesh KC, Arun Nepal, Ajit Tamang, Nirmala Tags: Original Research Source Type: research

Middle Cranial Fossa Encephalocele and Cerebrospinal Fluid Leakage: Etiology, Approach, Outcomes
Conclusions Middle cranial fossa tegmen defects are most commonly seen in obese females and are spontaneous in origin. The most common location was the tegmen mastoideum, and these defects were most commonly repaired through the transmastoid approach, with no greater risk of recurrence. [...] Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Journal of Neurological Surgery Part B: Skull Base)
Source: Journal of Neurological Surgery Part B: Skull Base - May 28, 2019 Category: Neurosurgery Authors: McNulty, Beth Schutt, Christopher A. Bojrab, Dennis Babu, Seilesh Tags: Original Article Source Type: research

Pneumococcal conjugate vaccines for preventing acute otitis media in children.
CONCLUSIONS: Administration of the licenced CRM197-PCV7 and PHiD-CV10 during early infancy is associated with large relative risk reductions in pneumococcal AOM. However, the effects of these vaccines on all-cause AOM is far more uncertain. We found no evidence of a beneficial effect on all-cause AOM of administering PCVs in high-risk infants, after early infancy (i.e. in children one year and above), and in older children with a history of respiratory illness. Compared to control vaccines, PCVs were associated with an increase in mild local reactions (redness, swelling), fever, and pain and/or tenderness. We found no evid...
Source: Cochrane Database of Systematic Reviews - May 28, 2019 Category: General Medicine Authors: Fortanier AC, Venekamp RP, Boonacker CW, Hak E, Schilder AG, Sanders EA, Damoiseaux RA Tags: Cochrane Database Syst Rev Source Type: research

Simultaneous Bilateral Same-Day Endoscopic Myringoplasty Using Tragal Cartilage From One Ear.
Abstract The aim of this study is to investigate the outcomes of bilateral same-day endoscopic myringoplasty using tragal cartilage from one ear in patients with bilateral chronic otitis media. In this retrospective study, medical records of 62 (84 ears) patients aged between 18 and 65 years who underwent endoscopic myringoplasty at our center between January 2015 and December 2017 were evaluated. Patients were classified into 2 groups according to surgical procedure they received: unilateral myringoplasty (group 1) and bilateral same-day myringoplasty (group 2). The comparisons were made between groups in terms o...
Source: Ear, Nose and Throat Journal - May 28, 2019 Category: ENT & OMF Authors: Deniz B, Ihsan K, Ismail G, Oguzhan KR, Muge O Tags: Ear Nose Throat J Source Type: research

[Recurrent infections of the upper aerodigestive tract in patients with primary immunodeficiency].
CONCLUSION: The prevalence of ENT infections in patients with a primary immunodeficiency is increased compared to the normal population. For the ENT specialist, these findings underline the necessity of including primary immunodeficiency in the differential diagnosis and initiating targeted diagnostic methods where indicated. Interdisciplinary collaboration with rheumatologists and immunologists is highly recommended, particularly for pediatric patients. PMID: 31119330 [PubMed - as supplied by publisher] (Source: HNO)
Source: HNO - May 25, 2019 Category: ENT & OMF Tags: HNO Source Type: research

Measles Hospitalizations at a United States Children’s Hospital 2011–2017
Conclusions: Clinicians should be aware of measles complications and treatment. Public and private health efforts should continue to focus on immunization, given significant implications of measles infections for patients and healthcare systems. Future studies may assess complications of measles across the United States as individual outbreaks often occur in specific populations, making generalization of results challenging. (Source: The Pediatric Infectious Disease Journal)
Source: The Pediatric Infectious Disease Journal - May 25, 2019 Category: Infectious Diseases Tags: Original Studies Source Type: research

Etiology of Childhood Otorrhea in Luanda, Angola, and a Review of Otitis Media in African Children
Conclusions: In Angola, Gram-negative rods emerged as common causative agents of otorrhea in children followed by S. aureus. The magnitude of chronic otorrhea in Africa represents a cause for public health concern. (Source: The Pediatric Infectious Disease Journal)
Source: The Pediatric Infectious Disease Journal - May 25, 2019 Category: Infectious Diseases Tags: Original Studies Source Type: research

Respiratory Microbiota Predicts Clinical Disease Course of Acute Otorrhea in Children With Tympanostomy Tubes
Background: Acute otitis media (AOM) is one of the most common childhood infections, generally thought to be caused by ascension of bacteria from the nasopharynx (NP) to the middle ear. Using 16S ribosomal RNA–based sequencing, we evaluated the relationship between the NP and middle ear fluid (MEF) microbiota in children with AOM with tympanostomy tubes (AOMT) as a proxy for AOM and explored whether microbiota profiling predicts natural disease course. Methods: Microbiota profiles of paired NP and MEF samples of 94 children below 5 years of age with uncomplicated AOMT were determined. Results: Local diversity...
Source: The Pediatric Infectious Disease Journal - May 25, 2019 Category: Infectious Diseases Tags: Translational Medicine Reports Source Type: research

Anaerobic Bacteriological Profile of Brain Abscess in a Tertiary Care Center in Southern India.
This study was done to determine the anaerobic bacteriological profile of brain abscess, their distribution according to sociodemographic variables, anatomical location, management and the outcome during the subjects' stay in a neurosciences' speciality hospital. We included 190 cases of confirmed anaerobic brain abscess from the year 1998 to 2017. The median age was 22 years with more males (73% of 190 cases) than females. The Bacteroides spp. were the most common (64%) anaerobic organisms isolated followed by Gram positive anaerobic cocci (51%). While 67% of the samples showed purely anaerobic bacteria on culture, remain...
Source: Anaerobe - May 24, 2019 Category: Microbiology Authors: Shruthi U, Prabhu Raj AR, Kumari H B V, Nagarathna C Tags: Anaerobe Source Type: research

Consensus on treatment of obstructive Eustachian tube dysfunction with balloon Eustachian tuboplasty.
CONCLUSIONS: BET is a surgical, minimally invasive treatment that has shown its effectiveness and safety in obstructive Eustachian tube dysfunction in adults and children. It is most effective in barotrauma and serous otitis media. PMID: 31133274 [PubMed - as supplied by publisher] (Source: Acta Otorrinolaringologica Espanola)
Source: Acta Otorrinolaringologica Espanola - May 24, 2019 Category: ENT & OMF Authors: Plaza G, Navarro JJ, Alfaro J, Sandoval M, Marco J Tags: Acta Otorrinolaringol Esp Source Type: research

Effect of a participatory intervention in women ’s self-help groups for the prevention of chronic suppurative otitis media in their children in Jumla Nepal: a cluster-randomised trial
Chronic suppurative otitis media (CSOM) causes preventable deafness and disproportionately affects children living in poverty. Our hypothesis was that health promotion in women ’s groups would increase their kn... (Source: BMC Pediatrics)
Source: BMC Pediatrics - May 23, 2019 Category: Pediatrics Authors: Susan Clarke, Robyn Richmond, Heather Worth, Rajendra Wagle and Andrew Hayen Tags: Research article Source Type: research

Clinical, Immunological, and Genetic Features in Patients with Activated PI3K δ Syndrome (APDS): a Systematic Review
AbstractActivated phosphoinositide 3-kinase delta syndrome (APDS) is a novel primary immunodeficiency (PID) caused by heterozygous gain of function mutations in PI3K δ catalytic p110δ (PIK3CD) or regulatory p85 α (PIK3R1) subunits leading to APDS1 and APDS2, respectively. Patients with APDS present a spectrum of clinical manifestations, particularly recurrent respiratory infections and lymphoproliferation. We searched PubMed, Web of Science, and Scopus databases for APDS patients and screened for eligibility criteria. A total of 243 APDS patients were identified from 55 articles. For all patients, demogra...
Source: Clinical Reviews in Allergy and Immunology - May 21, 2019 Category: Allergy & Immunology Source Type: research

Effect of CT manifestations of cholesteatoma on MMP-2, MMP-9 and IL-6 in the serum of patients.
Authors: Wu Y, Tang X, Shao W, Lu Y Abstract Effect of CT manifestations of cholesteatomatous otitis media on matrix metalloproteinase-2 (MMP-2), matrix metalloproteinase-9 (MMP-9) and interleukin-6 (IL-6) in the serum of patients was investigated. A total of 176 patients with cholesteatomatous otitis media were enrolled as the study group and 181 patients with simple otitis media were enrolled as the control group. Patients were admitted to the Changxing People's Hospital from January 2010 to December 2016. The patients in the study group were classified according to the 64-row spiral CT diagnosis. The expression ...
Source: Experimental and Therapeutic Medicine - May 17, 2019 Category: General Medicine Tags: Exp Ther Med Source Type: research

[Research Articles] Detecting middle ear fluid using smartphones
We present an accessible solution that uses speakers and microphones within existing smartphones to detect middle ear fluid by assessing eardrum mobility. We conducted a clinical study on 98 patient ears at a pediatric surgical center. Using leave-one-out cross-validation to estimate performance on unseen data, we obtained an area under the curve (AUC) of 0.898 for the smartphone-based machine learning algorithm. In comparison, commercial acoustic reflectometry, which requires custom hardware, achieved an AUC of 0.776. Furthermore, we achieved 85% sensitivity and 82% specificity, comparable to published performance measure...
Source: Science Translational Medicine - May 15, 2019 Category: Biomedical Science Authors: Chan, J., Raju, S., Nandakumar, R., Bly, R., Gollakota, S. Tags: Research Articles Source Type: research

Chemically Assisted Dissection With Sodium 2-Mercaptoethanesulfonate (MESNA) in the Surgical Management of Pediatric Cholesteatoma
Objective: To evaluate the effectiveness of the chemically assisted dissection with sodium 2-mercaptoethanesulfonate (MESNA), in the reduction of residual and recurrent cholesteatoma after mastoidectomy in children with chronic cholesteatomatous otitis media (CCOM). Study Design: Retrospective case–control study. Setting: Tertiary referral center. Population: One hundred forty mastoidectomies performed in patients under 18 years of age for the treatment of CCOM. Interventions: Chemically assisted dissection (CAD) with MESNA compared with surgical dissection without MESNA. Main Outcome Measures: Recid...
Source: Otology and Neurotology - May 14, 2019 Category: ENT & OMF Tags: PEDIATRIC OTOLOGY Source Type: research

Chronic Otitis Media and its Correlation with Unilateral Sensorineural Hearing Loss in a Tertiary Care Centre of North India
In this study, 840 patients of unilateral COM were included. Audiometry was done and data analyzed. Majority of patients showing SNHL had COM for over a period of 5 years. Squamosal disease showed early progression to SNHL than mucosal disease. Higher frequencies were found to be more affect ed and maximum bone gap was seen at 4000 Hz. There was significant difference in mean bone conduction threshold between diseased ear and normal ear at all frequencies (p value  
Source: Indian Journal of Otolaryngology and Head and Neck Surgery - May 13, 2019 Category: ENT & OMF Source Type: research

Otitis Externa.
CONCLUSION: With correct assessment of the different types of otitis externa, rapidly effective targeted treatment can be initi- ated, so that complications will be avoided and fewer cases will progress to chronic disease. PMID: 31064650 [PubMed - in process] (Source: Deutsches Arzteblatt International)
Source: Deutsches Arzteblatt International - May 10, 2019 Category: General Medicine Tags: Dtsch Arztebl Int Source Type: research

Management of Acquired Cholesteatoma Associated With Patulous Eustachian Tube and Habitual Sniffing.
Authors: Choi SW, Lee DJ, Lee SH, Oh SJ, Kong SK Abstract Objectives: To investigate the effect of surgical treatment with eustachian tube (ET) catheter insertion in patients with acquired cholesteatoma associated with patulous eustachian tube (PET) and habitual sniffing. Methods: Nine ears of nine patients (two men and seven women; age, 20 to 65 years; average, 37.9±12.0 years) of acquired cholesteatoma associated with PET and habitual sniffing who underwent cholesteatoma surgery with simultaneous additional ET catheter insertion were examined in this study. Successful treatment was defined as stoppage ...
Source: Clinical and Experimental Otorhinolaryngology - May 10, 2019 Category: ENT & OMF Tags: Clin Exp Otorhinolaryngol Source Type: research

Subversion of host immune responses by otopathogens during otitis media.
The objective of this review article is to discuss our current understanding about the mechanisms through which otopathogens escape host immunity to induce OM. A better knowledge about the molecular mechanisms leading to subversion of host immune responses will provide novel clues to develop effective treatment modalities for OM. PMID: 31075181 [PubMed - as supplied by publisher] (Source: Journal of Leukocyte Biology)
Source: Journal of Leukocyte Biology - May 10, 2019 Category: Hematology Authors: Parrish JM, Soni M, Mittal R Tags: J Leukoc Biol Source Type: research

Expression of Endoplasmic Reticulum Stress-Related mRNAs in Chronic Otitis Media
Conclusions: sXBP1 appears to be involved in chronic otitis media-associated inflammation, including otorrhea. ATF6 is associated with the destruction of ossicles. Our results suggest that certain ER stress-related genes are expressed in chronic otitis media-associated inflammation.ORL (Source: ORL)
Source: ORL - May 5, 2019 Category: ENT & OMF Source Type: research