A multi-centre, pragmatic, three-arm, individually randomised, non-inferiority, open trial to compare immediate orally administered, immediate topically administered or delayed orally administered antibiotics for acute otitis media with discharge in children: The Runny Ear Study (REST): study protocol
DiscussionIt is unclear whether prescribing orally administered antibiotics to children with AOMd results in a reduction in symptoms or a shorter duration of illness. The REST trial should allow us to compare the non-inferiority of: immediate topically administered ciprofloxacin ear drops, or delayed orally administered amoxicillin (clarithromycin) against immediate orally administered amoxicillin (clarithromycin). We aim to recruit 399 patients from 175 practices in the UK. Using the TRANSFoRm software to randomise participants to the trial will enable recruitment for a relatively uncommon condition.Trial registrationName...
Source: Trials - June 2, 2020 Category: Research Source Type: clinical trials
Wideband Tympanometry in Otitis Media With Effusion
Condition: Otitis Media With Effusion Intervention: Diagnostic Test: Wideband Tympanometry Sponsor: Pamukkale University Completed (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - May 20, 2020 Category: Research Source Type: clinical trials
V114 and Acute Otitis Media (V114-032/PNEU-ERA)
Condition: Acute Otitis Media (AOM) Interventions: Biological: V114; Other: Pediatric vaccines Sponsor: Merck Sharp & Dohme Corp. Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - December 10, 2019 Category: Research Source Type: clinical trials
