Fungal Infections of the External Auditory Canal and Emerging Pathogens
Fungal infections of the external auditory canal can range from common (otomycosis) to life threatening (necrotizing otitis externa). Proper identification of fungal pathogens is necessary to guide appropriate therapy, and a high index of suspicion for fungal causes of ear canal disease is critical. Fungal pathogens may be an especially important cause of ear canal disease in certain populations, including patients with diabetes, patients recently treated with antibiotics, and immunosuppressed patients. Opportunistic fungal infections of the ear canal are an emerging concern. (Source: Otolaryngologic clinics of North America)
Source: Otolaryngologic clinics of North America - August 7, 2023 Category: ENT & OMF Authors: Erika McCarty Walsh, Matthew B. Hanson Source Type: research

< em > Pseudomonas aeruginosa < /em > -induced mitochondrial dysfunction inhibits proinflammatory cytokine secretion and enhances cytotoxicity in mouse macrophages in a reactive oxygen species (ROS)-dependent way
J Zhejiang Univ Sci B. 2023 Aug 1:1-11. doi: 10.1631/jzus.B2300051. Online ahead of print.ABSTRACTPseudomonas aeruginosa belongs to the genus Pseudomonas and is a common Gram-negative, exclusively aerobic, conditionally pathogenic bacterium with the characteristics of easy colonization, mutation, and multidrug resistance (Deng et al., 2015; Azam and Khan, 2019; Jurado-Martín et al., 2021). It is mainly distributed in the air, soil, water, intestinal tract, and skin surface of humans and domestic animals and can cause complications such as ulcerative keratitis, otitis externa, skin and soft tissue infections, respiratory i...
Source: J Zhejiang Univ Sci ... - August 1, 2023 Category: Science Authors: Haitao Yang Yan Wang Hui Fan Feixue Liu Huimiao Feng Xueqing Li Mingyi Chu Enzhuang Pan Daoyang Teng Huizhen Chen Jingquan Dong Source Type: research

< em > Pseudomonas aeruginosa < /em > -induced mitochondrial dysfunction inhibits proinflammatory cytokine secretion and enhances cytotoxicity in mouse macrophages in a reactive oxygen species (ROS)-dependent way
J Zhejiang Univ Sci B. 2023 Aug 1:1-11. doi: 10.1631/jzus.B2300051. Online ahead of print.ABSTRACTPseudomonas aeruginosa belongs to the genus Pseudomonas and is a common Gram-negative, exclusively aerobic, conditionally pathogenic bacterium with the characteristics of easy colonization, mutation, and multidrug resistance (Deng et al., 2015; Azam and Khan, 2019; Jurado-Martín et al., 2021). It is mainly distributed in the air, soil, water, intestinal tract, and skin surface of humans and domestic animals and can cause complications such as ulcerative keratitis, otitis externa, skin and soft tissue infections, respiratory i...
Source: J Zhejiang Univ Sci ... - August 1, 2023 Category: Science Authors: Haitao Yang Yan Wang Hui Fan Feixue Liu Huimiao Feng Xueqing Li Mingyi Chu Enzhuang Pan Daoyang Teng Huizhen Chen Jingquan Dong Source Type: research

< em > Pseudomonas aeruginosa < /em > -induced mitochondrial dysfunction inhibits proinflammatory cytokine secretion and enhances cytotoxicity in mouse macrophages in a reactive oxygen species (ROS)-dependent way
J Zhejiang Univ Sci B. 2023 Aug 1:1-11. doi: 10.1631/jzus.B2300051. Online ahead of print.ABSTRACTPseudomonas aeruginosa belongs to the genus Pseudomonas and is a common Gram-negative, exclusively aerobic, conditionally pathogenic bacterium with the characteristics of easy colonization, mutation, and multidrug resistance (Deng et al., 2015; Azam and Khan, 2019; Jurado-Martín et al., 2021). It is mainly distributed in the air, soil, water, intestinal tract, and skin surface of humans and domestic animals and can cause complications such as ulcerative keratitis, otitis externa, skin and soft tissue infections, respiratory i...
Source: J Zhejiang Univ Sci ... - August 1, 2023 Category: Science Authors: Haitao Yang Yan Wang Hui Fan Feixue Liu Huimiao Feng Xueqing Li Mingyi Chu Enzhuang Pan Daoyang Teng Huizhen Chen Jingquan Dong Source Type: research

< em > Pseudomonas aeruginosa < /em > -induced mitochondrial dysfunction inhibits proinflammatory cytokine secretion and enhances cytotoxicity in mouse macrophages in a reactive oxygen species (ROS)-dependent way
J Zhejiang Univ Sci B. 2023 Aug 1:1-11. doi: 10.1631/jzus.B2300051. Online ahead of print.ABSTRACTPseudomonas aeruginosa belongs to the genus Pseudomonas and is a common Gram-negative, exclusively aerobic, conditionally pathogenic bacterium with the characteristics of easy colonization, mutation, and multidrug resistance (Deng et al., 2015; Azam and Khan, 2019; Jurado-Martín et al., 2021). It is mainly distributed in the air, soil, water, intestinal tract, and skin surface of humans and domestic animals and can cause complications such as ulcerative keratitis, otitis externa, skin and soft tissue infections, respiratory i...
Source: J Zhejiang Univ Sci ... - August 1, 2023 Category: Science Authors: Haitao Yang Yan Wang Hui Fan Feixue Liu Huimiao Feng Xueqing Li Mingyi Chu Enzhuang Pan Daoyang Teng Huizhen Chen Jingquan Dong Source Type: research

< em > Pseudomonas aeruginosa < /em > -induced mitochondrial dysfunction inhibits proinflammatory cytokine secretion and enhances cytotoxicity in mouse macrophages in a reactive oxygen species (ROS)-dependent way
J Zhejiang Univ Sci B. 2023 Aug 1:1-11. doi: 10.1631/jzus.B2300051. Online ahead of print.ABSTRACTPseudomonas aeruginosa belongs to the genus Pseudomonas and is a common Gram-negative, exclusively aerobic, conditionally pathogenic bacterium with the characteristics of easy colonization, mutation, and multidrug resistance (Deng et al., 2015; Azam and Khan, 2019; Jurado-Martín et al., 2021). It is mainly distributed in the air, soil, water, intestinal tract, and skin surface of humans and domestic animals and can cause complications such as ulcerative keratitis, otitis externa, skin and soft tissue infections, respiratory i...
Source: J Zhejiang Univ Sci ... - August 1, 2023 Category: Science Authors: Haitao Yang Yan Wang Hui Fan Feixue Liu Huimiao Feng Xueqing Li Mingyi Chu Enzhuang Pan Daoyang Teng Huizhen Chen Jingquan Dong Source Type: research

An Overview of Acute Otitis Externa
Acute otitis externa, cellulitis of the external auditory canal, is most frequently due to bacteria. Patients may present with otalgia, aural fullness, hearing loss, and otorrhea. Its diagnosis is a clinical one. Treatment is focused on analgesia, treating the underlying infection and preventing recurrence. (Source: Otolaryngologic clinics of North America)
Source: Otolaryngologic clinics of North America - July 27, 2023 Category: ENT & OMF Authors: Ann Woodhouse Plum, Michele Wong Source Type: research

Evaluation of in vitro activity of herbal formula Di Er You and herb Coptis against bacteria isolated from dogs with otitis externa
Am J Vet Res. 2023 Jul 29:1-7. doi: 10.2460/ajvr.23.03.0065. Online ahead of print.ABSTRACTOBJECTIVE: To determine the in vitro activity of the herbal formula Di Er You (DEY) and the single-herb Coptis against bacteria cultured from dogs with otitis externa.ANIMALS: 32 client-owned dogs diagnosed with otitis externa.METHODS: A sample of otic debris from each patient was collected and plated onto a fresh Sheep's Blood Agar plate in the hospital. After bacterial growth was confirmed, 4 wells were created, numbered randomly, and treated with saline (placebo), DEY, Coptis, and Zymox Otic Enzymatic Solution with 1% Hydrocortiso...
Source: American Journal of Veterinary Research - July 25, 2023 Category: Veterinary Research Authors: Jacquelyn N B Olson Deng-Shan Shiau Aituan Ma Source Type: research

Evaluation of in vitro activity of herbal formula Di Er You and herb Coptis against bacteria isolated from dogs with otitis externa
Am J Vet Res. 2023 Jul 29:1-7. doi: 10.2460/ajvr.23.03.0065. Online ahead of print.ABSTRACTOBJECTIVE: To determine the in vitro activity of the herbal formula Di Er You (DEY) and the single-herb Coptis against bacteria cultured from dogs with otitis externa.ANIMALS: 32 client-owned dogs diagnosed with otitis externa.METHODS: A sample of otic debris from each patient was collected and plated onto a fresh Sheep's Blood Agar plate in the hospital. After bacterial growth was confirmed, 4 wells were created, numbered randomly, and treated with saline (placebo), DEY, Coptis, and Zymox Otic Enzymatic Solution with 1% Hydrocortiso...
Source: American Journal of Veterinary Research - July 25, 2023 Category: Veterinary Research Authors: Jacquelyn N B Olson Deng-Shan Shiau Aituan Ma Source Type: research

Evaluation of in vitro activity of herbal formula Di Er You and herb Coptis against bacteria isolated from dogs with otitis externa
Am J Vet Res. 2023 Jul 29:1-7. doi: 10.2460/ajvr.23.03.0065. Online ahead of print.ABSTRACTOBJECTIVE: To determine the in vitro activity of the herbal formula Di Er You (DEY) and the single-herb Coptis against bacteria cultured from dogs with otitis externa.ANIMALS: 32 client-owned dogs diagnosed with otitis externa.METHODS: A sample of otic debris from each patient was collected and plated onto a fresh Sheep's Blood Agar plate in the hospital. After bacterial growth was confirmed, 4 wells were created, numbered randomly, and treated with saline (placebo), DEY, Coptis, and Zymox Otic Enzymatic Solution with 1% Hydrocortiso...
Source: American Journal of Veterinary Research - July 25, 2023 Category: Veterinary Research Authors: Jacquelyn N B Olson Deng-Shan Shiau Aituan Ma Source Type: research

Evaluation of in vitro activity of herbal formula Di Er You and herb Coptis against bacteria isolated from dogs with otitis externa
Am J Vet Res. 2023 Jul 29:1-7. doi: 10.2460/ajvr.23.03.0065. Online ahead of print.ABSTRACTOBJECTIVE: To determine the in vitro activity of the herbal formula Di Er You (DEY) and the single-herb Coptis against bacteria cultured from dogs with otitis externa.ANIMALS: 32 client-owned dogs diagnosed with otitis externa.METHODS: A sample of otic debris from each patient was collected and plated onto a fresh Sheep's Blood Agar plate in the hospital. After bacterial growth was confirmed, 4 wells were created, numbered randomly, and treated with saline (placebo), DEY, Coptis, and Zymox Otic Enzymatic Solution with 1% Hydrocortiso...
Source: American Journal of Veterinary Research - July 25, 2023 Category: Veterinary Research Authors: Jacquelyn N B Olson Deng-Shan Shiau Aituan Ma Source Type: research

Neoplasms of the Ear Canal
Primary EAC neoplasms include benign and malignant lesions of bony, glandular or cutaneous origin. Small, benign slow growing bony neoplasms are often asymptomatic, diagnosed incidentally and might not require intervention. Both malignant and benign neoplasms of cutaneous and glandular origin can present with symptoms of chronic otitis externa, leading to delays in diagnosis. Prompt biopsy of soft tissue lesions associated with non-resolving otitis externa are warranted. Local and regional imaging is helpful to understand disease extent and origin, but even early-stage malignant neoplasms require aggressive surgical treatm...
Source: Otolaryngologic clinics of North America - July 24, 2023 Category: ENT & OMF Authors: Mallory Raymond Source Type: research

Are Britains rivers safe for family recreational activities in 2023?
We have fond memories of spending our family summers playing in British rivers. However, the Environmental Agency (EA) highlights alarmingly frequent and prolonged discharges of untreated sewage into our rivers, through storm overflow spills1—averaging 825 spills each day, totalling nearly 1.8 million hours over 2022. Concerns must be raised whether all of these releases are necessary, and why none of our rivers now meet legal water quality standards. Clean water and sanitation is one of the most important modern public health interventions. As human excrement contains over 50 pathogens,2 the accidental ingestion of ...
Source: Archives of Disease in Childhood - July 19, 2023 Category: Pediatrics Authors: Philip, E., Finlay, F., Talbot, J. Tags: PostScript Source Type: research

Radiotherapy-induced Pathology of the Ear
Acute radiotherapy (RT)-induced external ear soft tissue changes start with erythema and dry desquamation and may progress to moist desquamation and epidermal ulceration. Chronic RT-induced changes include epithelial atrophy and subcutaneous fibrosis. Although RT-induced radiation dermatitis has been well studied, interventions for soft tissue disease involving the external auditory canal (EAC) warrant investigation. Medical management includes topical steroid treatment for EAC radiation dermatitis and topical antibiotic therapy for suppurative otitis externa. Hyperbaric oxygen and pentoxifylline –vitamin E therapy have ...
Source: Otolaryngologic clinics of North America - July 4, 2023 Category: ENT & OMF Authors: Kaitlyn A. Brooks, Jennifer H. Gross Source Type: research

Nanocrystalline silver for the treatment of otitis externa
ConclusionOut of 50 patients, 32 responded early to treatment, 15 were partial responders, and 3 did not respond to treatment. The antimicrobial and anti-inflammatory properties of silver, particularly when used in the nanocrystalline form, have been shown to be highly effective in managing this condition. Further research is warranted to fully explore the potential of nanocrystalline silver in treating otitis externa and other related conditions. (Source: Indian Journal of Otolaryngology and Head and Neck Surgery)
Source: Indian Journal of Otolaryngology and Head and Neck Surgery - July 3, 2023 Category: ENT & OMF Source Type: research