A systematic review focused on lubricant use and sperm quality: Improving human reproductive success by informing lubricants toxicity
AbstractLubricants play a pivotal role in human reproductive health, particularly concerning their impact on sperm parameters. In this systematic review, we assess the implications of both synthetic and natural or organic lubricants on sperm health and fertility, based on a compilation of 20 distinct studies. Synthetic lubricants, including K-Y Jelly, Replens, and Astroglide, predominantly containing ingredients like methylparaben and glycerin, have been linked to detrimental effects on sperm motility and chromatin integrity. Chemical characteristics, notably osmolality and pH, are central to understanding these effects. D...
Source: Journal of Applied Toxicology - January 31, 2024 Category: Toxicology Authors: Eloiza Adriane Dal Molin, Gabriel Adan Ara újo Leite, Virgínia Meneghini Lazzari Tags: REVIEW ARTICLE Source Type: research

Genes, Vol. 15, Pages 173: Extra Virgin Olive Oil Phenolic Compounds Modulate the Gene Expression of Biomarkers Involved in Fibroblast Proliferation and Differentiation
odríguez Extra virgin olive oil phenolic compounds have been identified as possible biostimulant agents against different pathological processes, including alterations in healing processes. However, there is little evidence on the molecular mechanisms involved in this process. The aim was to analyse the effect of hydroxytyrosol, tyrosol, and oleocanthal on fibroblast gene expression. PCR was used to determine the expression of different differentiation markers, extracellular matrix elements, and growth factors in cultured human fibroblasts CCD-1064Sk treated with different doses of hydroxytyrosol (10−5 M...
Source: Genes - January 28, 2024 Category: Genetics & Stem Cells Authors: Anabel Gonz ález-Acedo Rebeca Illescas-Montes Elvira de Luna-Bertos Concepci ón Ruiz Javier Ramos-Torrecillas Olga Garc ía-Martínez Luc ía Melguizo-Rodríguez Tags: Article Source Type: research

Molecules, Vol. 29, Pages 625: Extraction Optimization and Qualitative/Quantitative Determination of Bioactive Abietane-Type Diterpenes from Three Salvia Species (Common Sage, Greek Sage and Rosemary) by 1H-qNMR
The objective of this study was the optimization of the extraction process and the qualitative and quantitative determination of the bioactive metabolites: 12-O-methylcarnosic acid (12MCA), carnosic acid (CA), carnosol (CS), 7-O-methyl-epi-rosmanol (7MER) and rosmanol (RO) in infusions, decoctions, turbulent flow extracts, tinctures and oleolites from three Salvia species: Salvia officinalis L.(common sage, SO), Salvia fruticosa Mill.(Greek sage, SF) and Salvia rosmarinus Spenn (syn Rosmarinus officinalis L.) (rosemary, SR), using Quantitative Proton Nuclear Magnetic Resonance Spectroscopy (1H-qNMR). Regarding the aqueous ...
Source: Molecules - January 28, 2024 Category: Chemistry Authors: Panagiotis Kallimanis Prokopios Magiatis Angeliki Panagiotopoulou Kostas Ioannidis Ioanna Chinou Tags: Article Source Type: research

Molecules, Vol. 29, Pages 525: Chemical Data and Relationships for a Scoring Algorithm of Extra Virgin Olive Oil & rsquo;s Nutritional Value
Molecules, Vol. 29, Pages 525: Chemical Data and Relationships for a Scoring Algorithm of Extra Virgin Olive Oil’s Nutritional Value Molecules doi: 10.3390/molecules29020525 Authors: Lorenzo Cecchi Filippo Conticelli Bruno Zanoni Carlotta Breschi Maria Bellumori Nadia Mulinacci Extra virgin olive oil (EVOO) is a valuable product and is highly appreciated by consumers for its great nutritional value. However, to date, there has been a lack of uniform systems capable of ranking the nutritional value of EVOO based on its chemical composition in terms of macro- and micronutrients (including phenolic...
Source: Molecules - January 21, 2024 Category: Chemistry Authors: Lorenzo Cecchi Filippo Conticelli Bruno Zanoni Carlotta Breschi Maria Bellumori Nadia Mulinacci Tags: Article Source Type: research

Effect of Extra-Virgin Olive Oil on Hand Foot Syndrome and hs-CRP in Patients Receiving Capecitabine: A Randomized Trial
CONCLUSION: This study demonstrates the potential benefits of incorporating unrefined EVOO into the regimen of patients undergoing capecitabine chemotherapy. EVOO supplementation was associated with lower incidences of HFS and a reduction in hs-CRP levels, indicating its possible role in preventing HFS development and mitigating inflammation.PMID:38213043 (Source: Acta medica Indonesiana)
Source: Acta medica Indonesiana - January 12, 2024 Category: Internal Medicine Authors: Yenny Dian Andayani Mgs Irsan Saleh Aru Wisaksono Sudoyo Zulkhair Ali Legiran Legiran Radiyati Umi Partan Eddy Yuristo Fadhyl Zuhry Lubis Source Type: research