A review of obstructive sleep apnea and lung cancer: epidemiology, pathogenesis, and therapeutic options
Despite undeniable advances in modern medicine, lung cancer still has high morbidity and mortality rates. Lung cancer is preventable and treatable, and it is important to identify new risk factors for lung cancer, especially those that can be treated or reversed. Obstructive sleep apnea (OSA) is a very common sleep-breathing disorder that is grossly underestimated in clinical practice. It can cause, exacerbate, and worsen adverse outcomes, including death and various diseases, but its relationship with lung cancer is unclear. A possible causal relationship between OSA and the onset and progression of lung cancer has been e...
Source: Frontiers in Immunology - March 28, 2024 Category: Allergy & Immunology Source Type: research

A New Window to the Brain: Exosomes as a Promising Approach to Understand Mechanisms of Cognitive Deficits associated with Obstructive Sleep Apnea
Affecting nearly 1 billion individuals worldwide, obstructive sleep apnea (OSA) is a common, underdiagnosed, undertreated sleep disorder where airway collapse leads to intermittent hypoxic events while asleep (1). OSA is an independent risk factor for cognitive impairment, cognitive decline, and dementia. Studies have found consistent impairments in immediate recall, delayed recall, verbal and motor learning, attention, episodic memory, and executive functioning (2-4). Several studies have shown that the gold standard treatment for OSA, continuous positive airway pressure (CPAP), can improve cognitive domains including pro...
Source: The American Journal of Geriatric Psychiatry - March 28, 2024 Category: Geriatrics Authors: Ellen E. Lee Tags: Editorial Source Type: research

Corrigendum to 'Management of obstructive sleep apnea syndrome type 1 in children and adolescents - A French consensus' [Arch Pediatr (2023) 510-16]
Arch Pediatr. 2024 Mar 26:S0929-693X(24)00024-1. doi: 10.1016/j.arcped.2024.02.001. Online ahead of print.NO ABSTRACTPMID:38538468 | DOI:10.1016/j.arcped.2024.02.001 (Source: Archives de Pediatrie)
Source: Archives de Pediatrie - March 27, 2024 Category: Pediatrics Authors: G Aubertin M Akkari A Andrieux C Colas des Francs B Fauroux P Franco F Gagnadoux O Gallet de Santerre B Grollemund S Hartley D Jaffuel L Lafond C M Schr öder C Schweitzer C Charley-Monaca Source Type: research

Central sleep apnoea: not just one phenotype
Eur Respir Rev. 2024 Mar 27;33(171):230141. doi: 10.1183/16000617.0141-2023. Print 2024 Jan 31.ABSTRACTRecent scientific findings in the field of sleep disordered breathing have characterised a variety of phenotypes in obstructive sleep apnoea. These findings have prompted investigations aiming to achieve a more precise differentiation and description of the entities of central sleep apnoea (CSA). There is increasing evidence for the heterogeneity of CSA in terms of underlying aetiology, pathophysiological concepts, treatment response and outcome. Assigning patients to these phenotypes allows for the selection of individua...
Source: Respiratory Care - March 27, 2024 Category: Respiratory Medicine Authors: Winfried Randerath S ébastien Baillieul Renaud Tamisier Source Type: research

Can the width of lower tongue base preoperative sonography measurements predict hypoxemia during esophagogastroduodenoscopy under sedation in ASA I-II patients?
Conclusionsː The width of the lower tongue base, measured as the DLA by US examination can be used to effectively predict the risk of hypoxemia during EGD under sedation.PMID:38537186 | DOI:10.11152/mu-4326 (Source: Medical Ultrasonography)
Source: Medical Ultrasonography - March 27, 2024 Category: Radiology Authors: Hao Wu Min Xia Xu Chen Sheng Wang Wei Zhang Source Type: research

Central sleep apnoea: not just one phenotype
Recent scientific findings in the field of sleep disordered breathing have characterised a variety of phenotypes in obstructive sleep apnoea. These findings have prompted investigations aiming to achieve a more precise differentiation and description of the entities of central sleep apnoea (CSA). There is increasing evidence for the heterogeneity of CSA in terms of underlying aetiology, pathophysiological concepts, treatment response and outcome. Assigning patients to these phenotypes allows for the selection of individualised therapies. Major pathophysiological characteristics include loop gain, apnoeic threshold, breathi...
Source: European Respiratory Review - March 27, 2024 Category: Respiratory Medicine Authors: Randerath, W., Baillieul, S., Tamisier, R. Tags: Sleep medicine Sleep and Breathing Conference Reviews Source Type: research

The Alarming Rate of Malnutrition after Single Anastomosis Sleeve Ileal Bypass. A single Centre Experience
ConclusionDespite good short-term weight loss and improvement of obesity-associated complications, SASI is accompanied by high alarming malnutrition, even in short-term follow-up. Novel MBS should be judged for their long-term effects and compared to well-tested standard operations before they are used in routine clinical practice.Graphical Abstract (Source: Obesity Surgery)
Source: Obesity Surgery - March 27, 2024 Category: Surgery Source Type: research

Surgical Management of Pediatric Obstructive Sleep Apnea Beyond T & A – Tongue Base and Larynx
Pediatric patients with persistent obstructive sleep apnea (OSA) after adenotonsillectomy often have additional sites of upper airway obstruction such as the tongue base or larynx. Sleep endoscopy and cross-sectional, dynamic imaging can be used to direct the surgical management of persistent OSA. The tongue base is one of the most common sites of obstruction in children with persistent OSA, especially for patients with Trisomy 21. Lingual tonsillectomy, tongue suspension, and/or posterior midline glossectomy may be used to address lingual tonsil hypertrophy and tongue base obstruction. Epiglottopexy and/or supraglottoplas...
Source: Otolaryngologic clinics of North America - March 26, 2024 Category: ENT & OMF Authors: Matthew Maksimoski, Carol Li Source Type: research

Comorbid Insomnia and Sleep Apnea
Insomnia and obstructive sleep apnea (OSA) are 2 of the most prevalent sleep disorders and frequently co-occur. Cognitive behavioral therapy for insomnia is the first line treatment for insomnia and has been shown to improve compliance with positive airway pressure therapy. Other alternatives to OSA treatment may have higher acceptance in those with comorbid insomnia and sleep apnea (COMISA). Surgery, particularly hypoglossal nerve stimulation, appears to be well tolerated and may improve insomnia in those with COMISA. Otolaryngologists must be cognizant of the common presentation of COMISA in patients seeking surgical tre...
Source: Otolaryngologic clinics of North America - March 26, 2024 Category: ENT & OMF Authors: Kathleen M. Sarber, Reena Dhanda Patil Source Type: research

The Impact of Insomnia and Depression on Asthma Control
J Asthma. 2024 Mar 25:1-6. doi: 10.1080/02770903.2024.2335367. Online ahead of print.ABSTRACTPoor sleep quality is often reported by individuals with asthma, particularly by those who have poor asthma control overall. However, there is little understanding of how underlying sleep disorders such as insomnia may impact asthma control. Furthermore, given the frequent overlap of depression and insomnia, the incremental impact of mood disorders and insomnia on asthma control remains unclear.We conducted a retrospective analysis of patients at a large asthma center to further elucidate connections between these disease processes...
Source: Journal of Asthma - March 25, 2024 Category: Respiratory Medicine Authors: Sarah Rhoads Jack Edinger Aastha Khatiwada Joy Zimmer Pearlanne Zelarney Michael E Wechsler Source Type: research

Association of lipid-modifying therapy with risk of obstructive sleep apnea: A drug-target mendelian randomization study
CONCLUSIONS: The present study presented genetic evidence supporting the association of LDL-C-lowering therapy by CETP inhibition with reduced risk of OSA. These findings provided novel insights into the role of lipid management in patients with OSA and encouraged further clinical validations and mechanistic investigations.PMID:38521370 | DOI:10.1016/j.taap.2024.116909 (Source: Toxicology and Applied Pharmacology)
Source: Toxicology and Applied Pharmacology - March 23, 2024 Category: Toxicology Authors: Juanjuan Zou Shengnan Qi Xiaojing Sun Yijing Zhang Yan Wang Yanzhong Li Ze-Hua Zhao Dapeng Lei Source Type: research

Association of lipid-modifying therapy with risk of obstructive sleep apnea: A drug-target mendelian randomization study
CONCLUSIONS: The present study presented genetic evidence supporting the association of LDL-C-lowering therapy by CETP inhibition with reduced risk of OSA. These findings provided novel insights into the role of lipid management in patients with OSA and encouraged further clinical validations and mechanistic investigations.PMID:38521370 | DOI:10.1016/j.taap.2024.116909 (Source: Toxicology and Applied Pharmacology)
Source: Toxicology and Applied Pharmacology - March 23, 2024 Category: Toxicology Authors: Juanjuan Zou Shengnan Qi Xiaojing Sun Yijing Zhang Yan Wang Yanzhong Li Ze-Hua Zhao Dapeng Lei Source Type: research

Advances in Pharyngeal Surgery Over the Past 10  Years
This article is a review of advances in pharyngeal surgery over the past 10  years regarding literature, surgical technique, assessment, collaboration, and future direction in the management of adult and pediatric obstructive sleep apnea. (Source: Otolaryngologic clinics of North America)
Source: Otolaryngologic clinics of North America - March 23, 2024 Category: ENT & OMF Authors: Stuart G. Mackay, James D. Every Source Type: research

Management of Obstructive Sleep Apnea in the Infant and Newborn
Obstructive sleep apnea in newborns and infants presents a unique challenge with distinct differences in sleep physiology, etiologies, and management compared to older children. The indications for and interpretation of polysomnography are less well defined in infants. There are also no broadly accepted clinical practice guidelines for treating sleep apnea in this age group. Etiologies include general causes of upper airway obstruction in infants such as laryngomalacia, micrognathia, and nasal obstruction in addition to adenotonsillar hypertrophy. Treatment strategies must be tailored to the specific anatomic features and ...
Source: Otolaryngologic clinics of North America - March 23, 2024 Category: ENT & OMF Authors: Jillian N. Sanford, Derek J. Lam Source Type: research