Mediterranean diet in the targeted prevention and personalized treatment of chronic diseases: evidence, potential mechanisms, and prospects
AbstractThe prevalence of chronic diseases is currently a major public health issue worldwide and is exploding with the population growth and aging. Dietary patterns are well known to play a important role in our overall health and well-being, and therefore, poor diet and malnutrition are among the most critical risk factors for chronic disease. Thus, dietary recommendation and nutritional supplementation have significant clinical implications for the targeted treatment of some of these diseases. Multiple dietary patterns have been proposed to prevent chronic disease incidence, like Dietary Approaches to Stop Hypertension ...
Source: EPMA Journal - April 16, 2024 Category: International Medicine & Public Health Source Type: research
Robotic gastrectomy was reliable option for overweight patients with gastric cancer: a propensity score matching study
ConclusionRG conferred comparable lymph node dissection, postoperative recovery, and oncologic outcomes in a selected cohort of patients with BMI ≥ 25 kg/m2. (Source: Surgical Endoscopy)
Source: Surgical Endoscopy - April 16, 2024 Category: Surgery Source Type: research
A case of congenital hyperinsulinism presenting with diabetes after long-term diazoxide therapy
AbstractCongenital hyperinsulinism (CHI) is the most common form of persistent hypoglycemia in infants, and diazoxide is the most widely used drug for its treatment. Diazoxide suppresses insulin secretion and attenuates hypoglycemia by binding to sulfonylurea receptor 1 and activating KATP channels. While the short-term side effects of this drug, such as edema and blood cell abnormalities, are well known, the clinical course after its long-term oral administration remains unclear. Furthermore, there are currently no case reports clearly demonstrating a causal relationship between diazoxide and impaired glucose tolerance. W...
Source: Diabetology International - April 16, 2024 Category: Endocrinology Source Type: research
Patients with diabetes and obesity exhibit characteristics in eating and coping behaviors and personality traits
ConclusionsThese results suggest that there are some characteristics in eating and coping behaviors and some personality traits between obese and non-obese patients with diabetes. Treatment based on such characteristics may be useful for patients with diabetes and obesity. (Source: Diabetology International)
Source: Diabetology International - April 16, 2024 Category: Endocrinology Source Type: research
Impact of SGLT-2 inhibitors on modifiable cardiovascular risk factors in Romanian patients with type 2 diabetes mellitus
Modifiable cardiovascular risk factors are high blood pressure, smoking, diabetes, sedentary lifestyle, obesity, and hypercholesterolemia. (Source: Diabetology and Metabolic Syndrome)
Source: Diabetology and Metabolic Syndrome - April 16, 2024 Category: Endocrinology Authors: Adriana Gherbon, Mirela Frandes, Darius D îrpeş, Romulus Timar and Bogdan Timar Tags: Research Source Type: research
Precision Medicine in Bariatric Procedures
Obesity is a multi-factorial disease that is influenced by genetic, epigenetic, and environmental factors. Precision medicine is a practice wherein prevention and treatment strategies take individual variability into account. It involves using a variety of factors including deep phenotyping using clinical, physiologic, and behavioral characteristics, ‘omics assays (eg, genomics, epigenomics, transcriptomics, and microbiomics among others), and environmental factors to devise practices that are individualized to subsets of patients. Personalizing the therapeutic modality to the individual can lead to enhanced effectivenes...
Source: Gastrointestinal Endoscopy Clinics of North America - April 16, 2024 Category: Gastroenterology Authors: Khushboo Gala, Wissam Ghusn, Andres Acosta Source Type: research
Transgenic human C-reactive protein affects oxidative stress but not inflammation biomarkers in the aorta of spontaneously hypertensive rats
C-reactive protein (CRP) is an acute inflammatory protein detected in obese patients with metabolic syndrome. Moreover, increased CRP levels have been linked with atherosclerotic disease, congestive heart fail... (Source: BMC Cardiovascular Disorders)
Source: BMC Cardiovascular Disorders - April 16, 2024 Category: Cardiology Authors: Ivana Nemeckova, Samira Eissazadeh, Jana Urbankova Rathouska, Jan Silhavy, Hana Malinska, Michal Pravenec and Petr Nachtigal Tags: Research Source Type: research
Impact of obesity-related indicators on first-pass effect in patients with ischemic stroke receiving mechanical thrombectomy
ConclusionLower BMI, non-intracranial atherosclerotic stenosis, non-internal carotid artery occlusion, and lower TC levels were independently associated with increased rates of FPE in patients with AIS who received MT therapy. FPE was correlated with better clinical outcomes after MT. (Source: Neuroradiology)
Source: Neuroradiology - April 16, 2024 Category: Radiology Source Type: research
The impact of severe obesity on image quality and ventricular function assessment in echocardiography and cardiac MRI
This study sought to evaluate the impact of severe obesity on image quality and ventricular function assessment in cardiovascular magnetic resonance (MRI) and trans-thoracic echocardiography (TTE). We studied 100 consecutive patients who underwent clinically indicated cardiac MRI and TTE studies within 12 months between July 2017 and December 2020; 50 (28 females and 22 males; 54.5 ± 18.7 years) with normal body mass index (BMI) (18.5–25 kg/m2) and 50 (21 females and 29 males; 47.2 ± 13.3 years) with severe obesity (BMI ≥ 40 kg/m2). MRI and TTE image quality scores were compared within and across...
Source: The International Journal of Cardiovascular Imaging - April 16, 2024 Category: Radiology Source Type: research
Obesity drugs aren’t always forever. What happens when you quit?
Nature, Published online: 16 April 2024; doi:10.1038/d41586-024-01091-8Many researchers think that Wegovy and Ozempic should be taken for life, but myriad factors can force people off them. (Source: Nature AOP)
Source: Nature AOP - April 16, 2024 Category: Research Authors: McKenzie Prillaman Source Type: research
Circadian misalignment proxies, BMI, and chronic conditions: the role for weekday to weekend sleep differences
ConclusionsOur findings, which demonstrate that even a slight weekend sleep extension and variability of just 1 h is associated with higher values of BMI, suggest incorporating measures for sleep consistency and regularity into clinical protocols and public health guidelines to prevent and treat obesity and related diseases. (Source: Sleep and Breathing)
Source: Sleep and Breathing - April 16, 2024 Category: Respiratory Medicine Source Type: research
Response to Dr. Hung
(Source: Obesity Surgery)
Source: Obesity Surgery - April 16, 2024 Category: Surgery Source Type: research
Comments on: The impact of Aprepitant on Nausea and Vomiting Following Laparoscopic Sleeve Gastrectomy: A Blinded Randomized Controlled Trial
(Source: Obesity Surgery)
Source: Obesity Surgery - April 16, 2024 Category: Surgery Source Type: research
The Apo gene's genetic variants: hidden role in Asian vascular risk
AbstractVascular risk factors, including diabetes, hypertension, hyperlipidemia, and obesity, pose significant health threats with implications extending to neuropsychiatric disorders such as stroke and Alzheimer's disease. The Asian population, in particular, appears to be disproportionately affected due to unique genetic predispositions, as well as epigenetic factors such as dietary patterns and lifestyle habits. Existing management strategies often fall short of addressing these specific needs, leading to greater challenges in prevention and treatment. This review highlights a significant gap in our understanding of the...
Source: Neurogenetics - April 16, 2024 Category: Genetics & Stem Cells Source Type: research
Alpha lipoic acid administration improved both peripheral sensitivity to insulin and liver clearance of insulin reducing potential risk of diabetes and nonalcoholic fatty liver disease in overweight/obese PCOS patients
Volume 40, Issue 1, December 2024 . (Source: Gynecological Endocrinology)
Source: Gynecological Endocrinology - April 16, 2024 Category: Endocrinology Authors: Alessandro D. GenazzaniChristian BattipagliaLaura RusceGreta PrampoliniClaudia AioFrancesco RicciardielloMartina FoschiAlessandra SponzilliElisa SempriniTabatha PetrilloGynecological Endocrinology Center, Department of Obstetrics and Gynecology, Universit Source Type: research
