Mechanisms of spinophilin-dependent pancreas dysregulation in obesity
Am J Physiol Endocrinol Metab. 2024 Apr 17. doi: 10.1152/ajpendo.00099.2023. Online ahead of print.ABSTRACTSpinophilin is an F-actin binding and protein phosphatase 1 (PP1) targeting protein that acts as a scaffold of PP1 to its substrates. Spinophilin knockout (Spino-/-) mice have decreased fat mass, increased lean mass, and improved glucose tolerance, with no difference in feeding behaviors. While spinophilin is enriched in neurons, its roles in non-neuronal tissues, such as beta cells of the pancreatic islets, are unclear. We have corroborated and expanded upon previous studies to determine that Spino-/- mice have decre...
Source: American Journal of Physiology. Endocrinology and Metabolism - April 17, 2024 Category: Physiology Authors: Kaitlyn C Stickel Nikhil R Shah Emily T Claeboe Kara S Orr Amber L Mosley Emma H Doud Teri L Belecky-Adams Anthony J Baucum Source Type: research
A systematic review of the effect of semaglutide on lean mass: insights from clinical trials
CONCLUSION: Semaglutide displays potential for weight loss primarily through fat mass reduction. However, concerns arise from notable reductions in lean mass, especially in trials with a larger number of patients.PMID:38629387 | DOI:10.1080/14656566.2024.2343092 (Source: Expert Opinion on Pharmacotherapy)
Source: Expert Opinion on Pharmacotherapy - April 17, 2024 Category: Drugs & Pharmacology Authors: Alexia Bikou Foteini Dermiki-Gkana Michail Penteris Theodoros K Constantinides Christos Kontogiorgis Source Type: research
Caveolin-2 palmitoylation turnover facilitates insulin receptor substrate-1-directed lipid metabolism by insulin receptor tyrosine kinase
Biochim Biophys Acta Mol Basis Dis. 2024 Apr 15:167173. doi: 10.1016/j.bbadis.2024.167173. Online ahead of print.ABSTRACTHere, we show that insulin induces palmitoylation turnover of Caveolin-2 (Cav-2) in adipocytes. Acyl protein thioesterases-1 (APT1) catalyzes Cav-2 depalmitoylation, and zinc finger DHHC domain-containing protein palmitoyltransferase 21 (ZDHHC21) repalmitoylation of the depalmitoylated Cav-2 for the turnover, thereby controlling insulin receptor (IR)-Cav-2-insulin receptor substrate-1 (IRS-1)-Akt-driven signaling. Insulin-induced palmitoylation turnover of Cav-2 facilitated glucose uptake and fat storage...
Source: Biochimica et Biophysica Acta - April 17, 2024 Category: Biochemistry Authors: Moonjeong Choi Jaewoong Lee Kyuho Jeong Yunbae Pak Source Type: research
Association between Maternal Body Mass Index and Fetal Acidosis in Term Twin Pregnancies: A Retrospective Cohort Study
CONCLUSION: Maternal BMI was not associated with fetal acidosis in term twin pregnancies. Further research is required to corroborate study findings due to small sample size.PMID:38631433 | DOI:10.1016/j.jogc.2024.102464 (Source: Journal of Obstetrics and Gynaecology Canada : JOGC)
Source: Journal of Obstetrics and Gynaecology Canada : JOGC - April 17, 2024 Category: OBGYN Authors: Najla Tabbara Najmus Sehr Ansari Hemasree Kandraju Cynthia V Maxwell Vibhuti Shah Source Type: research
Maternal prepregnancy weight as an independent risk factor for congenital heart defects: systematic review and meta-analysis stratified by cardiac defect subtypes and severity
CONCLUSIONS: Maternal weight emerged as a crucial modifiable risk factor for preventing CHDs, particularly the severe forms. Future research is needed to investigate whether weight management prior to pregnancy might serve as a preventive measure against CHDs. Additionally, for pregnant women with obesity, fetal echocardiography ought to be a routine diagnostic procedure. This article is protected by copyright. All rights reserved.PMID:38629488 | DOI:10.1002/uog.27659 (Source: The Ultrasound Review of Obstetrics and Gynecology)
Source: The Ultrasound Review of Obstetrics and Gynecology - April 17, 2024 Category: Radiology Authors: N Salmeri A Seidenari P I Cavoretto M Papale M Candiani A Farina Source Type: research
Discontinuation of blood pressure-lowering, glucose-lowering, and lipid-lowering medications after bariatric surgery in patients with morbid obesity: a nationwide cohort study in South Korea
CONCLUSIONS: BS was associated with a decrease in the use of medications for hypertension, diabetes mellitus (DM), and dyslipidemia.PMID:38631926 | DOI:10.1016/j.soard.2024.03.008 (Source: Surgery for Obesity and Related Diseases : official journal of the American Society for Bariatric Surgery)
Source: Surgery for Obesity and Related Diseases : official journal of the American Society for Bariatric Surgery - April 17, 2024 Category: Surgery Authors: Soo Min Jeon Yeongkeun Kwon Dohyang Kim Jinseub Hwang Yoonseok Heo Sungsoo Park Jin-Won Kwon Source Type: research
Unhealthy Food and Beverage Marketing to Children in the Digital Age: Global Research and Policy Challenges and Priorities
Annu Rev Nutr. 2024 Apr 17. doi: 10.1146/annurev-nutr-062322-014102. Online ahead of print.ABSTRACTFood and nonalcoholic beverage marketing is implicated in poor diet and obesity in children. The rapid growth and proliferation of digital marketing has resulted in dramatic changes to advertising practices and children's exposure. The constantly evolving and data-driven nature of digital food marketing presents substantial challenges for researchers seeking to quantify the impact on children and for policymakers tasked with designing and implementing restrictive policies. We outline the latest evidence on children's experien...
Source: Annual Review of Nutrition - April 17, 2024 Category: Nutrition Authors: Emma Boyland Kathryn Backholer Monique Potvin Kent Marie A Bragg Fiona Sing Tilakavati Karupaiah Bridget Kelly Source Type: research
Mechanistic correlation of molecular pathways in obesity-mediated stroke pathogenesis
Pharmacol Rep. 2024 Apr 18. doi: 10.1007/s43440-024-00590-9. Online ahead of print.ABSTRACTObesity, a prominent risk factor for the development of heart attacks and several cardiovascular ailments. Obesity ranks as the second most significant avoidable contributor to mortality, whereas stroke stands as the second leading cause of death on a global scale. While changes in lifestyle have been demonstrated to have significant impacts on weight management, the long-term weight loss remains challenging, and the global prevalence of obesity continues to rise. The pathophysiology of obesity has been extensively studied during the...
Source: Pharmacological Reports - April 17, 2024 Category: Drugs & Pharmacology Authors: Heena Khan Chanchal Tiwari Palak Kalra Daksha Vyas Amarjot Kaur Grewal Thakur Gurjeet Singh Source Type: research
Mechanisms of spinophilin-dependent pancreas dysregulation in obesity
Am J Physiol Endocrinol Metab. 2024 Apr 17. doi: 10.1152/ajpendo.00099.2023. Online ahead of print.ABSTRACTSpinophilin is an F-actin binding and protein phosphatase 1 (PP1) targeting protein that acts as a scaffold of PP1 to its substrates. Spinophilin knockout (Spino-/-) mice have decreased fat mass, increased lean mass, and improved glucose tolerance, with no difference in feeding behaviors. While spinophilin is enriched in neurons, its roles in non-neuronal tissues, such as beta cells of the pancreatic islets, are unclear. We have corroborated and expanded upon previous studies to determine that Spino-/- mice have decre...
Source: Am J Physiol Endocri... - April 17, 2024 Category: Endocrinology Authors: Kaitlyn C Stickel Nikhil R Shah Emily T Claeboe Kara S Orr Amber L Mosley Emma H Doud Teri L Belecky-Adams Anthony J Baucum Source Type: research
Metabolic outcomes in obese mice undergoing one-anastomosis gastric bypass (OAGB) with a long or a short biliopancreatic limb
Am J Physiol Endocrinol Metab. 2024 Apr 17. doi: 10.1152/ajpendo.00327.2023. Online ahead of print.ABSTRACTOne-anastomosis gastric bypass (OAGB) has gained importance as a safe and effective operation to treat morbid obesity. It is not known whether a long biliopancreatic limb (BPL) in OAGB surgery compared to a short BPL results in beneficial metabolic outcomes. 5-week-old male C57BL/6J mice fed a high-fat diet for 8 weeks underwent OAGB surgery with defined short and long BPL lengths, or sham surgery combined with caloric restriction. Weight loss, glucose tolerance, obesity-related comorbidities, endocrine effects, gut m...
Source: Am J Physiol Endocri... - April 17, 2024 Category: Endocrinology Authors: Ioannis I Lazaridis Angela J T Bosch Lena Keller Andy J Y Low Jeanne Tamarelle Seraina O Moser Denise V Winter Cristina G ómez Caspar J Peterson Romano Schneider Marko Kraljevi ć Alex Odermatt Pascale Vonaesch Ralph Peterli Tarik Delko Claudia Cavelti-W Source Type: research
Mechanistic correlation of molecular pathways in obesity-mediated stroke pathogenesis
Pharmacol Rep. 2024 Apr 18. doi: 10.1007/s43440-024-00590-9. Online ahead of print.ABSTRACTObesity, a prominent risk factor for the development of heart attacks and several cardiovascular ailments. Obesity ranks as the second most significant avoidable contributor to mortality, whereas stroke stands as the second leading cause of death on a global scale. While changes in lifestyle have been demonstrated to have significant impacts on weight management, the long-term weight loss remains challenging, and the global prevalence of obesity continues to rise. The pathophysiology of obesity has been extensively studied during the...
Source: Pharmacological Reports - April 17, 2024 Category: Drugs & Pharmacology Authors: Heena Khan Chanchal Tiwari Palak Kalra Daksha Vyas Amarjot Kaur Grewal Thakur Gurjeet Singh Source Type: research
Mechanisms of spinophilin-dependent pancreas dysregulation in obesity
Am J Physiol Endocrinol Metab. 2024 Apr 17. doi: 10.1152/ajpendo.00099.2023. Online ahead of print.ABSTRACTSpinophilin is an F-actin binding and protein phosphatase 1 (PP1) targeting protein that acts as a scaffold of PP1 to its substrates. Spinophilin knockout (Spino-/-) mice have decreased fat mass, increased lean mass, and improved glucose tolerance, with no difference in feeding behaviors. While spinophilin is enriched in neurons, its roles in non-neuronal tissues, such as beta cells of the pancreatic islets, are unclear. We have corroborated and expanded upon previous studies to determine that Spino-/- mice have decre...
Source: American Journal of Physiology. Endocrinology and Metabolism - April 17, 2024 Category: Physiology Authors: Kaitlyn C Stickel Nikhil R Shah Emily T Claeboe Kara S Orr Amber L Mosley Emma H Doud Teri L Belecky-Adams Anthony J Baucum Source Type: research
Metabolic outcomes in obese mice undergoing one-anastomosis gastric bypass (OAGB) with a long or a short biliopancreatic limb
Am J Physiol Endocrinol Metab. 2024 Apr 17. doi: 10.1152/ajpendo.00327.2023. Online ahead of print.ABSTRACTOne-anastomosis gastric bypass (OAGB) has gained importance as a safe and effective operation to treat morbid obesity. It is not known whether a long biliopancreatic limb (BPL) in OAGB surgery compared to a short BPL results in beneficial metabolic outcomes. 5-week-old male C57BL/6J mice fed a high-fat diet for 8 weeks underwent OAGB surgery with defined short and long BPL lengths, or sham surgery combined with caloric restriction. Weight loss, glucose tolerance, obesity-related comorbidities, endocrine effects, gut m...
Source: American Journal of Physiology. Endocrinology and Metabolism - April 17, 2024 Category: Physiology Authors: Ioannis I Lazaridis Angela J T Bosch Lena Keller Andy J Y Low Jeanne Tamarelle Seraina O Moser Denise V Winter Cristina G ómez Caspar J Peterson Romano Schneider Marko Kraljevic Alex Odermatt Pascale Vonaesch Ralph Peterli Tarik Delko Claudia Cavelti-Wed Source Type: research
Serum levels of sirtuins, leptin and adiponectin in women with pregnancy-induced hypertension
CONCLUSIONS: High leptin levels in PIH women during 3rd trimester might be helpful to predict the necessity for a caesarian section. Blood levels of sirtuins 1, 3 and 6 measured after the 20th week of gestation cannot be regarded as a single diagnostic test for PIH or preeclampsia. More studies to clarify significance of sirtuins in PIH and PE development and diagnosis are needed.PMID:38631184 | DOI:10.1016/j.cyto.2024.156612 (Source: Cytokine)
Source: Cytokine - April 17, 2024 Category: Molecular Biology Authors: Magdalena Gola ńska-Wróblewska Jolanta Fryczak Agnieszka Siejka Source Type: research
Association between Maternal Body Mass Index and Fetal Acidosis in Term Twin Pregnancies: A Retrospective Cohort Study
CONCLUSION: Maternal BMI was not associated with fetal acidosis in term twin pregnancies. Further research is required to corroborate study findings due to small sample size.PMID:38631433 | DOI:10.1016/j.jogc.2024.102464 (Source: Journal of Obstetrics and Gynaecology Canada : JOGC)
Source: Journal of Obstetrics and Gynaecology Canada : JOGC - April 17, 2024 Category: OBGYN Authors: Najla Tabbara Najmus Sehr Ansari Hemasree Kandraju Cynthia V Maxwell Vibhuti Shah Source Type: research
