A Study to Evaluate the Safety and Preliminary Efficacy of ATA3219 in Participants With Relapsed/Refractory B-cell Non-Hodgkin Lymphoma
Conditions: Relapsed/Refractory B-cell Non-Hodgkin Lymphoma; Diffuse Large B-cell Lymphoma (DLBCL); DLBCL/High-grade B-cell Lymphoma With MYC and BCL2 Rearrangements; Anaplastic Lymphoma Kinase-Positive Large B-Cell Lymphoma; LBCL With IRF4 Rearrangement; High-grade B-cell Lymphoma With 11q Aberration; Epstein-Barr Virus-Positive DLBCL; DLBCL Associated With Chronic Inflammation; Fibrin-associated LBCL; Primary Cutaneous DLBCL, Leg Type; Intravascular LBCL; Primary Mediastinal LBCL; High-grade B-cell Lymphoma; DLBCL Arising From Transformed Indolent Lymphoma; Mediastinal Gray Zone Lymphoma; FL Grade 3B; MCL Interventions: ...
Source: ClinicalTrials.gov - February 13, 2024 Category: Research Source Type: clinical trials

Phase Ib Study of Rocbrutinib in Combination With R-CHOP in Patients With Newly Diagnosed B-cell Non-Hodgkin Lymphoma
Conditions: B-cell Non-Hodgkin Lymphoma Interventions: Drug: Rocbrutinib; Biological: Rituximab; Drug: Cyclophosphamide; Drug: doxorubicin; Drug: Vincristin; Drug: Prednisone Sponsors: Guangzhou Lupeng Pharmaceutical Company LTD. Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - February 9, 2024 Category: Research Source Type: clinical trials

Pembrolizumab and Tazemetostat to Overcome Immune Tolerance Following ASCT or CAR T-cell Therapy in Patients With Aggressive B-Cell Non-Hodgkin's Lymphoma
Conditions: B-Cell Non-Hodgkin Lymphoma Interventions: Procedure: Biospecimen Collection; Procedure: Computed Tomography; Procedure: Echocardiography; Biological: Pembrolizumab; Procedure: Positron Emission Tomography; Drug: Tazemetostat Sponsors: Northwestern University; National Cancer Institute (NCI) Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - February 5, 2024 Category: Research Source Type: clinical trials

Epcoritamab Compared to Observation for Treating B-cell Lymphoma Patients Not in Complete Remission After CD19-directed CAR-T Therapy
Conditions: Diffuse Large B-Cell Lymphoma, Not Otherwise Specified; Primary Mediastinal Large B-Cell Lymphoma; Transformed Indolent B-Cell Non-Hodgkin Lymphoma to Diffuse Large B-Cell Lymphoma Interventions: Procedure: Biopsy; Procedure: Biospecimen Collection; Procedure: Computed Tomography; Biological: Epcoritamab; Procedure: Magnetic Resonance Imaging; Other: Patient Observation; Procedure: Positron Emission Tomography Sponsors: Academic and Community Cancer Research United Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - February 2, 2024 Category: Research Source Type: clinical trials

A Trial to Learn How Effective and Safe Odronextamab is Compared to Standard of Care for Adult Participants With Previously Treated Aggressive B-cell Non-Hodgkin Lymphoma
Conditions: B-Cell Non-Hodgkin Lymphoma (B-NHL) Interventions: Drug: Odronextamab; Drug: Ifosfamide; Drug: Carboplatin; Drug: Etoposide; Drug: Rituximab; Drug: Dexamethasone; Drug: Cisplatin; Drug: Cytarabine; Drug: Gemcitabine Sponsors: Regeneron Pharmaceuticals Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 30, 2024 Category: Research Source Type: clinical trials

A Study of GLB-002 in Patients With Relapsed or Refractory Non-Hodgkin Lymphomas
Conditions: Non-Hodgkin Lymphoma Interventions: Drug: GLB-002 Sponsors: Hangzhou GluBio Pharmaceutical Co., Ltd. Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 23, 2024 Category: Research Source Type: clinical trials

This Phase I/II Trial Assesses Fourth-gen CAR T Cells Targeting CD19/CD22 for Highly Resistant B-cell Lymphomas (PMBCL/CNS-BCL). It Explores Safety, Efficacy, and Simplifying Cell Production, Enrolling Patients From Multiple Centers
Conditions: Acute Lymphoblastic Leukemia, Adult B-Cell; Acute Lymphoblastic Leukemia, in Relapse; Non-Hodgkin Lymphoma, B-cell; Diffuse Large B Cell Lymphoma; Central Nervous System Lymphoma; Lymphoma, Follicular; MCL Interventions: Biological: CD19/CD22-CAR T cells Sponsors: Essen Biotech Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 19, 2024 Category: Research Source Type: clinical trials

Fourth-gen CAR T Cells Targeting CD19/CD22 for Highly Resistant B-cell Lymphoma/Leukemia (PMBCL/CNS-BCL).
Conditions: Acute Lymphoblastic Leukemia, Adult B-Cell; Acute Lymphoblastic Leukemia, in Relapse; Non-Hodgkin Lymphoma, B-cell; Diffuse Large B Cell Lymphoma; Central Nervous System Lymphoma; Lymphoma, Follicular; MCL Interventions: Biological: CD19/CD22-CAR T cells Sponsors: Essen Biotech Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 19, 2024 Category: Research Source Type: clinical trials

C752 for Refractory/Relapsed B Cell Non-Hodgkin Lymphoma
Conditions: Lymphoma, B-Cell; CAR-T Interventions: Biological: C752 Sponsors: 920th Hospital of Joint Logistics Support Force of People ' s Liberation Army of China; Shanghai PerHum Therapeutics Co., Ltd. Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 18, 2024 Category: Research Source Type: clinical trials

CC-99282 + Rituximab Early Post CART for Non-Hodgkin's Lymphoma
Conditions: Recurrent B-Cell Non-Hodgkin Lymphoma; Recurrent Diffuse Large B-Cell Lymphoma; Recurrent Follicular Lymphoma; Recurrent High Grade B-Cell Lymphoma; Recurrent Primary Mediastinal Large B-Cell Lymphoma; Recurrent Transformed Indolent B-Cell Non-Hodgkin Lymphoma to Diffuse Large B-Cell Lymphoma; Refractory B-Cell Non-Hodgkin Lymphoma; Refractory Diffuse Large B-Cell Lymphoma; Refractory Follicular Lymphoma; Refractory High Grade B-Cell Lymphoma; Refractory Primary Mediastinal Large B-Cell Lymphoma; Refractory Transformed Indolent B-Cell Non-Hodgkin Lymphoma to Diffuse Large B-Cell Lymphoma Interventions: Procedur...
Source: ClinicalTrials.gov - January 17, 2024 Category: Research Source Type: clinical trials

CLIC-2201 for the Treatment of Relapsed/Refractory B Cell Malignancies
Conditions: B-Cell Leukemia; Non-Hodgkin ' s Lymphoma; B-cell Acute Lymphoblastic Leukemia; Diffuse Large B Cell Lymphoma; High-grade B-cell Lymphoma; Primary Mediastinal Large B-cell Lymphoma (PMBCL); Mantle Cell Lymphoma; B-cell Lymphoma Interventions: Biological: CLIC-2201 Sponsors: British Columbia Cancer Agency Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 17, 2024 Category: Research Source Type: clinical trials

F01 in the Treatment of Relapsed/Refractory Non-hodgkin's Lymphoma
Conditions: Non-Hodgkin ' s Lymphoma Interventions: Drug: After preconditioning with chemotherapy, F01 will be evaluated. Sponsors: Shanghai Simnova Biotechnology Co.,Ltd.; Wuhan Union Hospital, China Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 15, 2024 Category: Research Source Type: clinical trials

TGRX-814 Chinese Phase I/II in Patients With Hematological Malignancies
Conditions: Hematologic Malignancy; Non Hodgkin Lymphoma; Acute Myeloid Leukemia; Acute Lymphoblastic Leukemia, Adult; Myelodysplastic Syndromes Interventions: Drug: TGRX-814 Sponsors: Shenzhen TargetRx, Inc.; Institute of Hematology& Blood Diseases Hospital, China Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 15, 2024 Category: Research Source Type: clinical trials

The Pathogenesis and Prognostic Factors of Lymphoma
Conditions: Lymphoma; Hodgkin Lymphoma; Non-hodgkin Lymphoma Interventions: Other: Real-world regimen Sponsors: Shanghai Zhongshan Hospital Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 12, 2024 Category: Research Source Type: clinical trials

B-Cell Activating Factor Receptor (BAFFR)-Based Chimeric Antigen Receptor T-Cells With Fludarabine and Cyclophosphamide Lymphodepletion for the Treatment of Relapsed or Refractory B-cell Hematologic Malignancies
Conditions: B-Cell Non-Hodgkin Lymphoma; Recurrent Chronic Lymphocytic Leukemia; Recurrent Diffuse Large B-Cell Lymphoma; Recurrent Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Small Lymphocytic Lymphoma; Recurrent Transformed Chronic Lymphocytic Leukemia; Refractory Chronic Lymphocytic Leukemia; Refractory Diffuse Large B-Cell Lymphoma; Refractory Follicular Lymphoma; Refractory Mantle Cell Lymphoma; Refractory Marginal Zone Lymphoma; Refractory Small Lymphocytic Lymphoma; Refractory Transformed Chronic Lymphocytic Leukemia Interventions: Biological: Autologous BAFFR-tar...
Source: ClinicalTrials.gov - January 5, 2024 Category: Research Source Type: clinical trials