Johnson & Johnson Initiates Second Global Phase 3 Clinical Trial of its Janssen COVID-19 Vaccine Candidate
November 15, 2020 -- The Phase 3 ENSEMBLE study of the single-dose regimen of JNJ-78436735, the investigational vaccine candidate for the prevention of COVID-19 being developed by the Janssen Pharmaceutical Companies of Johnson & Johnson, continues to enroll and vaccinate study participants. ENSEMBLE is proceeding to enroll up to 60,000 participants worldwide.In addition to the single-dose regimen ENSEMBLE study, Janssen has now initiated the two-dose regimen ENSEMBLE 2 trial. ENSEMBLE 2 is a complementary, planned, pivotal, large-scale, multi-country Phase 3 trial that will study the safety and efficacy of a two-dose ...
Source: Johnson and Johnson - November 16, 2020 Category: Pharmaceuticals Tags: Our Company Source Type: news

Rural practices struggling to deliver 'urban-focused' PCN targets, NIHR report warns
GPs in rural areas are struggling to deliver primary care network (PCN) targets because national policy is built around 'leading light' networks in urban areas, a study has found. (Source: GP Online News)
Source: GP Online News - November 13, 2020 Category: Primary Care Tags: Primary care networks Source Type: news

New National Patient Recruitment Centres for late phase commercial clinical research
(NIHR Clinical Research Network Eastern) The National Institute for Health Research has launched five new Patient Recruitment Centres to enable more late phase commercial clinical research to be delivered within the NHS. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - November 12, 2020 Category: Infectious Diseases Source Type: news

People of Black and Asian ethnicity up to twice as likely to be infected with COVID-19 as those of White ethnicity
(National Institute for Health Research) People of Black ethnicity are twice as likely to be infected with COVID-19 compared to those of White ethnicity. People from Asian backgrounds are 1.5 times more likely to become infected with the virus compared to White individuals. Those of Asian ethnicities may be at higher risk of admission to an intensive therapy unit (ITU) and death. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - November 12, 2020 Category: Infectious Diseases Source Type: news

#8Investments to enable everyone, everywhere, to be physically active
Researchers from the University of Bristol and NIHR ARC West have contributed to the International Society for Physical Activity and Health (ISPAH) ‘ Eight Investments That Work for Physical Activity ‘ , released today [10 November]. (Source: University of Bristol news)
Source: University of Bristol news - November 10, 2020 Category: Universities & Medical Training Tags: Health, International, Research; Faculty of Health Sciences, Faculty of Health Sciences, Population Health Sciences, Faculty of Social Sciences and Law, Faculty of Social Sciences and Law, School for Policy Studies; Press Release Source Type: news

Confusion and tensions over PCNs despite their ‘early operational success’
Major system challenges have been uncovered during primary care networks’ first year of operation, according to a study for the National Institute for Health Research. (Source: HSJ)
Source: HSJ - November 10, 2020 Category: UK Health Source Type: news

National infection control campaigns led to a rapid decline in superbug infections in UK intensive care units, NIHR Dissemination Centre
Expert commentary is provided on research that found a 97% reduction in MRSA bloodstream infections in ICU patients between 2007 and 2016, and a 78% decrease in bloodstream infections overall, demonstrating the success of the national drive to control infection. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - November 9, 2020 Category: Consumer Health News Source Type: news

Brain and nerve complications are more common than expected in younger patients with severe COVID-19, NIHR
NIHR Alert. People aged under 60 who are hospitalised with COVID-19 are more likely than expected to experience severe psychiatric symptoms. Research found that altered mental states such as psychosis are being reported in these younger patients. It confirmed that strokes and other neurological symptoms are common in severe COVID-19. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - November 4, 2020 Category: Consumer Health News Source Type: news

Featured Review: Mental health of refugees, asylum seekers, and internally displaced persons
Migrants who have been forced to leave their home, such as refugees, asylum seekers, and internally displaced persons (IDP), are likely to experience stressors which may lead to mental health problems. The efficacy of interventions for mental health promotion, prevention, and treatment may differ in this population. A recent systematic review from theCochrane Common Mental Disorders group looked at this topic: 'An overview of systematic reviews on mental health promotion, prevention, and treatment of common mental disorders for refugees, asylum seekers, and internally displaced persons. 'Supported by the National Institute...
Source: Cochrane News and Events - October 28, 2020 Category: Information Technology Authors: Lydia Parsonson Source Type: news

New risk model estimates likelihood of death or hospitalisation from COVID-19, NIHR
A model that can calculate a person ' s risk of becoming infected and then seriously ill due to COVID-19 has been shown to accurately estimate risk during the first wave of the pandemic in England, in new research funded by the NIHR. The model, developed using routine anonymised data from more than 8 million adults in 1205 general practices across England, uses a number of factors such as a person ' s age, ethnicity and existing medical conditions to predict their risk of catching COVID-19 and then dying or being admitted to hospital. The model has the potential to provide doctors and the public with more nuanced inform...
Source: Current Awareness Service for Health (CASH) - October 22, 2020 Category: Consumer Health News Source Type: news

World's first participants for Novavax phase 3 Covid-19 vaccine trial enroll through NIHR Patient Recruitment Centre, NIHR
The world ' s first participants to take part in a phase 3 trial of the Novavax Covid-19 vaccine candidate were recently recruited at a new NIHR National Patient Recruitment Centre (NPRC) based in Blackpool. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - October 21, 2020 Category: Consumer Health News Source Type: news

Most psoriasis patients taking immunosuppressants survive COVID-19
(National Institute for Health Research) Patients with psoriasis who are taking drugs that affect their immune system have high rates of survival from COVID-19. According to the first findings from a global registry of psoriasis and COVID-19 patients, led by Guy's and St Thomas' clinicians, over 90% survive. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - October 20, 2020 Category: Infectious Diseases Source Type: news

New risk model estimates likelihood of death or hospitalization from COVID-19
(National Institute for Health Research) Evidence-based model uses a range of factors such as age, sex, ethnicity and existing medical conditions to predict risk of death or hospitalization from COVID-19. Model provides nuanced information on people's risk of serious illness due to COVID-19 and has the potential to help patients and doctors reach a shared understanding of risk. The 'living' risk prediction model will be updated regularly as our understanding of COVID-19 increases and more data become available. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - October 20, 2020 Category: Infectious Diseases Source Type: news

New global programme funded to target COVID-19 neurological disease
(University of Liverpool) The University of Liverpool is leading a new global project to better understand how and why COVID-19 affects the brain in order to develop measures to help improve patient outcomes. The University has secured £ 860,000 from the National Institute for Health Research (NIHR), in partnership with UK Research and Innovation (UKRI) to establish the COVID-Neuro Global programme in partnership with five leading research organisations in Brazil, India and Malawi. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - October 16, 2020 Category: International Medicine & Public Health Source Type: news

Living with Covid19: themed review, NIHR
Key Messages The novel coronavirus (Covid19) pandemic declared by the World Health Organisation in March 2020 has had far-reaching effects upon people ' s lives, health care systems and wider society. As yet there is little research into the number of people at risk of developing ongoing Covid19. Early attention has been on the acute illness generated by the virus, but it is becoming clear that, for some people, Covid19 infection is a long term illness. This rapid and dynamic review draws on the lived experience of patients and expert consensus as well as published evidence to better understand the impact of ongoing effect...
Source: Current Awareness Service for Health (CASH) - October 15, 2020 Category: Consumer Health News Source Type: news