Case 3: Neonate Presenting with Acute Liver Failure and Shock
(Source: NeoReviews recent issues)
Source: NeoReviews recent issues - March 1, 2016 Category: Pediatrics Authors: Adachi, K., Barron, S., Gell, J., Yeganeh, N. Tags: Pediatric Drug Labeling Update Index of Suspicion in the Nursery Source Type: news
Case 2: A Late Preterm Newborn with Cyanosis
(Source: NeoReviews recent issues)
Source: NeoReviews recent issues - March 1, 2016 Category: Pediatrics Authors: Brecht, M., Goddard, T., Mordaunt, D., Kelly, A., Barnett, C. Tags: Pediatric Drug Labeling Update Index of Suspicion in the Nursery Source Type: news
Case 1: A Newborn with Acute-Onset Respiratory Distress and Encephalopathy
(Source: NeoReviews recent issues)
Source: NeoReviews recent issues - March 1, 2016 Category: Pediatrics Authors: Lukka, S., Venugopal, A. P., Karri, H. K., Subramanian, S., Murki, S. Tags: Pediatric Drug Labeling Update Index of Suspicion in the Nursery Source Type: news
Neonatal Hemochromatosis: Evaluation of the Neonate with Hepatic Failure
(Source: NeoReviews recent issues)
Source: NeoReviews recent issues - March 1, 2016 Category: Pediatrics Authors: Chu, A., De Beritto, T., Kesavan, K., Hageman, J. R., Azzam, R. Tags: Pediatric Drug Labeling Update Articles Source Type: news
Ambiguous Genitalia: Evaluation and Management in the Newborn
Infants born with ambiguous genitalia pose challenges to medical providers and can cause parental anxiety and distress. Disorders of sexual development (DSD) are classified into 3 major categories (46,XY DSD, 46,XX DSD, and sex chromosome DSD). A thorough history, physical examination, and appropriate diagnostic testing are needed to identify the underlying etiology. An understanding of normal sexual development can help clinicians tailor their initial diagnostic evaluation for an infant with ambiguous genitalia. The involvement of a multidisciplinary team that is experienced in DSD is essential. Sex assignment should be m...
Source: NeoReviews recent issues - March 1, 2016 Category: Pediatrics Authors: McCann-Crosby, B. Tags: Pediatric Drug Labeling Update Articles Source Type: news
The Placenta as a Diagnostic Tool for the Neonatologist
We describe common anatomic and histologic lesions of the placenta that are associated with the aforementioned clinical problems, and describe how such placental findings can help the clinician in routine diagnosis and management. We discuss the current gaps in diagnostic usefulness of the placenta, and how ongoing research is the key to optimizing the placental examination to improve neonatal outcomes. (Source: NeoReviews recent issues)
Source: NeoReviews recent issues - March 1, 2016 Category: Pediatrics Authors: Yallapragada, S. G., Mestan, K. K., Ernst, L. M. Tags: Pediatric Drug Labeling Update Articles Source Type: news
International Perspectives: Clinical Kernicterus in Preterm Infants in Japan
In recent years, clinical kernicterus has been diagnosed in preterm infants on the basis of motor (kinetic) disorders such as choreoathetosis and dystonia, impairment in auditory neuropathy-type hearing, and abnormal pallidal signals on head magnetic resonance imaging. In Japan, it is currently estimated that at least 8 to 9 cases of kernicterus (approximately 2 per 1,000 cases) occur annually in preterm infants of less than 30 weeks’ gestation. Therefore, there is an urgent need to revise our jaundice management approach in preterm infants. Two major characteristics of Japanese preterm infants who develop clinical k...
Source: NeoReviews recent issues - March 1, 2016 Category: Pediatrics Authors: Morioka, I., Nakamura, H., Iwatani, S., Wong, R. J., Iijima, K. Tags: Pediatric Drug Labeling Update Articles Source Type: news
A Late Preterm Infant With Head and Neck Masses Noted At Delivery
(Source: NeoReviews recent issues)
Source: NeoReviews recent issues - February 1, 2016 Category: Pediatrics Authors: Shetty, A., Kelly, K. N., Khan, O., Sriram, S. Tags: Pediatric Drug Labeling Update Visual Diagnosis Source Type: news
Strip of the Month: February 2016
(Source: NeoReviews recent issues)
Source: NeoReviews recent issues - February 1, 2016 Category: Pediatrics Authors: Schneider, P., Tien, S. H. Tags: Pediatric Drug Labeling Update Index of Suspicion in the Nursery Source Type: news
Case 2: A Neonate Presenting With Poor Feeding and Cough
(Source: NeoReviews recent issues)
Source: NeoReviews recent issues - February 1, 2016 Category: Pediatrics Authors: Nandula, P. S., Bhat, R. I. Tags: Pediatric Drug Labeling Update Index of Suspicion in the Nursery Source Type: news
Case 1: Recurrent Apnea in a Preterm Neonate
(Source: NeoReviews recent issues)
Source: NeoReviews recent issues - February 1, 2016 Category: Pediatrics Authors: Bandya, P., Thukral, A., Nangia, S. Tags: Pediatric Drug Labeling Update Index of Suspicion in the Nursery Source Type: news
Promotion of Early Pregnancy Events in Mice and Humans by Uterine Natural Killer Cells
Mammalian pregnancy is a unique immunologic situation in which the maternal immune system recognizes and accepts an antigenically disparate tissue, the conceptus. Currently, our understanding of human peri-implantation and early gestational events is largely based on animal studies, particularly mice. Although immune cells are present in the uterus before conception or blastocyst implantation, huge increases in immune cell numbers and the differentiation of specialized lymphocyte subsets are induced in species with hemochorial placentation during the process of decidualization. (Source: NeoReviews recent issues)
Source: NeoReviews recent issues - February 1, 2016 Category: Pediatrics Authors: Felker, A. M., Croy, B. A. Tags: Pediatric Drug Labeling Update Articles Source Type: news
Pharmacology Review: The Role of Biomarkers and Surrogate End Points in Drug Development for Neonatal Pulmonary Arterial Hypertension
Pulmonary arterial hypertension (PAH) is a rare disease in newborns, infants, and children. It is associated with significant morbidity and mortality, but has limited treatment options. Except for inhaled nitric oxide, which is approved for persistent pulmonary hypertension of the newborn (PPHN), no drug is approved for the treatment of newborns, infants, and children with PAH. The lack of developmentally appropriate pediatric efficacy end points and pediatric clinical trials contribute to this unmet medical need. The noninvasive biomarkers reported in the literature that can be used as potential surrogate end points to as...
Source: NeoReviews recent issues - February 1, 2016 Category: Pediatrics Authors: Sun, H., Stockbridge, N., Ariagno, R. L., Murphy, D. Tags: Pediatric Drug Labeling Update Articles Source Type: news
Chronic Inflammatory Lesions of the Placenta and Preterm Birth
A successful pregnancy largely relies on proper immune regulation in the gravid uterus. This review describes immune mechanisms that permit the fetal allograft to continue to grow to term. Chronic inflammatory lesions may be manifestations of altered immune status in the placenta and are often present in preterm placentas. These lesions are compared with the more common acute inflammatory lesions of pregnancy, and described with respect to their pathology and clinical significance. (Source: NeoReviews recent issues)
Source: NeoReviews recent issues - February 1, 2016 Category: Pediatrics Authors: Katzman, P. J. Tags: Pediatric Drug Labeling Update Articles Source Type: news
Impact of Obesity on Uteroplacental Immunology and Placental Pathology
Obesity is a growing problem. Currently 1 in 3 reproductive-age women is obese. This is significant because obesity is associated with an increased risk of gestational diabetes mellitus (GDM), preterm birth, fetal growth abnormalities, preeclampsia, and stillbirth. Obesity alone increases the risk of stillbirth by threefold, whereas GDM increases this risk to approximately 10-fold. How obesity and GDM affect placental and fetal growth are beginning to be understood, but the underlying pathophysiology leading to bad pregnancy outcomes is essentially unknown. This review will discuss the effects of obesity and GDM on fetopla...
Source: NeoReviews recent issues - February 1, 2016 Category: Pediatrics Authors: Morgan, T. K. Tags: Pediatric Drug Labeling Update Articles Source Type: news
