Could Correcting Metabolic Dysfunction Treat Rheumatoid Arthritis?
(MedPage Today) -- Alterations in tryptophan metabolism are common among patients with rheumatoid arthritis (RA), researchers found, and preclinical studies suggest that correcting them is a viable treatment strategy. Participants in France's... (Source: MedPage Today Rheumatology)
Source: MedPage Today Rheumatology - November 28, 2023 Category: Rheumatology Source Type: news

Another Long-Acting Steroid Shot Impresses in Knee OA
(MedPage Today) -- SAN DIEGO -- Two intra-articular injections of a liposomal formulation of dexamethasone given 6 months apart provided a year of pain relief for patients with osteoarthritis (OA) of the knee, a researcher said here. In a phase... (Source: MedPage Today Rheumatology)
Source: MedPage Today Rheumatology - November 16, 2023 Category: Rheumatology Source Type: news

Novel Gout Drug Aces Mid-Stage Tests
(MedPage Today) -- SAN DIEGO -- An investigational once-daily oral agent that inhibits urate transporter-1 (URAT1) as a means of forcing uric acid excretion showed good efficacy and safety in a pair of phase II trials reported here. In one of... (Source: MedPage Today Rheumatology)
Source: MedPage Today Rheumatology - November 16, 2023 Category: Rheumatology Source Type: news

CAR T-Cell Approach to Autoimmune Disease Gains Traction
(MedPage Today) -- SAN DIEGO -- Chimeric antigen receptor (CAR) T-cell therapy increasingly looks like the next big thing in autoimmune rheumatic disease (ARD) therapy, with new reports here continuing to demonstrate positive results, and with... (Source: MedPage Today Rheumatology)
Source: MedPage Today Rheumatology - November 15, 2023 Category: Rheumatology Source Type: news

Novel IL-17A Blocker Continues to Impress in PsA
(MedPage Today) -- SAN DIEGO -- The triple-action investigational agent known as izokibep was highly effective against psoriatic arthritis (PsA) over 46 weeks in a new analysis of the product's first phase II trial, a researcher said here. Following... (Source: MedPage Today Rheumatology)
Source: MedPage Today Rheumatology - November 14, 2023 Category: Rheumatology Source Type: news

'Naked' Gene Therapy Promising for Osteoarthritis
(MedPage Today) -- SAN DIEGO -- Boosting levels of interleukin-10 (IL-10) via intra-articular gene therapy is a viable approach for treating osteoarthritis (OA) of the knee, results of a phase II study indicated. Although the randomized, placebo... (Source: MedPage Today Rheumatology)
Source: MedPage Today Rheumatology - November 14, 2023 Category: Rheumatology Source Type: news

Long-Acting Steroid Gives 14 Weeks of Knee OA Relief
(MedPage Today) -- SAN DIEGO -- A novel extended-release formulation of fluticasone propionate provided long-lasting symptom improvement with a single injection in patients with knee osteoarthritis (OA), according to a phase II study presented... (Source: MedPage Today Rheumatology)
Source: MedPage Today Rheumatology - November 13, 2023 Category: Rheumatology Source Type: news

B-Cell Depletion Helps Maintain Kidney Function in Lupus Nephritis
(MedPage Today) -- SAN DIEGO -- Treatment with the B-cell depleting agent obinutuzumab (Gazyva) helped patients with lupus nephritis avoid the most serious adverse outcomes, according to a post hoc analysis of randomized trial data. Among 125... (Source: MedPage Today Rheumatology)
Source: MedPage Today Rheumatology - November 10, 2023 Category: Rheumatology Source Type: news

JAK Inhibitor Safety Study Seen Altering Practice in the VA
(MedPage Today) -- Safety risks found in a postmarketing trial with the Janus-associated kinase (JAK) inhibitor tofacitinib (Xeljanz) appear to have influenced prescribing patterns across the class for rheumatoid arthritis (RA) patients in the... (Source: MedPage Today Rheumatology)
Source: MedPage Today Rheumatology - November 2, 2023 Category: Rheumatology Source Type: news

Spinal Surgery Redux: Advancing Our Approach to Back Pain
(MedPage Today) -- Lower back pain has been the leading cause of years lived with disability since 1990, and it continues to be a significant concern for public health on a global scale. In the U.S., 72.3 million adults currently suffer from chronic... (Source: MedPage Today Rheumatology)
Source: MedPage Today Rheumatology - October 30, 2023 Category: Rheumatology Source Type: news

Sjogren's Without Dryness? Yes, It's a Thing
(MedPage Today) -- More than 10% of patients diagnosed with primary Sjögren's syndrome at a French referral center reported little to no dryness in the mouth or eyes, and these individuals differed from the more typical Sjögren's patients... (Source: MedPage Today Rheumatology)
Source: MedPage Today Rheumatology - October 30, 2023 Category: Rheumatology Source Type: news

Bimekizumab Data in axSpA Look Good Through 1 Year
(MedPage Today) -- Researchers have now reported full 52-week results from the two parallel phase III trials of the interleukin-17 (IL-17) blocker bimekizumab in axial spondyloarthritis (axSpA), following interim data published early this year... (Source: MedPage Today Rheumatology)
Source: MedPage Today Rheumatology - October 5, 2023 Category: Rheumatology Source Type: news

Everything (Maybe) You Wanted to Know About Sarilumab for PMR
(MedPage Today) -- Clinicians and others curious about the data underlying February's FDA approval of sarilumab (Kevzara) for polymyalgia rheumatica (PMR) can now be sated, at least partially, with publication today of the chief registration trial... (Source: MedPage Today Rheumatology)
Source: MedPage Today Rheumatology - October 5, 2023 Category: Rheumatology Source Type: news

Rheum Patients on HCQ: Stick With It or Face Heart Consequences
(MedPage Today) -- High levels of adherence to prescribed antimalarial drugs for lupus and rheumatoid arthritis (RA) was associated with markedly lower cardiovascular event rates in one Canadian province, researchers found. Rates for a composite... (Source: MedPage Today Rheumatology)
Source: MedPage Today Rheumatology - September 11, 2023 Category: Rheumatology Source Type: news

U.S. Unveils First 10 Drugs for Medicare Price Negotiations
(MedPage Today) -- The Centers for Medicare & Medicaid Services (CMS) took a historic step forward in its plans to negotiate the prices of Medicare's most costly prescription drugs by naming the first 10 up for negotiation on Tuesday. The... (Source: MedPage Today Rheumatology)
Source: MedPage Today Rheumatology - August 29, 2023 Category: Rheumatology Source Type: news