Science Saturday: A new understanding of the inner workings of CAR-T cell therapy
Mayo Clinic researchers have biomanufactured chimeric antigen receptor-T cell therapy (CAR-T cell therapy) in a new way to track the cells' cancer-fighting journey and predict toxic side effects. This Mayo Clinic breakthrough, published in Cancer Immunology Research, also could unravel the mystery of how to unleash CAR-T cell therapy to destroy solid tumors. "This new technology allows us to image CAR-T cells after they are given to patients and study their fate," says Saad Kenderian, M.B., Ch.B., a Mayo… (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - September 11, 2021 Category: Research Source Type: news
Consumer Health: What do you know about hepatitis?
World Hepatitis Day will be observed on Wednesday, July 28, which makes this a good time to learn more about hepatitis. Hepatitis is inflammation of the liver, usually caused by specific viruses. The five main strains of the hepatitis virus are referred to as types A, B, C, D and E. While they all cause liver disease, they differ in geographic prevalence, severity of illness and prevention methods. In the U.S., the most common forms… (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - July 28, 2021 Category: Research Source Type: news
20-year Mayo Clinic study suggests return to play is manageable for athletes with most genetic heart diseases
ROCHESTER, Minn. — Receiving the diagnosis of a genetic heart disease such as long QT syndrome, which can cause sudden cardiac death, has long been a game-ender for young athletes. But a 20-year study at Mayo Clinic following such athletes who were allowed to return to play suggests that the risks can be managed t hrough a shared decision-making process. The retrospective study findings will be presented at the annual meeting of the Heart Rhythm Society… (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - July 27, 2021 Category: Research Source Type: news
Science Saturday: Researchers find widespread sex bias in molecular biology tools
Widely used sex-biased maps of molecular biology are holding back individualized medicine, say Mayo Clinic scientists. Maps clarify how places are connected. In biology, the same is true for databases that map out how aspects of biology are connected. Different biological databases examine genes (genomics), how those gene instructions are read (transcriptomics), what is made from the gene instructions (proteomics), and how that gene product breaks down in the body (metabolomics). Called omics for simplicity,… (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - July 10, 2021 Category: Research Source Type: news
Science Saturday: Melanoma test to help some patients avoid surgical biopsy
More than 100,00 people in the U.S. are expected to be diagnosed with melanoma this year — double the number of cases compared to 30 years ago, according to the American Academy of Dermatology Association. "Melanoma accounts for only about 2% of skin cancers, but it causes a majority of skin cancer deaths," says Alexander Meves, M.D., a Mayo Clinic dermatologist whose laboratory in Mayo Clinic's Center for Individualized Medicine works on cutting-edge methods to diagnose and treat melanoma.… (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - July 3, 2021 Category: Research Source Type: news
Tumor cell PD-L1 may mediate sensitivity to chemotherapy in colorectal cancer treatment
ROCHESTER, Minn. — Data in a study by Mayo Clinic Cancer Center researchers indicates that the level of tumor cell PD-L1, a protein that acts as a brake to keep the body's immune responses under control, may be an important factor for sensitivity to chemotherapy in colorectal cancer treatment. The study was published Friday, July 2, in Oncogene. "We have identified a mechanism by which absent or low levels of tumor cell PD-L1, which is commonly found… (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - July 2, 2021 Category: Research Source Type: news
Science Saturday: The regenerative alternative to hip replacement for baseball player
Mikaili Robertson has a passion for playing college sports, so the second baseman was devastated when at age 18 he learned he needed a hip replacement. Worried his playing days might be over, he turned to Mayo Clinic and a surgery that -- along with a cadaver tissue transplant -- would tap the body's power to assist [...] (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - June 19, 2021 Category: Research Source Type: news
Science Saturday: Mayo researchers study the genetic basis of high cholesterol in adults
In a new study published in NPJ Genomic Medicine, Mayo Clinic researchers found that genetic testing may help identify patients with high cholesterol, or hypercholesterolemia. It also may have implications for the clinical management of patients diagnosed with high cholesterol due to a genetic disorder, or familial hypercholesterolemia. "In our study, we found more than 50% of the [...] (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - June 12, 2021 Category: Research Source Type: news
How clinical trials work: COVID-19 and beyond
Clinical trials help researchers discover and apply critical advances in patient care. Clinical trials follow rigorous scientific processes that usually take many years to complete. However, during the COVID-19 pandemic, people have been able to see and experience clinical trials operating on fast-forward. And a lot of people are wondering, "How do clinical trials work?"In [...] (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - June 11, 2021 Category: Research Source Type: news
Science Saturday: Patients need to know how their data affects their health outcomes
In the near future, genome sequencing, among other biological measures, will be as routine as X-rays and cholesterol testing. The challenge, though, will be accurately interpreting the vast amount of data and effectively using it to guide decisions about health care. In a position statement published in Hepatology, Mayo Clinic researchers layout perspectives of various stakeholders [...] (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - June 5, 2021 Category: Research Source Type: news
Groundbreaking Early Cancer Detection Test Studied at Mayo Clinic Introduced Nationally
Mayo Clinic today recognized the debut of a groundbreaking multi-cancer early cancer detection (MCED) test called Galleri? that can detect more than 50 types of cancers[1] through a simple blood draw. The Galleri test is intended to complement U.S. guideline-recommended cancer screenings. Mayo Clinic Oncologist Minetta Liu, M.D. was involved in the development of the new test. [...] (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - June 4, 2021 Category: Research Source Type: news
Fatigue, perceived cognitive impairment and mood disorders associated with post-COVID-19 syndrome
ROCHESTER, Minn. ???-- Patients diagnosed with post-COVID-19 syndrome, also known as "PCS," "COVID-19 long-haul syndrome" and "Post-Acute Sequelae of SARS COV-2," experience symptoms such as mood disorders, fatigue and perceived cognitive impairment that can negatively affect returning to work and resuming normal activities, according to a Mayo Clinic study published in Mayo Clinic Proceedings. The [...] (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - May 12, 2021 Category: Research Source Type: news
Science Saturday: Mayo study examines how Latino participants experience genomic medicine
How do people from minority communities experience genomic medicine in diverse health-care settings? How do they integrate genetic knowledge into their understandings of health-care needs? These answers are critical to researchers as multiple efforts are underway to increase the inclusion of racial minority participants in genomic research and new forms of individualized medicine. Richard Sharp. [...] (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - May 8, 2021 Category: Research Source Type: news
Science Saturday: Using AI to reveal causes of complex diseases
Researchers within Mayo Clinic's Center for Individualized Medicine have developed an artificial intelligence (AI) platform that can uncover causal drivers and relationships embedded within complex biomedical data. Nicholas Chia, Ph.D.,?John Kalantari, Ph.D., and Kia Khezeli, Ph.D., recently tested their machine-learning framework, called Causal Relation and Inference Search Platform (CRISP) on multiomic colorectal cancer samples alongside [...] (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - April 24, 2021 Category: Research Source Type: news
High vaccination rate is key to future course of COVID-19 pandemic, Mayo Clinic computer modeling shows
The Mayo Clinic data scientists who developed highly accurate computer modeling to predict trends for COVID-19 cases nationwide have new research that shows how important a high rate of vaccination is to reducing case numbers and controlling the pandemic. Vaccination is making a striking difference in Minnesota and keeping the current level of positive cases [...] (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - April 23, 2021 Category: Research Source Type: news
