Mayo Clinic to lead new radiotracer trial for detecting pancreatic cancer
ROCHESTER, Minn. — In an academic-industrial collaboration, Mayo Clinic is assessing in a clinical trial a new radiotracer in pancreatic cancer imaging. As part of the investigation, the new agent, 68Ga-Fibroblast-Activation-Protein-Inhibitors (FAPI)-46 (68Ga-FAPI-46), will be compared with 18-fluorodeoxyglucose ( FDG), which is the current standard-of-care radiotracer, in positron emission tomography (PET) imaging of pancreatic cancer. "The research will focus on pancreatic cancer and evaluate whether this radiotracer does what it's supposed to do, and whether it… (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - January 30, 2023 Category: Research Source Type: news
Science Saturday: Mayo researchers streamline genetic testing in heart failure clinic, improve clinical care
In a new study published in Genetics in Medicine, Mayo Clinic researchers streamlined genetic testing and counseling for patients with dilated cardiomyopathy, a type of heart muscle disease that causes the heart chambers (ventricles) to thin and stretch, growing larger. "We showed that this practice intervention increased t he uptake and yield of genetic testing and counseling in our Heart Failure Clinic," says Naveen Pereira, M.D., a Mayo Clinic cardiologist and senior author of the study. "This may have… (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - January 28, 2023 Category: Research Source Type: news
Science Saturday: Engineering tissue to strengthen underdeveloped hearts
Could cells taken from a small patch of skin become heart muscle and repair a rare congenital heart defect? It's a scientific question that Timothy Nelson, M.D., Ph.D., and collaborators hope to answer for those born with an underdeveloped left heart chamber — a rare, complex condition known as hypoplastic left heart syndrome (HLHS). Discovering the first cell-based therapy to rebuild heart tissue for HLHS has been a decade-long r esearch passion for Dr. Nelson, who is the director… (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - January 21, 2023 Category: Research Source Type: news
Mayo Clinic researchers identify women with twice the risk of cancer in both breasts
ROCHESTER, Minn. — Women with cancer in one breast may be at higher risk of developing cancer in the opposite breast if they are carriers of specific genetic changes that predispose them to develop breast cancer, according to a study led by the Mayo Clinic Comprehensive Cancer Center. The findings, published in th e Journal of Clinical Oncology, will help personalize approaches to breast cancer screening and risk factors, study authors say. The study used data… (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - January 19, 2023 Category: Research Source Type: news
Science Saturday: MayoComplete next-generation sequencing -- Transforming comprehensive cancer care
For patients facing a cancer journey, navigating diagnosis and treatment can be extremely daunting. Fear of the unknown is compounded by a confusing ocean of emerging information on discoveries and technological advancements. While each wave of progress brings about new types of treatment, including targeted and immune therapies linked to improved outcomes, the cancer ’s nuances must be understood for these pioneering treatments to work. Laboratory testing offers crucial information to help patients traverse the shifting… (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - January 7, 2023 Category: Research Source Type: news
Science Saturday: Aspiring to deliver new cures for complex conditions
Mayo Clinic is building toward a future when biologics can cure cancer, kidney disease and diabetes. Mayo marks 2022 as a year of significant strides in accelerating science to make and deliver regenerative biotherapeutics. The goal is to offer new options, based on rigorous research in cell and gene therapies, for disorders with few available treatments. The Mayo Clinic Center for Regenerative Biotherapeutics has a new strategy of advancing regenerative discoveries toward early-stage clinical trials and industry… (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - December 31, 2022 Category: Research Source Type: news
Socioeconomic status measure helps researchers develop artificial intelligence models, improving equity in health care
Social determinants of health impact people ’s well-being and quality of life. These social determinants — conditions such as access to nutrition, safe and affordable housing, jobs, transportation, and access to health care — are some of the factors that lead to disparities in health and health care if they are not addressed. "Defining and assessing social determinants of health really invites clinicians, educators, and researchers to embrace a broader understanding of health in the social… (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - December 28, 2022 Category: Research Source Type: news
NIH's All of Us Research Program returns health-related DNA results to participants
The National Institutes of Health's (NIH) All of Us Research Program has begun returning personalized health-related DNA results to more than 155,000 participants. The reports detail whether participants have an increased risk for specific health conditions and how their bodies might process certain medications. The All of Us Research Program collects participants' blood, urine, and saliva samples. These biosamples are stored and managed for research at a specialized All of Us Research Program biobank at Mayo Clinic. "It is rewarding for us at the… (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - December 19, 2022 Category: Research Source Type: news
Science Saturday: Researchers investigate precision nutrition to improve health, prevent diseases
Could prescribing specific nutrients, grains, fruits and vegetables tailored to a person's DNA and other biological characteristics help improve their health? Precision nutrition took center stage at Mayo Clinic's Individualizing Medicine Conference Nov. 2 –3, 2022, in Rochester, Minnesota, where some of the world’s top experts shared their knowledge of the potential benefits of tailoring nutrients and dietary guidance to a person's genes, metabolism, microbiome and other distinguishing characteristics. The ultimate goal of the holistic approach i s to… (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - December 17, 2022 Category: Research Source Type: news
Science Saturday: A preclinical step toward treating chronic dry mouth
Mayo Clinic researchers replicated chronic dry mouth from radiation damage in preclinical models, laying the foundation for stem cell research to regenerate salivary tissue after cancer. This discovery uses targeted X-radiation to mimic human injury and establish a lab model for testing cellular therapies for dry mouth. The study is published in Radiation Research. "The team was satisfied to see a 50% reduction in chronic salivary function with radiation in mice — our first and major… (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - December 3, 2022 Category: Research Source Type: news
Real-world evidence study of regenerative medicine and shoulder surgery
Applying regenerative medicine to a common shoulder surgery could have an impact on the need for follow-up revision surgery in some patients, according to a Mayo Clinic study of real-world evidence.Mayo Clinic researchers analyzed the largest set of data available to determine if adding bone marrow aspirate concentrate to repaired tissue after standard rotator cuff surgery would improve outcomes for patients. Bone marrow aspirate is fluid taken from a patient's bone marrow that contains concentrated growth factors,… (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - November 16, 2022 Category: Research Source Type: news
AI transforms smartwatch ECG signals into a diagnostic tool for heart failure
Two health tech advances are at the heart of a study published in Nature Medicine: an app and backend infrastructure to let patients remotely share smartwatch ECG data with their clinicians in an easy and secure way, and the modification of a proven 12-lead ECG artificial intelligence (AI) algorithm to enable it to run on a single-lead watch ECG recording. An AI algorithm applied to Apple Watch ECG recordings successfully identified a weak heart pump… (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - November 14, 2022 Category: Research Source Type: news
Science Saturday: Seeking a cellular therapy for chronic kidney disease
Every year, more than 130,000 people in the U.S. are diagnosed with end-stage kidney disease, with most cases caused by diabetes. Newer therapies show promise to slow kidney failure rates, but none stop progression to end-stage kidney failure. The research goal of LaTonya Hickson, M.D., is to develop a cell-based therapy that slows — or even stops — diabetic kidney disease from advancing to end-stage kidney disease. "It is going to take a multipronged approach. By utilizing… (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - November 12, 2022 Category: Research Source Type: news
Beating the odds for a transplant
When the phone rang in the middle of a Sunday night news program, and the caller ID flashed Mayo Clinic, Dennis Pinkerton and his wife, Rhonda, knew it was a pivotal moment. The doctor on the line delivered news he thought he'd never hear. A pair of donor lungs — kept alive and breathing on a high-tech machine — were a perfect match. "It felt like a miracle. I live only about 10 minutes from… (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - November 10, 2022 Category: Research Source Type: news
Science Saturday: AI enables early identification, intervention in debilitating lung disease
In a new study published in Nature Medicine, Mayo Clinic and several research collaborators from across the U.S., describe a successful new artificial intelligence, or AI, -enabled tool to identify idiopathic pulmonary fibrosis, also called IPF, before patients have recognizable symptoms. This tool could alert a patient's primary care team of a probable IPF diagnosis based on comorbidities and risk scores. The tool should prompt earlier referral to pulmonary specialty care to confirm the diagnosis with CT scanning… (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - October 29, 2022 Category: Research Source Type: news
