Could bioprinted skin uncover a new treatment for eczema?
Bioprinted Skin Mayo Clinic has developed its first 3D prototype of human skin bioprinted to model inflammatory skin disease. 3D bioprinting is a technology that mixes bioinks with living cells to print natural tissue-like structures in three dimensions. This new technology provides the most human-like skin model for studying inflammatory conditions such as atopic dermatitis  — more commonly known as eczema — a chronic inflammatory skin condition that causes dry, itchy and inflamed skin. The 3D bioprinting… (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - July 21, 2023 Category: Research Source Type: news

Mayo Clinic researchers pave the way for individualized obesity therapy, tailoring interventions to a person's needs
In a pilot study of 165 people, Mayo Clinic researchers looked at the effectiveness of two different approaches to weight loss: a standard lifestyle intervention and individualized therapy. The standard lifestyle intervention included a reduced diet, exercise and behavior therapy. The individualized approach was based on phenotypes and included different interventions depending on the person's predominant underlying cause of obesity. A diet based on phenotypes considers a person's genetic and phenotypic characteristics to create a… (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - July 12, 2023 Category: Research Source Type: news

Science Saturday: Study finds senescent immune cells promote lung tumor growth
Macrophages are a type of white blood cell that are among the body's first line of defense against infection. In addition to killing harmful microorganisms, macrophages typically can initiate a response against tumors. However, macrophages, like other cells, can enter a state called senescence, which is linked to aging, disease and multiple physiological problems. When cells become senescent, they stop dividing, but they do not die and are not always eliminated from the body. They… (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - June 17, 2023 Category: Research Source Type: news

Science Saturday: Mayo Clinic doctor visits of the future could be powered by 'omics' research
To glimpse the future of medicine, step inside Mayo Clinic's cutting-edge Center for Individualized Medicine. There, physicians, researchers, data scientists, artificial intelligence engineers and bioethicists are working side-by-side to investigate massive "omics" data sets. The innovative approach is the result of thousands of patients who are participating in omics-related research studies and clinical trials.  The multidisciplinary teams are in pursuit of discovering hidden biological signatures and patterns of diseases, including cancer. Their hope and expectations are… (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - May 27, 2023 Category: Research Source Type: news

Mayo Clinic Q and A: Targeting pain with restorative neuromodulation
DEAR MAYO CLINIC: For the last 20 years, I've worked a physically demanding job. As a result, chronic back pain has been an issue. I'm ready to retire and want to enjoy activities, such as traveling, golf and playing with my grandkids, pain-free. I've been told I'm not a candidate for back surgery. What options are available to help alleviate and manage my pain? ANSWER: The field of pain medicine has traditionally been a specialty associated with… (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - May 2, 2023 Category: Research Source Type: news

Researchers test DNA editing, recommend steps to improve accuracy
By studying the effects of DNA variants between people, researchers can gain insights into the genetics of diseases. It allows them to tailor medical treatment to a person's genetic makeup. Modeling variants in an experimental setup is a common way for researchers to gain this knowledge. The CRISPR-Cas9 system, a broadly used gene editing tool, allows researchers to precisely change the sequence of a genome and study the effects of that genetic variation on cellular… (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - May 2, 2023 Category: Research Source Type: news

Science Saturday: A twist of fate led to regenerative medicine
A chance meeting on a student shuttle bus put Wenchun Qu, M.D., Ph.D., on a new direction that years later would culminate in becoming the Jorge and Leslie Bacardi Associate Director of the Mayo Clinic Center for Regenerative Biotherapeutics in Florida. During a ride to the University of Southern California (USC) where Dr. Qu was completing doctoral studies in the 1990s, he struck up a conversation with a young man he routinely saw on the bus. "I asked… (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - April 29, 2023 Category: Research Source Type: news

Minnesota Partnership for Biotechnology and Medical Genomics awards three collaborative research grants
(ROCHESTER and MINNEAPOLIS, Minn.) — Mayo Clinic and University of Minnesota are pleased to announce three collaborative research grants totaling $5.82 million through the Minnesota Partnership for Biotechnology and Medical Genomics (MNP). MNP is funded by the State of Minnesota and provides support for innovative research conducted by collaborative teams from the University of Minnesota and Mayo Clinic. This year's awards support projects that seek to advance health outcomes in the areas of neuromodulation therapy,… (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - April 28, 2023 Category: Research Source Type: news

Mayo Clinic study suggests improved time efficiency, accuracy with AI-automated head and neck radiotherapy model
ROCHESTER, Minn. — A study conducted by Mayo Clinic suggests artificial intelligence could potentially improve time efficiency and standardization for radiation therapy planning in patients with head and neck cancers. The validation study, published in Frontiers in Oncology, evaluated the efficiency of an algorith m trained by Mayo Clinic and developed in collaboration with Google Health. Radiation therapy planning for head and neck cancers requires a heavy time investment from multiple specialty areas due to the… (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - April 27, 2023 Category: Research Source Type: news

Mayo Clinic study puts price tag on cost of menopause symptoms for women in the workplace
JACKSONVILLE, Fla. — Menopause-related symptoms such as hot flashes, night sweats, mood changes, sleep disturbances, joint aches and cognitive difficulties damage the quality of life for millions of women. They also can adversely affect women in the workplace. A newly published Mayo Clinic study puts numbers on that cost: an estimated $1.8 billion in lost work time per year and $26.6 billion annually when medical expenses are added, in the U.S. alone. "The takeaway for… (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - April 26, 2023 Category: Research Source Type: news

Science Saturday: COVID-19 -- the pandemic that's forever changed laboratory testing
Like many people throughout the world, Matthew Binnicker, Ph.D., remembers exactly where he was and what he was doing when COVID-19 was classified as a pandemic. “Those first few months of the pandemic will be forever ingrained in my memory,” he says. For Dr. Binnicker, director of Mayo Clinic’s Clinical Virology Laboratory, two important dates stand out above the rest. “One was Feb. 17, 2020, when Dr. (William) Morice and I were talking about whether the department should… (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - April 15, 2023 Category: Research Source Type: news

Science Saturday: New standards and open access can help natural language processing
Clinical notes in medical records are rich sources of data about human health. But tapping them for medical research can be challenging because these data come from various sources — and they all look different. "There's no standardization in how data is organized and classified across medical records systems," says Sunyang Fu, Ph.D., a Mayo Clinic biomedical informatics researcher. Even the language people use to talk about health can insert discrepancies in how data are… (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - March 18, 2023 Category: Research Source Type: news

'Deaths of Despair' contribute to 17% rise in Minnesota's death rate during COVID-19 pandemic
ROCHESTER, Minn. — According to a new study published by Mayo Clinic researchers, the COVID-19 pandemic was linked to a 17% increase in the death rate in Minnesota during the first year of the pandemic compared to the two previous years. Deaths were driven by both COVID-19 and other causes linked with preventable "deaths of despair," such as overdose, alcohol use and malnutrition. The study analyzed Minnesota death certificate data available through the Rochester Epidemiology… (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - March 13, 2023 Category: Research Source Type: news

Science Saturday: Researchers elucidate details about the role of inflammation in liver regeneration
The liver has the greatest regenerative capacity of any organ in the body, making it possible for surgeons to treat cancerous and noncancerous diseases with extensive surgical approaches. However, underlying chronic liver diseases, like cirrhosis or nonalcoholic steatohepatitis, are known to inhibit the liver's ability to regenerate after surgery. Without regeneration, the liver cannot function, and patients can develop postoperative liver failure — often a lethal complication. In a recent paper published in JHEP Reports, Mayo… (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - March 4, 2023 Category: Research Source Type: news

Obesity makes it harder to diagnose and treat heart disease
ROCHESTER, Minn. — Being overweight impacts your heart health in more ways than you might think. A new JACC review paper from Mayo Clinic outlines how obesity affects the common tests used to diagnose heart disease and impacts treatments. Cardiovascular disease is the leading cause of death in the U.S. and globall y, yet it is largely preventable. "Excess fat acts as a kind of filter and can skew test readings to under-or overdiagnosis," says senior… (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - February 28, 2023 Category: Research Source Type: news