Lower Risk of ER-Negative Breast Cancer Linked to Vegetable Consumption
Consuming more vegetables is associated with a lower risk of estrogen receptor (ER)-negative breast cancer, according to a new study published in the Journal of the National Cancer Institute. (Source: Cancer Network)
Source: Cancer Network - February 6, 2013 Category: Cancer & Oncology Source Type: news

The Ethics of Quality and the Quality of Ethics
My suggestion, as unrealistic as it is, would be to encourage the creation and maintenance of parallel groups of quality measures: one set to satisfy the reportable measures of quality that affect reimbursements and pay for performance, and a second set that would be developed by and adapted to each institution to measure and drive improvements in those things we felt were true measures of high quality care. (Source: Cancer Network)
Source: Cancer Network - February 6, 2013 Category: Cancer & Oncology Source Type: news

World Cancer Day 2013 Focuses on Busting Cancer Myths
February 4 marks World Cancer Day 2013, an initiative of the Union for International Cancer Control, based in Geneva. The UICC, founded in 1933, is an important force in global cancer control efforts, and it now includes 760 organizations from 155 countries. (Source: Cancer Network)
Source: Cancer Network - February 5, 2013 Category: Cancer & Oncology Source Type: news

Smart Phone Apps Lack Accuracy to Detect Melanoma
The overall diagnostic accuracy of smart phone applications designed to help nonclinicians identify malignant skin lesions was highly variable, with three of four of the applications wrongly classifying 30% of melanomas. (Source: Cancer Network)
Source: Cancer Network - February 4, 2013 Category: Cancer & Oncology Source Type: news

Women Catch Up to Men in Smoking-Related Mortality Risk
Women have caught up to men with regard to the risk of death from cigarette smoking, according to analyses of three study cohorts spanning multiple decades and hundreds of thousands of individuals. (Source: Cancer Network)
Source: Cancer Network - February 2, 2013 Category: Cancer & Oncology Source Type: news

Nasal Mass in 62-Year-Old Patient
A 62-year-old man presented with symptoms of nasal congestion. Physical and radiographic imaging shows the presence of a nasal mass. Biopsy was performed. What is your diagnosis? (Source: Cancer Network)
Source: Cancer Network - February 1, 2013 Category: Cancer & Oncology Source Type: news

ASCO GI: Improved GIST Survival With Residual Tumor Removal Post-Maintenance Imatinib
Assigning patients with gastrointestinal stromal tumor (GIST) to undergo surgical resection of residual tumor after disease control with maintenance imatinib was beneficial to patient survival, according to the results of a retrospective study presented at the ASCO 2013 Gastrointestinal Cancers Symposium. (Source: Cancer Network)
Source: Cancer Network - February 1, 2013 Category: Cancer & Oncology Source Type: news

Novel Multiple Myeloma Treatments and Agents in Development
In this interview we discuss the current management and latest treatments and agents in development for multiple myeloma with Dr. Kenneth Anderson of the Dana-Farber Cancer Institute. (Source: Cancer Network)
Source: Cancer Network - January 31, 2013 Category: Cancer & Oncology Source Type: news

FDA Approves Imatinib (Gleevec) for Pediatric ALL
The US Food and Drug Administration has approved imatinib (Gleevec) for the treatment of newly diagnosed Philadelphia chromosome–positive acute lymphoblastic leukemia (Ph+ ALL) in children. (Source: Cancer Network)
Source: Cancer Network - January 30, 2013 Category: Cancer & Oncology Source Type: news

ASCO GI: Three Molecular Colorectal Cancer Subtypes in New Diagnostic Classification System
An international group of researchers have collaborated on an unbiased genome-wide analysis of colorectal cancer, coming up with three distinct molecular subtypes that are potentially clinically relevant and are varying in their biology and clinical outcomes. (Source: Cancer Network)
Source: Cancer Network - January 30, 2013 Category: Cancer & Oncology Source Type: news

Single-Tube Assay for CLL Optimizes Detection of Minimal Residual Disease
A single tube 10-color assay for the detection of residual disease in chronic lymphocytic leukemia provides at least equivalent results to the international standardized flow cytometry approach to detection and requires fewer cells, uses fewer reagents, and allows for simpler analysis, according to a new study. (Source: Cancer Network)
Source: Cancer Network - January 30, 2013 Category: Cancer & Oncology Source Type: news

“I Can’t Afford Any More Advances in Cancer Care, Doc!”
The reality is that new biological agents are often priced like a Ferrari, and patients who are covered under a pharmacy benefit are required to fork over not a fixed copay but a percentage of the pill’s cost, each and every month ‘til eternity or death, whichever comes first. (Source: Cancer Network)
Source: Cancer Network - January 29, 2013 Category: Cancer & Oncology Source Type: news

ASCO GI: Phase III Bevacizumab Results of the AVEX and TRIBE Trials
The same week that bevacizumab (Avastin) received a new indication for the treatment of metastatic colorectal cancer, results from two phase III trials involving the drug were presented at the American Society of Clinical Oncology 2013 Gastrointestinal Cancers Symposium (ASCO GI) held January 24–26 in San Francisco. (Source: Cancer Network)
Source: Cancer Network - January 28, 2013 Category: Cancer & Oncology Source Type: news

ASCO GI: Oral Chemo S-1 Increases Survival in Pancreatic Cancer, Japanese Study Shows
An oral fluoropyrimidine, S-1, used as an adjuvant therapy in Japanese patients with resected pancreatic cancer has shown an improved overall survival compared with the standard adjuvant therapy gemcitabine (Gemzar). (Source: Cancer Network)
Source: Cancer Network - January 28, 2013 Category: Cancer & Oncology Source Type: news

Inotuzumab Ozogamicin/Rituximab Combo for Lymphoma Yields High Response Rates, Long PFS
The combination of two antibody-based targeting agents—inotuzumab ozogamicin and rituximab—demonstrated high response rates and long progression-free survival in patients with relapsed follicular lymphoma or relapsed diffuse large-B-cell lymphoma (DLBCL) in an international phase I/II multicenter, open-label study. (Source: Cancer Network)
Source: Cancer Network - January 26, 2013 Category: Cancer & Oncology Source Type: news

A 45-Year-Old Woman With an Incidental Finding on MRI
A healthy 45-year-old woman undergoes an MRI for persistent headaches. The headaches resolve with conservative management. However, there is an incidental finding on the MRI of a homogeneously enhancing mass in the right jugular foramen. What is your diagnosis? (Source: Cancer Network)
Source: Cancer Network - January 25, 2013 Category: Cancer & Oncology Source Type: news

ASCO GI: Docetaxel for Advanced Esophagogastric Adenocarcinoma Improves Survival in Second-Line Setting
Adding the chemotherapy docetaxel to active symptom control in advanced esophagogastric adenocarcinoma improves survival of patients. These are the results of the phase III COUGAR-02 trial. (Source: Cancer Network)
Source: Cancer Network - January 25, 2013 Category: Cancer & Oncology Source Type: news

Complete GIST Resection Increased With Prolonged Preoperative Imatinib
The use of imatinib mesylate preoperatively for a maximum of 12 months resulted in a high rate of complete microscopic resection in a group of patients with marginally resectable gastrointestinal stromal tumor (GIST), according to the results of a phase II trial. (Source: Cancer Network)
Source: Cancer Network - January 24, 2013 Category: Cancer & Oncology Source Type: news

Can Metastasis of Triple-Negative Breast Cancer Be Thwarted?
Researchers have demonstrated how a particularly aggressive type of breast cancer, triple-negative disease, spreads to other parts of the body. The results may lead to new therapies that could treat metastatic breast cancer. (Source: Cancer Network)
Source: Cancer Network - January 24, 2013 Category: Cancer & Oncology Source Type: news

ASCO GI: Latest Treatments and Research in Gastrointestinal Cancers
In this interview we discuss the latest treatments and research for gastrointestinal cancers with Dr. Cathy Eng, associate professor, department of gastrointestinal medical oncology, The University of Texas MD Anderson Cancer Center. (Source: Cancer Network)
Source: Cancer Network - January 24, 2013 Category: Cancer & Oncology Source Type: news

Enzyme Linked to Most Common Brain Tumor
Higher levels of the enzyme kallikrein 6 (KLK6) are associated with glioblastoma multiforme, the most common type of brain tumor, according to a new study from researchers at the Mayo Clinic. (Source: Cancer Network)
Source: Cancer Network - January 23, 2013 Category: Cancer & Oncology Source Type: news

Study: Enzyme Plays Important Role in CML Stem Cell Reprogramming
Researchers have identified an enzyme that plays an important role in the reprogramming of malignant progenitor cells in chronic myeloid leukemia. The enzyme, ADAR1, could represent a target for selecting and eradicating leukemia stem cells. (Source: Cancer Network)
Source: Cancer Network - January 19, 2013 Category: Cancer & Oncology Source Type: news

Markers Can ID Aggressive Smoking-Associated Bladder Cancer
Researchers have identified bladder cancer markers that can predict which patients may have the most aggressive, fatal type of the disease. It was also discovered that smoking can affect the course of bladder cancer development, leading to more aggressive forms of the disease. (Source: Cancer Network)
Source: Cancer Network - January 17, 2013 Category: Cancer & Oncology Source Type: news

Thoracic Mass Discovered in 56-Year-Old Patient
A 56-year-old woman presents with hypoglycemia and chest pain. Radiographic imaging shows the presence of a large thoracic mass that appears to be attached to the pleura. What is your diagnosis? (Source: Cancer Network)
Source: Cancer Network - January 17, 2013 Category: Cancer & Oncology Source Type: news

Clinical Trials Need to Control for the Influence of Palliative Care on Outcomes
To insure standardization of all aspects of care during the conduct of a clinical trial, clinical trials should include guideline-based criteria for the management of all symptoms of cancer and its treatment, and failure to adhere to any of the standards for symptom management during the conduct of the trial should result in an equal level of protocol violation. (Source: Cancer Network)
Source: Cancer Network - January 16, 2013 Category: Cancer & Oncology Source Type: news

Tremelimumab No Match vs Metastatic Melanoma Standard of Care
The anti–cytotoxic T-lymphocyte–associated antigen 4 (CTLA-4) antibody tremelimumab failed to achieve a significant improvement in survival among patients with metastatic melanoma compared with the standard of care treatments used in the comparator arm, according to the results of a phase III study. (Source: Cancer Network)
Source: Cancer Network - January 16, 2013 Category: Cancer & Oncology Source Type: news

Everolimus Reduces Size of Noncancerous Kidney Tumors
The mTOR inhibitor everolimus (Afinitor) has been found to significantly reduce the size of angiomyolipomas, the slow-growing benign tumors commonly associated with tuberous sclerosis complex (TSC) and sporadic lymphangioleiomyomatosis, according to the results of the phase III EXIST-2 study. (Source: Cancer Network)
Source: Cancer Network - January 16, 2013 Category: Cancer & Oncology Source Type: news

mTOR Inhibitors in the Treatment of Breast Cancer
Efforts to identify clinical biomarkers of response or resistance to mTOR inhibitors are ongoing. This review will summarize results of preclinical and clinical studies as well as ongoing clinical trials with mTOR or dual PI3K/mTOR inhibitors. (Source: Cancer Network)
Source: Cancer Network - January 15, 2013 Category: Cancer & Oncology Source Type: news

Focal Therapy: A New Active Surveillance Tool?
Focal therapy is an appealing addition to our current AS strategies. As a “lesser evil,” focal therapy is showing promise as a therapy that can provide cancer control, while also avoiding many of the radical treatment–associated morbidities. (Source: Cancer Network)
Source: Cancer Network - January 15, 2013 Category: Cancer & Oncology Source Type: news

Focal Therapy of Prostate Cancer—The Challenge
The ideal utilization of focal therapy is to treat a smaller prostate cancer in which you can ablate, excise, or render inconsequential a tumor that affects a relatively small fraction of the gland. (Source: Cancer Network)
Source: Cancer Network - January 15, 2013 Category: Cancer & Oncology Source Type: news

Evolution of the Concept of Focal Therapy for Prostate Cancer
In this review we focus on the recent evolution of the concept of focal therapy and the potential applications of this management approach within an array of options currently available for patients with localized prostate cancer. (Source: Cancer Network)
Source: Cancer Network - January 15, 2013 Category: Cancer & Oncology Source Type: news

Early Palliative Care: Moving From ‘Why’ to ‘How’
Integrating palliative care from the time of diagnosis can support both patients and families through difficult periods and prepare them for the journey ahead. It can improve quality of life while curtailing healthcare spending and increasing satisfaction with oncology care. (Source: Cancer Network)
Source: Cancer Network - January 15, 2013 Category: Cancer & Oncology Source Type: news

Integrating Palliative Care Into Oncology Care: Confronting the Barriers
The body of research addressing the palliative care−oncology collaboration continues to accumulate; however, sustained efforts are needed to ensure that we are providing the best possible care for our patients. (Source: Cancer Network)
Source: Cancer Network - January 15, 2013 Category: Cancer & Oncology Source Type: news

TORn in Two Over Breast Cancer Drug Resistance
Knowing the genetic makeup of patient tumors permits the development of new DNA-based diagnostics, such as BEAMing and PARE. By incorporating these new tools into future trials, we should be able to concurrently learn about drug resistance and significantly improve patient responses. (Source: Cancer Network)
Source: Cancer Network - January 15, 2013 Category: Cancer & Oncology Source Type: news

How to Maximize the Potential of mTOR Inhibitors in Breast Cancer—More Questions Than Answers
Such a systematic review of the current status of mTOR inhibitors in the treatment of breast cancer demonstrates holes in our knowledge of the role of the tumor, the host, and metabolic factors in breast cancer progression. (Source: Cancer Network)
Source: Cancer Network - January 15, 2013 Category: Cancer & Oncology Source Type: news

Does the NCI Have a Problem With Cancer Screening?
Reading the contents of the NCI Cancer Bulletin in recent years, I have become increasingly concerned by what I perceive as an irrational, pervasive, and persistent editorial bias against cancer screening. (Source: Cancer Network)
Source: Cancer Network - January 14, 2013 Category: Cancer & Oncology Source Type: news

Mildly Pruritic Skin Eruption in 44-Year-Old Taiwanese Immigrant
Several years ago, a 44-year-old nonsmoking Taiwanese immigrant to the United States sought medical attention for the skin eruption depicted. This disorder had been present since he was 25; he notes an involuntary 35-pound weight loss and increasing fatigue. What is the patient’s skin disease? (Source: Cancer Network)
Source: Cancer Network - January 14, 2013 Category: Cancer & Oncology Source Type: news

How Accurate Are Clinical Trial Publications?
An analysis of 164 phase III breast cancer trials shows bias in reporting the primary endpoint and toxicity results, according to results of a recent study. (Source: Cancer Network)
Source: Cancer Network - January 14, 2013 Category: Cancer & Oncology Source Type: news

Study: Lung Screening Alone Does Not Change Risk Perceptions for Lung Cancer
Participants in the National Lung Screening Trial did not change their perceptions of risk for lung cancer and smoking-related disease between prescreening enrollment and a 1-year follow-up visit, regardless of the result of the screening test. (Source: Cancer Network)
Source: Cancer Network - January 12, 2013 Category: Cancer & Oncology Source Type: news

Study: Beta-Blockers May Help Lung Cancer Patients Live Longer
Lung cancer patients who take beta-adrenergic receptor antagonists (beta-blockers) may survive longer and have a lower rate of tumor spread, according to a new study. (Source: Cancer Network)
Source: Cancer Network - January 11, 2013 Category: Cancer & Oncology Source Type: news

Annual Report: Deaths From Cancer Are Declining
The annual report to the nation on the status of cancer in the United States, published Monday, shows cancer death rates overall continue to decline. The number of people who die as a result of their cancer has been steadily declining since the 1990s, and over the 9-year period between 2000 and 2009, the report shows a 1.8% decrease in death rates per year among men and a 1.4% decrease among women. (Source: Cancer Network)
Source: Cancer Network - January 11, 2013 Category: Cancer & Oncology Source Type: news

Altered Dosing of Vemurafenib Could Delay or Prevent Resistance
Researchers using a mouse model of melanoma were able to prevent resistance to vemurafenib by altering the dosing schedule from a continuous daily dose to an intermittent dose. (Source: Cancer Network)
Source: Cancer Network - January 10, 2013 Category: Cancer & Oncology Source Type: news

Immune Cells, Cytokines Predict Recurrence in Stage I Lung Adenocarcinoma
Expression of certain immune markers in tumor and surrounding cells can help predict probabilities of recurrence in patients with stage I lung adenocarcinoma, according to new researcher. (Source: Cancer Network)
Source: Cancer Network - January 9, 2013 Category: Cancer & Oncology Source Type: news

Multiple Liver Nodules Discovered in 43-Year-Old Patient
A 43-year-old man presented with abdominal pain. Radiographic imaging shows the presence of multiple liver nodules. Wedge resection was performed. What is your diagnosis? (Source: Cancer Network)
Source: Cancer Network - January 8, 2013 Category: Cancer & Oncology Source Type: news

Study: US Cancer Screening Rates Declined Over Last Decade
There has been a decline in overall cancer screening among the US population. Only colorectal cancer screening rates met current screening goals. Cancer survivors specifically met current national screening goals with the exception of cervical cancer screening. (Source: Cancer Network)
Source: Cancer Network - January 5, 2013 Category: Cancer & Oncology Source Type: news

Adding Sorafenib to Chemo Combo Fails to Improve Metastatic Melanoma Survival
No improvement in overall survival was seen in patients with metastatic melanoma who were assigned treatment with sorafenib in combination with carboplatin/paclitaxel for the treatment of their disease, according to the results of a double-blind, phase III study. (Source: Cancer Network)
Source: Cancer Network - January 4, 2013 Category: Cancer & Oncology Source Type: news

New Genetic Links to Colorectal Cancer Identified
Using a large genome-wide study of more than 28,000 individuals, three new genetic links to colorectal cancer have been identified, holding the potential for new therapeutic targets. (Source: Cancer Network)
Source: Cancer Network - January 3, 2013 Category: Cancer & Oncology Source Type: news

Partial Nephrectomy Procedural Window Widened With Use of ICE Technique
A new technique of robotic partial nephrectomy has the potential for better preservation of kidney function and better cancer control during partial nephrectomy by allowing surgeons more time to perform the procedure compared with traditional open surgery, according to the results of a recently published case series. (Source: Cancer Network)
Source: Cancer Network - January 2, 2013 Category: Cancer & Oncology Source Type: news

Reflections on My Visit to a Chinese Medical School—and an Unplanned Side Trip to a Chinese Hospital
As is nearly always the case with international travel, and especially in a place so different from what we are accustomed to in the United States, the whole experience was delightfully eye-opening, both for those dimensions of medical care and education that struck me as remarkably similar, as well as those that seemed wholly foreign. (Source: Cancer Network)
Source: Cancer Network - December 19, 2012 Category: Cancer & Oncology Source Type: news