Promising Biomarker for HPV-Related Oropharyngeal Cancer
More than one-third of patients with oropharyngeal cancer were seropositive for HPV16 E6 an average of 6 years prior to their cancer diagnosis compared with less than 1% of healthy controls, a new study has found. (Source: Cancer Network)
Source: Cancer Network - July 23, 2013 Category: Cancer & Oncology Source Type: news

The F-Word
Fat. It isn’t said in polite company, and doctors never use it with patients because it is considered rude and inflammatory. But fat is now a disease. OK—obesity is a disease. The American Medical Association has proclaimed it as such, and now we are free to discuss it unhindered by rules of etiquette. (Source: Cancer Network)
Source: Cancer Network - July 23, 2013 Category: Cancer & Oncology Source Type: news

Dramatic Effects of Quit Smart Tobacco Cessation Program Seen in Newly Diagnosed Cancer Patients
At ONS Congress 2013, Bruce Grant explains how integrating a nurse-driven tobacco cessation program for newly diagnosed oncology patients, called Quit Smart, into regularly scheduled appointments boosted the long-term quit rate (abstract 136806). (Source: Cancer Network)
Source: Cancer Network - July 22, 2013 Category: Cancer & Oncology Source Type: news

Irregular Vaginal Bleeding in 43-Year-Old Patient
A 43-year-old woman presents with irregular vaginal bleeding. An endometrial mass is identified. (Source: Cancer Network)
Source: Cancer Network - July 22, 2013 Category: Cancer & Oncology Source Type: news

GAUGUIN: Higher Obinutuzumab Dose Shows Promise in Non-Hodgkin Lymphoma
The phase II portion of the GAUGUIN study found promising activity with the anti-CD20 antibody obinutuzumab in patients with relapsed or refractory indolent NHL. (Source: Cancer Network)
Source: Cancer Network - July 22, 2013 Category: Cancer & Oncology Source Type: news

Novel Agents Increased Risk for Engraftment Syndrome in Older Myeloma Patients
Older multiple myeloma patients exposed to novel agents prior to autologous peripheral blood stem cell transplantation were at increased risk for engraftment syndrome. (Source: Cancer Network)
Source: Cancer Network - July 22, 2013 Category: Cancer & Oncology Source Type: news

Study Links Omega-3 Fatty Acids and Prostate Cancer Risk
A large and prospective study shows that a high concentration of omega-3 fatty acids is linked to a higher risk of aggressive prostate cancer. (Source: Cancer Network)
Source: Cancer Network - July 21, 2013 Category: Cancer & Oncology Source Type: news

Combined Immunotherapies Show Promise in Metastatic Melanoma
The results of two studies indicate that combining antibodies against the programmed death 1 (PD-1) receptor with an antibody against cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) improved treatment outcomes for patients with advanced melanoma, without a significant increase in adverse events. (Source: Cancer Network)
Source: Cancer Network - July 17, 2013 Category: Cancer & Oncology Source Type: news

Death With Dignity Program Well Accepted at Seattle Cancer Center
Patients who received a prescription for a lethal dose of secobarbital as part of a Death with Dignity program qualitatively described being grateful for the prescription, whether or not it was used, according to a recent study. (Source: Cancer Network)
Source: Cancer Network - July 16, 2013 Category: Cancer & Oncology Source Type: news

Gender Inequalities Exist in Diagnosis of Bladder, Renal Cancers
General practitioners took longer to suspect a diagnosis of bladder or renal cancer in women compared with men, according to a recent study. (Source: Cancer Network)
Source: Cancer Network - July 16, 2013 Category: Cancer & Oncology Source Type: news

Remembering Old Lessons in Prostate Cancer: Avoiding Errors 'in PARPituity'
The “experts” should maintain a stringent standard regarding what merits further development and reconsider carefully and critically the available data before committing to PARP inhibition, attacks on the PI3K pathway, and vasoactive agents in prostate cancer! (Source: Cancer Network)
Source: Cancer Network - July 15, 2013 Category: Cancer & Oncology Source Type: news

'Economies of Scale' Yield Multiple Benefits for a Private, Physician-Run Oncology Practice
The community oncology practice is the nation’s headquarters in the war on cancer. Eighty-five percent of all cancer patients receive their treatment in local community oncology practices. (Source: Cancer Network)
Source: Cancer Network - July 15, 2013 Category: Cancer & Oncology Source Type: news

Targeted Therapy in the Treatment of Castration-Resistant Prostate Cancer
In this review, we focus on the testosterone/androgen receptor pathway that is being targeted with potent new agents; we also discuss other important alternative biologic pathways that have given rise to new therapeutics that may attenuate prostate cancer growth, survival, and propagation. (Source: Cancer Network)
Source: Cancer Network - July 15, 2013 Category: Cancer & Oncology Source Type: news

Extended Surgery for Retroperitoneal Sarcoma: Too Much Surgery for Some and Not Enough for Others?
Recently controversy has emerged regarding the extent of resection that constitutes optimal surgical management of retroperitoneal soft tissue sarcoma. (Source: Cancer Network)
Source: Cancer Network - July 15, 2013 Category: Cancer & Oncology Source Type: news

Extended Surgery for Retroperitoneal Sarcoma: The Key to Maximizing the Potential for Cure and Survival
Surgery is the mainstay of treatment for localized soft-tissue sarcoma (STS). It consists primarily of resection of the tumor along with a cuff of surrounding healthy tissue. (Source: Cancer Network)
Source: Cancer Network - July 15, 2013 Category: Cancer & Oncology Source Type: news

Management of Lymph Node–Positive Prostate Cancer: The Role of Surgery and Radiation Therapy
Current evidence for the management of lymph node–positive prostate cancer suggests both a disease-control and survival benefit to systemic ADT plus surgery and radiation. (Source: Cancer Network)
Source: Cancer Network - July 15, 2013 Category: Cancer & Oncology Source Type: news

A Large Cystic Pancreatic Mass in a 45-Year-Old Female
The patient is an otherwise healthy 45-year-old female who presented to her primary care physician with 6 weeks of increasing left upper quadrant abdominal pain with radiation to the back. She underwent an abdominal ultrasound, which revealed a large cystic abdominal mass. (Source: Cancer Network)
Source: Cancer Network - July 15, 2013 Category: Cancer & Oncology Source Type: news

High-Dose Interleukin-2: Is It Still Indicated for Melanoma and RCC in an Era of Targeted Therapies?
In this review, we examine the currently approved options available for these disease processes, including the newer agents and selected combinatorial approaches under investigation, and we attempt to identify the role of high-dose IL-2 in the context of current clinical practice. (Source: Cancer Network)
Source: Cancer Network - July 15, 2013 Category: Cancer & Oncology Source Type: news

Can I Pray With You?
A 40-year-old woman with no significant family history of cancer came to me for a second opinion about her widely metastatic infiltrating gastric cancer. (Source: Cancer Network)
Source: Cancer Network - July 15, 2013 Category: Cancer & Oncology Source Type: news

Clarifying the Use of Ruxolitinib in Patients With Myelofibrosis
In this article, we provide updated data on ruxolitinib therapy for patients with myelofibrosis and offer expert opinion on the appropriate use of this agent in the community practice. (Source: Cancer Network)
Source: Cancer Network - July 15, 2013 Category: Cancer & Oncology Source Type: news

Muscle Density Linked to Survival in Metastatic RCC
A high skeletal muscle density has been linked to a twofold prolonged survival in patients with metastatic renal cell carcinoma compared with patients with low muscle density, according to a new study. (Source: Cancer Network)
Source: Cancer Network - July 15, 2013 Category: Cancer & Oncology Source Type: news

EUTOS Score Validated for Predicting Treatment Outcomes With TKI Therapy
A new study validates a simple prognostic score, the EUTOS score, as a useful tool in predicting the therapeutic effects of TKIs for chronic myeloid leukemia. (Source: Cancer Network)
Source: Cancer Network - July 12, 2013 Category: Cancer & Oncology Source Type: news

LUX-LUNG 3 and 4 Show Afatinib Effective in EGFR-mutated NSCLC
Two new studies show that afatinib, an orally bioavailable ERBB family blocker, could be effective in patients with non–small-cell lung cancer (NSCLC) who progressed on other therapies and in patients with advanced lung adenocarcinomas and EGFR mutations. (Source: Cancer Network)
Source: Cancer Network - July 12, 2013 Category: Cancer & Oncology Source Type: news

FDA Approves Afatinib for Advanced Lung Cancer
The FDA approved afatinib (Gilotrif) as a first-line therapy for patients with metastatic non-small-cell lung cancer whose tumors harbor certain mutations in the epidermal growth factor receptor gene. (Source: Cancer Network)
Source: Cancer Network - July 12, 2013 Category: Cancer & Oncology Source Type: news

Ponatinib Receives Marketing Authorization in Europe for CML and Ph+ ALL
ARIAD has received marketing authorization from the European Commission for ponatinib (Iclusig) in chronic myeloid leukemia and acute lymphoblastic leukemia. (Source: Cancer Network)
Source: Cancer Network - July 12, 2013 Category: Cancer & Oncology Source Type: news

ASCO Adds New Drug to Breast Cancer Prevention Guidelines
The American Society of Clinical Oncology (ASCO) has updated its guidelines on treating women at high risk of developing breast cancer with pharmacologic drugs. (Source: Cancer Network)
Source: Cancer Network - July 10, 2013 Category: Cancer & Oncology Source Type: news

Developing Novel Treatments Using the AML Genome
In this interview we discuss acute myeloid leukemia therapy approaches and new molecular targets based on genetic analyses of the disease with a leukemia expert. (Source: Cancer Network)
Source: Cancer Network - July 10, 2013 Category: Cancer & Oncology Source Type: news

Pertuzumab Granted Priority Review for Neoadjuvant HER2-Positive Breast Cancer
Last week, the FDA announced that it would grant priority review to pertuzumab (Perjeta), as a neoadjuvant treatment for women with HER2-positive early-stage breast cancer. (Source: Cancer Network)
Source: Cancer Network - July 9, 2013 Category: Cancer & Oncology Source Type: news

Role of Aspirin in Colorectal Cancer Prevention and Treatment
In this interview we discuss the role of aspirin in colorectal cancer prevention and treatment. Various studies have suggested that a daily aspirin pill can help prevent certain types of cancers. Other studies suggest that there may even be a role for aspirin in treating cancer. (Source: Cancer Network)
Source: Cancer Network - July 9, 2013 Category: Cancer & Oncology Source Type: news

Particulate Air Pollution Contributes to Lung Cancer Risk in Huge European Study
A study including 17 cohorts with a total of more than 300,000 individuals found that ambient air pollution of various types contributes to lung cancer incidence across nine European countries. (Source: Cancer Network)
Source: Cancer Network - July 9, 2013 Category: Cancer & Oncology Source Type: news

Patient Presents With Right Leg Pain
A 29-year-old woman presents with pain in the right leg. Radiographic imaging shows the presence of a lesion centered at the epiphysis of the femur. Surgical excision was performed. What is your diagnosis? (Source: Cancer Network)
Source: Cancer Network - July 8, 2013 Category: Cancer & Oncology Source Type: news

Bone Metastases in Lung Cancer Patients Linked With Poorer Prognosis
A pair of studies from the ASCO annual meeting examined bone metastases from lung cancer, with one study finding that survival in patients was poorer in patients with bone metastases, and another study finding that the development of bone metastases could predict subsequent development of metastasis in the brain. (Source: Cancer Network)
Source: Cancer Network - July 8, 2013 Category: Cancer & Oncology Source Type: news

Enlarged Spleen in 34-Year-Old Patient
A 34-year-old man presents with mild splenic enlargement. Resection of the spleen is performed. What is your diagnosis? (Source: Cancer Network)
Source: Cancer Network - July 8, 2013 Category: Cancer & Oncology Source Type: news

Young White Men More Likely Than Women to Die from Melanoma
Adolescent and young white men are at a more than 50% increased risk for death from melanoma than women of the same age, a new study has found. The researchers called the difference “alarming.” (Source: Cancer Network)
Source: Cancer Network - July 7, 2013 Category: Cancer & Oncology Source Type: news

Study: Red Meat Tied to Poor Colorectal Cancer Outcomes
A study of colorectal cancer survivors shows those who consume higher amounts of red and processed meats before a colorectal cancer diagnosis are at higher risk of death from any cause compared to those who eat less of both types of meat. (Source: Cancer Network)
Source: Cancer Network - July 4, 2013 Category: Cancer & Oncology Source Type: news

Recurrence After Tamoxifen Could Be Dictated by Gene Expression
The expression levels of two genes could indicate whether a woman with estrogen receptor-positive breast cancer is at risk for recurrence after 5 years of tamoxifen therapy and should receive subsequent therapy. (Source: Cancer Network)
Source: Cancer Network - July 3, 2013 Category: Cancer & Oncology Source Type: news

PHARE: One-Year Trastuzumab Remains Standard for HER2-Positive Breast Cancer
A 6-month regimen of treatment with trastuzumab for HER2-positive breast cancer failed to show noninferiority with the standard 12-month treatment regimen after 3.5 years of follow-up in the open-label, randomized, phase III PHARE trial. (Source: Cancer Network)
Source: Cancer Network - July 3, 2013 Category: Cancer & Oncology Source Type: news

Patient With Multiple Brain Metastases
A 59-year-old with a primary asymptomatic bronchogenic adenocarcinoma and multiple brain metastases. The patient was treated with cyclic chemotherapy consisting of: docetaxel (Taxotere), carboplatin, and bevacizumab (Avastin). What portion of the patient’s therapy is most likely responsible for the acne-like eruption? (Source: Cancer Network)
Source: Cancer Network - July 1, 2013 Category: Cancer & Oncology Source Type: news

Are You Special? Should We All Be Special?
If you or your loved one had cancer, how would you go about picking their treating oncologist? What would you want to know about their experience in that disease? And if a patient asks you how many cases you have treated with their diagnosis, will you look at them and be totally honest? (Source: Cancer Network)
Source: Cancer Network - June 30, 2013 Category: Cancer & Oncology Source Type: news

Boost in Use of Latest Technologies for Low-Risk Prostate Cancer Patients
From 2004 to 2009, use of advanced treatment technologies increased among prostate cancer patients with low-risk disease and high risk of noncancer mortality. (Source: Cancer Network)
Source: Cancer Network - June 29, 2013 Category: Cancer & Oncology Source Type: news

BRAF-Mutated Colon Cancer May Be Less Responsive to Aspirin's Positive Effects
An analysis of two colorectal cancer studies found that patients with BRAF mutations were less sensitive to the effects of aspirin as treatment or prevention. (Source: Cancer Network)
Source: Cancer Network - June 28, 2013 Category: Cancer & Oncology Source Type: news

Bone Metastases Result in Worse Outcomes for RCC Patients
Bone metastases result in poorer outcomes for those patients with advanced renal cell carcinoma (RCC), who were treated with a molecularly targeted therapy. The results were presented in two separate analyses at the annual ASCO meeting. (Source: Cancer Network)
Source: Cancer Network - June 27, 2013 Category: Cancer & Oncology Source Type: news

Tool Predicts Salivary Gland Cancer Recurrence Risk
Researchers have developed and tested a nomogram that uses various factors and can predict risk of recurrence in patients with major salivary gland carcinoma. (Source: Cancer Network)
Source: Cancer Network - June 27, 2013 Category: Cancer & Oncology Source Type: news

Ovarian Cancer Therapies in Development
Today we speak with Dr. Robert Coleman about several new agents that have shown promise in early-stage clinical trials for ovarian cancer. (Source: Cancer Network)
Source: Cancer Network - June 27, 2013 Category: Cancer & Oncology Source Type: news

Cost Effectiveness for Stage I Lung Cancer Therapies
Researchers found that the more cost-effective option (surgery vs SBRT) in stage I lung cancer depends on whether the disease is clearly or marginally operable. (Source: Cancer Network)
Source: Cancer Network - June 26, 2013 Category: Cancer & Oncology Source Type: news

Fifteen Ways to Attract Malpractice Lawsuits: A Free Guide
Here’s a fun fact: most doctors will be sued at least once during their career. Physicians in high-risk specialties such a surgery have a 99% chance of being sued by age 65; even low-risk specialists have a 75% probability. (Source: Cancer Network)
Source: Cancer Network - June 26, 2013 Category: Cancer & Oncology Source Type: news

Guidelines for Treatment of Multiple Myeloma-Related Bone Disease Released
The International Myeloma Working Group recently released new recommendations to aid physicians in the treatment of bone disease related to multiple myeloma. (Source: Cancer Network)
Source: Cancer Network - June 26, 2013 Category: Cancer & Oncology Source Type: news

Escitalopram for Head and Neck Cancer Patients Cut Depression in Half
Prophylactic use of the SSRI escitalopram decreased the occurrence of depression in patients with head and neck cancers by 50% and resulted in significantly improved quality of life for 3 months after drug cessation, according to the results of the PROTECT trial. (Source: Cancer Network)
Source: Cancer Network - June 25, 2013 Category: Cancer & Oncology Source Type: news

Ibrutinib Yields Durable Responses in CLL
Monotherapy with the investigational oral Bruton's tyrosine kinase inhibitor ibrutinib was well tolerated and produced durable responses in a phase Ib/II, open-label, multicenter study of 85 patients with relapsed/refractory chronic lymphocytic leukemia or small lymphocytic lymphoma. (Source: Cancer Network)
Source: Cancer Network - June 25, 2013 Category: Cancer & Oncology Source Type: news

PET/MR Outperforms PET/CT in Detecting Prostate Cancer Recurrence
A new imaging approach, combining PET with magnetic resonance (MR), was shown to be more sensitive in detecting recurrent prostate cancer compared with PET/CT. (Source: Cancer Network)
Source: Cancer Network - June 25, 2013 Category: Cancer & Oncology Source Type: news