Slide Show: Breast Carcinoma
This breast cancer slide show features pathology slides of DCIS, LCIS, Paget’s disease, and invasive ductal and lobular carcinoma at various magnifications. (Source: Cancer Network)
Source: Cancer Network - August 16, 2013 Category: Cancer & Oncology Source Type: news

Prostate Cancer Prevention Trial: Long-Term Follow-Up
The long-term follow-up of the Prostate Cancer Prevention Trial confirms that finasteride reduces the risk of low-grade prostate cancer by one-third, but there were no significant survival differences between the two study arms. (Source: Cancer Network)
Source: Cancer Network - August 16, 2013 Category: Cancer & Oncology Source Type: news

“I’m the Decider! (Is That OK with You?)”
Today, after reviewing a CT scan (and screwing my courage to the sticking-place) I went into an exam room, looked a patient in the eye and said: “The liver lesions have started to grow again. I think we need to change your treatment.” (Source: Cancer Network)
Source: Cancer Network - August 15, 2013 Category: Cancer & Oncology Source Type: news

Introducing a New Resource for Readers of ONCOLOGY: The American College of Radiology Appropriateness Criteria
The ACR Appropriateness Criteria®, and their mission to improve the knowledge of practicing oncologists and the level of care our patients receive, is wholly consistent with the goals of ONCOLOGY. We are hopeful that our readership will find the ACR Appropriateness Criteria® a valuable resource in their day-to-day practice. I personally look forward to future guidelines in this series. (Source: Cancer Network)
Source: Cancer Network - August 15, 2013 Category: Cancer & Oncology Source Type: news

Ductal Carcinoma In Situ of the Breast: ‘Making the Punishment Fit the Crime’
To make the punishment fit the crime, you would want the decision of whether or not to use adjuvants to be informed by the degree of risk that the DCIS would recur. What factors can predict for an increased risk of recurrence, or more importantly, the risk of an invasive breast cancer occurring? (Source: Cancer Network)
Source: Cancer Network - August 15, 2013 Category: Cancer & Oncology Source Type: news

Nonseminomatous Germ Cell Tumor of Testis and Interrupted Treatment
A 22-year-old man presented to the emergency department with a 5-cm painful testicular mass that had increased in size over the previous month. Tumor markers were drawn and an inguinal orchiectomy was performed. (Source: Cancer Network)
Source: Cancer Network - August 15, 2013 Category: Cancer & Oncology Source Type: news

Oral Oncolytics: Part 1—Financial, Adherence, and Management Challenges
The management of patients receiving treatment with oral oncolytics presents challenges such as cost, adherence, monitoring of side effects, and safe handling. (Source: Cancer Network)
Source: Cancer Network - August 15, 2013 Category: Cancer & Oncology Source Type: news

First-Line Treatment for Patients With CML in Chronic Phase: Second-Generation TKIs Are the Therapy of Choice
How often do we choose the “second best” treatment as initial therapy for our patients with cancer? The management of chronic myeloid leukemia should be no different. (Source: Cancer Network)
Source: Cancer Network - August 15, 2013 Category: Cancer & Oncology Source Type: news

First-Line Treatment for Patients With CML in Chronic Phase: Why Imatinib Is an Appropriate Choice
I am very comfortable in using imatinib as initial therapy in most patients who present in chronic phase, with the possible exception of patients with more advanced disease and higher Sokal scores. (Source: Cancer Network)
Source: Cancer Network - August 15, 2013 Category: Cancer & Oncology Source Type: news

The Impact of Molecular Testing on Treatment of Cancer of Unknown Primary Origin
The preponderance of data support the accuracy of molecular assay diagnoses in about 80% to 90% of patients with known advanced primary cancers and in patients with cancer of unknown primary origin. (Source: Cancer Network)
Source: Cancer Network - August 15, 2013 Category: Cancer & Oncology Source Type: news

Announcing a New Series: Understanding Unusual Dysproteinemias
In a new series, beginning this month and running into early 2014, experts on five “unusual dysproteinemias” will share their insights into diagnosis and management. (Source: Cancer Network)
Source: Cancer Network - August 15, 2013 Category: Cancer & Oncology Source Type: news

Unusual Myelomas: A Review of IgD and IgE Variants
Although survival of patients with IgD or IgE multiple myeloma is shorter in comparison to those with IgG or IgA multiple myeloma, the outcome for patients with IgD and IgE subtypes is improving with the use of novel agents and autologous transplantation. (Source: Cancer Network)
Source: Cancer Network - August 15, 2013 Category: Cancer & Oncology Source Type: news

ACR Appropriateness Criteria® Localized Nodal Indolent Lymphoma
The present guidelines review epidemiology, pathology, presentation, workup, staging, prognostic factors, and treatment options for patients with localized nodal indolent lymphoma, with an emphasis on radiation guidelines, including radiation dose, field design, and radiation techniques. (Source: Cancer Network)
Source: Cancer Network - August 15, 2013 Category: Cancer & Oncology Source Type: news

Use of Molecular Biomarkers to Inform Adjuvant Therapy for Colon Cancer
In this review, we will discuss adjuvant chemotherapy in non-metastatic colon cancer, the existing prognostic and predictive molecular biomarkers in the field, and how to integrate these molecular biomarkers into the decision about whether to administer adjuvant therapy. (Source: Cancer Network)
Source: Cancer Network - August 15, 2013 Category: Cancer & Oncology Source Type: news

One-Two Punch May Improve Cancer Treatment Results
A new study demonstrates a way to exploit a metabolic vulnerability of senescent cells. The strategy provides evidence for an anticancer approach that targets a cellular process or condition of the cell rather than a distinct molecular pathway. (Source: Cancer Network)
Source: Cancer Network - August 14, 2013 Category: Cancer & Oncology Source Type: news

Some Blood Pressure Drugs Increase Breast Cancer Risk
Use of calcium-channel blockers for treatment of high blood pressure for more than 10 years can increase the risk of breast cancer for women after menopause, a new study shows. (Source: Cancer Network)
Source: Cancer Network - August 13, 2013 Category: Cancer & Oncology Source Type: news

Patterns of Recurrence Differ by Breast Cancer Node-Negative Subtype
A study defining patterns of recurrence in node-negative breast cancer patients could help guide surveillance recommendations and future therapeutic approaches. (Source: Cancer Network)
Source: Cancer Network - August 12, 2013 Category: Cancer & Oncology Source Type: news

Adrenal Lesion Discovered in 50-Year-Old Patient
A 50-year-old patient had an abdomen MRI to evaluate an adrenal lesion detected during the work-up of abdominal pain. Based on the images from the abdomen MRI, what is your diagnosis? (Source: Cancer Network)
Source: Cancer Network - August 12, 2013 Category: Cancer & Oncology Source Type: news

Robotic Ultrasound Beneficial for Robotic Partial Nephrectomy
Surgeons saw advantages in robotic, over laparoscopic, ultrasound probes during robotic partial nephrectomy, and similar perioperative outcomes and margin rates. (Source: Cancer Network)
Source: Cancer Network - August 12, 2013 Category: Cancer & Oncology Source Type: news

Post-Orchiectomy Surveillance Is Sufficient for Men With Stage I Seminoma
At the 2013 ASCO meeting, investigators of a large Danish study have concluded that surveillance alone following surgery for stage I seminoma is sufficient, sparing patients in this setting from the unnecessary expense and associated toxicities of chemotherapy and radiation treatment. (Source: Cancer Network)
Source: Cancer Network - August 10, 2013 Category: Cancer & Oncology Source Type: news

Surveillance for Stage I Seminoma: Part I
Dr. Bruce Roth discusses the large Danish study reported at ASCO (abstract 4502) that showed surveillance alone is sufficient after orchiectomy for stage I seminoma. (Source: Cancer Network)
Source: Cancer Network - August 9, 2013 Category: Cancer & Oncology Source Type: news

Surveillance for Stage I Seminoma: Part II
Dr. Bruce Roth discusses the large Danish study reported at ASCO (abstract 4502) that showed surveillance alone is sufficient after orchiectomy for stage I seminoma, focusing on its impact on post-surgery radiation therapy in this setting. (Source: Cancer Network)
Source: Cancer Network - August 9, 2013 Category: Cancer & Oncology Source Type: news

Epidemiology of Seminoma
Dr. Bruce Roth, Professor of Oncology in the Division of Medicine at Siteman Cancer Center, Washington University at St. Louis, spoke at the 2013 ASCO meeting about topics in seminoma. Here he discusses the epidemiology of seminoma. (Source: Cancer Network)
Source: Cancer Network - August 9, 2013 Category: Cancer & Oncology Source Type: news

Recurrence and Relapse in Testicular Cancer
Dr. Bruce Roth, Siteman Cancer Center, spoke at the 2013 ASCO meeting about topics in seminoma. Here he discusses recurrence, relapse, and seminomatous vs nonseminomatous testicular cancer. (Source: Cancer Network)
Source: Cancer Network - August 9, 2013 Category: Cancer & Oncology Source Type: news

Pazopanib Shows Promise in Phase I Pediatric Sarcoma Trial
The multikinase angiogenesis inhibitor pazopanib was well tolerated and exhibited some responses in pediatric patients with soft-tissue sarcomas and other refractory solid tumors in a phase I trial. (Source: Cancer Network)
Source: Cancer Network - August 8, 2013 Category: Cancer & Oncology Source Type: news

Case Report Shows Tattoos May Hide Melanoma
Melanoma can hide in pigmented tattoos, according to a new case report describing a young man with a malignant melanoma that developed within a large tattoo. (Source: Cancer Network)
Source: Cancer Network - August 8, 2013 Category: Cancer & Oncology Source Type: news

USPSTF Supports Low-Dose CT Lung Screening in Draft Recommendation
Based largely on evidence from the NLST, the USPSTF recently issued a draft recommendation for annual lung cancer screening using low-dose CT in high-risk individuals. (Source: Cancer Network)
Source: Cancer Network - August 8, 2013 Category: Cancer & Oncology Source Type: news

3D Imaging Could Improve Colorectal Cancer Screening
A new endoscopy technology called photometric stereo endoscopy, which captures the topography of the colon surface to create a 3D image, could be a more robust way to screen for precancerous lesions of the colon. (Source: Cancer Network)
Source: Cancer Network - August 8, 2013 Category: Cancer & Oncology Source Type: news

NLST: Lung Screening Benefits High-Risk Individuals Most
Results from the National Lung Screening Trial showed that screening for lung cancer with low-dose computed tomography yielded the most benefit among individuals who were at highest risk for cancer and less benefit in lower risk people. (Source: Cancer Network)
Source: Cancer Network - August 7, 2013 Category: Cancer & Oncology Source Type: news

Many Sarcoma Surgeries Performed by Non-Oncologic Surgeons
Almost half of the resections performed for deep and malignant extremity soft-tissue sarcomas are done by non-oncology surgeons including orthopedic surgeons and general surgeons, according to a new study. (Source: Cancer Network)
Source: Cancer Network - August 7, 2013 Category: Cancer & Oncology Source Type: news

Tools Affect Prostate Cancer Screening Decisions, Not Rates
Both Internet and print-based decision aids equally helped men make important decisions related to prostate cancer screening, but did not affect actual screening rates. (Source: Cancer Network)
Source: Cancer Network - August 7, 2013 Category: Cancer & Oncology Source Type: news

HPV Linked to Increased Esophageal Cancer Risk
A meta-analysis by researchers in Australia shows that those infected with the human papillomavirus have a threefold higher risk of developing esophageal squamous cell carcinoma. (Source: Cancer Network)
Source: Cancer Network - August 7, 2013 Category: Cancer & Oncology Source Type: news

Digital Mammography Plus Tomosynthesis Improves Breast Cancer Screening
A new study shows that the combination of digital mammography plus tomosynthesis results in fewer false positive results compared with digital mammography alone. Women under the age of 50 and those with dense breasts had the greatest benefit. (Source: Cancer Network)
Source: Cancer Network - August 6, 2013 Category: Cancer & Oncology Source Type: news

Saving Kidney Tissue May Not Improve Survival in Renal Cancer
Undergoing nephron-sparing surgery for small renal masses substantially reduced the risk of moderate renal dysfunction compared with radical nephrectomy, but not that of kidney failure among patients enrolled in the EORTC 30904 trial. (Source: Cancer Network)
Source: Cancer Network - August 5, 2013 Category: Cancer & Oncology Source Type: news

Intrahepatic Mass Found in 53-Year-Old Patient
A 53-year-old man presents with abdominal pain. Diagnostic imaging shows the presence of an intrahepatic mass. Open biopsy is performed. What is your diagnosis? (Source: Cancer Network)
Source: Cancer Network - August 5, 2013 Category: Cancer & Oncology Source Type: news

Model Predicts Risk of Breast and Gynecologic Cancers
Using easy-to-obtain risk factors for breast, ovarian, and endometrial cancers, researchers have come up with models that can predict an individual woman’s absolute risk for developing each type of cancer. (Source: Cancer Network)
Source: Cancer Network - August 4, 2013 Category: Cancer & Oncology Source Type: news

Chemoradiation Therapy for the Treatment of Bone Metastases
The combination of the chemotherapy capecitabine with external beam radiation was found to be both safe and effective in treating pain from bone metastases in patients with advanced breast cancer. (Source: Cancer Network)
Source: Cancer Network - August 2, 2013 Category: Cancer & Oncology Source Type: news

Personalized Medicine Gives Rise to New Ethical Questions
There are risks to privacy and informed consent embedded in the many exciting discoveries of personalized approaches to medicine. These risks vary greatly. (Source: Cancer Network)
Source: Cancer Network - July 31, 2013 Category: Cancer & Oncology Source Type: news

Early Treatment of High-Risk Smoldering Multiple Myeloma Improves Outcomes
Early treatment with lenalidomide and dexamethasone in patients with high-risk smoldering myeloma significantly delayed progression to symptomatic disease and prolonged survival with a good safety profile. (Source: Cancer Network)
Source: Cancer Network - July 31, 2013 Category: Cancer & Oncology Source Type: news

Painful Neck Mass in 48-Year-Old Patient
A 48-year-old man presents with a mildly painful right neck mass. Resection of the mass is performed. What is your diagnosis? (Source: Cancer Network)
Source: Cancer Network - July 30, 2013 Category: Cancer & Oncology Source Type: news

Managing Pain and Treating Bone Metastases in Prostate Cancer
The ALSYMPCA phase III clinical trial, recently published, demonstrated that radium-223 dichloride was well-tolerated and resulted in an improvement in overall survival by 3.6 months compared with placebo. (Source: Cancer Network)
Source: Cancer Network - July 30, 2013 Category: Cancer & Oncology Source Type: news

Sentinel Node Biopsy Adequate for Staging Oral Cancer
Neck dissection may no longer be the only surgical option for pathologic staging of the neck in patients with oral cavity squamous cell carcinoma, according to a new study. (Source: Cancer Network)
Source: Cancer Network - July 29, 2013 Category: Cancer & Oncology Source Type: news

Study: Cancer Risk Higher for Taller Women After Menopause
A study published today has linked higher stature in women after menopause with a higher risk of developing any of 19 cancer types. (Source: Cancer Network)
Source: Cancer Network - July 26, 2013 Category: Cancer & Oncology Source Type: news

Use of Surveillance CT Scans to Detect DLBCL Relapse
A study from the Mayo Clinic/University of Iowa assessing the use of surveillance CT scans to detect DLBCL relapses found that the majority of relapses occurred outside of regularly scheduled visits and concluded that it is important to educate patients to be more alert to signs and symptoms of relapse. (Source: Cancer Network)
Source: Cancer Network - July 26, 2013 Category: Cancer & Oncology Source Type: news

State of CML Treatments
In this interview, we discuss the current state of therapies available in treating CML patients and the role of newer agents. (Source: Cancer Network)
Source: Cancer Network - July 25, 2013 Category: Cancer & Oncology Source Type: news

Crizotinib Ups PFS in ALK-Positive NSCLC
The ALK-inhibitor crizotinib leads to longer progression-free survival than chemotherapy in patients with advanced ALK-positive non-small-cell lung cancer (NSCLC), according to results of a phase III clinical trial. (Source: Cancer Network)
Source: Cancer Network - July 25, 2013 Category: Cancer & Oncology Source Type: news

Gene Expression Test Shows Promise for Lung Cancer Diagnosis
An assay system for gene expression analysis of paraffin-embedded patient samples is predictive of lung cancer histologic type, according to results published in the Journal of Molecular Diagnostics. (Source: Cancer Network)
Source: Cancer Network - July 25, 2013 Category: Cancer & Oncology Source Type: news

Diffuse Large B-Cell Lymphoma: Challenging Patients and Evolving Management
Dr. Brian Link discusses challenges in managing very elderly patients with diffuse large B-cell lymphoma and looks ahead to future management of DLBCL in general. (Source: Cancer Network)
Source: Cancer Network - July 25, 2013 Category: Cancer & Oncology Source Type: news

Reassessing Imaging Surveillance in Diffuse Large B-Cell Lymphoma
Dr. Brian Link discusses clinical implications of the large Mayo Clinic/ University of Iowa study (ASCO abstract 8504) showing patient symptoms rather than scheduled surveillance imaging drove detection of relapses in patients with diffuse large B-cell lymphoma (DLBCL). (Source: Cancer Network)
Source: Cancer Network - July 25, 2013 Category: Cancer & Oncology Source Type: news

New Ways Prostate Cancer Overcomes Current Treatments
Researchers have identified pathways that are important for prostate cancer growth after the tumor becomes resistant to androgen therapies. (Source: Cancer Network)
Source: Cancer Network - July 24, 2013 Category: Cancer & Oncology Source Type: news