Do Oncogenic Drivers Exist in Squamous Cell Carcinoma of the Lung?
The Cancer Genome Atlas provides us with our first thorough insight into the genetic heterogeneity of squamous cell carcinoma of the lung; whether these findings will translate into personalized squamous cell lung cancer therapy is yet to be determined. (Source: Cancer Network)
Source: Cancer Network - September 15, 2013 Category: Cancer & Oncology Source Type: news

Squamous Cell Lung Cancer: Where Do We Stand and Where Are We Going?
The Cancer Genome Atlas results have led to some encouraging advances in the clinical perspective on squamous cell lung cancer and spurred new initiatives targeting patients with squamous cell lung cancer, giving us hope for future improvements in clinical management and therapeutic outcomes for this subgroup of lung cancer patients. (Source: Cancer Network)
Source: Cancer Network - September 15, 2013 Category: Cancer & Oncology Source Type: news

Short Course of Chemo Effective in Early-Stage HER2 Breast Cancer
Combining four cycles of docetaxel and cyclophosphamide with 1 year of trastuzumab may be a viable treatment option for women with HER2-amplified early-stage breast cancer regardless of their TOP2A status, according to the results of a phase II study. (Source: Cancer Network)
Source: Cancer Network - September 14, 2013 Category: Cancer & Oncology Source Type: news

Variations in Melanoma Treatment May Affect Outcomes in Elderly
Older patients with melanoma were diagnosed with thicker melanomas, and experienced longer time to excision and a higher frequency of insufficient excision margins compared with their younger counterparts in a multicenter study in France. (Source: Cancer Network)
Source: Cancer Network - September 13, 2013 Category: Cancer & Oncology Source Type: news

Dasatinib Shows Promise for Pediatric CML, ALL Patients
A phase I study of dasatinib in children and adolescents with chronic myeloid leukemia (CML) and other malignancies determined dosing for further studies and suggested the drug is well tolerated and effective in these patients. (Source: Cancer Network)
Source: Cancer Network - September 13, 2013 Category: Cancer & Oncology Source Type: news

Pazopanib Noninferior to Sunitinib for Metastatic RCC
A head-to-head comparison of pazopanib and sunitinib for the treatment of metastatic renal cell carcinoma showed that the two drugs resulted in similar progression-free survival, but also indicated that pazopanib may have a favorable safety profile. (Source: Cancer Network)
Source: Cancer Network - September 12, 2013 Category: Cancer & Oncology Source Type: news

Slide Show: Nasal Tumors
This nasal tumor slide show features pathology images of nasal neuroblastoma, rhabdomyosarcoma, melanoma, hemangiopericytoma, and lymphoma at various magnifications. (Source: Cancer Network)
Source: Cancer Network - September 12, 2013 Category: Cancer & Oncology Source Type: news

Perceived Cognitive Decline in Breast Cancer Patients
Two studies presented at the ASCO Breast Cancer Symposium 2013 focused on studying cognitive function in women with early-stage breast cancer, focusing on the relationship between perceived and measurable cognitive decline, and factors that may help to predict cognitive decline. (Source: Cancer Network)
Source: Cancer Network - September 11, 2013 Category: Cancer & Oncology Source Type: news

Post-Treatment Biomarker Changes Improved Breast Cancer Survival
About 40% of women experienced a change in at least one biomarker from primary to residual breast cancer after undergoing neoadjuvant chemotherapy, according to the results of a study presented at the ASCO Breast Cancer Symposium. (Source: Cancer Network)
Source: Cancer Network - September 11, 2013 Category: Cancer & Oncology Source Type: news

“Self-Eating” Cells May Help Prevent Melanoma Progression
A new study in early-stage melanoma patients shows that “self-eating” cells, or autophagy, can keep the cancer in check and may lead to a better prognosis. (Source: Cancer Network)
Source: Cancer Network - September 11, 2013 Category: Cancer & Oncology Source Type: news

Biomarker May Predict Prostate Cancers Requiring Treatment
Researchers have now identified a 3-gene signature that could indicate whether a particular early-stage prostate cancer is indolent. The test relies on a tissue sample, a PSA test, and a histology assessment. (Source: Cancer Network)
Source: Cancer Network - September 11, 2013 Category: Cancer & Oncology Source Type: news

Nine of Ten Women Cannot Quantify Lifetime Breast Cancer Risk
More than 90% of women about to undergo a mammography were unable to accurately quantify their risk for breast cancer, either over- or underestimating their risk, according to the results of a large-scale survey presented at the ASCO Breast Cancer Symposium 2013. (Source: Cancer Network)
Source: Cancer Network - September 10, 2013 Category: Cancer & Oncology Source Type: news

After Radiation for DCIS, No Increase in Cardiovascular Mortality, Morbidity
The exposure of the heart to radiation during radiotherapy for ductal carcinoma in situ (DCIS) did not increase cardiovascular mortality or morbidity, according to a study by researchers in the Netherlands. (Source: Cancer Network)
Source: Cancer Network - September 10, 2013 Category: Cancer & Oncology Source Type: news

Lightly Pigmented Skin Lesion on 35-Year-Old Patient
A 35-year-old man presented with a lightly pigmented lesion on the skin of the right arm. Complete surgical excision of the lesion was performed. What is your diagnosis? (Source: Cancer Network)
Source: Cancer Network - September 9, 2013 Category: Cancer & Oncology Source Type: news

Batch MRI Breast Cancer Screening Possibility with Accelerated Protocol
Expert radiologists were able to screen magnetic resonance images and rule out breast cancer diagnosis with a negative predictive value of about 99% using an abridged breast MRI protocol in a single-center study presented Saturday at the ASCO Breast Cancer Symposium 2013. (Source: Cancer Network)
Source: Cancer Network - September 9, 2013 Category: Cancer & Oncology Source Type: news

Promising Marker for Response to EGFR Inhibitors
The ratio of two protein levels may predict clinical benefit of EGFR inhibitors. Low levels of a protein called Mig6 (mitogen-inducible gene 6) and high levels of EGFR corresponded to a higher clinical response rate and progression-free survival in a small prospective cohort of lung cancer patients treated with the anti-EGFR therapy gefitinib. (Source: Cancer Network)
Source: Cancer Network - September 9, 2013 Category: Cancer & Oncology Source Type: news

Multiple Myeloma Patients Had Continued Response to ASCT Past 100-Day Disease Assessment
Patients with multiple myeloma who underwent autologous stem cell transplantation may have a continued response to the treatment even after the traditional disease assessment at 100 days. A new study indicates that this continued response maintained prognostic value and should be taken into account when considering post-transplant therapies. (Source: Cancer Network)
Source: Cancer Network - September 8, 2013 Category: Cancer & Oncology Source Type: news

Identifying Indolent vs Potentially Aggressive DCIS, More Research Needed
As part of our coverage for the ASCO Breast Cancer Symposium 2013, we spoke with Dr. Susan K. Boolbol, chief of the division of breast surgery at the Appel-Venet Comprehensive Breast Service at Beth Israel Medical Center in New York City, who is chairing a general session panel discussion on the overdiagnosis of breast cancer. (Source: Cancer Network)
Source: Cancer Network - September 7, 2013 Category: Cancer & Oncology Source Type: news

Smoke Alarm! Is It Now OK to Smoke?
How long ago did we learn that smoking caused lung cancer? The USPSTF is poised to recommend annual screening CT scans for the detection of lung cancer in high risk individuals. Are there enough CT scanners to handle the volume? The LLC’s are forming now to put a dedicated lung screening CT machine next to every convenience store. Get your carton and CT in one stop! (Source: Cancer Network)
Source: Cancer Network - September 7, 2013 Category: Cancer & Oncology Source Type: news

Carbon Ion Radiotherapy Works for Spinal Sarcoma
Carbon ion radiotherapy is a safe and effective method for treating unresectable spinal sarcomas, according to a retrospective analysis from one center in Japan. (Source: Cancer Network)
Source: Cancer Network - September 6, 2013 Category: Cancer & Oncology Source Type: news

Night Shifts Implicated in Increased Prostate Cancer Risk
Shift work is positively associated with higher levels of prostate-specific antigen (PSA) levels in men between the ages of 40 and 65, according to results of a new study. (Source: Cancer Network)
Source: Cancer Network - September 5, 2013 Category: Cancer & Oncology Source Type: news

Extensive Hair Loss Following Second Round of Chemotherapy
A 65-year-old man experienced extensive hair loss following the second round of a chemotherapeutic regimen. The alopecia ultimately evolved into total hair loss, although near total recovery occurred about 4 months following cessation of chemotherapy. What drug is most likely responsible for this degree of hair loss? (Source: Cancer Network)
Source: Cancer Network - September 4, 2013 Category: Cancer & Oncology Source Type: news

Notch1 Regulates Tumor Formation, Possible Lung Cancer Target
Bench and mouse studies have shown that the Notch1 gene is a crucial contributor to tumorigenesis in non-small-cell lung cancer (NSCLC). It aids tumor initiation by suppressing apoptosis, or programmed cell death, which is regulated by p53. (Source: Cancer Network)
Source: Cancer Network - September 4, 2013 Category: Cancer & Oncology Source Type: news

HER2-Positive Breast Cancer Patients Prefer Subcutaneous Trastuzumab
Results of the PrefHer study indicated that when given the option between subcutaneous trastuzumab and intravenous trastuzumab, significantly more patients with HER2-positive breast cancer preferred the subcutaneous administration. (Source: Cancer Network)
Source: Cancer Network - September 3, 2013 Category: Cancer & Oncology Source Type: news

Aggressiveness of Prostate Tumors May Not Change as Cancer Evolves
Prostate tumors may not readily evolve from low to high grade, according to a new study. The results have important clinical implications for patients and clinicians when choosing active surveillance or treatment. (Source: Cancer Network)
Source: Cancer Network - September 2, 2013 Category: Cancer & Oncology Source Type: news

Gefitinib Lung Cancer Trial Terminated Early
A randomized phase III trial of adjuvant gefitinib in patients with completely resected non–small-cell lung cancer (NSCLC) was closed early, but available results suggest that the drug is unlikely to benefit this group of patients. (Source: Cancer Network)
Source: Cancer Network - September 2, 2013 Category: Cancer & Oncology Source Type: news

Slide Show: Non–Small-Cell Lung Cancer Pathology
This non–small-cell lung cancer slide show features pathology images of adenocarcinoma; bronchioloalveolar, large-cell, and colloid carcinoma; and squamous cell carcinoma. (Source: Cancer Network)
Source: Cancer Network - August 30, 2013 Category: Cancer & Oncology Source Type: news

New Screening Tool for Ovarian Cancer Shows Promise
Researchers have demonstrated that a two-step screening test can identify ovarian cancer early, before the disease progresses to an advanced, poor prognosis stage. (Source: Cancer Network)
Source: Cancer Network - August 29, 2013 Category: Cancer & Oncology Source Type: news

Mass Found in Jaw of 43-Year-Old Patient
A 43-year-old man presents with pain and a mass in the mandible. Resection of the mass is performed. What is your diagnosis? (Source: Cancer Network)
Source: Cancer Network - August 28, 2013 Category: Cancer & Oncology Source Type: news

Implementing Patient-Centered Outcomes in Cancer Trials
In this interview we discuss why patient-centered research is important, why this type of information is frequently ignored, and paths toward implementing this information into cancer trials. (Source: Cancer Network)
Source: Cancer Network - August 28, 2013 Category: Cancer & Oncology Source Type: news

X-ray Reveals Intrapulmonary Mass in 38-Year-Old Patient
An otherwise healthy 38-year-old woman was found to have an intrapulmonary mass during a routine radiographic examination. What is your diagnosis? (Source: Cancer Network)
Source: Cancer Network - August 28, 2013 Category: Cancer & Oncology Source Type: news

Improved Survival in Foreign-Born Hispanics With Lung Cancer
Among non–small-cell lung carcinoma (NSCLC) patients, foreign-born Hispanics show less cancer-related mortality compared with US-born Hispanics and non-Hispanic whites, in part due to social and cultural environment, according to results of a new study. (Source: Cancer Network)
Source: Cancer Network - August 27, 2013 Category: Cancer & Oncology Source Type: news

Mass Found in Face of 1-Year-Old Child
A 1-year-old child presented with a mass in the face over the maxillary region. Resection of the mass was performed. What is your diagnosis? (Source: Cancer Network)
Source: Cancer Network - August 27, 2013 Category: Cancer & Oncology Source Type: news

Maintenance Rituximab in Advanced Follicular Lymphoma
Maintenance therapy with rituximab showed some improvement over observation, though it did not reach significance, among older patients with advanced follicular lymphoma who responded to a brief chemoimmunotherapy induction regimen followed by rituximab consolidation therapy. (Source: Cancer Network)
Source: Cancer Network - August 25, 2013 Category: Cancer & Oncology Source Type: news

Priming With Azacitidine Can Chemosensitize DLBCL Patients, Achieve Good Responses
A phase I study showed that azacitidine priming followed by standard chemotherapy could be an effective approach to resistance in patients with newly diagnosed diffuse large B-cell lymphoma (DLBCL). (Source: Cancer Network)
Source: Cancer Network - August 24, 2013 Category: Cancer & Oncology Source Type: news

CMS Seeks Physicians’ Views on Making Payment Data Public
The Center for Medicare and Medicaid Services is inviting physicians to comment on a proposal to make individual physician payment data accessible to the public. (Source: Cancer Network)
Source: Cancer Network - August 23, 2013 Category: Cancer & Oncology Source Type: news

Cancer Centers Struggle With Cost, Complexity of Measuring Quality
Most community cancer centers are only beginning to measure quality of care and are struggling with the challenge of collecting data while adding services and keeping costs in check, concluded a recent survey by the Association of Community Cancer Centers (ACCC). (Source: Cancer Network)
Source: Cancer Network - August 23, 2013 Category: Cancer & Oncology Source Type: news

In Intermediate-Risk Nasopharyngeal Cancers, PET/CT Appropriate for Detecting Distant Metastases
Researchers in China have found that the use of [18F] fluorodeoxyglucose PET/CT detected a greater number of distant metastases than conventional work-up imaging in patients with nasopharyngeal carcinoma. (Source: Cancer Network)
Source: Cancer Network - August 23, 2013 Category: Cancer & Oncology Source Type: news

Four New Gene Variants Linked to Myeloma
Researchers in London have identified a number of new genetic variants that are linked to myeloma, and one specifically linked to a telomerase RNA component gene called TERC, that helps to control the aging process by acting as a cell’s internal clock. (Source: Cancer Network)
Source: Cancer Network - August 22, 2013 Category: Cancer & Oncology Source Type: news

Casting a Jaundiced Eye on Peer Review
The first obvious problem with peer review is delay. On other occasions, I observed what appeared to be strong and persistent bias on the part of reviewers that ultimately led to rejection or intrusive revision of the manuscript. (Source: Cancer Network)
Source: Cancer Network - August 22, 2013 Category: Cancer & Oncology Source Type: news

Understanding Complex Tumor Heterogeneity
While personalized medicine is seen as a way to target an individual cancer patient’s tumors, using targeted agents, immunotherapy, and chemotoxic drugs, researchers are increasingly finding that not only do the cancers of individuals vary widely, but that tumors within a patient can also be quite different at the molecular level. (Source: Cancer Network)
Source: Cancer Network - August 21, 2013 Category: Cancer & Oncology Source Type: news

Incidence of HPV-Related Oropharyngeal Cancer on the Rise in Canada
Researchers in Canada have shown for the first time that the incidence of HPV-related oropharyngeal cancers is increasing among the Canadian population. (Source: Cancer Network)
Source: Cancer Network - August 21, 2013 Category: Cancer & Oncology Source Type: news

Bacteria in Mouth May Promote Colorectal Cancer
Two separate studies have found direct evidence that F. nucleatum, a bacteria found in the mouth and in periodontal plaques, promotes growth of colorectal tumors. (Source: Cancer Network)
Source: Cancer Network - August 21, 2013 Category: Cancer & Oncology Source Type: news

Pattern in Lung Cancer Pathology May Predict Recurrence Risk
Identification of a significant micropapillary component within lung adenocarcinomas predicts a higher risk of relapse following lung-sparing surgery, according to results of a new study. (Source: Cancer Network)
Source: Cancer Network - August 20, 2013 Category: Cancer & Oncology Source Type: news

Slide Show: Esophageal Cancer
This esophageal cancer slide show features pathology slides of Barrett’s esophagus, esophageal adenocarcinoma, small-cell carcinoma, and squamous cell carcinoma and sarcomatoid carcinoma of the esophagus. (Source: Cancer Network)
Source: Cancer Network - August 20, 2013 Category: Cancer & Oncology Source Type: news

Using Quality-Measures Data to Address Sleep-Wake Disturbances
At ONS Congress 2013, Janet Gordils-Perez, Carla Schaefer, and Jacquelyn Lauria from CINJ discuss evidence-based tools developed to support nursing assessment and effective interventions for patients with sleep-wake disturbances (abstract 120187). (Source: Cancer Network)
Source: Cancer Network - August 19, 2013 Category: Cancer & Oncology Source Type: news

Fertility-Preservation Education Program at MSKCC Boosts Nurse Discussion of Options, Referrals
At ONS Congress 2013, Rebekah Clark discusses a standardized fertility-preservation education program that boosted nurse-patient discussion of fertility options from 0 to 71% and referrals for interested patients from 17% to 80% (abstract 95960). (Source: Cancer Network)
Source: Cancer Network - August 19, 2013 Category: Cancer & Oncology Source Type: news

Age Not Predictive of Recurrence in HER2 Breast Cancer
A retrospective analysis of the HERA trial indicated that young age was not associated with early recurrence in women with HER2-positive breast cancer, despite previous research suggesting that young age at diagnosis might be a risk factor for recurrence and death. (Source: Cancer Network)
Source: Cancer Network - August 19, 2013 Category: Cancer & Oncology Source Type: news

Marker Could Predict Dabrafenib Response in Melanoma
Researchers found that circulating cell-free DNA could represent a possible predictive marker of response in advanced melanoma patients treated with dabrafenib. (Source: Cancer Network)
Source: Cancer Network - August 19, 2013 Category: Cancer & Oncology Source Type: news

Education Aids in Decision-Making to Prepare for End of Life
Being offered a brief, dedicated discussion of end-of-life decisions relatively early in the trajectory of advanced cancer led to an earlier placement of do-not-resuscitate orders and decreased the likelihood that patients died in a hospital, a new study showed. (Source: Cancer Network)
Source: Cancer Network - August 17, 2013 Category: Cancer & Oncology Source Type: news