Anxiety: An Early Indicator of Alzheimer ’s Disease?
A new study suggests an association between elevated amyloid beta levels and the worsening of anxiety symptoms. The findings support the hypothesis that neuropsychiatric symptoms could represent the early manifestation of Alzheimer ’s disease in older (Source: BWH for Journalists)
Source: BWH for Journalists - January 12, 2018 Category: Research Source Type: news

Slow-Release Pill Developed to Deliver HIV Therapeutics
Using an ingestible “mini pill box,” researchers investigate a once weekly pill to combat HIV (Source: BWH for Journalists)
Source: BWH for Journalists - January 9, 2018 Category: Research Source Type: news

Topiramate in Early Pregnancy Increases Risk of Oral Clefts
Study finds that taking a higher dose of the drug in the first trimester increases risk of cleft lip or cleft palate more than taking a lower dose. (Source: BWH for Journalists)
Source: BWH for Journalists - December 27, 2017 Category: Research Source Type: news

Testing the Accuracy of FDA-Approved and Lab-Developed Cancer Genetics Tests
Study finds that both laboratory-developed tests and FDA-approved companion diagnostics performed equally well (Source: BWH for Journalists)
Source: BWH for Journalists - December 14, 2017 Category: Research Source Type: news

Up to $70 Million To Be Awarded to Advance Alzheimer ’s Disease Clinical Trials
Reisa Sperling, MD, and collaborators will build the Alzheimer ’s Clinical Trials Consortium (ACTC) to accelerate, expand Alzheimer’s disease therapeutic research. (Source: BWH for Journalists)
Source: BWH for Journalists - December 11, 2017 Category: Research Source Type: news

Dana-Farber/Brigham and Women & #39;s Cancer Center launches new program to target aggressive thyroid cancers
New program specializes in targeted treatments for patients with advanced and aggressive thyroid cancers. (Source: BWH for Journalists)
Source: BWH for Journalists - December 7, 2017 Category: Research Source Type: news

Removing Cancer Cell Debris Improves Conventional Cancer Treatments
Researchers from Brigham and Women ’s Hospital and colleagues show that leftover debris can stimulate inflammation and tumor growth, but that molecules called resolvins can block that unwanted inflammatory response. (Source: BWH for Journalists)
Source: BWH for Journalists - November 30, 2017 Category: Research Source Type: news

Weight loss and risk of death: Rheumatoid arthritis findings may have wider implications
Findings from previous studies regarding lower weight being associated with higher mortality may not be directly related to RA and instead reflect a more generalized phenomenon. (Source: BWH for Journalists)
Source: BWH for Journalists - November 30, 2017 Category: Research Source Type: news

Performance-Enhancing Drugs Sold Via the Internet Are Inaccurately Labeled
Selective androgen receptor modulators (SARMs) found to contain substances not listed on the label or amounts of drug different from label. (Source: BWH for Journalists)
Source: BWH for Journalists - November 28, 2017 Category: Research Source Type: news

Social Networks and Survival: Social Ties Could Help with Cancer Management
women with stronger social networks had better survival after colorectal cancer diagnosis (Source: BWH for Journalists)
Source: BWH for Journalists - November 21, 2017 Category: Research Source Type: news

Investigating Patterns of Degeneration in Alzheimer ’s Disease
Researchers from Brigham and Women ’s Hospital have found that factors encoded in the DNA of brain cells contribute to the patterns of degeneration, or vulnerability, in AD. (Source: BWH for Journalists)
Source: BWH for Journalists - November 16, 2017 Category: Research Source Type: news

A Delicate Crossing: Controller Developed to Open the Blood-Brain Barrier with Precision
Controller offers finer degree of control and safety when opening the blood-brain barrier in preclinical models (Source: BWH for Journalists)
Source: BWH for Journalists - November 13, 2017 Category: Research Source Type: news

PCSK9 Inhibitor Improves Outcomes for Patients with Peripheral Artery Disease
LDL-cholesterol-lowering drug evolocumab reduced risk of major cardiovascular events and major adverse limb events among peripheral artery disease sub-population from the FOURIER trial. (Source: BWH for Journalists)
Source: BWH for Journalists - November 13, 2017 Category: Research Source Type: news

Response After Single Treatment with Canakinumab Predicts Which Patients Will Benefit Most
New analysis from CANTOS finds that measuring hsCRP levels after one dose of canakinumab can identify individuals likely to see greatest improvements from continued treatment. (Source: BWH for Journalists)
Source: BWH for Journalists - November 13, 2017 Category: Research Source Type: news

New Blood Test Developed to Diagnose Ovarian Cancer
Non-invasive diagnostic tool being developed to measure circulating microRNAs to predict ovarian cancer with specificity. (Source: BWH for Journalists)
Source: BWH for Journalists - October 31, 2017 Category: Research Source Type: news

Uncovering a Reversible Master Switch for Development
Kuroda lab identifies a reversible “master switch” that sits on potentially all developmental genes in a model organism, the fruit fly (Source: BWH for Journalists)
Source: BWH for Journalists - October 25, 2017 Category: Research Source Type: news

Using Networks to Understand Tissue-Specific Gene Regulation
Researchers have discerned that different tissue functions arise from a core biological machinery (Source: BWH for Journalists)
Source: BWH for Journalists - October 24, 2017 Category: Research Source Type: news

The Skinny on Lipid Immunology
New insights into the basis for T cell receptor (TCR) autoreactivity to self-phospholipids, with implications for autoimmune diseases (Source: BWH for Journalists)
Source: BWH for Journalists - October 20, 2017 Category: Research Source Type: news

Investigating the Most Common Genetic Contributor to Parkinson ’s Disease
Essential role of LRRK in the brain during aging may help to shed light on the causes of PD in human patients (Source: BWH for Journalists)
Source: BWH for Journalists - October 19, 2017 Category: Research Source Type: news

Study of Clinical Genome Sequencing in the Active-Duty Military Begins
The MilSeq Project, a research collaboration between the U.S. Air Force and academic sites, explores the use of DNA sequencing in routine care of healthy Air Force service members (Source: BWH for Journalists)
Source: BWH for Journalists - October 19, 2017 Category: Research Source Type: news

Dana-Farber and Brigham and Women & #39;s researchers laud FDA approval of CAR T-cell therapy for non-Hodgkin Lymphoma
Dana-Farber/Brigham and Women's one of the only centers certified to offer new approach (Source: BWH for Journalists)
Source: BWH for Journalists - October 19, 2017 Category: Research Source Type: news

Meeting an Unmet Need: Surgical Implant that Grows with a Child
A novel growth-accommodating implant could revolutionize cardiac repair (Source: BWH for Journalists)
Source: BWH for Journalists - October 10, 2017 Category: Research Source Type: news

New Congenital Heart Disease Genes Uncovered
Discoveries from “Bench to Bassinet” investigators may help answer parents’ questions about the genetic causes of heart conditions and long-term effects. (Source: BWH for Journalists)
Source: BWH for Journalists - October 9, 2017 Category: Research Source Type: news

Healing and Sealing
New Surgical Sealant Derived from Human Protein Seals Without Sutures (Source: BWH for Journalists)
Source: BWH for Journalists - October 4, 2017 Category: Research Source Type: news

Neuro-Immune Crosstalk in Allergic Asthma
Study reveals a way in which the nervous system communicates with the immune system and allergic inflammation gets amplified. (Source: BWH for Journalists)
Source: BWH for Journalists - September 28, 2017 Category: Research Source Type: news

Uncovering Why Psoriasis Recurs
Study identifies population of resident T cells that may initiate psoriasis and allow skin lesions to recur after therapy ends (Source: BWH for Journalists)
Source: BWH for Journalists - September 25, 2017 Category: Research Source Type: news

New Tool Demonstrates High Cost of Lack of Sleep in the Workplace and Calculates Benefit of Sleep Health Education
Fatigue Cost Calculator Developed at Brigham Health introduced at National Safety Council Congress and Expo (Source: BWH for Journalists)
Source: BWH for Journalists - September 25, 2017 Category: Research Source Type: news

Insulin Therapy Initially Declined and Delayed by an Average of Two Years
New research by BWH has found 30 percent of type 2 diabetic patients don ’t begin insulin when it’s initially recommended. (Source: BWH for Journalists)
Source: BWH for Journalists - September 14, 2017 Category: Research Source Type: news

Rare Genetic Cause of Peritoneal Mesothelioma Points to Targeted Therapy
Genetic rearrangement in the ALK gene found in young women with mesothelioma may be targetable with FDA-approved drugs. (Source: BWH for Journalists)
Source: BWH for Journalists - September 14, 2017 Category: Research Source Type: news

New Genetic Cause Discovered for Photosensitive Blood Disorder
Researchers from BWH have uncovered a new genetic cause for erythropoietic protoporphyria (Source: BWH for Journalists)
Source: BWH for Journalists - September 14, 2017 Category: Research Source Type: news

Later Circadian Timing of Food Intake Is Associated with Increased Body Fat
BWH investigators examine the relationships between body fat and body mass index, and the timing of food consumption, to time of day and to the body ’s circadian or body clock. (Source: BWH for Journalists)
Source: BWH for Journalists - September 8, 2017 Category: Research Source Type: news

Later Circadian Timing of Food Intake Is Associated with Increased Body
BWH investigators examine the relationships between body fat and body mass index, and the timing of food consumption, to time of day and to the body ’s circadian or body clock. (Source: BWH for Journalists)
Source: BWH for Journalists - September 8, 2017 Category: Research Source Type: news

Drugs Targeting the Beta2-Adrenoreceptor Linked to Parkinson ’s Disease
BWH researchers identify drugs to prevent abnormal clumps of alpha-synuclein from forming in the brain (Source: BWH for Journalists)
Source: BWH for Journalists - August 31, 2017 Category: Research Source Type: news

Breastfeeding Reduces Risk of Endometriosis Diagnosis
Women in the Nurses ’ Health Study II who breastfed were significantly less likely to be diagnosed with endometriosis. (Source: BWH for Journalists)
Source: BWH for Journalists - August 28, 2017 Category: Research Source Type: news

Inflammatory Hypothesis Confirmed: Reducing Inflammation Without Lowering Cholesterol Cuts Risk of Cardiovascular Events
Landmark randomized clinical trial of high-risk patients finds that a drug targeting inflammation reduced risk of major adverse cardiovascular events (Source: BWH for Journalists)
Source: BWH for Journalists - August 27, 2017 Category: Research Source Type: news

Anti-Inflammatory Therapy Cuts Risk of Lung Cancer
Cardiovascular study gives researchers a unique opportunity to explore and disrupt cancer ’s progression. (Source: BWH for Journalists)
Source: BWH for Journalists - August 27, 2017 Category: Research Source Type: news

Population Health Impact of Infants Born Small for Gestational Age in Low-and Middle-Income Countries
Reducing Percentage of Babies Born of Low Birth Weight Could Lower Newborn Deaths (Source: BWH for Journalists)
Source: BWH for Journalists - August 20, 2017 Category: Research Source Type: news

Online Team-based Game Helps Patients with Diabetes Lower Blood Glucose
Randomized, controlled clinical trial of Veterans with type 2 diabetes finds sustained improvements in glucose control. (Source: BWH for Journalists)
Source: BWH for Journalists - August 8, 2017 Category: Research Source Type: news

Clues about Immune Resolution Identified in Blood
New profiling procedure identifies immunoresolvents in coagulated human blood (Source: BWH for Journalists)
Source: BWH for Journalists - August 1, 2017 Category: Research Source Type: news

Brigham and Women ’s Hospital Welcomes Leader in Orthopaedic Surgery
The Department of Orthopaedic Surgery at Brigham and Women ’s Hospital welcomed Richard Wilk, MD, as the chief of the Hip Preservation Service. (Source: BWH for Journalists)
Source: BWH for Journalists - July 27, 2017 Category: Research Source Type: news

Benefits of Continued Statin Use After Adverse Reactions
Patients who continued receiving statin prescriptions had lower rates of death and cardiovascular events. (Source: BWH for Journalists)
Source: BWH for Journalists - July 24, 2017 Category: Research Source Type: news

Kidney Disease Risk Score Can Be Built Into Patients ’ Electronic Health Records
Automatic calculator can be built into EHRs to display kidney disease risk score (Source: BWH for Journalists)
Source: BWH for Journalists - July 21, 2017 Category: Research Source Type: news

Brigham Names New Senior Vice President of Human Resources
Paula Squires, MBA, SHRM-SCP, SPHR, will start Oct. 14. (Source: BWH for Journalists)
Source: BWH for Journalists - July 18, 2017 Category: Research Source Type: news

Improving ICU Care and Communication through Technology Use
Researchers tested a structured& technology-centered program that was focused on team communication& patient engagement (Source: BWH for Journalists)
Source: BWH for Journalists - July 17, 2017 Category: Research Source Type: news

New Approach Shows Promising Results for Stem Cell Based Therapy for Skin-to-Brain Cancer in Preclinical Models
Stem cells loaded with oncolytic viruses target skin cancer metastases in the brain (Source: BWH for Journalists)
Source: BWH for Journalists - July 10, 2017 Category: Research Source Type: news

New Insights into Why the Immune System Fails to See Cancer
Study explores relationship between how the immune system sees peripheral tissues and cancers. (Source: BWH for Journalists)
Source: BWH for Journalists - June 29, 2017 Category: Research Source Type: news

Sequencing Healthy Patients Reveals That Many Carry Rare Genetic Disease Risks
First-ever randomized trial examines the impact of whole genome sequencing in healthy primary care patients (Source: BWH for Journalists)
Source: BWH for Journalists - June 26, 2017 Category: Research Source Type: news

Predicting cognitive deficits in people with Parkinson ’s disease
New tool may improve clinical trial design and aid in treatment development (Source: BWH for Journalists)
Source: BWH for Journalists - June 20, 2017 Category: Research Source Type: news

Why We Get Diarrhea
Investigators explore the immune mechanism that drives diarrhea and its role in clearing infections (Source: BWH for Journalists)
Source: BWH for Journalists - June 14, 2017 Category: Research Source Type: news

New Class of Type 2 Diabetes Drug Associated with Rare, Life-Threatening Outcome
Investigators quantify risk of diabetic ketoacidosis for patients taking SGLT2 inhibitors (Source: BWH for Journalists)
Source: BWH for Journalists - June 7, 2017 Category: Research Source Type: news