The Peter Pan Syndrome: Oncohistones Stall Development in Pediatric Cancers
CCR Grand Rounds
Dr. Jabado ’ s research focuses on elucidating genetic signatures of pediatric astrocytomas and examining how they compare to adults. These are deadly brain tumors that originate in the brain and include glioblastomas (GBM, the highest grade of astrocytomas), which are one of the deadliest cancers in humans. Her group uncovered that pediatric high-grade astrocytomas (HGA) are molecularly and genetically distinct from adult tumors. They also identified a new molecular mechanism driving pediatric HGA, namely recurrent somatic driver mutations in the tail of histone 3 variants (H3.3 and H3.1). These mutatio...
Source: Videocast - All Events - October 21, 2019 Category: General Medicine Tags: Upcoming Events Source Type: video
A patient-scientist ’ s road toward primary prevention in genetic prion disease
NIH Director's Wednesday Afternoon Lecture Series
In 2010, Sonia Vallabh watched her 52 year old mother die of a rapid, mysterious, undiagnosed neurodegenerative disease. One year later, Sonia learned that her mother's disease had been genetic prion disease, and that she herself had inherited the causal mutation, making it very likely she would suffer the same fate in 20 years' time. There was no prevention, treatment, or cure available. Despite having no prior training in biology, Sonia and her husband Eric Minikel set out to re-train themselves as scientists and devote their lives to searching for a treatment or cure for...
Source: Videocast - All Events - October 10, 2019 Category: General Medicine Tags: Upcoming Events Source Type: video
Brain Machine Interfaces: from basic science to neuroprostheses and neurological recovery
NIH Director's Wednesday Afternoon Lecture Series
Miguel Nicolelis, M.D., Ph.D., is the Duke School of Medicine Distinguished Professor of Neuroscience at Duke University, Professor of Neurobiology, Biomedical Engineering, Neurology, Neurosurgery and Psychology and Neuroscience, and founder of Duke's Center for Neuroengineering. He is Founder and Scientific Director of the Edmond and Lily Safra International Institute for Neuroscience of Natal. Dr. Nicolelis is also founder of the Walk Again Project, an international consortium of scientists and engineers, dedicated to the development of an exoskeleton device to assist sev...
Source: Videocast - All Events - October 10, 2019 Category: General Medicine Tags: Upcoming Events Source Type: video
The Neuropathological Diagnosis of Chronic Traumatic Encephalopathy (CTE): Next Steps (Day 2)
Chronic Traumatic Encephalopathy (CTE) is a devastating neurodegenerative disease of unknown origin and with poorly defined risk factors, pathological characteristics, and incidence rates. The purpose of this workshop is to determine the strategies, next steps, and approaches needed to overcome barriers for developing consensus criteria for the neuropathological diagnosis of CTE.
Previously, NINDS has sponsored two CTE Neuropathology Consensus Conferences. This workshop is intended to bring the key CTE neuropathology investigators together to (1) assess the state of science for the neuropathology, (2) present the range of...
Source: Videocast - All Events - September 16, 2019 Category: General Medicine Tags: Upcoming Events Source Type: video
The Neuropathological Diagnosis of Chronic Traumatic Encephalopathy (CTE): Next Steps (Day 1)
Chronic Traumatic Encephalopathy (CTE) is a devastating neurodegenerative disease of unknown origin and with poorly defined risk factors, pathological characteristics, and incidence rates. The purpose of this workshop is to determine the strategies, next steps, and approaches needed to overcome barriers for developing consensus criteria for the neuropathological diagnosis of CTE.
Previously, NINDS has sponsored two CTE Neuropathology Consensus Conferences. This workshop is intended to bring the key CTE neuropathology investigators together to (1) assess the state of science for the neuropathology, (2) present the range of...
Source: Videocast - All Events - September 16, 2019 Category: General Medicine Tags: Upcoming Events Source Type: video
Brief Prevention Interventions for Young Adults: Strengthening Effects (Day 2)
College age remains a significant risk period for hazardous/extreme drinking among males and females. Recent data suggests that while drinking patterns are converging across sexes, college-age females are engaging in greater levels of binge drinking. Although brief interventions (BI) designed to reduce alcohol consumption and related harms in college and young adult populations have shown positive effects, the rigor of research on this topic has been impaired by limited outcome measurement, measurement inconsistencies, variability in methodologies, and modest effect sizes. There is a paucity of studies that use comparative...
Source: Videocast - All Events - September 16, 2019 Category: General Medicine Tags: Upcoming Events Source Type: video
Brief Prevention Interventions for Young Adults: Strengthening Effects (Day 1)
College age remains a significant risk period for hazardous/extreme drinking among males and females. Recent data suggests that while drinking patterns are converging across sexes, college-age females
are engaging in greater levels of binge drinking. Although brief interventions (BI) designed to reduce alcohol consumption and related harms in college and young adult populations have shown positive effects, the rigor of research on this topic has been impaired by limited outcome measurement, measurement inconsistencies, variability in methodologies, and modest effect sizes. There is a paucity of studies that use comparativ...
Source: Videocast - All Events - September 16, 2019 Category: General Medicine Tags: Upcoming Events Source Type: video
Integrative Omics Approaches to Identify New Therapeutic Cancer Targets
CCR Grand Rounds
Kimberly Stegmaier, M.D., Professor of Pediatrics at Harvard Medical School and the Ted Williams Chair at Dana-Farber Cancer Institute, has advanced the application of genomics to drug and protein target discovery for pediatric cancers. She is the Vice Chair for Pediatric Oncology Research, co-director of the Pediatric Hematologic Malignancy Program and an attending physician providing clinical care in Pediatric Oncology at the Dana-Farber Cancer Institute and Boston Children ’ s Hospital. Dr. Stegmaier is also an Institute Member of the Broad Institute of Harvard and MIT. She has served as a Council Mem...
Source: Videocast - All Events - June 17, 2019 Category: General Medicine Tags: Upcoming Events Source Type: video
Opiates on the brain
NIH Director's Wednesday Afternoon Lecture Series
Dr. Kieffer is a basic scientist and neurobiologist. She isolated the first gene encoding an opioid receptor, a landmark in neuroscience research to understanding molecular bases of opioid transmission and opioid-mediated mechanisms underlying pain control, mood disorders and addiction. Her team elucidated the role of each opioid receptor in both known and unknown areas of opioid physiology and behaviors using gene knockout in mice. She showed that mu receptors mediate both analgesic and addictive actions of morphine, and are responsible for drug and social reward. Her team...
Source: Videocast - All Events - April 24, 2019 Category: General Medicine Tags: Upcoming Events Source Type: video
How could brain-computer interfaces be used in the real world?
Katherine Pratt of the Center for Neurotechnology at University of Washington answers the question on this edition of "Ask a Scientist."This is an NSF Multimedia Gallery item. (Source: NSF Multimedia Gallery)
Source: NSF Multimedia Gallery - April 19, 2019 Category: Science Source Type: video
The Science of Interoception and Its Roles in Nervous System Disorders (Day 2)
The objectives of this workshop are to identify gaps in research related to the science of interoception, its role(s) in nervous system disorders, and to develop strategies and recommendations to facilitate the advancement of this area of research. The workshop will bring together expertise from diverse fields including basic neuroscience, psychology, physiology, and clinical research to deliberate two important dynamic connections – the connections between brain and body and the connections between basic research and human/clinical research. The primary focus areas for the workshop include: the neural circuitry underlyi...
Source: Videocast - All Events - March 19, 2019 Category: General Medicine Tags: Upcoming Events Source Type: video
The Science of Interoception and Its Roles in Nervous System Disorders (Day 1)
The objectives of this workshop are to identify gaps in research related to the science of interoception, its role(s) in nervous system disorders, and to develop strategies and recommendations to facilitate the advancement of this area of research. The workshop will bring together expertise from diverse fields including basic neuroscience, psychology, physiology, and clinical research to deliberate two important dynamic connections – the connections between brain and body and the connections between basic research and human/clinical research. The primary focus areas for the workshop include- the neural circuitry underlyi...
Source: Videocast - All Events - March 19, 2019 Category: General Medicine Tags: Upcoming Events Source Type: video
Stewart J. Tepper, MD, FAHS - Exploring the Latest Evidence on New and Emerging Therapies for Migraine Prevention: What Are the Potential Implications on Clinical Practice?
Exploring the Latest Evidence on New and Emerging Therapies for Migraine Prevention: What Are the Potential Implications on Clinical Practice? (Source: Peerview CME/CE Video Podcast - Neurology International)
Source: Peerview CME/CE Video Podcast - Neurology International - March 4, 2019 Category: Neurology Authors: PVI, PeerView Institute for Medical Education Tags: Science, Medicine Source Type: video
Deborah I. Friedman, MD, MPH - Improving the Recognition and Management of Migraine in an Era of Expanding Options for Acute Treatment and Prevention: How Is the Role of the Primary Care Clinician Evolving?
Improving the Recognition and Management of Migraine in an Era of Expanding Options for Acute Treatment and Prevention: How Is the Role of the Primary Care Clinician Evolving? (Source: Peerview CME/CE Video Podcast - Neurology International)
Source: Peerview CME/CE Video Podcast - Neurology International - March 4, 2019 Category: Neurology Authors: PVI, PeerView Institute for Medical Education Tags: Science, Medicine Source Type: video
Marwan Sabbagh, MD, FAAN - Taking Stock of Potential Advances in the Early Diagnosis of Alzheimer ’s Disease: What Are the Implications for Treatment?
Taking Stock of Potential Advances in the Early Diagnosis of Alzheimer’s Disease: What Are the Implications for Treatment? (Source: Peerview CME/CE Video Podcast - Neurology International)
Source: Peerview CME/CE Video Podcast - Neurology International - February 19, 2019 Category: Neurology Authors: PVI, PeerView Institute for Medical Education Tags: Science, Medicine Source Type: video
