A methodological review of randomised n-of-1 trials
Conclusionsn-of-1 trials are still underused and the application of the n-of-1 design for the evaluation of health technologies for rare diseases has been particularly limited. We have summarised the characteristics of randomised n-of-1 trials in rare and non-rare conditions. We hope that it can inform researchers in the design of future n-of-1 studies. Further work is required to provide guidance on specific design considerations, implementation, and statistical analysis of these studies.Trial registrationNot applicable. (Source: Trials)
Source: Trials - April 16, 2024 Category: Research Source Type: clinical trials
Differences in Corneal Structure and Function in Patients With Sjogrens vs. Non-Sjogrens Dry Eye
Conditions: Sjogren ' s Syndrome; Dry Eye; Neurotrophic Keratitis Interventions: Diagnostic Test: Eye Exam Sponsors: Johns Hopkins University Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 15, 2024 Category: Research Source Type: clinical trials
Cognitive Functioning in Adults With Somatic Diseases and General Population From a Biopsychosocial Perspective
Conditions: Aphasia; Development, Human; Neuropathology Interventions: Diagnostic Test: Psychological assessment Sponsors: Bartosz M. Radtke Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 15, 2024 Category: Research Source Type: clinical trials
On-Premise and Remote Robotic Neurointervention
Conditions: Cerebrovascular Disease Interventions: Device: Remedy Robot Sponsors: Remedy Robotics, Inc.; Unity Health Toronto Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 15, 2024 Category: Research Source Type: clinical trials
Concussion in French Non-professional Handball League : Efficiency of a Concussion Protocol, the White Card Process
Conditions: Brain Concussion; Cerebral Concussion Sponsors: University Hospital, Bordeaux Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 15, 2024 Category: Research Source Type: clinical trials
Effect of Acupuncture on the Microbiota-gut-brain Axis in Crohn's Disease
Conditions: Crohn Disease Interventions: Other: Acupuncture treatment; Other: Sham acupuncture Sponsors: Shanghai Institute of Acupuncture, Moxibustion and Meridian; Fudan University Completed (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 15, 2024 Category: Research Source Type: clinical trials
Physiological and Functional Effects of Percutaneous Neuromodulation vs Transcutaneous Neuromodulation
Conditions: Stroke/Brain Attack Interventions: Device: Percutaneous neuromodulation; Device: Transcutaneous neuromodulation; Device: Placebo-percutaneous; Device: Placebo-transcutaneous; Device: Percutaneous neuromodulation or Transcutaneous neuromodulation (optional) Sponsors: University of Extremadura Active, not recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 15, 2024 Category: Research Source Type: clinical trials
Targeting Personalized Brain States Reflecting Strong and Weak Corticospinal Tract Output in Real-time
Conditions: Neurotypical Adults Interventions: Device: Personalized brain state-dependent single-pulse TMS Sponsors: University of Texas at Austin; Emory University Active, not recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 15, 2024 Category: Research Source Type: clinical trials
Enhancing Epilepsy Management With Precision Deep Brain Stimulation
Conditions: Epilepsy, Drug Resistant Interventions: Device: Neuromodulation programming Sponsors: Nova Scotia Health Authority Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 15, 2024 Category: Research Source Type: clinical trials
Identifying Personalized Brain States Predicting Residual Corticospinal Tract Output After Stroke
Conditions: Stroke Interventions: Device: Single-pulse TMS Sponsors: University of Texas at Austin; Emory University Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 15, 2024 Category: Research Source Type: clinical trials
A Comparative Analysis of Prognostic Factors for Functional Outcomes in Patients With Acute Subdural Hematoma
Conditions: Acute Subdural Hematoma; Acquired Brain Injury Interventions: Procedure: Decompressive craniectomy with evacuation of subdural hematoma Sponsors: Charles University, Czech Republic; Military University Hospital, Prague Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 15, 2024 Category: Research Source Type: clinical trials
Evaluation of Neuromuscular Morphometry of the Vaginal Wall
Conditions: Pelvic Organ Prolapse Sponsors: Gaziosmanpasa Research and Education Hospital; T.C. ORDU ÜNİVERSİTESİ Completed (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 12, 2024 Category: Research Source Type: clinical trials
Establishment of an Interdisciplinary Functional Neurological Disorder (FND) Treatment Program and Development of a Clinical Care Pathway for FND
Conditions: Functional Neurological Disorder; Convulsion, Non-Epileptic; Functional Seizure Sponsors: University of Alabama at Birmingham Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 12, 2024 Category: Research Source Type: clinical trials
Comparing the Efficacy of Two Neurofeedback Protocols for Generalized Anxiety Disorder
Conditions: Generalized Anxiety Disorder Interventions: Device: EEG Neurofeedback Sponsors: Shahid Beheshti University of Medical Sciences Completed (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 12, 2024 Category: Research Source Type: clinical trials
Stress in Pregnancy During the Covid19 Pandemic and Impact on the Newborn Neurodevelopment
Conditions: Covid19 and Pregnancy Interventions: Other: Severity of infection, time of infection.; Other: Mental health assessment; Other: biological Sponsors: Fundaci ón Pública Andaluza para la gestión de la Investigación en Sevilla Active, not recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 12, 2024 Category: Research Source Type: clinical trials
