The Regulatory Role of miRNA 27 Follistatin Like Protein-1 Gene in Multiple Scelerosis
Conditions: Multiple Sclerosis Interventions: Diagnostic Test: micro RNA 27- FLP1 gene expression; Diagnostic Test: The Expanded Disability Status Scale (EDSS); Diagnostic Test: Electrophysiological assessment:; Diagnostic Test: MRI examination MRI brain: Sponsors: Assiut University Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 4, 2024 Category: Research Source Type: clinical trials

A Multi-center Clinical Longitudinal Study of Neuropathic Pain by Collecting Data
Conditions: Pain Interventions: Device: A multi-center clinical longitudinal study of neuropathic pain by collecting data on patients ' brain physiology and cognitive function Sponsors: Xinhua Hospital, Shanghai Jiao Tong University School of Medicine Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 4, 2024 Category: Research Source Type: clinical trials

Effect of Postoperative Prolonged sedation with Dexmedetomidine after successful reperfusion with Endovascular Thrombectomy on long-term prognosis in patients with acute ischemic stroke (PPDET): study protocol for a randomized controlled trial
DiscussionThis randomized clinical trial is expected to verify the hypothesis that postoperative prolonged sedation with DEX after successful reperfusion may promote the long-term prognosis of patients with AIS and may reduce the related socio-economic burden.Trial registrationClinicalTrials.gov NCT04916197. Prospectively registered on 7 June 2021. (Source: Trials)
Source: Trials - March 4, 2024 Category: Research Source Type: clinical trials

Physiological-based cord clamping in very preterm infants: the Aeration, Breathing, Clamping 3 (ABC3) trial —statistical analysis plan for a multicenter randomized controlled trial
DiscussionThe findings of this trial will provide evidence for future clinical guidelines on optimal cord clamping management at birth.Trial registrationClinicalTrials.gov NCT03808051. Registered on 17 January 2019. (Source: Trials)
Source: Trials - March 4, 2024 Category: Research Source Type: clinical trials

A proof of concept phase II study with the PDE-4 inhibitor roflumilast in patients with mild cognitive impairment or mild Alzheimer ’s disease dementia (ROMEMA): study protocol of a double-blind, randomized, placebo-controlled, between-subjects trial
DiscussionThe outcomes of the present study aim to elucidate the significance of the PDE4 inhibition mechanism as a prospective therapeutic target for enhancing cognitive function in individuals with (a)MCI and mild AD dementia. Identifying positive effects within these patient cohorts could extend the relevance of this treatment to encompass a broader spectrum of neurological disorders.Trial registrationThe Medical Ethics Committee of MUMC  + granted ethics approval for the 4th version of the protocol on September 10th, 2020. The trial was registered at the European Drug Regulatory Affairs Clinical Trials (EudraCT) re...
Source: Trials - March 4, 2024 Category: Research Source Type: clinical trials

Validation of Ipswich Touch Test for Diabetic Peripheral Neuropathy Screening in Primary Care
Conditions: Diabetic Foot Interventions: Diagnostic Test: Ipswich touch test Sponsors: Ponlawat Hanchana, MD Completed (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 1, 2024 Category: Research Source Type: clinical trials

Spinal Cord Stimulation and Small Fiber Peripheral Neuropathy
Conditions: Diabetic Peripheral Neuropathy Interventions: Device: Spinal Cord Stimulator Implantation (SCS) Sponsors: Ohio State University; Neuright, Inc. Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 1, 2024 Category: Research Source Type: clinical trials

NerveTrend vs. NerveAssure in Prevention of Recurrent Laryngeal Nerve Injury During Thyroid Surgery
Conditions: Thyroid Diseases; Surgery; Recurrent Laryngeal Nerve Injuries Interventions: Device: Neuromonitoring of the recurrent laryngeal nerves Sponsors: Marcin Barczynski Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 1, 2024 Category: Research Source Type: clinical trials

Effectiveness of Non-invasive Phrenic Nerve Neuromodulation in Subjects With Inflammatory Bowel Disease and Neck Pain.
Conditions: Inflammatory Bowel Diseases; Neck Pain Interventions: Device: Non-invasive Neuromodulation; Other: Cervico-dorsal Massage Sponsors: University of Seville Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 1, 2024 Category: Research Source Type: clinical trials

HA-WBRT-SIB for Brain Metastasis of Lung Cancer
Conditions: Lung Neoplasm; Brain Metastases; Simultaneous Integrated Boost; Hippocampal Avoidance; Cognitive Function Interventions: Radiation: HA-WBRT-SIB Sponsors: Cancer Institute and Hospital, Chinese Academy of Medical Sciences Completed (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 1, 2024 Category: Research Source Type: clinical trials

Effects of Antihypertensive Drug Treatment on Brain Blood Flow, Cognition, and Regulation of Nervous System in Older Adults With Hypertension.
Conditions: Essential Hypertension; Older Adults Interventions: Drug: chlorthalidone 25 mg; Other: Placebo Sponsors: University of Texas Southwestern Medical Center Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 1, 2024 Category: Research Source Type: clinical trials

Effects of rTMS on Respiratory Function and Gut Microbiota in Patients With Brain Injury
Conditions: Brain Injuries; Respiratory Function Impaired; Gut Microbiota Interventions: Device: active rTMS; Device: sham rTMS Sponsors: Nanfang Hospital, Southern Medical University Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 1, 2024 Category: Research Source Type: clinical trials

Neurocognitive and Genomic Predictors of Persistent Pain and Opioid Misuse After Spine Surgery
Conditions: Lumbar Spine Pathology; Elective Spine Surgery Interventions: Other: No Intervention Sponsors: Icahn School of Medicine at Mount Sinai Active, not recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 1, 2024 Category: Research Source Type: clinical trials

Effect of Green Tea Supplementation in Older Adult Women
Conditions: Female; Older Adults; Ability (Without Comorbidities and/or Injuries) to Carry Out a Physical Activity Program Adapted Interventions: Dietary Supplement: Green tea (Camellia sinensis) 1000 mg as extract Sponsors: University of Valladolid; Sanidad de Castilla y Le ón; Instituto de Neurociencia de Castillas y Leon Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 1, 2024 Category: Research Source Type: clinical trials

Treatment of Neuropathic Pain Following Spinal Cord Injury - a rTMS Approach
Conditions: Neuropathic Pain Interventions: Device: Repetitive Transcranial Magnetic Stimulation (rTMS) Sponsors: University of Calgary Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - February 29, 2024 Category: Research Source Type: clinical trials