Anticancer Drug Restores Hearing in Some Patients with Neurofibromatosis (The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins)
... (Source: National Comprehensive Cancer Network)
Source: National Comprehensive Cancer Network - March 14, 2016 Category: Cancer & Oncology Source Type: news
Neurofibromatosis — Best Data Yet on Risks for Cancer Neurofibromatosis — Best Data Yet on Risks for Cancer
Patients with neurofibromatosis 1 have been reported to be at an increased risk for several malignancies. A Finnish study refines this risk and reports the risk for breast cancer. Survival is also worse for these patients. Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - March 7, 2016 Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news
Tia Leigh with NF1 overjoyed to have her leg amputated
Tia Leigh, 14, from Cwmbran, Wales, was diagnosed with the genetic disorder neurofibromatosis type 1 as a baby. It made her right leg hugely swollen and lumpy - and 7cm longer than her left. (Source: the Mail online | Health)
Source: the Mail online | Health - January 27, 2016 Category: Consumer Health News Source Type: news
Generation of Noninvasive, Quantifiable, Orthotopic Animal Models for NF2-Associated Schwannoma and Meningioma
Schwannomas and meningiomas are nervous system tumors that can occur sporadically or in patients with neurofibromatosis type 2 (NF2). Mutations of the Neurofibromatosis 2 (NF2) gene are frequently observed in these tumors. Schwannomas and meningiomas cause significant morbidities, and an FDA-approved medical therapy is currently not available. The development of preclinical animal models that accurately capture the clinical characteristics of these tumors will facilitate the evaluation of novel therapeutic agents for the treatment of these tumors, ultimately leading to more productive clinical trials. Here, we describe the...
Source: Springer protocols feed by Molecular Medicine - December 31, 2015 Category: Molecular Biology Source Type: news
Toxic secretions from intracranial tumor damage the inner ear
In some cases of vestibular schwannoma, a sometimes-lethal tumor often associated with neurofibromatosis 2 (NF2), secretions from the tumor contain toxic molecules that damage the inner ear. The findings explain why some vestibular schwannomas cause hearing loss even though they are not large enough to compress nearby structures that control hearing. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - December 22, 2015 Category: Science Source Type: news
Researchers examine how neurofibromatosis causes premature cardiovascular disease
(Medical College of Georgia at Georgia Regents University) It's a fairly common genetic condition that can surface as a series of dark skin spots and result in a host of maladies from tumors to premature cardiovascular disease. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - November 19, 2015 Category: Cancer & Oncology Source Type: news
Adding antiangiogenesis increases effectiveness of radiation against NF2-associated tumors
Treatment with antiangiogenesis drugs may improve the effectiveness of radiation treatment of nervous system tumors that interfere with the hearing of patients with the genetic disorder neurofibromatosis 2, investigators report. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - November 10, 2015 Category: Science Source Type: news
Khadija Khatoon with huge growths says she is 'happy to be made this way'
WARNING GRAPHIC CONTENT: Khadija Khatoon, from India, has severe distorted features, thought to be caused by neurofibromatosis, a genetic condition causing swellings or lumps (Source: the Mail online | Health)
Source: the Mail online | Health - November 6, 2015 Category: Consumer Health News Source Type: news
Predictors of Mortality in Neurofibromatosis 2Predictors of Mortality in Neurofibromatosis 2
This study examined the effects of a range of clinical and molecular genetic factors and their impact on outcome in patients with neurofibromatosis 2. Journal of Medical Genetics (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - November 6, 2015 Category: Consumer Health News Tags: Pathology & Lab Medicine Journal Article Source Type: news
What Life Is Like With A Disfigured Face
(Photo: © Anthony Gerace) In a world obsessed with beauty, living with a facial disfigurement can be hard. Neil Steinberg explores the past and present to find out what it’s like to look different.“Take your ear off for me, please,” Rosie Seelaus says to Randy James, who is sitting on a black exam chair in a special room designed for viewing colors in the Craniofacial Center on the Near West Side of Chicago.He reaches up and detaches his right ear, which she created for him out of silicone seven years before. The ear is shabby, stained from skin oil and mottled by daily use. Viewed under various lights in the neu...
Source: Science - The Huffington Post - June 26, 2015 Category: Science Source Type: news
Mutations May Flag Conversion of Neurofibromas to MalignancyMutations May Flag Conversion of Neurofibromas to Malignancy
Mutations associated with the subset of benign neurofibromas that become malignant are seen as potential keys to a biomarker in patients with neurofibromatosis 1. Medscape Medical News (Source: Medscape Neurology and Neurosurgery Headlines)
Source: Medscape Neurology and Neurosurgery Headlines - May 14, 2015 Category: Neurology Tags: Neurology & Neurosurgery News Source Type: news
A new mouse model for the study of neurofibromatosis
(IDIBELL-Bellvitge Biomedical Research Institute) The research group of the neurofibromatosis of the Catalan Institute of Oncology, the Institute of Biomedical Research of Bellvitge and the Institute of Medicicina Predictive and Personalized Cancer has developed new mouse models for the study of principal malignant tumor associated with neurofibromatosis type 1. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - April 16, 2015 Category: Cancer & Oncology Source Type: news
Neurofibromatosis type 1 and attention deficit hyperactivity disorder: a case study and literature review - Miguel CS, Chaim-Avancini TM, Silva MA, Louzã MR.
BACKGROUND: The cognitive profile of children with neurofibromatosis type 1 (NF1) and attention deficit hyperactivity disorder (ADHD) has been well characterized, but few studies have evaluated the cognitive abilities of adults with NF1 and ADHD. O... (Source: SafetyLit: All (Unduplicated))
Source: SafetyLit: All (Unduplicated) - April 12, 2015 Category: Global & Universal Tags: Distraction, Fatigue, Chronobiology, Vigilance, Workload Source Type: news
Your NEJM Group Today: Segmental Neurofibromatosis Image, Humor vs. Straight-Forward Education, Washington IM opening (FREE)
By The Editors
NEJM Group offers so many valuable resources for practicing clinicians. Here's what we chose for you today:NEJM Clinical … (Source: Physician's First Watch current issue)
Source: Physician's First Watch current issue - March 9, 2015 Category: Primary Care Source Type: news
Teenagers and young adults with neurofibromatosis type 1 are more likely to experience loneliness than siblings without the illness - Ejerskov C, Lasgaard M, Østergaard JR.
AIM: Our clinical observations raised concerns that teenagers and young people with neurofibromatosis type 1 (NF1) might feel lonely and we decided to investigate their experiences and compare them with unaffected siblings. We also assessed predictive fact... (Source: SafetyLit: All (Unduplicated))
Source: SafetyLit: All (Unduplicated) - February 5, 2015 Category: Global & Universal Tags: Age: Adolescents Source Type: news
