Improvement of synaptic plasticity and cognitive function in RASopathies —a monocentre, randomized, double-blind, parallel-group, placebo-controlled, cross-over clinical trial (SynCoRAS)
DiscussionThe study is targeting impairments in synaptic plasticity and cognitive impairment, one of the main health problems of patients with RASopathies. Recent first results with LOV in patients with NF1 have shown an improvement in synaptic plasticity and cognition. Within this clinical trial, it is investigated if these findings can be transferred to patients with NS. LTG is most likely a more effective and promising substance improving synaptic plasticity and, consecutively, cognitive function. It is expected that both substances are improving synaptic plasticity as well as alertness. Changes in alertness may be a pr...
Source: Trials - June 6, 2023 Category: Research Source Type: clinical trials
Multi-parametric Biomarker Development to Predict Malignant Conversion in Patients With Neurofibromatosis Type 1
Conditions: Neurofibromatosis 1; Malignant Peripheral Nerve Sheath Tumor (MPNST) of Soft Tissue (Diagnosis); Atypical Neurofibroma Intervention: Diagnostic Test: Whole Body Magnetic Resonance Imaging Sponsor: Johns Hopkins University Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 10, 2023 Category: Research Source Type: clinical trials
Observational Study of Advanced Data Analytics in Genetic Conditions
Conditions: Neurofibromatosis; Williams Syndrome; 22q11.2 Deletion Syndrome Intervention: Sponsor: National Human Genome Research Institute (NHGRI) Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - December 20, 2022 Category: Research Source Type: clinical trials
