Eight months of integrated yoga, hydrotherapy and acupuncture on serum IgE levels and symptoms severity of a patient with chronic allergic rhinosinusitis: A case report
A 27-year-old man with Allergic rhino sinusitis presented to our hospital in July 2020 with complaints of continuous sneezing, coughing while rising from bed for half an hour, and the same complaints repeated in the afternoon for half an hour, as well as a continuous dry cough for half an hour in the evening. He also had complaints of itching and skin rashes, particularly in his limbs. He underwent yoga (45 minutes, 5 –6 days a week) including Jalaneti (a yogic cleansing technique, i.e. nasal irrigation with warm salt water for twice a week), hydrotherapy (enema using neem leaves paste mixed with water and steam bath on ...
Source: Journal of Bodywork and Movement Therapies - March 25, 2024 Category: Physiotherapy Authors: K. Umadevi, E. Vijaya Bharathi, A. Mooventhan, L. Nivethitha Source Type: research

Antimicrobial phytoconstituents from < em > Azadirachta indica < /em > (neem) with potential inhibitor against FtsZ protein of < em > Pseudomonas aeruginosa < /em >
This study is focused on evaluating the potential inhibitory activity of eleven phytocompounds from Azadirachta indica against the nucleotide-binding site of the FtsZ protein of P. aeruginosa through a cheminformatics approach. FtsZ is an indispensable and highly conserved protein in prokaryotic cell division. Docking studies revealed favourable binding energies (ΔG= - 8.3 to - 5.4 kcal/mol) for all selected phytoconstituents. Finally, we selected Nimbiol (CID 11119228), as a lead compound, exhibiting a binding energy (ΔG= -7.8 kcal/mol) for the target. Based on our findings, Nimbiol shows potential as an anti-FtsZ compo...
Source: Natural Product Research - March 22, 2024 Category: Biochemistry Authors: Mauricio E Orozco-Ugarriza Nicole Paola Arrieta Caldera Yenifer Olivo-Mart ínez Source Type: research

Antimicrobial phytoconstituents from < em > Azadirachta indica < /em > (neem) with potential inhibitor against FtsZ protein of < em > Pseudomonas aeruginosa < /em >
This study is focused on evaluating the potential inhibitory activity of eleven phytocompounds from Azadirachta indica against the nucleotide-binding site of the FtsZ protein of P. aeruginosa through a cheminformatics approach. FtsZ is an indispensable and highly conserved protein in prokaryotic cell division. Docking studies revealed favourable binding energies (ΔG= - 8.3 to - 5.4 kcal/mol) for all selected phytoconstituents. Finally, we selected Nimbiol (CID 11119228), as a lead compound, exhibiting a binding energy (ΔG= -7.8 kcal/mol) for the target. Based on our findings, Nimbiol shows potential as an anti-FtsZ compo...
Source: Cell Research - March 22, 2024 Category: Cytology Authors: Mauricio E Orozco-Ugarriza Nicole Paola Arrieta Caldera Yenifer Olivo-Mart ínez Source Type: research

Antimicrobial phytoconstituents from < em > Azadirachta indica < /em > (neem) with potential inhibitor against FtsZ protein of < em > Pseudomonas aeruginosa < /em >
This study is focused on evaluating the potential inhibitory activity of eleven phytocompounds from Azadirachta indica against the nucleotide-binding site of the FtsZ protein of P. aeruginosa through a cheminformatics approach. FtsZ is an indispensable and highly conserved protein in prokaryotic cell division. Docking studies revealed favourable binding energies (ΔG= - 8.3 to - 5.4 kcal/mol) for all selected phytoconstituents. Finally, we selected Nimbiol (CID 11119228), as a lead compound, exhibiting a binding energy (ΔG= -7.8 kcal/mol) for the target. Based on our findings, Nimbiol shows potential as an anti-FtsZ compo...
Source: Natural Product Research - March 22, 2024 Category: Biochemistry Authors: Mauricio E Orozco-Ugarriza Nicole Paola Arrieta Caldera Yenifer Olivo-Mart ínez Source Type: research

The immunomodulatory impact of naturally derived neem leaf glycoprotein on the initiation progression model of 4NQO induced murine oral carcinogenesis: a preclinical study
DiscussionEfficacy of NLGP was tested first time in sequential carcinogenesis model and proved effective in delaying the initial progression. NLGP normalizes type 1 immunity including activation of the CD8+T effector functions, reduction of regulatory T cell functions, along with changes in EMT to make the host systemically alert to combat the carcinogenic threat. (Source: Frontiers in Immunology)
Source: Frontiers in Immunology - March 22, 2024 Category: Allergy & Immunology Source Type: research

Synergistic effects of epoxyazadiradione (EAD) and paclitaxel against triple-negative breast cancer cells
CONCLUSION: To conclude, EAD could be the drug of choice for combined treatment with paclitaxel in a chemotherapy regimen.PMID:38482560 | DOI:10.1111/fcp.13000 (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - March 14, 2024 Category: Cancer & Oncology Authors: Kunnathully Sudhan Sijisha Rajitha Anusha Sulochana Priya Source Type: research

Synergistic effects of epoxyazadiradione (EAD) and paclitaxel against triple-negative breast cancer cells
CONCLUSION: To conclude, EAD could be the drug of choice for combined treatment with paclitaxel in a chemotherapy regimen.PMID:38482560 | DOI:10.1111/fcp.13000 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - March 14, 2024 Category: Cancer & Oncology Authors: Kunnathully Sudhan Sijisha Rajitha Anusha Sulochana Priya Source Type: research

Synergistic effects of epoxyazadiradione (EAD) and paclitaxel against triple-negative breast cancer cells
CONCLUSION: To conclude, EAD could be the drug of choice for combined treatment with paclitaxel in a chemotherapy regimen.PMID:38482560 | DOI:10.1111/fcp.13000 (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - March 14, 2024 Category: Cancer & Oncology Authors: Kunnathully Sudhan Sijisha Rajitha Anusha Sulochana Priya Source Type: research

Synergistic effects of epoxyazadiradione (EAD) and paclitaxel against triple-negative breast cancer cells
CONCLUSION: To conclude, EAD could be the drug of choice for combined treatment with paclitaxel in a chemotherapy regimen.PMID:38482560 | DOI:10.1111/fcp.13000 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - March 14, 2024 Category: Cancer & Oncology Authors: Kunnathully Sudhan Sijisha Rajitha Anusha Sulochana Priya Source Type: research

IDF23-0555 Decrease of glycemia with extracts of Plathymenia reticulate Benth and Azadirachta indica (Neem) in obese rats
(Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - March 1, 2024 Category: Endocrinology Authors: L.V. Oliveira Silva, F. Oliveira Magalh ães, P. Ibler Bernardo Ceron, G. Braga de Paula Cançado, B. Rabelo Tavares, I. Faria de Mello, M.E. Franco, S. Ferreira, M. Silva Paiva, C. Schlischka, R. Pacheco Policarpo, L. Augusto Alves Silva Tags: Other Complications Source Type: research

IDF23-0546 Weight gain reduction with extracts of Plathymenia reticulate Benth and Neem in type 2 diabetic rats
(Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - March 1, 2024 Category: Endocrinology Authors: C. Schlischka Sivieri, G. Braga de Paula Can çado, F. Oliveira Magalhães, L. Augusto Alves Silva, I. Faria de Mello, M.E. Franco, S. Ferreira, M. Silva Paiva, L.V. Oliveira Silva, M.E. Santos Resende, R. Pacheco Policarpo, B. Rabelo Tavares Tags: Other Complications Source Type: research

IDF23-0541 Decrease of lipids with extracts of Plathymenia reticulata Benth and Azadirachta indica (Neem) in obese rats
(Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - March 1, 2024 Category: Endocrinology Authors: S. Ferreira, F. Oliveira Magalh ães, G. Braga de Paula Cançado, L. Augusto Alves Silva, C. Sivieri Schlischka, L. Vitória Oliveira Silva, M.E. Franco, M.E. Santos Resende, P. Ibler Bernardo Ceron, B. Rabelo Tavares, R. Pacheco Policarpo, I. Faria de Me Tags: Other Complications Source Type: research

Preparation and characterization of biodegradable food packaging films using lemon peel pectin and chitosan incorporated with neem leaf extract and its application on apricot fruit
Int J Biol Macromol. 2024 Feb 25:130358. doi: 10.1016/j.ijbiomac.2024.130358. Online ahead of print.ABSTRACTThe present study aims to develop and characterize biodegradable packaging films from lemon peel-derived pectin and chitosan incorporated with a bioactive extract from neem leaves. The films (PCNE) contained varying concentrations of neem leaf extract and were comprehensively assessed for their physical, optical, mechanical, and antimicrobial attributes. The thickness, moisture content, water solubility, and water vapor permeability of the biodegradable packaging films increased with the increasing concentration of n...
Source: International Journal of Biological Macromolecules - February 27, 2024 Category: Biochemistry Authors: Sadia Firdaus Faizan Ahmad Sadaf Zaidi Source Type: research

Thinking green: insecticidal effect of biorational solutions against Triatoma pallidipennis Stal (Hemiptera: Triatominae)
Acta Trop. 2024 Feb 19:107152. doi: 10.1016/j.actatropica.2024.107152. Online ahead of print.ABSTRACTThe control of triatomine vectors depends almost exclusively on conventional insecticides. These compounds can, nevertheless, cause negative effects on environmental and human health as well as induce resistance in triatomines. Therefore, we need to look for more sustainable alternatives. Triatoma pallidipennis is one of the main chagasic vectors in Mexico. We evaluated the insecticidal effectiveness of two oils (neem and cinnamon), and two desiccants (potassium salts of fatty acids and diatomaceous earth), on 3rd instar ny...
Source: Acta Tropica - February 21, 2024 Category: Infectious Diseases Authors: Reyna Vargas-Abasolo Jos é D Rivera-Duarte V íctor Manuel Almaraz-Valle Mario Mejia-Mandujano Liliana Aguilar-Marcelino Alex C órdoba-Aguilar Source Type: research

Thinking green: insecticidal effect of biorational solutions against Triatoma pallidipennis Stal (Hemiptera: Triatominae)
Acta Trop. 2024 Feb 19:107152. doi: 10.1016/j.actatropica.2024.107152. Online ahead of print.ABSTRACTThe control of triatomine vectors depends almost exclusively on conventional insecticides. These compounds can, nevertheless, cause negative effects on environmental and human health as well as induce resistance in triatomines. Therefore, we need to look for more sustainable alternatives. Triatoma pallidipennis is one of the main chagasic vectors in Mexico. We evaluated the insecticidal effectiveness of two oils (neem and cinnamon), and two desiccants (potassium salts of fatty acids and diatomaceous earth), on 3rd instar ny...
Source: Acta Tropica - February 21, 2024 Category: Infectious Diseases Authors: Reyna Vargas-Abasolo Jos é D Rivera-Duarte V íctor Manuel Almaraz-Valle Mario Mejia-Mandujano Liliana Aguilar-Marcelino Alex C órdoba-Aguilar Source Type: research