Identification of the neuronal suppressor of cataplexy, sudden weakening of muscle tone
(Kanazawa University) Narcolepsy is a disorder caused by losing orexin neurons, marked by excessive daytime sleepiness and cataplexy, sudden weakening of muscle tone. Previously, we found two kinds of neurons preventing narcolepsy by receiving information from orexin neurons. Here, we have discovered that serotonin neuron, one of the two neurons above, inhibits cataplexy by reducing the amygdala activity, which controls emotion. Current discovery should lead to comprehension of the narcolepsy mechanism and to therapy development for cataplexy. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - May 13, 2017 Category: International Medicine & Public Health Source Type: news

The spectrum of REM sleep-related episodes in children with type 1 narcolepsy - Antelmi E, Pizza F, Vandi S, Neccia G, Ferri R, Bruni O, Filardi M, Cantalupo G, Liguori R, Plazzi G.
Type 1 narcolepsy is a central hypersomnia due to the loss of hypocretin-producing neurons and characterized by cataplexy, excessive daytime sleepiness, sleep paralysis, hypnagogic hallucinations and disturbed nocturnal sleep. In children, close to the dis... (Source: SafetyLit)
Source: SafetyLit - May 9, 2017 Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news

Sleepy teen finds relief in narcolepsy diagnosis
For as long as Maeve Sheehy can remember, she’s had short spells of feeling like she was about to fall over. “It wasn’t like feeling faint, it was more like my knees would buckle underneath me,” says Maeve, now 16. “I would instinctually try to keep from falling by bracing myself.” Sometimes the bracing didn’t work and Maeve would topple over. If she was with friends, she’d pretend she had tripped, to cover it up. But she secretly worried something was wrong with her. When she tried to explain the falling feeling to her parents and doctors, she was told she was probably dehydrated. More mysterious symptoms ...
Source: Thrive, Children's Hospital Boston - May 2, 2017 Category: Pediatrics Authors: Ellen Greenlaw Tags: Our Patients’ Stories Center for Pediatric Sleep Disorders Dr. Eric Zhou Dr. Kiran Maski Narcolepsy Source Type: news

Jazz Pharmaceuticals reports positive data from TONES 2 trial of JZP-110 in narcolepsy
Irish biopharmaceutical firm Jazz Pharmaceuticals has reported positive efficacy results from the Phase III TONES 2 clinical trial of JZP-110 to treat adults with narcolepsy-associated excessive sleepiness. (Source: Drug Development Technology)
Source: Drug Development Technology - April 27, 2017 Category: Pharmaceuticals Source Type: news

Runner: Having narcolepsy is harder than a marathon
For years, Julie Flygare kept her condition private. She hadn't liked people's reactions on the occasions when she had opened up and shared her story. People thought it was a joke or not important. (Source: CNN.com - Health)
Source: CNN.com - Health - April 27, 2017 Category: Consumer Health News Source Type: news

Your NEJM Group Today: Addressing the Opioid Epidemic / Narcolepsy Score / Massachusetts Primary Care Opportunities (FREE)
By the Editors Check out the latest from NEJM Group: NEJM Clinical Practice Center: Perspective: The FDA has proposed allowing public health considerations to … (Source: Physician's First Watch current issue)
Source: Physician's First Watch current issue - April 24, 2017 Category: Primary Care Source Type: news

Narcolepsy More Prevalent in Influenza-vaccinated Youth in Norway Narcolepsy More Prevalent in Influenza-vaccinated Youth in Norway
Norwegian registry data confirm reports of an association between vaccination during the 2009 influenza A (H1N1) pandemic and subsequent development of narcolepsy in young people, according to researchers.Reuters Health Information (Source: Medscape Allergy Headlines)
Source: Medscape Allergy Headlines - March 31, 2017 Category: Allergy & Immunology Tags: Neurology & Neurosurgery News Source Type: news

Narcolepsy is my sleepy superpower
My talent is almost more like a superpower. I have the ability to fall asleep wherever and whenever. Now I know you’re probably thinking all teenagers have this power, but trust me, I’m a little different. At any time or place, I have the ability to take a nap. Intrigued by my power, experts and doctors conducted multiple tests and studies on me. When the results came back, it was clear I wasn’t normal. One doctor even admitted, “These are numbers I’ve never seen before.” Developing my superpower I first began developing my sleepy superpower in the fall of my junior year after transferring to Middlesex School. ...
Source: Thrive, Children's Hospital Boston - March 22, 2017 Category: Pediatrics Authors: Jake Shusterman Tags: Our Patients’ Stories Dr. Kiran Maski Narcolepsy Sleep Center Source Type: news

Artist Illustrates The Realities Of Mental Health, From A(nxiety) To Z
"I'm doing everything wrong." "Everyone's laughing at me." "I think I left the door open." Anxiety comes in different shapes and sizes. #atozofmentalhealth - - - - - #365daysofart #drawingaday #36daysoftype @36daysoftype #36days_A #36daysoftype04 #mentalhealth #art #typography #lettering #colors #anxiety #watercolor #igart #sketchbook #digitalart #illustration #selflove #care #mentalhealthawareness #endthestigma A post shared by Sonaksha Iyengar (@sonaksha) on Feb 21, 2017 at 8:22am PST A is for anxiety, which itself comes in many shapes and colors. B is for bipolar disorder, a ter...
Source: Healthy Living - The Huffington Post - March 7, 2017 Category: Consumer Health News Source Type: news

Ministers lose fight to stop payouts over swine flu jab narcolepsy cases
Dozens of children who developed sleep disorder after getting vaccine could get compensation after high court rulingDozens of children who developed narcolepsy as a result of a swine flu vaccine could be compensated after the high court rejecteda government appeal to withhold payments.Six million people in Britain, and more across Europe, were given the Pandemrix vaccine made by GlaxoSmithKline during the 2009-10 swine flu pandemic, but the jab was withdrawn after doctors noticed asharp rise in narcolepsy among those who received it.Continue reading... (Source: Guardian Unlimited Science)
Source: Guardian Unlimited Science - February 9, 2017 Category: Science Authors: Ian Sample Science editor Tags: Science Vaccines and immunisation Swine flu Health Society World news UK news Source Type: news

Mylan Agreed to Pay $96.5 Mln in Provigil Antitrust Class Action Mylan Agreed to Pay $96.5 Mln in Provigil Antitrust Class Action
Mylan NV has agreed to pay $96.5 million to settle claims by drug purchasers that it delayed launching a generic version of Cephalon Inc ' s narcolepsy drug Provigil (modafinil) in exchange for payment from Cephalon.Reuters Health Information (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - February 7, 2017 Category: Consumer Health News Tags: Medscape Today News Source Type: news

The Future of Sleep
By Brandon R. Peters, MD When considering the means to optimize well-being and function, there must be a prominent place reserved for sleep. Along with diet and exercise, it is a pillar of health, deserving both a daily commitment and unwavering respect. Though often slighted, sleep medicine has been a growth industry for decades, and its future holds both promise and opportunity. Sleep may be one of the most important things that you do on a daily basis. It is the means by which our brains self-cleanse and remove metabolic waste products. Memory is consolidated. Problem solving occurs as new associations and connection...
Source: Healthy Living - The Huffington Post - January 27, 2017 Category: Consumer Health News Source Type: news

What is in the Differential Diagnosis of Fatigue?
Discussion Fatigue is a subjective feeling of decreased energy, tiredness or feeling of exhaustion. Lethargy is often used synonymously, but lethargy is a state of being drowsiness or sleepy, and implies mental status changes. Both can cause the person to be apathetic or less active. Fatigue is a common state that almost everyone experiences multiple times in his or her lifetime. For most people it is a relatively acute or short-term chronic problem, often with a relatively easily identifiable problem cause, such as inadequate sleep, acute illness, or overexertion. For some, it can be less readily identifiable such as dep...
Source: PediatricEducation.org - January 23, 2017 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

FDA Approves Xyrem (sodium oxybate) Oral Solution Generic with a REMS Program
January 18, 2017 -- The FDA has approved the first generic version of Xyrem (sodium oxybate) Oral Solution, to treat cataplexy and excessive daytime sleepiness in patients with narcolepsy, which is a potentially debilitating disease. Cataplexy is a... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - January 18, 2017 Category: Pharmaceuticals Source Type: news

FDA approves generic version of Jazz Pharma's sleep disorder drug
(Reuters) - The U.S. Food and Drug Administration said it had approved the first generic version of Xyrem, Jazz Pharmaceuticals Plc's drug to treat patients with narcolepsy, a kind of sleeping disorder. (Source: Reuters: Health)
Source: Reuters: Health - January 17, 2017 Category: Consumer Health News Tags: healthNews Source Type: news