225Ac-DOTA-Anti-CD38 Daratumumab Monoclonal Antibody With Fludarabine, Melphalan and Total Marrow and Lymphoid Irradiation as Conditioning Treatment for Donor Stem Cell Transplant in Patients With High-Risk Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia and Myelodysplastic Syndrome
Conditions: Acute Lymphoblastic Leukemia; Acute Myeloid Leukemia; Myelodysplastic Syndrome Interventions: Biological: Actinium Ac 225-DOTA-Daratumumab; Procedure: Biospecimen Collection; Procedure: Bone Marrow Aspiration; Procedure: Bone Marrow Biopsy; Procedure: Computed Tomography; Biological: Daratumumab; Procedure: Echocardiography; Drug: Fludarabine; Procedure: Hematopoietic Cell Transplantation; Biological: Indium In 111-DOTA-Daratumumab; Drug: Melphalan; Procedure: Multigated Acquisition Scan; Procedure: Radionuclide Imaging; Procedure: Single Photon Emission Computed Tomography; Drug: Sirolimus; Drug: Tacrolimus; R...
Source: ClinicalTrials.gov - March 1, 2024 Category: Research Source Type: clinical trials

Phase I/II Study of a Combination of Decitabine and Cedazuridine (ASTX727) and ASTX029, an ERK Inhibitor, for Patients With RAS Pathway Mutant Myelodysplastic Syndromes and Myelodysplastic/Myeloproliferative Neoplasms
Conditions: Pathway Mutant Myelodysplastic Syndromes; Myelodysplastic Neoplasm; Myeloproliferative Neoplasm Interventions: Drug: ASTX029; Drug: ASTX727 Sponsors: M.D. Anderson Cancer Center Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - February 29, 2024 Category: Research Source Type: clinical trials

Sirolimus+Abatacept+Mycophenolate Mofetil for Prophylaxis of aGVHD in Patients Receiving Haplo-HSCT Who Are Intolerant to Calcineurin Inhibitors
Conditions: Acute Leukemia; Myelodysplastic Syndromes; Severe Aplastic Anemia Interventions: Drug: Sirolimus; Drug: Abatacept; Drug: MMF; Drug: ATG Sponsors: Peking University People ' s Hospital Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - February 28, 2024 Category: Research Source Type: clinical trials

A Novel Conditioning Regimen for Myelodysplastic Syndrome With Moderate High IPSS-M Score
Conditions: Myelodysplastic Syndromes Interventions: Drug: Azacitidine Injection Sponsors: Wuhan Union Hospital, China Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - February 28, 2024 Category: Research Source Type: clinical trials

OURA Ring Wearable Testing in MDS Patients: a Feasibility and Discovery Pilot Study
Conditions: MDS; Myelodysplastic Syndromes Interventions: Device: OURA Ring Sponsors: Sunnybrook Health Sciences Centre Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - February 21, 2024 Category: Research Source Type: clinical trials

Safety and Efficacy of RVU120 for Treatment of Relapsed/Refractory AML
Conditions: Acute Myeloid Leukemia (AML); High-risk Myelodysplastic Syndrome Interventions: Drug: RVU120 Sponsors: Ryvu Therapeutics SA Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - February 20, 2024 Category: Research Source Type: clinical trials

Trial of 2 Step ATG for Prevention of Acute GVHD Post Allogeneic Stem Cell Transplant
Conditions: Acute Leukemia; Myelodysplastic Syndrome; Myeloproliferative Disorders Interventions: Drug: ATG dosing platform when combined with standard tacrolimus and mini methotrexate Sponsors: University of Alabama at Birmingham Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - February 19, 2024 Category: Research Source Type: clinical trials

A Study to Find the Highest Dose of Imetelstat in Combination With Fludarabine and Cytarabine for Patients With AML, MDS or JMML That Has Come Back or Does Not Respond to Therapy
Conditions: Recurrent Acute Myeloid Leukemia; Recurrent Juvenile Myelomonocytic Leukemia; Recurrent Myelodysplastic Syndrome; Refractory Acute Myeloid Leukemia; Refractory Myelodysplastic Syndrome Interventions: Procedure: Biospecimen Collection; Procedure: Bone Marrow Aspiration; Procedure: Bone Marrow Biopsy; Drug: Cytarabine; Procedure: Echocardiography; Drug: Fludarabine; Drug: Hydrocortisone Sodium Succinate; Biological: Imetelstat; Drug: Leucovorin Calcium; Procedure: Lumbar Puncture; Drug: Methotrexate Sponsors: Children ' s Oncology Group Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - February 8, 2024 Category: Research Source Type: clinical trials

FBM Regimen in HSCT for MDS: a Phase IIb Clinical Study
Conditions: Myelodysplastic Syndrome With Excess Blasts-1; Myelodysplastic Syndrome With Excess Blasts-2; Myelodysplastic Syndromes Interventions: Drug: Fludarabine, Busulfan and Melphalan Sponsors: Ruijin Hospital Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - February 8, 2024 Category: Research Source Type: clinical trials

FBM Regimen in HSCT for MDS
Conditions: Myelodysplastic Syndrome With Excess Blasts-1; Myelodysplastic Syndrome With Excess Blasts-2; Myelodysplastic Syndromes Interventions: Drug: Fludarabine, Busulfan and Melphalan Sponsors: Ruijin Hospital Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - February 8, 2024 Category: Research Source Type: clinical trials

Clinical and Laboratory Parameters of Myelodysplastic Syndromes at Upper Egypt
Conditions: Myelodysplastic Syndromes Sponsors: Sohag University Completed (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - February 6, 2024 Category: Research Source Type: clinical trials

RVU120 for Treatment of Anemia in Patients With Lower-risk Myelodysplastic Neoplasms
Conditions: Low Risk Myelodysplastic Syndromes Interventions: Drug: RVU120 (SEL120) Sponsors: GCP-Service International West GmbH; Universit ätsklinikum Leipzig; Saint-Louis Hospital, Paris, France; University of Florence; University of Salamanca; Medical University of Warsaw; Ryvu Therapeutics SA; European Myelodysplastic Neoplasms Cooperative Group Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - February 6, 2024 Category: Research Source Type: clinical trials

Upfront Related Donor Transplantation in Patients With Myelodisplatic Syndrome : a Phase 2 Trial
Conditions: Myelodysplastic Syndromes Interventions: Biological: Hematopoietic stem-cell transplantation Sponsors: Assistance Publique - H ôpitaux de Paris Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 31, 2024 Category: Research Source Type: clinical trials

A Study of TQB3454 Tablets in Patients With Blood Tumors
Conditions: Acute Myeloid Leukemia; Myelodysplastic Syndromes Interventions: Drug: TQB3454 Tablets Sponsors: Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 23, 2024 Category: Research Source Type: clinical trials

TGRX-814 Chinese Phase I/II in Patients With Hematological Malignancies
Conditions: Hematologic Malignancy; Non Hodgkin Lymphoma; Acute Myeloid Leukemia; Acute Lymphoblastic Leukemia, Adult; Myelodysplastic Syndromes Interventions: Drug: TGRX-814 Sponsors: Shenzhen TargetRx, Inc.; Institute of Hematology& Blood Diseases Hospital, China Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 15, 2024 Category: Research Source Type: clinical trials