Utility of Low-Dose Duvelisib for Advanced Mycosis Fungoides: A Single-Institution Study
Oncologist. 2024 Jan 18:oyad345. doi: 10.1093/oncolo/oyad345. Online ahead of print.ABSTRACTDuvelisib, a small-molecule phosphatidylinositol 3-kinase-δ,γ inhibitor, has shown efficacy for mycosis fungoides (MF) at dosage ranges of 25-100 mg twice daily (BID), but with significant toxicity. We conducted a retrospective cohort study of patients with advanced MF treated with low-dose duvelisib (15 mg every other day to BID), in an effort to minimize toxicity. A total of 7 patients were included. The overall response rate on duvelisib was 71%, with the remaining patients maintaining stable disease. Mean modified Severity Wei...
Source: The Oncologist - January 20, 2024 Category: Cancer & Oncology Authors: Christopher Bazewicz Nicolena Verardi Oleg Akilov Source Type: research
Racial Disparities in Mycosis Fungoides/S ézary Syndrome-A Single-Center Observational Study of 292 Patients
CONCLUSIONS: AA/black patients with MF/SS have a significant worse survival outcome compared to white patients. The association between clinical phenotypes and survival differed between these groups. Further studies are required to investigate whether race-specific pathogenesis or genetic factors may explain these differences.PMID:38245472 | DOI:10.1016/j.clml.2023.12.017 (Source: Clinical Lymphoma and Myeloma)
Source: Clinical Lymphoma and Myeloma - January 20, 2024 Category: Cancer & Oncology Authors: Ashley R Gandham Shamir Geller Stephen W Dusza Thomas S Kupper Patricia L Myskowski Source Type: research
Computational Flow Cytometry Accurately Identifies Sezary Cells Based on Simplified Aberrancy and Clonality Features
Flow cytometric identification of circulating neoplastic cells (Sezary cells) in patients with mycosis fungoides (MF) and Sezary syndrome (SS) is essential for diagnosis, staging and prognosis. While recent advances have improved the performance of this laboratory assay, the complex immunophenotype of Sezary cells and overlap with reactive T cells demand a high level of analytic expertise. We utilized machine learning to simplify this analysis using only 2 pre-defined Sezary cell-gating plots. We studied 114 samples from 59 patients with SS/MF, and 66 samples from unique patients with inflammatory dermatoses. (Source: Jour...
Source: Journal of Investigative Dermatology - January 16, 2024 Category: Dermatology Authors: Jansen N. Seheult, Matthew J. Weybright, Dragan Jevremovic, Min Shi, Horatiu Olteanu, Pedro Horna Tags: Original Article Source Type: research
Allogeneic transplantation and cellular therapies in cutaneous T-cell lymphoma
Expert Rev Anticancer Ther. 2024 Jan-Feb;24(1-2):41-58. doi: 10.1080/14737140.2024.2305356. Epub 2024 Feb 12.ABSTRACTINTRODUCTION: Mycosis fungoides (MF) and Sezary syndrome (SS) are the most common types of cutaneous T-cell lymphoma. Although many available treatments offer temporary disease control, allogeneic hematopoietic stem cell transplant (allo-HSCT) is the only curative treatment option for advanced stage MF and SS. CAR T-cell therapy is a promising new avenue for treatment.AREAS COVERED: In this review, we discuss the evidence supporting the use of allo-HSCT for the treatment of MF/SS, including disease status at...
Source: Expert Review of Anticancer Therapy - January 15, 2024 Category: Cancer & Oncology Authors: Amrita Goyal Francine Foss Source Type: research
Effectiveness and tolerability of chlormethine gel for the management of mycosis fungoides: a multicenter real-life evaluation
ConclusionsOur observations support the use of CL gel in patients with early- and advanced-stage MF, making it a valuable treatment option. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - January 4, 2024 Category: Cancer & Oncology Source Type: research
Racial disparities in Mycosis Fungoides/S ézary Syndrome – A Single-center observational study of 292 patients.
In this study, we aim to characterize differences between AA/black and white patients with MF/SS. (Source: Clinical Lymphoma, Myeloma and Leukemia)
Source: Clinical Lymphoma, Myeloma and Leukemia - January 3, 2024 Category: Hematology Authors: Ashley R. Gandham, Shamir Geller, Stephen W. Dusza, Thomas S. Kupper, Patricia. L. Myskowski Tags: Original Study Source Type: research
Racial Disparities in Mycosis Fungoides/S ézary Syndrome–A Single-Center Observational Study of 292 Patients
We report worse survival in black patients compared to white patients with different survival risk for hypopigmentation, erythroderma and ulceration between the races. The underlying mechanisms require further investigation and may have impact on treatment strategies in these groups. (Source: Clinical Lymphoma, Myeloma and Leukemia)
Source: Clinical Lymphoma, Myeloma and Leukemia - January 3, 2024 Category: Hematology Authors: Ashley R. Gandham, Shamir Geller, Stephen W. Dusza, Thomas S. Kupper, Patricia. L. Myskowski Tags: Original Study Source Type: research
Cancers, Vol. 16, Pages 217: Identification of Skin Lesions by Snapshot Hyperspectral Imaging
This study pioneers the application of artificial intelligence (AI) and hyperspectral imaging (HSI) in the diagnosis of skin cancer lesions, particularly focusing on Mycosis fungoides (MF) and its differentiation from psoriasis (PsO) and atopic dermatitis (AD). By utilizing a comprehensive dataset of 1659 skin images, including cases of MF, PsO, AD, and normal skin, a novel multi-frame AI algorithm was used for computer-aided diagnosis. The automatic segmentation and classification of skin lesions were further explored using advanced techniques, such as U-Net Attention models and XGBoost algorithms, transforming images fro...
Source: Cancers - January 2, 2024 Category: Cancer & Oncology Authors: Hung-Yi Huang Hong-Thai Nguyen Teng-Li Lin Penchun Saenprasarn Ping-Hung Liu Hsiang-Chen Wang Tags: Article Source Type: research
Survival analysis and prognostic factors in a case series of 148 cutaneous T-cell lymphomas
CONCLUSIONS: Stage IVA and the presence of LCT at diagnosis stood out as independent factors of unfavorable prognosis. LCT was the variable that most significantly impacted the patients' survival and was closely associated with tumor skin involvement and stage IIB.PMID:38159841 | DOI:10.1016/j.ad.2023.12.002 (Source: Actas Dermo-Sifiliograficas)
Source: Actas Dermo-Sifiliograficas - December 30, 2023 Category: Dermatology Authors: C Moreno-V ílchez O Servitje Ó Íñiguez-Arroyo C Muniesa Source Type: research
Survival analysis and prognostic factors in a case series of 148 cutaneous T-cell lymphomas
CONCLUSIONS: Stage IVA and the presence of LCT at diagnosis stood out as independent factors of unfavorable prognosis. LCT was the variable that most significantly impacted the patients' survival and was closely associated with tumor skin involvement and stage IIB.PMID:38159841 | DOI:10.1016/j.ad.2023.12.002 (Source: Actas Dermo-Sifiliograficas)
Source: Actas Dermo-Sifiliograficas - December 30, 2023 Category: Dermatology Authors: C Moreno-V ílchez O Servitje Ó Íñiguez-Arroyo C Muniesa Source Type: research
Survival analysis and prognostic factors in a case series of 148 cutaneous T-cell lymphomas
CONCLUSIONS: Stage IVA and the presence of LCT at diagnosis stood out as independent factors of unfavorable prognosis. LCT was the variable that most significantly impacted the patients' survival and was closely associated with tumor skin involvement and stage IIB.PMID:38159841 | DOI:10.1016/j.ad.2023.12.002 (Source: Actas Dermo-Sifiliograficas)
Source: Actas Dermo-Sifiliograficas - December 30, 2023 Category: Dermatology Authors: C Moreno-V ílchez O Servitje Ó Íñiguez-Arroyo C Muniesa Source Type: research
Survival analysis and prognostic factors in a case series of 148 cutaneous T-cell lymphomas
CONCLUSIONS: Stage IVA and the presence of LCT at diagnosis stood out as independent factors of unfavorable prognosis. LCT was the variable that most significantly impacted the patients' survival and was closely associated with tumor skin involvement and stage IIB.PMID:38159841 | DOI:10.1016/j.ad.2023.12.002 (Source: Actas Dermo-Sifiliograficas)
Source: Actas Dermo-Sifiliograficas - December 30, 2023 Category: Dermatology Authors: C Moreno-V ílchez O Servitje Ó Íñiguez-Arroyo C Muniesa Source Type: research
A patient with widespread skin lesions presenting with massive pleural effusion
Tuberk Toraks. 2023 Dec;71(4):420-427. doi: 10.5578/tt.20239610.ABSTRACTMycosis fungoides is the most commonly seen type of cutaneous T-cell lymphoproliferative disease. While mycosis fungoides is linked to an increased risk of developing secondary malignancies, the occurrence of B-cell-originated disease in association with it is exceedingly rare. A 66-year-old male with persistent papillomatous skin eruption was admitted due to dyspnea. Chest X-ray, positron emission tomography, and chest computed tomography revealed axillary and mediastinal lymph node enlargement and right lower pulmonary lobe infiltration along with ri...
Source: Tuberkuloz ve Toraks - December 28, 2023 Category: Respiratory Medicine Authors: Asl ıhan Gürün Kaya Pervin Top çuoğlu Ayten Kay ı Cangır Nihal Kundak çı I şınsu Kuzu Aylin Ok çu Heper Demet Karnak Source Type: research
