Editors ’ Picks
Cutaneous T-cell lymphomas (CTCLs) comprise an incurable form of non-Hodgkin lymphoma, and advanced-stage forms of this disease, mycosis fungoides and Sezary syndrome, have poor prognosis. Previous case series documented long-lasting remission due to a graft-versus-lymphoma effect in patients treated with allogeneic hematopoietic stem cell transplantation (HSCT). In these studies, lymphoma relapse was common, and treatment-related morbidity and mortality were noted, leading to weaker recommendations for HSCT in this patient population. (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - April 19, 2024 Category: Dermatology Tags: Editors' Picks Source Type: research
Real-world study on the use of pegylated interferon alpha-2a for treatment of mycosis fungoides/S ézary syndrome using Time to Next Treatment as a measure of clinical benefit: An EORTC CLTG study
CONCLUSIONS: PEG IFN α-2a for MF/SS showed ORR of 53%, TTNT of 9.2 months, superiority of combination regimens in comparison to monotherapy and doses of 180 mcg/weekly related to higher ORR.PMID:38596857 | DOI:10.1093/bjd/ljae152 (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - April 10, 2024 Category: Dermatology Authors: Keila Mitsunaga Martine Bagot Caroline Ram-Wolff Emmanuella Guenova Christina von Gugelberg Emmilia Hodak Iris Amitay-Laish Evangelia Papadavid Constanze Jonak Stefanie Porkert Julia Scarisbrick Rona Applewaite Marie Beylot-Barry Jan Nicolay Pietro Quagli Source Type: research
Paediatric onset lymphomatoid papulosis: results of a multicentre retrospective cohort study, on behalf of the EORTC Cutaneous Lymphoma Tumours Group (CLTG)
CONCLUSIONS: We report epidemiological data from a large international cohort of children and adolescents with LyP. Overall the prognosis of the disease is good, with excellent survival rates for all patients. Due to increased risk of associated HM, a long-term follow-up should be recommended for LyP patients.PMID:38595050 | DOI:10.1093/bjd/ljae150 (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - April 10, 2024 Category: Dermatology Authors: Ma ël Blanchard Marie-Anne Morren Anne-Marie Busschots Esther Hauben Silvia Alberti-Violetti Emilio Berti Gianluca Avallone Gianluca Tavoletti Michele Panzone Pietro Quaglino Cristiana Colonna Rutger C Melchers Maarten H Vermeer Robert Gniadecki Christin Source Type: research
Real-world study on the use of pegylated interferon alpha-2a for treatment of mycosis fungoides/S ézary syndrome using Time to Next Treatment as a measure of clinical benefit: An EORTC CLTG study
CONCLUSIONS: PEG IFN α-2a for MF/SS showed ORR of 53%, TTNT of 9.2 months, superiority of combination regimens in comparison to monotherapy and doses of 180 mcg/weekly related to higher ORR.PMID:38596857 | DOI:10.1093/bjd/ljae152 (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - April 10, 2024 Category: Dermatology Authors: Keila Mitsunaga Martine Bagot Caroline Ram-Wolff Emmanuella Guenova Christina von Gugelberg Emmilia Hodak Iris Amitay-Laish Evangelia Papadavid Constanze Jonak Stefanie Porkert Julia Scarisbrick Rona Applewaite Marie Beylot-Barry Jan Nicolay Pietro Quagli Source Type: research
Paediatric onset lymphomatoid papulosis: results of a multicentre retrospective cohort study, on behalf of the EORTC Cutaneous Lymphoma Tumours Group (CLTG)
CONCLUSIONS: We report epidemiological data from a large international cohort of children and adolescents with LyP. Overall the prognosis of the disease is good, with excellent survival rates for all patients. Due to increased risk of associated HM, a long-term follow-up should be recommended for LyP patients.PMID:38595050 | DOI:10.1093/bjd/ljae150 (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - April 10, 2024 Category: Dermatology Authors: Ma ël Blanchard Marie-Anne Morren Anne-Marie Busschots Esther Hauben Silvia Alberti-Violetti Emilio Berti Gianluca Avallone Gianluca Tavoletti Michele Panzone Pietro Quaglino Cristiana Colonna Rutger C Melchers Maarten H Vermeer Robert Gniadecki Christin Source Type: research
Folliculotropic mycosis fungoides associated with follicular mucinosis: A case report and mini review
Clin Case Rep. 2024 Apr 5;12(4):e8731. doi: 10.1002/ccr3.8731. eCollection 2024 Apr.ABSTRACTKEY CLINICAL MESSAGE: F-MF is a rare non-classic variant of MF. In the case of hair loss, this should be a diagnostic consideration. The essence of the diagnosis of F-MF is a careful medical history, physical examination, and a combination of immunohistological and molecular analyses (Cureus. 2022; 14:e21231, Ann Saudi Med. 2012; 32:283, Oman Med J. 2012; 27:134, Int J Dermatol. 2016; 55:1396, Saudi Med J. 2018; 39:994 and Case Rep Oncol. 2018; 11:436).ABSTRACT: Mycosis fungoides (MF) is a primary cutaneous T-cell lymphoma with mult...
Source: Ann Oncol - April 8, 2024 Category: Cancer & Oncology Authors: Majed Saleh Aldayhum Mohammed Saad Alshahrani Mahmoud Rezk A Hussein Abdulmajeed Saad Alshahrani Toka M R Hussein Source Type: research
Folliculotropic mycosis fungoides associated with follicular mucinosis: A case report and mini review
Histological features of follicular mycosis fungoides. (A-B) Dense superficial and deep dermal lymphocytic infiltrate with a predominantly perifollicular/folliculocentric distribution extending into the mid-dermis. Atypical lymphocytes are located along the basal cell layer of the hair follicle epithelium. Some neoplastic lymphocytes are surrounded by a halo. Although there is epidermal thinning, there is no atypia or epidermotropism, or Pautrier microabscesses. The interfollicular epidermis is not involved. (Hematoxylin and eosin staining, original magnification, A:x20, B:x40). (C-D) Exocytosis of small and medium-sized h...
Source: Clinical Case Reports - April 5, 2024 Category: General Medicine Authors: Majed Saleh Aldayhum,
Mohammed Saad Alshahrani,
Mahmoud Rezk A. Hussein,
Abdulmajeed Saad Alshahrani,
Toka M. R. Hussein Tags: CASE REPORT Source Type: research
Genetic predisposition to early mycosis fungoides: investigating genetic polymorphisms in tissue-resident memory T-cell genes
CONCLUSIONS: The presence of genetic variations in one or more TRM functional gene may predispose patients to develop MF. Further studies involving a larger patient population and a comparative analysis of protein expression will be necessary to validate these findings.PMID:38546260 | DOI:10.1177/03000605241239034 (Source: Cell Research)
Source: Cell Research - March 28, 2024 Category: Cytology Authors: Nour Almaani Fatima Farhan Salsabiela Bani Hamad Eman A Abuhawileh Lana Koubaitary Mamoun Ahram Tariq N Aladily Source Type: research
Genomic profiling of Mycosis Fungoides identifies patients at high risk of disease progression
Blood Adv. 2024 Mar 21:bloodadvances.2023012125. doi: 10.1182/bloodadvances.2023012125. Online ahead of print.ABSTRACTMycosis fungoides (MF) is the most prevalent primary cutaneous T-cell lymphoma, with an indolent or aggressive course and poor survival. The pathogenesis of MF remains unclear, and prognostic factors in the early stages are not well-established. Here, we characterized the most recurrent genomic alterations using whole-exome sequencing of 67 samples from 48 patients from Lille University Hospital (France), including 18 sequential samples drawn across stages of the malignancy. Genomic data were analyzed on th...
Source: Adv Data - March 21, 2024 Category: Epidemiology Authors: L éa Fléchon In ès Arib Ankit K Dutta Lama Hasan Bou Issa Romanos Sklavenitis-Pistofidis Remi Tilmont Chip Stewart Romain Dubois St éphanie Poulain Marie-Christine Copin Sahir Javed Morgane Nudel Doriane Cavalieri Guillaume Escure Nicolas Gower Paul C Source Type: research
Mycosis Fungoides: successful re-treatment with Brentuximab Vedotin
Br J Dermatol. 2024 Mar 12:ljae097. doi: 10.1093/bjd/ljae097. Online ahead of print.NO ABSTRACTPMID:38470968 | DOI:10.1093/bjd/ljae097 (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - March 12, 2024 Category: Dermatology Authors: Mariel James Mano Nakamura Sean Whittaker Stephen Morris Source Type: research
Long term outcomes of nonmyeloablative allogeneic stem cell transplantation with TSEB TLI and ATG for Mycosis Fungoides and Sezary Syndrome
Bone Marrow Transplantation, Published online: 12 March 2024; doi:10.1038/s41409-024-02236-zLong term outcomes of nonmyeloablative allogeneic stem cell transplantation with TSEB TLI and ATG for Mycosis Fungoides and Sezary Syndrome (Source: Bone Marrow Transplantation)
Source: Bone Marrow Transplantation - March 12, 2024 Category: Hematology Authors: S. L. Morris B. R. Thomas R. Palanicawandar S. Whittaker F. Child M. Wain V. Sim R. Szydlo S. Mangar E. Olavarria S. Lozano Cerrada A. Muzamil E. Kanfer Source Type: research
Milia en plaque on the shoulder as an early manifestations of mycosis fungoides
Milia en plaque (MEP) is an uncommon skin condition identified as retroauricular confluent milium by Boulzer and Fouqet in 1903 [1]. It can be mistaken for other dermatoses like Favre-Racouchot nodular elastosis, steatocystoma multiplex, and nevus comedonicus. Milia en plaque can either be primary or secondary and is typically benign, often triggered by dermatological procedures like cryotherapy, as reported in this journal. In some cases, MEP can arise as a secondary manifestation of other diseases, including folliculotropic mycosis fungoides (FMF). Despite this association, there are few documented cases in the literatur...
Source: Dermatology Online Journal - March 12, 2024 Category: Dermatology Authors: Rodrigues, Felipe Tavares Source Type: research
Erythema gyratum repens-like presentation of folliculotropic mycosis fungoides
(Source: Dermatology Online Journal)
Source: Dermatology Online Journal - March 12, 2024 Category: Dermatology Authors: Hida, Yasutoshi Source Type: research
Mycosis fungoides-like eruptions associated with abatacept
Australas J Dermatol. 2024 Mar 7. doi: 10.1111/ajd.14249. Online ahead of print.NO ABSTRACTPMID:38454790 | DOI:10.1111/ajd.14249 (Source: The Australasian Journal of Dermatology)
Source: The Australasian Journal of Dermatology - March 8, 2024 Category: Dermatology Authors: Daichi Hoshina Yuri Nagata Source Type: research
Mycosis fungoides-like eruptions associated with abatacept
Australas J Dermatol. 2024 Mar 7. doi: 10.1111/ajd.14249. Online ahead of print.NO ABSTRACTPMID:38454790 | DOI:10.1111/ajd.14249 (Source: The Australasian Journal of Dermatology)
Source: The Australasian Journal of Dermatology - March 8, 2024 Category: Dermatology Authors: Daichi Hoshina Yuri Nagata Source Type: research
