Cerebrospinal fluid influx drives acute ischemic tissue swelling
Stroke affects millions each year. Poststroke brain edema predicts the severity of eventual stroke damage, yet our concept of how edema develops is incomplete and treatment options remain limited. In early stages, fluid accumulation occurs owing to a net gain of ions, widely thought to enter from the vascular compartment. Here, we used magnetic resonance imaging, radiolabeled tracers, and multiphoton imaging in rodents to show instead that cerebrospinal fluid surrounding the brain enters the tissue within minutes of an ischemic insult along perivascular flow channels. This process was initiated by ischemic spreading depola...
Source: ScienceNOW - March 11, 2020 Category: Science Authors: Mestre, H., Du, T., Sweeney, A. M., Liu, G., Samson, A. J., Peng, W., Mortensen, K. N., Staeger, F. F., Bork, P. A. R., Bashford, L., Toro, E. R., Tithof, J., Kelley, D. H., Thomas, J. H., Hjorth, P. G., Martens, E. A., Mehta, R. I., Solis, O., Blinder, P Tags: Medicine, Diseases, Neuroscience, Online Only r-articles Source Type: news
Fixel-based diffusion magnetic resonance imaging reveals novel associations between white matter microstructure and childhood aggressive behavior - Grazioplene R, Tseng WL, Cimino K, Kalvin C, Ibrahim K, Pelphrey KA, Sukhodolsky DG.
We examined white matter microstructure correlates of aggr... (Source: SafetyLit)
Source: SafetyLit - March 10, 2020 Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
NeuroPace Removes Barrier for Epilepsy Treatment Through FDA Nod
NeuroPace is spicing up the neuromodulation market a bit with a new nod from FDA for MRI labeling for the RNS system. The Mountain View, CA-based company’s RNS System treats patients living with seizures that do not respond to medication and first landed a PMA in November of 2013.
In a release, the company said individuals with focal onset seizures that also have brain anomalies that require monitoring, such as tuberous sclerosis, brain tumors or multiple sclerosis, as well as those with non-brain MRI requirements, can now be offered the RNS System as a treatment option.
The company added this will also a...
Source: MDDI - March 9, 2020 Category: Medical Devices Authors: Omar Ford Tags: Business Regulatory and Compliance Source Type: news
Combined Biopsy Method Better for Prostate Cancer Diagnosis
WEDNESDAY, March 4, 2020 -- Combined biopsy, including magnetic resonance imaging (MRI)-targeted and systematic biopsy, leads to more detection of prostate cancers among patients with MRI-visible lesions, according to a study published in the March... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - March 4, 2020 Category: Pharmaceuticals Source Type: news
Adding MRI-targeted biopsy leads to more reliable diagnosis of aggressive prostate cancer
(University of Maryland Medical Center) Using a combination of magnetic resonance imaging (MRI) to target and sample suspicious prostate tissue along with a standard prostate biopsy is significantly more likely to detect the most aggressive prostate cancers than standard biopsy alone. This finding, published today in the New England Journal of Medicine, could allow a higher percentage of prostate cancer patients to avoid unnecessary treatment for slow-growing prostate cancers that are not likely to spread. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - March 4, 2020 Category: Cancer & Oncology Source Type: news
