Clinical biomarker-based biological ageing and future risk of neurological disorders in the UK Biobank
Conclusions
Advanced BA calculated from routine clinical biomarker results increases the risk of subsequent neurological diagnoses including all-cause dementia and ischaemic stroke. (Source: Journal of Neurology, Neurosurgery and Psychiatry)
Source: Journal of Neurology, Neurosurgery and Psychiatry - April 12, 2024 Category: Neurosurgery Authors: Mak, J. K. L., McMurran, C. E., Hägg, S. Tags: Open access Neurodegeneration Source Type: research
Neurophysiological and imaging biomarkers of lower motor neuron dysfunction in motor neuron diseases/amyotrophic lateral sclerosis: IFCN handbook chapter
Clin Neurophysiol. 2024 Mar 20;162:91-120. doi: 10.1016/j.clinph.2024.03.015. Online ahead of print.ABSTRACTThis chapter discusses comprehensive neurophysiological biomarkers utilised in motor neuron disease (MND) and, in particular, its commonest form, amyotrophic lateral sclerosis (ALS). These encompass the conventional techniques including nerve conduction studies (NCS), needle and high-density surface electromyography (EMG) and H-reflex studies as well as novel techniques. In the last two decades, new methods of assessing the loss of motor units in a muscle have been developed, that are more convenient than earlier met...
Source: Clinical Neurophysiology - April 11, 2024 Category: Neurology Authors: Cindy Shin-Yi Lin James Howells Seward Rutkove Sanjeev Nandedkar Christoph Neuwirth Yu-Ichi Noto Nortina Shahrizaila Roger G Whittaker Hugh Bostock David Burke Hatice Tankisi Source Type: research
Neurophysiological and imaging biomarkers of lower motor neuron dysfunction in motor neuron diseases/amyotrophic lateral sclerosis: IFCN handbook chapter
Clin Neurophysiol. 2024 Mar 20;162:91-120. doi: 10.1016/j.clinph.2024.03.015. Online ahead of print.ABSTRACTThis chapter discusses comprehensive neurophysiological biomarkers utilised in motor neuron disease (MND) and, in particular, its commonest form, amyotrophic lateral sclerosis (ALS). These encompass the conventional techniques including nerve conduction studies (NCS), needle and high-density surface electromyography (EMG) and H-reflex studies as well as novel techniques. In the last two decades, new methods of assessing the loss of motor units in a muscle have been developed, that are more convenient than earlier met...
Source: Clinical Neurophysiology - April 11, 2024 Category: Neurology Authors: Cindy Shin-Yi Lin James Howells Seward Rutkove Sanjeev Nandedkar Christoph Neuwirth Yu-Ichi Noto Nortina Shahrizaila Roger G Whittaker Hugh Bostock David Burke Hatice Tankisi Source Type: research
Neurophysiological and imaging biomarkers of lower motor neuron dysfunction in motor neuron diseases/amyotrophic lateral sclerosis: IFCN handbook chapter
Clin Neurophysiol. 2024 Mar 20;162:91-120. doi: 10.1016/j.clinph.2024.03.015. Online ahead of print.ABSTRACTThis chapter discusses comprehensive neurophysiological biomarkers utilised in motor neuron disease (MND) and, in particular, its commonest form, amyotrophic lateral sclerosis (ALS). These encompass the conventional techniques including nerve conduction studies (NCS), needle and high-density surface electromyography (EMG) and H-reflex studies as well as novel techniques. In the last two decades, new methods of assessing the loss of motor units in a muscle have been developed, that are more convenient than earlier met...
Source: Clinical Neurophysiology - April 11, 2024 Category: Neurology Authors: Cindy Shin-Yi Lin James Howells Seward Rutkove Sanjeev Nandedkar Christoph Neuwirth Yu-Ichi Noto Nortina Shahrizaila Roger G Whittaker Hugh Bostock David Burke Hatice Tankisi Source Type: research
Massive ER protein disposal by reticulophagy receptors and selective disposal by TOLLIP
Autophagy. 2024 Apr 10. doi: 10.1080/15548627.2024.2340417. Online ahead of print.ABSTRACTProteostasis of the endoplasmic reticulum (ER) is maintained by coordinated action of two major catabolic pathways: proteasome-dependent ER-associated degradation (ERAD) and less characterized lysosomal pathways. Recent studies on ER-specific autophagy (termed "reticulophagy") have highlighted the importance of lysosomes for ER proteostasis. Key to this process are proteins termed reticulophagy receptors that connect ER fragments and Atg8-family proteins, facilitating the lysosomal degradation of both native and aberrant ER proteins i...
Source: Autophagy - April 10, 2024 Category: Cytology Authors: Yuki Hayashi Hidenori Ichijo Source Type: research
Massive ER protein disposal by reticulophagy receptors and selective disposal by TOLLIP
Autophagy. 2024 Apr 11:1-2. doi: 10.1080/15548627.2024.2340417. Online ahead of print.ABSTRACTProteostasis of the endoplasmic reticulum (ER) is maintained by coordinated action of two major catabolic pathways: proteasome-dependent ER-associated degradation (ERAD) and less characterized lysosomal pathways. Recent studies on ER-specific autophagy (termed "reticulophagy") have highlighted the importance of lysosomes for ER proteostasis. Key to this process are proteins termed reticulophagy receptors that connect ER fragments and Atg8-family proteins, facilitating the lysosomal degradation of both native and aberrant ER protei...
Source: Autophagy - April 10, 2024 Category: Cytology Authors: Yuki Hayashi Hidenori Ichijo Source Type: research
Increased endocytosis rate and enhanced lysosomal pathway of silica-coated superparamagnetic nanoparticles into M-HeLa cells compared with cultured primary motor neurons
AbstractThe unique properties of superparamagnetic iron oxide nanoparticles (SPIONs) enable their use as magnetic biosensors, targeted drug delivery, magnetothermia, magnetic resonance imaging, etc. Today, SPIONs are the only type of metal oxide nanoparticles approved for biomedical application. In this work, we analyzed the cellular response to the previously reported luminescent silica coated SPIONs of the two cell types: M-HeLa cells and primary motor neuron culture. Both internalization pathways and intracellular fate of SPIONs have been compared for these cell lines using fluorescence and transmission electron microsc...
Source: Histochemistry and Cell Biology - April 10, 2024 Category: Biomedical Science Source Type: research
Concentric needle jitter analysis of the genioglossus muscle in patients with motor neuron disease
CONCLUSION: CNE jitter analysis of genioglossus muscle may provide an useful information that may be suggestive of a diagnosis of MND/ALS.PMID:38591728 | DOI:10.1080/01616412.2024.2339096 (Source: Neurological Research)
Source: Neurological Research - April 9, 2024 Category: Neurology Authors: Aydan Koysuren Cagri Mesut Temucin Source Type: research
The Palliative Care Needs of Patients with Multiple Sclerosis, Parkinson's Related Diseases, and Motor Neurone Disease: A Secondary Analysis of the OPTCARE Neuro Trial Data
Journal of Palliative Medicine, Ahead of Print. (Source: Journal of Palliative Medicine)
Source: Journal of Palliative Medicine - April 9, 2024 Category: Palliative Care Authors: Mair éad Doherty Emeka Chukwusa Regina McQuillan Faith Cranfield Wei Gao Source Type: research
Fatigue in Spinal Muscular Atrophy: a fundamental open issue
Acta Myol. 2024 Mar 31;43(1):1-7. doi: 10.36185/2532-1900-402. eCollection 2024.ABSTRACTHereditary proximal 5q Spinal Muscular Atrophy (SMA) is a severe neuromuscular disorder with onset mainly in infancy or childhood. The underlying pathogenic mechanism is the loss of alpha motor neurons in the anterior horns of spine, due to deficiency of the survival motor neuron (SMN) protein as a consequence of the deletion of the SMN1 gene. Clinically, SMA is characterized by progressive loss of muscle strength and motor function ranging from the extremely severe, the neonatal onset type 1, to the mild type 4 arising in the adult lif...
Source: Acta Myologica - April 8, 2024 Category: Neurology Authors: Oscar Crisafulli Angela Berardinelli Giuseppe D'Antona Source Type: research
