Decoding the causes of motor neuron disease: A new study shows the impact of genetics
(Trinity College Dublin) Researchers from Trinity College Dublin have conducted the largest ever study involving 1117 people diagnosed with motor neurone disease to address the question of " nature versus nurture " in the causes of MND. The team from the Trinity MND Research Group found that one in 347 men and one in 436 women can be expected to develop motor neurone disease (MND) during their lifetime. Their research has been published in the American medical journal JAMA Neurology. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - July 24, 2019 Category: International Medicine & Public Health Source Type: news
Motor neurone disease researchers find link to microbes in gut
Study could eventually lead to new treatments for neurodegenerative conditionScientists have found tantalising clues that the devastating condition motor neurone disease may be linked to changes in microbes that live in the gut.Studies in mice revealed that animals bred to develop amyotrophic lateral sclerosis (ALS), a form of the disease that affectedthe cosmologist Stephen Hawking, improved and lived longer when they were given an organism calledAkkermansia muciniphila.Continue reading... (Source: Guardian Unlimited Science)
Source: Guardian Unlimited Science - July 22, 2019 Category: Science Authors: Ian Sample Science editor Tags: Motor neurone disease Medical research Science Society Microbiology Source Type: news
Gut bacteria may have motor neurone disease role
Finding could lead to the first treatment for the devastating disease. (Source: BBC News | Health | UK Edition)
Source: BBC News | Health | UK Edition - July 22, 2019 Category: Consumer Health News Source Type: news
Needs and preferences for psychological interventions of people with motor neuron disease - Weeks KR, Gould RL, Mcdermott C, Lynch J, Goldstein LH, Graham CD, McCracken L, Serfaty M, Howard R, Al-Chalabi A, White D, Bradburn M, Young T, Cooper C, Shaw DPJ, Lawrence V.
Background: There is a lack of knowledge about what factors may impede or facilitate engagement in psychological interventions in people with motor neuron disease (pwMND) and how such interventions can be adapted to best meet the needs of this popul... (Source: SafetyLit)
Source: SafetyLit - July 15, 2019 Category: International Medicine & Public Health Tags: Ergonomics, Human Factors, Anthropometrics, Physiology Source Type: news
Protein offers protection against nerve degeneration in ALS model
(Boston University School of Medicine) Increasing the levels of the anti-aging protein hormone Klotho improves the neurological deficits and prolongs life span in an experimental model with Amyotrophic Lateral Sclerosis (ALS). In addition, brain immune cells called microglia play an important role in protecting the brain against inflammation and, likely, motor neuron loss in this model. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - June 27, 2019 Category: International Medicine & Public Health Source Type: news
Family brand terminal illness assessments 'degrading'
Susan Hill had been diagnosed with motor neurone disease when she had "bizarre" benefit claim tests. (Source: BBC News | Health | UK Edition)
Source: BBC News | Health | UK Edition - June 21, 2019 Category: Consumer Health News Source Type: news
How mutations lead to neurodegenerative disease
(University of Adelaide) Scientists have discovered how mutations in DNA can cause neurodegenerative disease. The discovery is an important step towards better treatment to slow the progression or delay onset in a range of incurable diseases such as Huntington's and motor neurone disease - possibly through the use, in new ways, of existing anti-inflammatory drugs. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - May 13, 2019 Category: International Medicine & Public Health Source Type: news
'Cruel motor neurone disease robbed my Dad of summer that never was'
HAVE you ever read a novel and hoped you would die before you reached the final page? My dad did. (Source: Daily Express - Health)
Source: Daily Express - Health - April 27, 2019 Category: Consumer Health News Source Type: news
Spatiotemporal dynamics of molecular pathology in amyotrophic lateral sclerosis
Paralysis occurring in amyotrophic lateral sclerosis (ALS) results from denervation of skeletal muscle as a consequence of motor neuron degeneration. Interactions between motor neurons and glia contribute to motor neuron loss, but the spatiotemporal ordering of molecular events that drive these processes in intact spinal tissue remains poorly understood. Here, we use spatial transcriptomics to obtain gene expression measurements of mouse spinal cords over the course of disease, as well as of postmortem tissue from ALS patients, to characterize the underlying molecular mechanisms in ALS. We identify pathway dynamics, distin...
Source: ScienceNOW - April 3, 2019 Category: Science Authors: Maniatis, S., Äijö, T., Vickovic, S., Braine, C., Kang, K., Mollbrink, A., Fagegaltier, D., Andrusivova, Z., Saarenpää, S., Saiz-Castro, G., Cuevas, M., Watters, A., Lundeberg, J., Bonneau, R., Phatnani, H. Tags: Molecular Biology, Neuroscience reports Source Type: news
Lauren Sciences LLC wins AU$1 million grant award from FightMND
(Lauren Sciences LLC) Lauren Sciences LLC, the private New York biotechnology company developing transformative V-Smart ® Nanomedicines for brain diseases, today announced it was awarded an AU$1 million translational grant from FightMND. The FightMND grant will advance Lauren Sciences development of LAUR-301, its novel V-Smart ® Nanomedicine for ALS (amyotrophic lateral sclerosis), also known as Lou Gehrig's disease, or motor neuron disease (MND). (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - April 2, 2019 Category: International Medicine & Public Health Source Type: news
Scientists grow 'mini-brain on the move' that can contract muscle
Cambridge researchers grew ‘organoid’ that spontaneously connected to spinal cordScientists have grown a miniature brain in a dish with a spinal cord and muscles attached, an advance that promises to accelerate the study of conditions such as motor neurone disease.The lentil-sized grey blob of human brain cells were seen to spontaneously send out tendril-like connections to link up with the spinal cord and muscle tissue, which was taken from a mouse. The muscles were then seen to visibly contract under the control of the so-called brain organoid.Continue reading... (Source: Guardian Unlimited Science)
Source: Guardian Unlimited Science - March 18, 2019 Category: Science Authors: Hannah Devlin Science correspondent Tags: Neuroscience Medical research Biology Genetics Motor neurone disease Epilepsy Society Schizophrenia Mental health University of Cambridge Stem cells Source Type: news
'It's scary': motor neurone disease spikes sevenfold in rural NSW
In centres like Griffith and Wagga Wagga, locals fear there may be something in the waterAs a child, Tania Magoci spent every weekend at Lake Wyangan near Griffith, waterskiing, swimming and boating with her family.She and her siblings would use the serpentine concrete outlet into the lake as a slippery slide. In summer, the slime from algal blooms exacerbated by the run-off from the nearby farms made it more fun to slide down the chicanes.Continue reading... (Source: Guardian Unlimited Science)
Source: Guardian Unlimited Science - March 8, 2019 Category: Science Authors: Gabrielle Chan Tags: Motor neurone disease Health New South Wales election 2019 Australia news New South Wales politics Rural Australia Medical research Water Source Type: news
Man with motor neurone disease dies after removing mask
John King spoke days before his death to raise awareness of the effects of motor neurone disease. (Source: BBC News | Health | UK Edition)
Source: BBC News | Health | UK Edition - March 1, 2019 Category: Consumer Health News Source Type: news
Statins could protect against motor neurone disease
(Queen Mary University of London) High cholesterol has been found to be a possible risk factor for the development of motor neurone disease (MND), according to a large study of genetic data led in the UK by Queen Mary University of London, in collaboration with the National Institutes of Health in the USA. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 14, 2019 Category: International Medicine & Public Health Source Type: news
Robin Callard obituary
For more than 20 years Robin Callard, who has died of motor neurone disease aged 73, was professor of immunobiology at University College London, attached to the Institute of Child Health (ICH), clinical partner of Great Ormond Street hospital.Born and raised in Hamilton, New Zealand, Robin was the eldest child of Eddie Callard, an entrepreneurial Australian photographer, and Vivienne (nee Wilson), who ran a fashion shop. A fourth generation Kiwi, Vivienne was also a descendant of Joseph Priestley, the eighteenth-century radical polymath and scientist widely credited with the discovery of oxygen.Continue reading... (Source...
Source: Guardian Unlimited Science - February 13, 2019 Category: Science Authors: Michael White Tags: People in science Medical research UCL (University College London) Higher education Source Type: news
