Clinical Characteristics, Natural History, Health Care Measures, and Genetic Screening in Patients With ALS
Condition:   Motor Neuron Disease, Amyotrophic Lateral Sclerosis Intervention:   Sponsors:   Ambulanzpartner Soziotechnologie APST GmbH;   Charite University, Berlin, Germany Recruiting (Source:
Source: - May 10, 2023 Category: Research Source Type: clinical trials

Digital peer-to-peer support programme for informal caregivers of people living with motor neuron disease: study protocol for a multi-centre parallel group, single-blinded (outcome assessor) randomised controlled superiority trial
This study will examine the impact of a virtual peer support intervention on quality-of-life measures in informal caregivers of individuals with MND living in the community.Trial NCT04695210 (Source: Trials)
Source: Trials - February 20, 2023 Category: Research Source Type: clinical trials

Statistical analysis plan for the motor neuron disease systematic multi-arm adaptive randomised trial (MND-SMART)
DiscussionIn developing the statistical analysis plan, we had to carefully consider several issues such as multiple testing, estimand specification, interim analyses, and statistical analysis of the repeated measurements of ALS-FRS-R. This analysis plan attempts to balance multiple factors, including minimisation of bias, maximising power and precision, and deriving clinically interpretable summaries of treatment effects.Trial registrationEudraCT Number, 2019 –000099-41. Registered 2 October 2019,,NCT04302870. Registered 10 March 2020. (Source: Trials)
Source: Trials - January 16, 2023 Category: Research Source Type: clinical trials

Impairments of Neuro-muscular Communication in Motor-Neuron Disease: A Bio-Marker for Early and Personalised Diagnosis
Conditions:   ALS (Amyotrophic Lateral Sclerosis);   Postpoliomyelitis Syndrome;   Spinal Muscular Atrophy Intervention:   Procedure: 128 electrode electroencephalography (EEG), Bipolar surface electromyography (sEMG), High-density electromyography (HD-EMG) Sponsors:   University of Dublin, Trinity College;   Motor Neurone Disease Association, UK;   Irish Research Council, IE;   Research Motor Neuron, IE;   Thierry Latran Foundation, FR;   ALS Association, USA Recruiting (Source:
Source: - December 23, 2022 Category: Research Source Type: clinical trials