Fight Aging! Newsletter, April 3rd 2023
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - April 2, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

TDP-43 Aggregation Leads to Loss of Stathmin-2 Expression and Inability of Neurons to Regenerate Axons
Researchers here delve into the mechanisms by which TDP-43 aggregation contributes to the symptoms of neurodegenerative conditions in which it is involved. It disrupts expression of another gene, stathmin-2, degrading the ability of neurons to maintain axonal connections. This is a feature of ALS, the condition most readily associated with TDP-43 aggregation. The research here points to an approach to therapy: not restoration of appropriate TDP-43 behavior, but rather finding a way to force correct expression of stathmin-2. It remains the case that TDP-43 aggregation may well cause other problems unrelated to this mechanis...
Source: Fight Aging! - March 28, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Fight Aging! Newsletter, October 25th 2021
This study confirmed that the PSI could be a quantitative index of vascular aging and has potential for use in inferring arterial stiffness with an advantage over the rAIx. A Profile of Michael Greve and the Segment of the Longevity Industry that He Supports Would that the popular media produced more popular science articles about the longevity industry like this one. It is not just a profile of someone trying to make a difference in the world by advancing the state of medic...
Source: Fight Aging! - October 24, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Loss of Beneficial Microglial Function in Alzheimer's Disease
In this study, we performed RNA sequencing of microglia isolated from three representative neurodegenerative mouse models, AppNL-G-F/NL-G-F with amyloid pathology, rTg4510 with tauopathy, and SOD1G93A with motor neuron disease. In parallel, gene expression patterns of the human precuneus with early Alzheimer's change (n = 11) and control brain (n = 14) were also analyzed by RNA sequencing. We found that a substantial reduction of homeostatic microglial genes in rTg4510 and SOD1G93A microglia, whereas DAM genes were uniformly upregulated in all mouse models. The reduction of homeostatic microglial genes was c...
Source: Fight Aging! - October 22, 2021 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Carers Week 2020 research report: the rise in the number of unpaid carers during the coronavirus (Covid-19) outbreak
Carers UK - The six Carers Week charities — Carers UK, Age UK, Carers Trust, Motor Neurone Disease Association, Oxfam GB and Rethink Mental Illness — have published research based on polling carried out by YouGov in May 2020 of 4557 people over the age of 18 living in the UK.  The figures show an estimated 4.5 million people in the UK have become unpaid carers as a result of the Covid-19 pandemic. This is on top of the 9.1 million unpaid carers who were already caring before the outbreak, bringing the total to 13.6 million. 2.7 million women (59 per cent) and 1.8 million men (41 per cent) have started carin...
Source: Health Management Specialist Library - June 8, 2020 Category: UK Health Authors: The King ' s Fund Library Tags: Local authorities, public health and health inequalities Social care Source Type: blogs

Synchron Announces First Successful Clinical Implantation of Stentrode
Synchron, a spin-off from the University of Melbourne in Australia, has announced the first successful implantation of the Stentrode minimally invasive neural interface device in a person. The device is part of the Synchron brain-computer interface and combines the minimally invasive delivery of a vascular stent with the functionality of a neural implant. The company hopes that the device could unlock a range of capabilities, including giving paralyzed patients the ability to control assistive technologies such as wheelchairs or robotic arms. At present, brain-computer interfaces are largely in their infancy, and f...
Source: Medgadget - September 30, 2019 Category: Medical Devices Authors: Conn Hastings Tags: Neurology Neurosurgery Radiology Rehab Source Type: blogs

Review of motor neuron disease
(Source: Notes from Dr. RW)
Source: Notes from Dr. RW - March 13, 2019 Category: Internal Medicine Tags: neurology Source Type: blogs

Neurotech start-up Ctrl-labs raises $28M to reinvent human-computer interactions
___ Ctrl-labs raises $28 million from GV and Alexa Fund for neural interfaces (Venture Beat): “Ctrl-labs, a New York startup that’s developing a device capable of translating electrical muscle impulses into digital signals, today announced that it has raised $28 million in a funding round led by GV, Google’s venture capital arm, with participation from a swath of other heavy hitters including Amazon’s Alexa Fund, Lux Capital, Spark Capital, Matrix Partners, Breyer Capital, and Fuel Capital … Ctrl-kit leverages differential electromyography (EMG) to translate mental intent into action, specifically by measuring ch...
Source: SharpBrains - February 25, 2019 Category: Neuroscience Authors: SharpBrains Tags: Cognitive Neuroscience Technology Ctrl-labs digital signals electrical muscle impulses electromyography human-computer interactions neural interfaces neurotech TensorFlow Source Type: blogs

Remembering Stephen William Hawking
Stephen hawking as a man relied only on mathematics and quantum mechanics. He was categorical on emotions like existence of god and supernatural powers as he could peep through the entire universe and proved that it is the ‘Gravitational Force’ that is keeping the entire universe with all its galaxies and placatory system  in their respective order. His research on the origin of the universe, galaxies, stars and planets and his fascination for the Black holes knows no boundaries. His theoretical explanation of how the extinct and exhausted stars turn as Black Holes was just amazing. For a man that lived most of life s...
Source: Sciences Blog - March 21, 2018 Category: Science Authors: srinivas_s at (OMICS Publishing Group) Tags: OMICS Source Type: blogs

What Stephen Hawking Can Teach Us about Good Mental Health
I woke up Wednesday morning to the news that Stephen Hawking had passed away. My first thought made me smile — that this incredible scientist who seemed to just will himself to stay alive against overwhelming odds, died on March 14th — Pi Day. Maybe that was his choice. Who knows? Stephen Hawking was a thinker — a brilliant scientist, professor and author who was known for his groundbreaking work in physics and cosmology. His books aimed to make science accessible to everyone. His more well-known works include A Brief History of Time, The Universe in a Nutshell, and A Briefer History of Time. At the ag...
Source: World of Psychology - March 16, 2018 Category: Psychiatry & Psychology Authors: Janet Singer Tags: Celebrities Grief and Loss Health-related Inspiration & Hope Memory and Perception Personal ALS Amyotrophic Lateral Sclerosis Depression Gratitude Lou Gehrig's Disease Motor Neuron Disease Stephen Hawking Source Type: blogs

Brief Guide to the CTE Brains in the News. Part 2: Fred McNeill
Chronic traumatic encephalopathy (CTE) is the neurodegenerative disease of the moment, made famous by the violent and untimely deaths of many retired professional athletes. Repeated blows to the head sustained in contact sports such asboxing and American football can result in abnormal accumulations oftau protein (usually many years later). The autopsied brains from two of these individuals are shown below.Left: courtesy of Dr. Ann McKee inNYT. Right: courtesy of Dr. Bennett Omalu inCNN. These are coronal sections1 from the autopsied brains of: (L) Aaron Hernandez, aged 27; and(R) Fred McNeill, aged 63.Part 1 of this ...
Source: The Neurocritic - December 11, 2017 Category: Neuroscience Authors: The Neurocritic Source Type: blogs

Executive Functions in Health and Disease: New book to help integrate Cognitive Neuroscience and Neuropsychology
__________ Neuroscience used to be the monopoly of a few elite universities located in a handful of countries. Neuropsychology used to be a quaint niche discipline relatively unconnected to the larger world of neuroscience and content in its methods with paper-and-pencil tests. Neuroscience itself was relatively unconcerned with higher-order cognition, and the very term “cognitive neuroscience” was often met with rolled eyes by scientists working in more established areas of brain research (a personal observation made in the 1980s and even 1990s on more than one occasion). And the interest...
Source: SharpBrains - August 8, 2017 Category: Neuroscience Authors: Dr. Elkhonon Goldberg Tags: Cognitive Neuroscience Health & Wellness Professional Development Alexander-Luria clinical psychologists cognition cognitive-psychologists disease Executive-Functions frontal-lobe medical neurologists neuropsychologists Neuropsyc Source Type: blogs

MND costs: exploring the financial impact of motor neurone disease
This report finds that on average, people with motor neurone disease (MND) and their families spend the equivalent of £9,645 every year in regular and enhanced costs, as a direct result of the disease, plus a further £2,175 in one-off costs. It highlights the need for action to ease the financial impact of MND for people living with the disease and recommends that health and social care professionals should ensur e that people with MDN are signposted to financial advice and support as soon as possible after diagnosis.ReportPress release (Source: Health Management Specialist Library)
Source: Health Management Specialist Library - June 21, 2017 Category: UK Health Authors: The King ' s Fund Information & Knowledge Service Tags: Local authorities, public health and health inequalities Patient involvement, experience and feedback Source Type: blogs

Identifying Loss of Stem Cells as the Primary Cause of Sarcopenia
The decline in muscle mass and strength that occurs with aging, known as sarcopenia, is thought to correlate with a loss of motor neurons, theorized to be an important cause of the process. Researchers here point instead to loss of stem cells as the primary cause of age-related muscle decline. Stem cell activity is well known to fade with age, an evolutionary adaptation to increasing levels of tissue damage that may serve to reduce cancer risk. Progress in the stem cell research field to date, such as the development of therapies based on spurring more youthful levels of stem cell activity in the old, suggest that there is...
Source: Fight Aging! - June 7, 2017 Category: Research Authors: Reason Tags: Daily News Source Type: blogs