Clinical Pathogenesis, Molecular Mechanisms of Gastric Cancer Development
Curr Top Microbiol Immunol. 2023;444:25-52. doi: 10.1007/978-3-031-47331-9_2.ABSTRACTThe human pathogen Helicobacter pylori is the strongest known risk factor for gastric disease and cancer, and gastric cancer remains a leading cause of cancer-related death across the globe. Carcinogenic mechanisms associated with H. pylori are multifactorial and are driven by bacterial virulence constituents, host immune responses, environmental factors such as iron and salt, and the microbiota. Infection with strains that harbor the cytotoxin-associated genes (cag) pathogenicity island, which encodes a type IV secretion system (T4SS) con...
Source: Current Topics in Microbiology and Immunology - January 17, 2024 Category: Microbiology Authors: Lydia E Wroblewski Richard M Peek Source Type: research