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Molecular biologist David Sinclair shares evidence of reverse aging in mice at his lab at Harvard Medical School and talks about how this research will one day be applied to humans. Sinclair was onstage at the 2022 Life Itself conference, a health and wellness event presented in partnership with CNN. (Source: CNN.com - Health)
Source: CNN.com - Health - June 3, 2022 Category: Consumer Health News Source Type: news
Studying animal evolution to advance women ’s health
Breast cancer, osteoporosis and infertility don ’t just affect women — they also strike animals across the female tree of life.Yet many species have developed physical changes over millions of years that protect them from these conditions, begging the question: What if the key to preventing these and other disorders lies untapped in the animal king — er, queendom? That ’s the crux of a new UCLA paperpublished in PNAS Nexus that summarizes years of research measuring females ’ risk for common diseases across different species. The authors — a physician, an evolutionary biologist and a veterinarian — teamed...
Source: UCLA Newsroom: Health Sciences - May 31, 2022 Category: Universities & Medical Training Source Type: news
Researchers Use Machine Learning to Identify Thousands of New Marine RNA Viruses in Study of Interest to Microbiologists and Clinical Laboratory Scientists
Screening and analysis of ocean samples also identified a possible missing link in how the RNA viruses evolved An international team of scientists has used genetic screening and machine learning techniques to identify more than 5,500 previously unknown species of marine RNA viruses and is proposing five new phyla (biological groups) of viruses. The latter […]
The post Researchers Use Machine Learning to Identify Thousands of New Marine RNA Viruses in Study of Interest to Microbiologists and Clinical Laboratory Scientists appeared first on Dark Daily. (Source: Dark Daily)
Source: Dark Daily - May 27, 2022 Category: Laboratory Medicine Authors: Jillia Schlingman Tags: Digital Pathology Laboratory News Laboratory Pathology Molecular Diagnostics, Genetic Testing, Whole Gene Sequencing Ahmed Zayed PhD American Society for Microbiology anatomic pathology Center of Microbiome Science clinical laboratory cl Source Type: news
UCLA study identifies how the brain links memories
Our brains rarely record single memories. Instead, they store memories in groups so that the recollection of one significant memory triggers the recall of others that are connected chronologically. As we age, however, our brains gradually lose this ability to link related memories. Now, UCLA researchers have discovered a key molecular mechanism behind this memory linking. They ’ve also identified a way to restore this brain function genetically in aging mice — and an FDA-approved drug that achieves the same thing. Published today in the journal Nature, the findings suggest a new method for strengthening human mem...
Source: UCLA Newsroom: Health Sciences - May 25, 2022 Category: Universities & Medical Training Source Type: news
Roche ’s Polivy combination approved by European Commission for people with previously untreated diffuse large B-cell lymphoma
First new treatment option in more than 20 years to show a clinically meaningful improvement in progression-free survival is approved for people with previously untreated diffuse large B-cell lymphoma (DLBCL)Approval is based on pivotal data from the phase III POLARIX study, where Polivy plus R-CHP significantly improved progression-free survival with comparable safety versus the standard of care, R-CHOPFirst-line treatment with Polivy plus R-CHP has the potential to reduce the burden on patients and healthcare systems, associated with disease progression ¹Basel, 25 May 2022 - Roche (SIX: RO, ROG; OTCQX: RHHBY) today anno...
Source: Roche Investor Update - May 25, 2022 Category: Pharmaceuticals Source Type: news
Roche ’s Polivy combination approved by European Commission for people with previously untreated diffuse large B-cell lymphoma
First new treatment option in more than 20 years to show a clinically meaningful improvement in progression-free survival is approved for people with previously untreated diffuse large B-cell lymphoma (DLBCL)Approval is based on pivotal data from the phase III POLARIX study, where Polivy plus R-CHP significantly improved progression-free survival with comparable safety versus the standard of care, R-CHOPFirst-line treatment with Polivy plus R-CHP has the potential to reduce the burden on patients and healthcare systems, associated with disease progression ¹Basel, 25 May 2022 - Roche (SIX: RO, ROG; OTCQX: RHHBY) today anno...
Source: Roche Media News - May 25, 2022 Category: Pharmaceuticals Source Type: news
Roche ’s Polivy combination approved by European Commission for people with previously untreated diffuse large B-cell lymphoma
First new treatment option in more than 20 years to show a clinically meaningful improvement in progression-free survival is approved for people with previously untreated diffuse large B-cell lymphoma (DLBCL)Approval is based on pivotal data from the phase III POLARIX study, wherePolivy plus R-CHP significantly improved progression-free survival with comparable safety versus the standard of care, R-CHOPFirst-line treatment withPolivy plus R-CHP has the potential to reduce the burden on patients and healthcare systems, associated with disease progression1Basel, 25 May 2022 - Roche (SIX: RO, ROG; OTCQX: RHHBY) today announce...
Source: Roche Investor Update - May 25, 2022 Category: Pharmaceuticals Source Type: news
New Data Show TREMFYA ® (guselkumab) Binds to Both Inflammatory Cells and Interleukin (IL)-23, Supporting a Hypothesis for a Differentiated Mechanism from Risankizumab
SPRING HOUSE, PENNSYLVANIA, May 18, 2022 – The Janssen Pharmaceutical Companies of Johnson & Johnson today announced the first results of the in vitro MODIF-Y studies, supporting a hypothesis that may differentiate the mechanism of first-in-class TREMFYA® (guselkumab) from risankizumab due to the ability of TREMFYA to bind to CD64 positive (CD64+) cells in addition to interleukin (IL)-23 — both of which are key components of the immune system. 1,2 These findings, which are being presented at the Society for Investigative Dermatology (SID) annual meeting May 18-21, 2022 in Portland, Oregon, demonstrate TREMFYA bind...
Source: Johnson and Johnson - May 18, 2022 Category: Pharmaceuticals Tags: Innovation Source Type: news
STAFF SCIENTIST 1, Quantitative Molecular Biological Physics
The National Library of Medicine (NLM) ’s National Center for Biotechnology Information (NCBI) is recruiting for a Staff Scientist 1 in the Computational Biology Branch (CBB) that will contribute to NCBI’s mission to conduct research on fundamental biomedical problems at the molecular level using mathematical and computational method s. NLM is a component of the National Institutes of Health (NIH), part of the Department of Health and Human Services (DHHS). (Source: NLM General Announcements)
Source: NLM General Announcements - May 5, 2022 Category: Databases & Libraries Source Type: news
NCBI Posters at the Biology of Genomes Meeting
May 10-14, 2022 We are looking forward to the Biology of Genomes meeting, which will focus on “DNA sequence variation and its role in molecular evolution, population genetics and complex diseases, comparative genomics, large-scale studies of gene and protein expression, and genomic approaches to ecological systems.” NCBI will present three posters to highlight our Comparative … Continue reading NCBI Posters at the Biology of Genomes Meeting →
The post NCBI Posters at the Biology of Genomes Meeting appeared first on NCBI Insights. (Source: NCBI Insights)
Source: NCBI Insights - May 3, 2022 Category: Databases & Libraries Authors: NCBI Staff Tags: What's New CGR dbGaP Allele Frequency Aggregator (ALFA) Source Type: news
The New Science of Forgetting
A baby zebrafish is just half the size of a pea. A recent look inside its transparent brain, however, offers clues to the far bigger mystery of how we remember—and how we forget.
In an experiment that yielded insights into memory and the brain, a team of researchers at the University of Southern California taught the tiny creature to associate a bright light with a flash of heat, a temperature change the fish responded to by trying to swim away. Using a custom-designed microscope, the team then captured images of the animals’ brains in the moments before and after they learned to associate the light and the hea...
Source: TIME: Health - April 28, 2022 Category: Consumer Health News Authors: Corinne Purtill Tags: Uncategorized feature healthscienceclimate Neuroscience Source Type: news
Unexpected protein could play role in common brain disorder
Scientists have known for years that amyloid fibrils — fibrous, ropelike structures formed by closely linked protein molecules — are present in the brains of patients with Alzheimer’s and Parkinson’s diseases and likely play a role in the progression of these disorders. Now, UCLA biochemists have discovered such fibrils in the brains of people with a form of frontotemporal lobar degeneration, or FTLD, the most common neurodegenerative disorder after Alzheimer ’s and Parkinson’s. But surprisingly, the type of protein they expected to find in these potentially harmful fibrils wasn’t there at all; instead, a l...
Source: UCLA Newsroom: Health Sciences - April 19, 2022 Category: Universities & Medical Training Source Type: news
NLM Collaboration Improves Standards for Reporting Clinical Genomics Variants
The National Library of Medicine ’s (NLM) National Center for Biotechnology Information (NCBI) and the European Molecular Biology Laboratory’s European Bioinformatics Institute (EMBL-EBI) have released a set of standard transcripts for 99% of human protein coding genes and 99.8% of genes of clinical relevance. This set, part of the Matched Annotation from NCBI and EMBL-EBI (MANE) collection, harmonizes transcript and protein sets produced by this joint genome annotation effort. (Source: NLM General Announcements)
Source: NLM General Announcements - April 14, 2022 Category: Databases & Libraries Source Type: news
UCLA-led team creates first comprehensive map of human blood stem cell development
UCLA scientistsand colleagues have created a first-of-its-kind roadmap that traces each step in the development of blood stem cells in the human embryo, providing scientists with a blueprint for producing fully functional blood stem cells in the lab.The research,published todayin the journal Nature, could help expand treatment options for blood cancers like leukemia and inherited blood disorders such as sickle cell disease, saidDr. Hanna Mikkolaof theEli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA, who led the study.Blood stem cells, also called hematopoietic stem cells, have the abilit...
Source: UCLA Newsroom: Health Sciences - April 13, 2022 Category: Universities & Medical Training Source Type: news
U.S. FDA grants priority review to Roche ’s Actemra/RoActemra for the treatment of COVID-19 in hospitalised adults
If approved,Actemra/RoActemra would be the first U.S. FDA-approvedimmunomodulator for the treatment of COVID-19 inhospitalised patientsSince the beginning of the pandemic, more than one million peoplehospitalised with COVID-19 have been treated withActemra/RoActemra worldwide1Actemra/RoActemra is approved for the treatment of COVID-19 in many territories including the European UnionRoche has established a comprehensive access approach to improve availability ofActemra/RoActemra around the worldBasel, 04 April 2022 - Roche (SIX: RO, ROG; OTCQX: RHHBY) today announced that the U.S. Food and Drug Administration (FDA) has acce...
Source: Roche Investor Update - April 4, 2022 Category: Pharmaceuticals Source Type: news
