Structural identification and anti-neuroinflammatory effects of a pectin-arabinoglucuronogalactan complex, AOPB-1-1, isolated from Asparagus officinalis
Int J Biol Macromol. 2024 Apr 15:131593. doi: 10.1016/j.ijbiomac.2024.131593. Online ahead of print.ABSTRACTAsparagus officinalis L. is a horticultural crop that contains a variety of bioactive compounds with anti-inflammatory effects. Aqueous extracts of A. officinalis can noticeably improve the learning and memory function of model mice. Herein, a pectin-arabinoglucuronogalactan complex (AOPB-1-1) with a relative molecular weight of 90.8 kDa was isolated from A. officinalis. The repeating structural unit of AOPB-1-1 was identified through monosaccharide composition, methylation analysis, uronic acid reduction, partial ac...
Source: International Journal of Biological Macromolecules - April 17, 2024 Category: Biochemistry Authors: Junqiang Yang Yuechan Liao Chao Cao Qian Yu Dawei Zhang Chunyan Yan Source Type: research
Over-expression of Medicago Acyl-CoA-binding 2 genes enhance salt and drought tolerance in Arabidopsis
In this study, a total of eight ACBP genes were identified in the genome of Medicago truncatula and Medicago sativa, and they were clustered into four sub-families (Class I-IV). Many cis-acting elements related to abiotic response were identified in the promoter region of these ACBP genes, in particular light-responsive elements. These ACBP genes exhibited distinct expression pattern in various tissues, and the expression level of MtACBP1/MsACBP1 and MtACBP2/MsACBP2 gene pairs were significantly increased under NaCl treatment. Subcellular localization analysis showed that MtACBP1/MsACBP1 and MtACBP2/MsACBP2 were localized ...
Source: International Journal of Biological Macromolecules - April 17, 2024 Category: Biochemistry Authors: Wenxuan Du Haijun Huang Weiye Kong Wenbo Jiang Yongzhen Pang Source Type: research
OsATL32 ubiquitinates the reactive oxygen species-producing OsRac5-OsRbohB module to suppress rice immunity
This study provides insights into the molecular mechanism by which the E3 ligase OsATL32 targets a ROS-producing module to undermine rice immunity.PMID:38629772 | DOI:10.1111/jipb.13666 (Source: Journal of Integrative Plant Biology)
Source: Journal of Integrative Plant Biology - April 17, 2024 Category: Biology Authors: Yuqing Yan Hui Wang Yan Bi Jiajing Wang Muhammad Noman Dayong Li Fengming Song Source Type: research
A Structure-Activity Investigation of the Fungal Metabolite (-)-TAN-2483B: Inhibition of Bruton's tyrosine kinase
Chemistry. 2024 Apr 17:e202401051. doi: 10.1002/chem.202401051. Online ahead of print.ABSTRACTThe natural product (-)-TAN-2483B is a fungal secondary metabolite which displays promising anti-cancer and immunomodulatory activity. Our previous syntheses of (-)-TAN-2483B and sidechain analogues uncovered inhibitory activity against Bruton's tyrosine kinase (Btk), an established drug target for various leukaemia and immunological diseases. A structure-based computational study using ensemble docking and molecular dynamics was performed to determine plausible binding modes for (-)-TAN-2483B and analogues in the Btk binding site...
Source: Chemistry - April 17, 2024 Category: Chemistry Authors: Jordan McCone Paul H Teesdale-Spittle Jack U Flanagan Joanne E Harvey Source Type: research
Phthalates and substitute plasticizers: Main achievements from the European human biomonitoring initiative HBM4EU
Int J Hyg Environ Health. 2024 Apr 16;259:114378. doi: 10.1016/j.ijheh.2024.114378. Online ahead of print.ABSTRACTPhthalates and the substitute plasticizer DINCH belong to the first group of priority substances investigated by the European Human Biomonitoring Initiative (HBM4EU) to answer policy-relevant questions and safeguard an efficient science-to-policy transfer of results. Human internal exposure levels were assessed using two data sets from all European regions and Israel. The first collated existing human biomonitoring (HBM) data (2005-2019). The second consisted of new data generated in the harmonized "HBM4EU Alig...
Source: International Journal of Hygiene and Environmental health - April 17, 2024 Category: Environmental Health Authors: Antje Gerofke Rosa Lange Nina Vogel Phillipp Schmidt Till Weber Madlen David Hanne Frederiksen Kirsten Baken Eva Govarts Liese Gilles Laura Rodriguez Martin Žanna Martinsone Tiina Santonen Greet Schoeters Martin Scheringer Elena Dom ínguez-Romero Marta Source Type: research
The Role of Edible Bulbous Layers on Macro, Micro, and Heavy Metal Contents of Leek (Allium porrum) Plant
In this study, the degree of accumulation of biogenic element and heavy metal contents of different parts and edible layers of leeks cultivated in Konya in Turkey was revealed. The amounts of P and K of leek were determined from 154.69 (leaf top of leek) and 985.05 mg/kg (root of leek) to 1377.63 (onion part of leek) and 2688.50 mg/kg (root of leek), respectively. P and K contents of leek layers changed from 139.45 (1st layer) and 446.63 mg/kg (7th layer) to 1596.69 (2nd layer) and 2201.53 mg/kg (4th layer), respectively. While Ca amounts of leek parts vary between 577.09 (leaf of leek) and 666.87 mg/kg (root of leek), Mg ...
Source: Biological Trace Element Research - April 17, 2024 Category: Biology Authors: Fahad AlJuhaimi Duygu Ak çay Kulluk Isam A Mohamed Ahmed Fatma G ökmen Yılmaz Emad Karrar Mehmet Musa Özcan Source Type: research
Comparison of Limb Loading Characteristics and Subjective Functional Outcomes Between Sexes Following ACLR
CONCLUSION: Individuals approximately five months following ACLR, on average, offloaded their ACLR limb compared to the contralateral limb. Patients' tendency to offload their weight during a squat was influenced by sex. Relationships between limb loading metrics and PROs indicate patients who load their limbs disproportionately have a lower perception in their capability to complete activities of daily living and lower subjective knee function.PMID:38629487 | DOI:10.4085/1062-6050-0534.23 (Source: J Athl Train)
Source: J Athl Train - April 17, 2024 Category: Sports Medicine Authors: Dr Amelia S Bruce Leicht Mr Xavier D Thompson Dr Robin M Queen Dr Jordan Rodu Dr Michael J Higgins Dr Kevin M Cross Dr Brian C Werner Dr Jacob E Resch Dr Joe M Hart Source Type: research
Coping strategies of intensive care unit nurses reducing moral distress: A content analysis study
DISCUSSION: The intensive care unit nurses in dealing with ethical problems first try to solve the problem through discussion, but when they fail to resolve it peacefully, they resort to several coping strategies. Factors, such as increasing experience, lack of support from hospital managers and officials, poor communication between colleagues, the need to maintain hierarchy, fear of reprimand, and a sense of powerlessness, changed the nurses' preferred strategies. It is important for managers to provide a blame/punishment-free atmosphere for expression of ethical experiences; a supportive atmosphere in which staff can eng...
Source: Nursing Ethics - April 17, 2024 Category: Nursing Authors: Maryam Esmaeili Mojdeh Navidhamidi Saeideh Varasteh Source Type: research
Effects of < em > Crocus sativus < /em > and its constituent, safranal, and pioglitazone, on systemic inflammation and oxidative stress induced by paraquat aerosol in rats
CONCLUSION: C. sativus and safranal improved inhaled PQ-induced systemic inflammation and oxidative stress similar to those of dexamethasone and showed synergic effects with pioglitazone suggesting the possible PPARγ receptor-mediated effects of the plant and its constituent.PMID:38629099 | PMC:PMC11017852 | DOI:10.22038/IJBMS.2024.72996.15867 (Source: Methods of Information in Medicine)
Source: Methods of Information in Medicine - April 17, 2024 Category: Information Technology Authors: Arghavan Memarzia Seydeh Zahra Ghasemi Fatemeh Amin Zahra Gholamnezhad Mohammad Hossein Boskabady Source Type: research
Public Perception in Saudi Arabia Toward Herpes Zoster and Its Vaccination: A Cross-Sectional Study
Conclusion This study shows a general lack of awareness about HZ and its vaccination in Saudi Arabia, including misconceptions about vaccination availability, recommendations, and the disease's complications. Gender differences in attitude and interest highlight the potential for tailored educational campaigns. Addressing these issues is essential for improving vaccination rates and mitigating HZ's impact.PMID:38628378 | PMC:PMC11019398 | DOI:10.7759/cureus.58360 (Source: Herpes)
Source: Herpes - April 17, 2024 Category: Infectious Diseases Authors: Mohammad S AlKhowailed Hatim M Alotaibi Amwaj S Aljurays Reem A Mohammad Ghadeer M Alqahtani Waleed Al Abdulmonem Ahmed Alhumidi Homaidan T Alhomaidan Fuhaid M Alqossayir Source Type: research
Levels and Health Risk Assessments of Heavy Metals in Khat and Its Support Soil in Algesachi, Ilu Ababor, Ethiopia
CONCLUSION: The hazard index (HI) of metals in khat from study areas was less than 1 indicating a less likelihood of non-carcinogenic toxicological health effects. However, the presence of these toxic chemicals in soil and khat indicates product contamination and needs extensive further investigation involving other heavy metals.PMID:38628468 | PMC:PMC11020725 | DOI:10.1177/11786302241246455 (Source: Environmental Health Insights)
Source: Environmental Health Insights - April 17, 2024 Category: Environmental Health Authors: Shibiru Damana Abiyot Kelecha Geletu Ibrahim Umer Keru Source Type: research
Preclinical models of atherosclerosis: An overview
Iran J Basic Med Sci. 2024;27(5):535-542. doi: 10.22038/IJBMS.2024.74352.16148.ABSTRACTAtherosclerosis is a primary cause of illness and death globally and its mechanism is still unclear. Different animal models have been created to evaluate the progression of atherosclerosis, allowing researchers to carefully control the circumstances of the experiment as well as the nutrition and environmental risk factors. To investigate the negative effects of various interventions, pathophysiological alterations might be generated utilizing genetic or pharmacological methods. These models' molecular and pathophysiological mechanisms h...
Source: Atherosclerosis - April 17, 2024 Category: Cardiology Authors: Priyanka Arya Vikram Sharma Surabhi Thapliyal Rahul Sagar Priyanka Singh Source Type: research
Internuclear ophthalmoplegia following radial artery cardiac catheterization approach: An unusual presentation
We report a rare case in a 47-year-old man presenting with diplopia after radial artery angioplasty. Although the symptoms were resolved after 60 days, diagnosing this obstacle is necessary to reduce the patient and physician's anxiety.PMID:38628413 | PMC:PMC11017003 | DOI:10.4103/sjopt.sjopt_2_23 (Source: Atherosclerosis)
Source: Atherosclerosis - April 17, 2024 Category: Cardiology Authors: Seyed H Daryabari Seyed A Mosavi Seyed H Sharoubandi Hooman Zarei Source Type: research
Comparison of Limb Loading Characteristics and Subjective Functional Outcomes Between Sexes Following ACLR
CONCLUSION: Individuals approximately five months following ACLR, on average, offloaded their ACLR limb compared to the contralateral limb. Patients' tendency to offload their weight during a squat was influenced by sex. Relationships between limb loading metrics and PROs indicate patients who load their limbs disproportionately have a lower perception in their capability to complete activities of daily living and lower subjective knee function.PMID:38629487 | DOI:10.4085/1062-6050-0534.23 (Source: Journal of Athletic Training)
Source: Journal of Athletic Training - April 17, 2024 Category: Sports Medicine Authors: Dr Amelia S Bruce Leicht Mr Xavier D Thompson Dr Robin M Queen Dr Jordan Rodu Dr Michael J Higgins Dr Kevin M Cross Dr Brian C Werner Dr Jacob E Resch Dr Joe M Hart Source Type: research
Outcomes and predictors of left ventricle recovery in patients with severe left ventricular dysfunction undergoing transcatheter aortic valve implantation
CONCLUSIONS: LV recovery following TAVI and the extent of this recovery are major determinants of midterm mortality in patients with severe AS and severe LV dysfunction undergoing TAVI. Patients with no previous MI and those with an mAVG >40 mmHg show the best results following TAVI, which are at least equivalent to those for patients without severe LV dysfunction. (ClinicalTrials.gov: NCT04031274).PMID:38629416 | DOI:10.4244/EIJ-D-23-00948 (Source: EuroIntervention)
Source: EuroIntervention - April 17, 2024 Category: Cardiovascular & Thoracic Surgery Authors: Guy Witberg Amos Levi Yeela Talmor-Barkan Marco Barbanti Roberto Valvo Giuliano Costa Valentina Frittitta Ole de Backer Yannick Willemen Mark van Der Dorpel Matias Mon Atsushi Sugiura Mitsumasa Sudo Giulia Masiero Edoardo Pancaldi Dabit Arzamendi Sandra S Source Type: research
